Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties

Biochemistry

Volumn 48, Issue 6, 2009, Pages 1322-1331

  Genis, Caroli ^a   Sippel, Katherine H ^a   Case, Nicolette ^a   Cao, Wengang ^a   Avvaru, Balendu Sankara ^a   Tartaglia, Lawrence J ^a   Govindasamy, Lakshmanan ^a   Tu, Chingkuang ^a   Agbandje McKenna, Mavis ^a   Silverman, David N ^a   Rosser, Charles J ^a   McKenna, Robert ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITES; ANTICANCER PROPERTIES; CARBONIC ANHYDRASE; CARBONIC ANHYDRASE II; CONFORMATIONAL CHANGES; CYTOTOXIC; CYTOTOXICITY ASSAYS; DOUBLE MUTANTS; DRUG TARGETS; EXTRA CELLULAR MATRICES; IN-VITRO; OVER EXPRESSIONS; POTENT INHIBITORS; PROSTATE CANCER CELLS; RATIONAL DESIGNS; SELECTIVE TREATMENTS; STRUCTURAL INFORMATIONS; STRUCTURAL STUDIES; STRUCTURE-ACTIVITY RELATIONSHIPS; THERAPEUTIC TREATMENTS; X-RAY CRYSTAL STRUCTURES; X-RAY CRYSTALLOGRAPHIES;

BINDING SITES; ENZYME INHIBITION; STRUCTURAL DESIGN; SULFUR COMPOUNDS; X RAY CRYSTALLOGRAPHY;

CRYSTAL STRUCTURE;

ACETAZOLAMIDE; BENZOLAMIDE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE IX; CHLORZOLAMIDE; ETHOXZOLAMIDE; METHAZOLAMIDE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG DESIGN; DRUG INHIBITION; ENZYME ACTIVE SITE; HUMAN; IN VITRO STUDY; KINETICS; MUTANT; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; KINETICS; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS C-BCL-2; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 64349112165     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi802035f     Document Type: Article

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