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Volumn 33, Issue 1, 2013, Pages 1-18

Scleroderma therapy: Clinical overview of current trends and future perspective

Author keywords

Antifibrotics; Immunomodulators; Scleroderma; Vasoactive drugs

Indexed keywords

AMBRISENTAN; AMLODIPINE; ANTIFIBROTIC AGENT; ANTIOXIDANT; BERAPROST; BOSENTAN; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN RECEPTOR ANTAGONIST; FLUOXETINE; GLYCERYL TRINITRATE; ILOPROST; IMMUNOMODULATING AGENT; LOSARTAN; NICARDIPINE; NIFEDIPINE; PRAZOSIN; PROSTACYCLIN; PROSTACYCLIN DERIVATIVE; PROSTANOID; SILDENAFIL; SITAXSENTAN; TADALAFIL; TELMISARTAN; TREPROSTINIL; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNINDEXED DRUG; VARDENAFIL; VASODILATOR AGENT;

EID: 84872339710     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-012-2486-1     Document Type: Review
Times cited : (14)

References (169)
  • 1
    • 0027518266 scopus 로고
    • A radical proposal for the pathogenesis of scleroderma
    • 8425975 1:STN:280:DyaK3s7ksleitg%3D%3D
    • Murrell DF (1993) A radical proposal for the pathogenesis of scleroderma. J Am Acad Dermatol 28:78-85
    • (1993) J Am Acad Dermatol , vol.28 , pp. 78-85
    • Murrell, D.F.1
  • 2
    • 33645766009 scopus 로고    scopus 로고
    • Lipid peroxidation and trace elements in systemic sclerosis
    • 16249831
    • Tikly M, Channa K, Theodorou P et al (2006) Lipid peroxidation and trace elements in systemic sclerosis. Clin Rheumatol 25:320-324
    • (2006) Clin Rheumatol , vol.25 , pp. 320-324
    • Tikly, M.1    Channa, K.2    Theodorou, P.3
  • 3
    • 0028026729 scopus 로고
    • Micronutrient antioxidant status in patients with primary Raynaud's phenomenon and systemic sclerosis
    • Herrick AL, Rieley F, Schofield D et al (1992) Micronutrient antioxidant status in patients with primary Raynaud's phenomenon and systemic sclerosis. J Rheumatol 21:1477-1483
    • (1992) J Rheumatol , vol.21 , pp. 1477-1483
    • Herrick, A.L.1    Rieley, F.2    Schofield, D.3
  • 4
    • 0028866373 scopus 로고
    • Increased prevalence of symptomatic macrovascular disease in systemic sclerosis
    • 7492228 1:STN:280:DyaK28%2FpslOgsg%3D%3D
    • Veale DJ, Collidge TA, Belch J (1995) Increased prevalence of symptomatic macrovascular disease in systemic sclerosis. Ann Rheum Dis 54:853-855
    • (1995) Ann Rheum Dis , vol.54 , pp. 853-855
    • Veale, D.J.1    Collidge, T.A.2    Belch, J.3
  • 5
    • 0034082712 scopus 로고    scopus 로고
    • Macrovascular disease in systemic sclerosis
    • 10627425 1:STN:280:DC%2BD3c%2FpsVKjtg%3D%3D
    • Ho M, Veale DJ, Eastmond C et al (2000) Macrovascular disease in systemic sclerosis. Ann Rheum Dis 59:39-43
    • (2000) Ann Rheum Dis , vol.59 , pp. 39-43
    • Ho, M.1    Veale, D.J.2    Eastmond, C.3
  • 6
    • 32644443487 scopus 로고    scopus 로고
    • Accelerated atherosclerosis in autoimmune rheumatic diseases
    • 16301360
