Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 9, 2012, Pages 3063-3066

  Balboni, Gianfranco ^a   Congiu, Cenzo ^a   Onnis, Valentina ^a   Maresca, Alfonso ^b   Scozzafava, Andrea ^b   Winum, Jean Yves ^c   Maietti, Annalisa ^d   Supuran, Claudiu T ^b  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c INSTITUT CHARLES GERHARDT   (France)

^d UNIVERSITY OF FERRARA   (Italy)

Author keywords

Carbonic anhydrase; Coumarin; Flavone; Inhibitor; Resveratrol

Indexed keywords

CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE III; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IV; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE V; CARBONATE DEHYDRATASE VI; CARBONATE DEHYDRATASE VII; CARBONATE DEHYDRATASE XII; CARBONATE DEHYDRATASE XIII; CARBONATE DEHYDRATASE XIV; CHROMENE DERIVATIVE; COUMARIN DERIVATIVE; FLAVONE DERIVATIVE; LACTONE DERIVATIVE; RESVERATROL; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; MOUSE; NONHUMAN;

BENZOPYRANS; CARBONIC ANHYDRASE INHIBITORS; COUMARINS; FLAVONES; HUMANS; HYDROXYLATION; PROTEIN ISOFORMS; STRUCTURE-ACTIVITY RELATIONSHIP;

MAMMALIA; MURINAE;

EID: 84859843439     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.03.071     Document Type: Article

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