Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease

Movement Disorders

Volumn 13, Issue 3, 1998, Pages 383-393

  Kordower, Jeffrey H ^a   Freeman, Thomas B ^b   Chen, Er Yun ^a   Mufson, Elliott J ^a   Sanberg, Paul R ^b   Hauser, Robert A ^b   Snow, Barry ^c   Olanow, C Warren ^d  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Nigral; Transplant; Tyrosine hydroxylase innervation

Indexed keywords

TYROSINE 3 MONOOXYGENASE;

AGED; ARTICLE; AUTOPSY; CASE REPORT; DAILY LIFE ACTIVITY; DISEASE COURSE; DYSKINESIA; FEMALE; FETAL TISSUE TRANSPLANTATION; GRAFT SURVIVAL; HUMAN; IMMUNOREACTIVITY; INNERVATION; MOTOR PERFORMANCE; NIGRONEOSTRIATAL SYSTEM; PARKINSON DISEASE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUTAMEN; REINNERVATION; RIGHT HEMISPHERE;

BRAIN TISSUE TRANSPLANTATION; CORPUS STRIATUM; FEMALE; FETAL TISSUE TRANSPLANTATION; FOLLOW-UP STUDIES; GESTATIONAL AGE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOENZYME TECHNIQUES; MIDDLE AGED; NERVE REGENERATION; NEUROLOGIC EXAMINATION; PARKINSON DISEASE; PUTAMEN; SUBSTANTIA NIGRA; TISSUE SURVIVAL; TOMOGRAPHY, EMISSION-COMPUTED; TYROSINE 3-MONOOXYGENASE;

EID: 0031922226     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/mds.870130303     Document Type: Article

References (30)