    • Shoenfeld Y, Gerli R, Doria A et al (2005) Accelerated atherosclerosis in autoimmune rheumatic diseases. Circulation 112:3337-3347
    • (2005) Circulation , vol.112 , pp. 3337-3347
    • Shoenfeld, Y.1    Gerli, R.2    Doria, A.3
  • 7
    • 32644437182 scopus 로고    scopus 로고
    • Mechanisms of disease: Atherosclerosis in autoimmune diseases
    • Sherer Y, Shoenfeld Y (2006) Mechanisms of disease: atherosclerosis in autoimmune diseases. Nat Clin Pract Rheumatol 2:1-8
    • (2006) Nat Clin Pract Rheumatol , vol.2 , pp. 1-8
    • Sherer, Y.1    Shoenfeld, Y.2
  • 8
    • 0029905937 scopus 로고    scopus 로고
    • Systemic sclerosis: A vascular perspective
    • 1:STN:280:DyaK2s%2Fot1enug%3D%3D
    • LeRoy CE (1996) Systemic sclerosis: a vascular perspective. Rheum Dis Clin N Am 22:675
    • (1996) Rheum Dis Clin N Am , vol.22 , pp. 675
    • Leroy, C.E.1
  • 9
    • 33646712863 scopus 로고    scopus 로고
    • Macrovascular disease in systemic sclerosis
    • Furst D, Clements P (eds) Lippincott Williams and Wilkins, Baltimore
    • Matucci Cerinic M, Fiori G, Grenbaum E et al (2003) Macrovascular disease in systemic sclerosis. In: Furst D, Clements P (eds) Systemic sclerosis. Lippincott Williams and Wilkins, Baltimore
    • (2003) Systemic Sclerosis
    • Matucci Cerinic, M.1    Fiori, G.2    Grenbaum, E.3
  • 10
    • 34547485497 scopus 로고    scopus 로고
    • Relationship between change in skin score and disease outcome in diffuse cutaneous systemic sclerosis: Application of a latent linear trajectory model
    • 17599771
    • Shand L, Lunt M, Nihtyanova S et al (2007) Relationship between change in skin score and disease outcome in diffuse cutaneous systemic sclerosis: application of a latent linear trajectory model. Arthritis Rheum 56:2422-2431
    • (2007) Arthritis Rheum , vol.56 , pp. 2422-2431
    • Shand, L.1    Lunt, M.2    Nihtyanova, S.3
  • 11
    • 66149100618 scopus 로고    scopus 로고
    • EULAR recommendations for the treatment of systemic sclerosis: A report from the EULAR Scleroderma Trials and Research group (EUSTAR)
    • Kowal-Bielecka O, Landewe′ R, Avouac J et al (2009) EULAR recommendations for the treatment of systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group (EUSTAR). Ann Rheum Dis 68:620-628
    • (2009) Ann Rheum Dis , vol.68 , pp. 620-628
    • Kowal-Bielecka O, L.1
  • 12
    • 0031886413 scopus 로고    scopus 로고
    • Increased expression of TGF-beta receptors by scleroderma fibroblasts: Evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype
    • 9424086 1:CAS:528:DyaK1cXjslKhug%3D%3D
    • Kawakami T, Ihn H, Xu W et al (1998) Increased expression of TGF-beta receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype. J Invest Dermatol 110(1):47-51
    • (1998) J Invest Dermatol , vol.110 , Issue.1 , pp. 47-51
    • Kawakami, T.1    Ihn, H.2    Xu, W.3
  • 13
    • 33748551701 scopus 로고    scopus 로고
    • Scar wars: Is TGFbeta the phantom menace in scleroderma?
    • 16774692
    • Leask A (2006) Scar wars: is TGFbeta the phantom menace in scleroderma? Arthritis Res Ther 8(4):213
    • (2006) Arthritis Res Ther , vol.8 , Issue.4 , pp. 213
    • Leask, A.1
  • 14
    • 84872299059 scopus 로고    scopus 로고
    • Profibrotic Wnt signaling in human mesenchymal cells: Implications for scleroderma
    • Abstract Supplement
    • Wei, Jun, Leng et al (2009) Profibrotic Wnt signaling in human mesenchymal cells: implications for scleroderma. Arthritis Rheumatism, vol 60, Abstract Supplement
    • (2009) Arthritis Rheumatism , vol.60
    • Wei1    Jun2    Leng3
  • 15
    • 40649105572 scopus 로고    scopus 로고
    • Increased expression of Wnt2 and SFRP4 in Tsk Mouse Skin: Role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis
    • Julie B, Jennifer F, Kimberly J et al (2008) Increased expression of Wnt2 and SFRP4 in Tsk Mouse Skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis. J Investigat Dermatol 128:871-881
    • (2008) J Investigat Dermatol , vol.128 , pp. 871-881
    • Julie, B.1    Jennifer, F.2    Kimberly, J.3
  • 16
    • 44849130732 scopus 로고    scopus 로고
    • CD19 Regulates skin and lung fibrosis via toll-like receptor signaling in a model of Bleomycin-induced scleroderma
    • Ayumi Y, Yohei I, Kazuhiro K et al (2008) CD19 Regulates skin and lung fibrosis via toll-like receptor signaling in a model of Bleomycin-induced scleroderma. Am J Pathol 172(6):1650-1663
    • (2008) Am J Pathol , vol.172 , Issue.6 , pp. 1650-1663
    • Ayumi, Y.1    Yohei, I.2    Kazuhiro, K.3
  • 17
    • 57349109321 scopus 로고    scopus 로고
    • Antifibroblast antibodies in systemic sclerosis induce fibroblasts to produce profibrotic chemokines, with partial exploitation of toll-like receptor 4
    • Fineschi S, Goffin L, Rezzonico R et al (2008) Antifibroblast antibodies in systemic sclerosis induce fibroblasts to produce profibrotic chemokines, with partial exploitation of toll-like receptor 4. Arthritis Rheum 58(12):3913-3923
    • (2008) Arthritis Rheum , vol.58 , Issue.12 , pp. 3913-3923
    • Fineschi, S.1    Goffin, L.2    Rezzonico, R.3
  • 18
    • 78651068822 scopus 로고    scopus 로고
    • Toll-like receptor 3 upregulation by type i interferon in healthy and scleroderma dermal fibroblasts
    • Agarwal SK, Wu M, Livingston CK (2011) Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts. Arthritis Res Therapy 13:R3
    • (2011) Arthritis Res Therapy , vol.13
    • Agarwal, S.K.1    Wu, M.2    Livingston, C.K.3
  • 19
    • 0023722228 scopus 로고
    • Cutaneous hypoxia in patients with systemic sclerosis (Scleroderma)
    • 3415281 1:STN:280:DyaL1czisFGnsQ%3D%3D
    • Silverstein JL, Steen VD, Medsger TA et al (1988) Cutaneous hypoxia in patients with systemic sclerosis (Scleroderma). Arch Dermatol 124(9):1379-1382
    • (1988) Arch Dermatol , vol.124 , Issue.9 , pp. 1379-1382
    • Silverstein, J.L.1    Steen, V.D.2    Medsger, T.A.3
  • 20
    • 33750083588 scopus 로고    scopus 로고
    • Hypoxia induces expression of connective tissue growth factor in scleroderma skin fibroblasts
    • 17034590 1:CAS:528:DC%2BD28XhtlCgtLfE
    • Hong K-H, Yoo S-A, Kang S-S et al (2006) Hypoxia induces expression of connective tissue growth factor in scleroderma skin fibroblasts. Clin Exp Immunol 146(2):362-370
    • (2006) Clin Exp Immunol , vol.146 , Issue.2 , pp. 362-370
    • Hong, K.-H.1    Yoo, S.-A.2    Kang, S.-S.3
  • 21
    • 0036346511 scopus 로고    scopus 로고