1. Kordower JH, Freeman TB, Snow BJ, et al. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N Engl J Med 1995;332:1118-1124.
2. Hitchcock EH, Whitwell HL, Sofroniew MV, Bankiewicz KS. Survival of TH-positive and neuromelanin-containing cells in patients with Parkinson's disease after intrastriatal grafting of fetal ventral mesencephalon [Abstract]. Exp Neurol 1994;129:3.
3. Redmond DE Jr, Leranth C, Spencer DD, et al. Fetal graft survival. Lancet 1990;336:820-821.
4. Folkerth RD, Durso R. Survival and proliferation of non-neural tissues with obstruction of cerebral ventricle in a parkinsonian patient treated with fetal allografts. Neurology 1996;46:1219-1225.
5. Olanow CW, Kordower JH, Freeman TB. Fetal nigral transplantation for the treatment of Parkinson's disease. Trends Neurosci 1996;19:102-109.
6. Collier TJ, Kordower JH. Fetal nigral transplants for Parkinson's disease: a preclinical and clinical prospectus. In: Koller WC. Paulson G, eds. Therapeutic Approaches to Parkinson's Disease. New York, NY: Marcel Dekker, 1994:403-421.
7. Freeman TB, Olanow CW, Hauser RA, et al. Bilateral fetal nigral transplantation into the post-commissural putamen as a treatment for Parkinson's disease: six month follow-up. Ann Neurol 1995; 38:379-388.
8. Freed CR, Breeze RE, Rosenberg NL, et al. Transplantation of human fetal dopamine cells for Parkinson's disease. Results at one year. Arch Neurol 1990;47:505-512.
9. Freed CR, Breeze RE, Rosenberg NL, et al. Survival of implanted fetal dopamine cells and neurological improvement 12 to 46 months after transplantation for Parkinson's disease. N Engl J Med 1992;327:1549-1552.
10. Lindvall O, Brundin P, Widner H, et al. Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. Science 1990;247:574-577.
11. Lindvall O, Widner H, Rechrona S, et al. Transplantation of fetal dopamine neurons in Parkinson's disease: one-year clinical and neurophysiological observations in two patients with putaminal implants. Ann Neurol 1992;31:155-165.
12. Lindvall O, Sawle G, Widner H, et al. Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease. Ann Neurol 1994;35:172-180.
13. Peschanski M, Defer G, N'Guyen JP, et al. Bilateral motor improvement and alteration of L-dopa effect in two patients with Parkinson's disease following intrastriatal transplantation of fetal ventral mesencephaion. Brain 1994;117:487-499.
14. Spencer DD, Robbins RJ, Naftolin F, et al. Unilateral transplantation of human fetal mesencephalic tissue into the caudate nucleus of patients with Parkinson's disease. N Engl J Med 1992;327: 1541-1544.
15. Widner H, Tetrud J, Rechrona S, et al. Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP). N Engl J Med 1992;327:1556-1558.
16. Olanow CW, Freeman TB, Kordower JH. Fetal grafting for Parkinson's disease. In: Obeso J, DeLong M, eds. Advances in Neurology. New York, NY: Plenum Press, 1997. In press.
17. Hauser RA, Freeman TB, Kordower JH, et al. Fetal nigral transplantation for Parkinson's disease: 12-24 month evaluation [Abstract]. American Society for Neural Transplantation 1996;3:16.
18. Kordower JH, Rosenstein JM, Collier TJ, et al. Functional fetal nigral grafts in a patient with Parkinson's disease: chemoanatomic, ultrastructural, and metabolic studies. J Comp Neurol 1996;370: 203-230.
19. Langston JW, Widner H, Goetz CG, et al. Core assessment program for intracerebral transplantation (CAPIT). Mov Disord 1992; 7:2-13.
20. Vingerhoets FJG, Snow BJ, Schulzer M, et al. Reproducibility of fluorine-18-6-fluorodopa positron emission tomography in normal human subjects. J Nucl Med 1994;35:18-24.
21. Vingerhoets FJG, Schulzer M, Snow BJ, et al. Reproducibility of the fluorodopa PET indices in Parkinson's disease [Abstract]. Mov Disord 1994;9(suppl):119.
22. Abercrombie M. Estimation of nuclear population from microtome sections. Anat Rec 1946;94:239-247.
23. Pakkenberg BA, Moller HJ, Gundersen A, Mouritzen-Dam D, Pakkenberg H. The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method. J Neurol Neurosurg Psychiatry 1991;54:30-33.
24. Benabid AL, Pollak P, Seigneuret E, Hoffmann D, Gay E, Perret J. Chronic VIM thalamic stimulation in Parkinson's disease, essential tremor and extra-pyramidal dyskinesias. Acta Neurochir Suppl 1993;58:39-44.
25. Lang AE, Lozano A, Duff J, et al. Medial pallidotomy in late-stage Parkinson's disease and striatonigral degeneration. Adv Neurol 1997;74:199-211.
26. Kordower JH, Styren S, Clarke M, De Kosky ST, Olanow CW, Freeman TB. Fetal grafting for Parkinson's disease: expression of immune markers in two patients with functional fetal nigral grafts. Cell Transplant 1997;6:213-219.
27. Duan WM, Widner H, Frodl EM, Brundin P. Immune reactions following systemic immunization prior or subsequent to intrastriatal transplantation of allogeneic mesencephalic tissue in adult rats. Neuroscience 1995;64:629-641.
28. Freeman T, Sanberg PR, Nauert GM, et al. The influence of donor age on the survival of solid and suspension intraparenchymal human embryonic nigral grafts. Cell Transplant 1995;4:141-154.
29. Collier TJ, Gallagher MJ, Sladek CD. Cryopreservation and storage of embryonic rat mesencephalic dopamine neurons for one year: comparison to fresh tissue in culture and neural grafts. Brain Res 1993;623:249-257.
30. Freeman TB, Kordower JH. Human cadaver embryonic substantia nigra grafts: ontogeny, preoperative graft preparation and tissue storage. In: Lindvall O, Björklund A, Widner H, eds. Intracerebral Transplantation in Movement Disorders. New York, NY: Elsevier Press, 1991:163-170.