    • Mechanical stress is required for high-level expression of connective tissue growth factor
    • Schild C, Trueb B (2002) Mechanical stress is required for high-level expression of connective tissue growth factor. Exp Cell Res 274(1):83-91
    • (2002) Exp Cell Res , vol.274 , Issue.1 , pp. 83-91
    • Schild, C.1    Trueb, B.2
  • 22
    • 79952037889 scopus 로고    scopus 로고
    • Fibrosis in systemic sclerosis: Emerging concepts and implications for targeted therapy
    • 20863909 1:CAS:528:DC%2BC3cXis1ShsLs%3D
    • Wei J, Bhattacharyya S, Tourtellotte WG, Varga J (2010) Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy. Autoimmun Rev 10(5):267-275
    • (2010) Autoimmun Rev , vol.10 , Issue.5 , pp. 267-275
    • Wei, J.1    Bhattacharyya, S.2    Tourtellotte, W.G.3    Varga, J.4
  • 24
    • 0032929924 scopus 로고    scopus 로고
    • Activation of microvascular pericytes in autoimmune Raynaud's phenomenon and systemic sclerosis
    • 10323448 1:CAS:528:DyaK1MXjtlKjur0%3D
    • Rajkumar VS, Sundberg C, Abraham DJ, Rubin K, Black CM (1999) Activation of microvascular pericytes in autoimmune Raynaud's phenomenon and systemic sclerosis. Arthritis Rheum 42:930-941
    • (1999) Arthritis Rheum , vol.42 , pp. 930-941
    • Rajkumar, V.S.1    Sundberg, C.2    Abraham, D.J.3    Rubin, K.4    Black, C.M.5
  • 25
    • 0026604019 scopus 로고
    • Sequential dermal microvascular and perivascular changes in the development of scleroderma
    • 1517881 1:STN:280:DyaK38zovFSrtw%3D%3D
    • Prescott RJ, Freemont AJ, Jones CJP et al (1992) Sequential dermal microvascular and perivascular changes in the development of scleroderma. J Pathol 166:255-263
    • (1992) J Pathol , vol.166 , pp. 255-263
    • Prescott, R.J.1    Freemont, A.J.2    Jones, C.J.P.3
  • 26
    • 0034881398 scopus 로고    scopus 로고
    • Calcium-channel blockers for Raynaud's phenomenon in systemic sclerosis
    • 11508437 1:CAS:528:DC%2BD38XpvFw%3D
    • Thompson AE, Shea B, Welch V, Fenlon D, Pope JE (2001) Calcium-channel blockers for Raynaud's phenomenon in systemic sclerosis. Arthritis Rheum 44:1841-1847
    • (2001) Arthritis Rheum , vol.44 , pp. 1841-1847
    • Thompson, A.E.1    Shea, B.2    Welch, V.3    Fenlon, D.4    Pope, J.E.5
  • 28
    • 0026348794 scopus 로고
    • Double-blind placebo-controlled crossover study of oral nicardipine in the treatment of Raynaud's phenomenon
    • 1725892 1:STN:280:DyaK383lt1emsg%3D%3D
    • Wollersheim H, Thien T (1991) Double-blind placebo-controlled crossover study of oral nicardipine in the treatment of Raynaud's phenomenon. J Cardiovasc Pharmacol 18:813-818
    • (1991) J Cardiovasc Pharmacol , vol.18 , pp. 813-818
    • Wollersheim, H.1    Thien, T.2
  • 29
    • 0024394309 scopus 로고
    • The clinical effect of felodipine and nifedipine in Raynaud's phenomenon
    • 2676559 1:STN:280:DyaK3c%2FgsFKjsg%3D%3D
    • Schmidt JF, Valentin N, Neilsen SL (1989) The clinical effect of felodipine and nifedipine in Raynaud's phenomenon. Eur J Clin Pharmacol 37:191-192
    • (1989) Eur J Clin Pharmacol , vol.37 , pp. 191-192
    • Schmidt, J.F.1    Valentin, N.2    Neilsen, S.L.3
  • 30
    • 0030742362 scopus 로고    scopus 로고
    • Amlodipine in the treatment of Raynaud's phenomenon. A double-blind placebo-controlled crossover study
    • La Civita L, Pitaro N, Rossi M et al (1997) Amlodipine in the treatment of Raynaud's phenomenon. A double-blind placebo-controlled crossover study. Clin Drug Invest 13:126-131
    • (1997) Clin Drug Invest , vol.13 , pp. 126-131
    • La Civita, L.1    Pitaro, N.2    Rossi, M.3
  • 31
    • 0021959733 scopus 로고
    • A randomised double-blind trial of diltiazem in the treatment of Raynaud's phenomenon
    • Kahan A, Amor B, Menkes CJ (1985) A randomised double-blind trial of diltiazem in the treatment of Raynaud's phenomenon. Ann Rheumat Dis 44:30-33
    • (1985) Ann Rheumat Dis , vol.44 , pp. 30-33
    • Kahan, A.1    Amor, B.2    Menkes, C.J.3
  • 32
    • 0023391477 scopus 로고
    • Inefficacy of diltiazem in the treatment of Raynaud's phenomenon with associated connective tissue disease: A double blind placebo controlled study
    • Da costa J, Gomesja, Espirito Santo J et al (1987) Inefficacy of diltiazem in the treatment of Raynaud's phenomenon with associated connective tissue disease: a double blind placebo controlled study. J Rheumatol 14:858-859
    • (1987) J Rheumatol , vol.14 , pp. 858-859
    • Da Costa, J.1    Gomesja2    Espirito Santo, J.3
  • 33
    • 0020062994 scopus 로고
    • The treatment of severe Raynaud's phenomenon with verapamil
    • Kinney EL, Nicholas GG, Gallo J (1982) The treatment of severe Raynaud's phenomenon with verapamil. J Clin Pharmacol 22(1):74-76
    • (1982) J Clin Pharmacol , vol.22 , Issue.1 , pp. 74-76
    • Kinney, E.L.1    Nicholas, G.G.2    Gallo, J.3
  • 34
    • 16644379903 scopus 로고    scopus 로고
    • Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor 1
    • Allanore Y, Borderie D, Lemaréchal H, Ekindjian OG, Kahan A (2004) Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor 1. Arthritis Res Ther 6:R309-R314
    • (2004) Arthritis Res Ther , vol.6
    • Allanore Y, B.1
  • 36
    • 0031947367 scopus 로고    scopus 로고
    • Oral iloprost treatment in patients with Raynaud's phenomenon secondary to systemic sclerosis: A multicenter, placebo-controlled, double-blind study
    • 9550476 1:CAS:528:DyaK1cXislektr8%3D
    • Wigley FM, Korn JH, Csuka ME, Medsger TA Jr, Rothfield NF, Ellman M et al (1998) Oral iloprost treatment in patients with Raynaud's phenomenon secondary to systemic sclerosis: a multicenter, placebo-controlled, double-blind study. Arthritis Rheum 41:670-677
    • (1998) Arthritis Rheum , vol.41 , pp. 670-677
    • Wigley, F.M.1    Korn, J.H.2    Csuka, M.E.3    Medsger, Jr.T.A.4    Rothfield, N.F.5    Ellman, M.6
  • 37
    • 0031663570 scopus 로고    scopus 로고
    • Oral iloprost in Raynaud's phenomenon secondary to systemic sclerosis: A multicentre, placebo-controlled, dose-comparison study
    • 9783759 1:CAS:528:DyaK1cXmvVSgsLY%3D
    • Black CM, Halkier SA, Rensen L, Belch JJ, Ullman S, Madhok R et al (1998) Oral iloprost in Raynaud's phenomenon secondary to systemic sclerosis: a multicentre, placebo-controlled, dose-comparison study. Br J Rheumatol 37:952-960
    • (1998) Br J Rheumatol , vol.37 , pp. 952-960
    • Black, C.M.1    Halkier, S.A.2    Rensen, L.3    Belch, J.J.4    Ullman, S.5    Madhok, R.6
  • 38
    • 0024574059 scopus 로고
    • Comparison of intravenous infusions of iloprost and oral nifedipine in treatment of Raynaud's phenomenon in patients with systemic sclerosis: A double blind randomised study
    • 2467711 1:STN:280:DyaL1M7psVGhug%3D%3D
    • Rademaker M, Cooke ED, Almond NE, Beacham JA, Smith RE, Mant TG et al (1989) Comparison of intravenous infusions of iloprost and oral nifedipine in treatment of Raynaud's phenomenon in patients with systemic sclerosis: a double blind randomised study. BMJ 298:561-564
    • (1989) BMJ , vol.298 , pp. 561-564
    • Rademaker, M.1    Cooke, E.D.2    Almond, N.E.3    Beacham, J.A.4    Smith, R.E.5    Mant, T.G.6
  • 39
    • 0034837756 scopus 로고    scopus 로고
    • Effects of long-term cyclic iloprost therapy in systemic sclerosis with Raynaud's phenomenon. A randomized, controlled study
    • 11579708 1:STN:280:DC%2BD3MrjtlKnsw%3D%3D
    • Scorza R, Caronni M, Mascagni B et al (2001) Effects of long-term cyclic iloprost therapy in systemic sclerosis with Raynaud's phenomenon. A randomized, controlled study. Clin Exp Rheumatol 19:503-508
    • (2001) Clin Exp Rheumatol , vol.19 , pp. 503-508
    • Scorza, R.1    Caronni, M.2    Mascagni, B.3
  • 40
    • 0026722410 scopus 로고
    • Intravenous iloprost treatment of Raynaud's phenomenon and ischemic ulcers secondary to systemic sclerosis
    • 1279170 1:STN:280:DyaK3s%2FlvFSisw%3D%3D
    • Wigley FM, Seibold JR, Wise RA, McCloskey DA, Dole WP (1992) Intravenous iloprost treatment of Raynaud's phenomenon and ischemic ulcers secondary to systemic sclerosis. J Rheumatol 19:1407-1414
    • (1992) J Rheumatol , vol.19 , pp. 1407-1414
    • Wigley, F.M.1    Seibold, J.R.2    Wise, R.A.3    McCloskey, D.A.4    Dole, W.P.5
  • 41
    • 77953142653 scopus 로고    scopus 로고
    • From pathophysiology to novel therapeutic approaches
    • Hunzelmann N, Scleroderma TK (2010) From pathophysiology to novel therapeutic approaches. Exp Dermatol 19:393-400
    • (2010) Exp Dermatol , vol.19 , pp. 393-400
    • Hunzelmann, N.1    Scleroderma, T.K.2
  • 42
    • 0034696634 scopus 로고    scopus 로고
    • Inhaled Iloprost to treat severe pulmonary hypertension. An uncontrolled trial. German PPH study group
    • 10733442 1:CAS:528:DC%2BD3cXit1SmsLw%3D
    • Olschewski H, Ghofrani HA, Schmehl T, Winkler J, Wilkens H, Hoper MM et al (2000) Inhaled Iloprost to treat severe pulmonary hypertension. An uncontrolled trial. German PPH study group. Ann Intern Med 132:435-443
    • (2000) Ann Intern Med , vol.132 , pp. 435-443
    • Olschewski, H.1    Ghofrani, H.A.2    Schmehl, T.3    Winkler, J.4    Wilkens, H.5    Hoper, M.M.6
  • 43
    • 17144452827 scopus 로고    scopus 로고
    • Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized controlled trial
    • 10733441 1:CAS:528:DC%2BD3cXit1SmsL8%3D
    • Badesch DB, Tapson VF, McGoon MD, Brundage BH, Rubin LJ, Wigley FM et al (2000) Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized controlled trial. Ann Intern Med 132:425-434
    • (2000) Ann Intern Med , vol.132 , pp. 425-434
    • Badesch, D.B.1    Tapson, V.F.2    McGoon, M.D.3    Brundage, B.H.4    Rubin, L.J.5    Wigley, F.M.6
  • 44
    • 0037151645 scopus 로고    scopus 로고
    • Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: Prognostic factors and survival
    • 12204511 1:CAS:528:DC%2BD38XntVKjsr0%3D
    • Sitbon O, Humbert M, Nunes H, Parent F, Garcia G, Herve′ P et al (2002) Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival. J Am Coll Cardiol 40:780-788
    • (2002) J Am Coll Cardiol , vol.40 , pp. 780-788
    • Sitbon, O.1    Humbert, M.2    Nunes, H.3    Parent, F.4    Garcia, G.5    Herve, P.6
  • 45
    • 0037126044 scopus 로고    scopus 로고
    • Survival in primary pulmonary hypertension: The impact of epoprostenol therapy
    • 12234951 1:CAS:528:DC%2BD38XntVKksb0%3D
    • McLaughlin VV, Shillington A, Rich S (2002) Survival in primary pulmonary hypertension: the impact of epoprostenol therapy. Circulation 106:1477-1482
    • (2002) Circulation , vol.106 , pp. 1477-1482
    • McLaughlin, V.V.1    Shillington, A.2    Rich, S.3
  • 46
    • 4143121167 scopus 로고    scopus 로고
    • Treprostinil, a prostacyclin analogue, in pulmonary arterial hypertension associated with connective tissue disease
    • 15302727 1:CAS:528:DC%2BD2cXns1CrtbY%3D
    • Oudiz RJ, Schilz RJ, Barst RJ, Galie N, Rich S, Rubin LJ et al (2004) Treprostinil, a prostacyclin analogue, in pulmonary arterial hypertension associated with connective tissue disease. Chest 126:420-427
    • (2004) Chest , vol.126 , pp. 420-427
    • Oudiz, R.J.1    Schilz, R.J.2    Barst, R.J.3    Galie, N.4    Rich, S.5    Rubin, L.J.6
  • 47
    • 0029908392 scopus 로고    scopus 로고
    • Controlled multicenter double blind trial of an oral analog of prostacyclin in the treatment of primary Raynaud's phenomenon
    • 8923366 1:STN:280:DyaK2s%2Fot1WhsQ%3D%3D
    • Vayssairat M (1996) Controlled multicenter double blind trial of an oral analog of prostacyclin in the treatment of primary Raynaud's phenomenon. J Rheumatol 23:1917-1920
    • (1996) J Rheumatol , vol.23 , pp. 1917-1920
    • Vayssairat, M.1
  • 48
    • 0032876554 scopus 로고    scopus 로고
    • Preventive effect of an oral prostacyclin analog, beraprost sodium, on digital necrosis in systemic sclerosis. French Microcirculation Society Multicenter Group for the Study of Vascular Acrosyndromes
    • 10529135 1:CAS:528:DyaK1MXmvFaqt7Y%3D
    • Vayssairat M (1999) Preventive effect of an oral prostacyclin analog, beraprost sodium, on digital necrosis in systemic sclerosis. French Microcirculation Society Multicenter Group for the Study of Vascular Acrosyndromes. J Rheumatol 26(10):2173-2178
    • (1999) J Rheumatol , vol.26 , Issue.10 , pp. 2173-2178
    • Vayssairat, M.1
  • 49
    • 0036569119 scopus 로고    scopus 로고
    • Effects of Beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: A randomized, double-blind, placebo-controlled trial
    • Galie' N, Humbert M, Vachie′ry J-L et al (2002) Effects of Beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial. J Am Coll Cardiol 39:1496-1502
    • (2002) J Am Coll Cardiol , vol.39 , pp. 1496-1502
    • Galie, N.1    Humbert, M.2    Vachiery, J.-L.3
  • 50
    • 36049042221 scopus 로고    scopus 로고
    • Prevention of vascular damage in scleroderma and autoimmune Raynaud's phenomenon: A multicenter, randomized, double-blind, placebo-controlled trial of the angiotensin-converting enzyme inhibitor quinapril
    • 17968938 1:STN:280:DC%2BD2snpvFSntg%3D%3D
    • Gliddon AE, Doré CJ, Black CM (2007) Prevention of vascular damage in scleroderma and autoimmune Raynaud's phenomenon: a multicenter, randomized, double-blind, placebo-controlled trial of the angiotensin-converting enzyme inhibitor quinapril. Arthritis Rheum 56(11):3837-3846
    • (2007) Arthritis Rheum , vol.56 , Issue.11 , pp. 3837-3846
    • Gliddon, A.E.1    Doré, C.J.2    Black, C.M.3
  • 51
    • 0033511724 scopus 로고    scopus 로고
    • Losartan therapy for Raynaud's phenomenon and scleroderma: Clinical and biochemical findings in a fifteen-week, randomized, parallel-group, controlled trial
    • 10616013 1:CAS:528:DC%2BD3cXjslamsg%3D%3D
    • Dziadzio M, Denton CP, Smith R et al (1999) Losartan therapy for Raynaud's phenomenon and scleroderma: clinical and biochemical findings in a fifteen-week, randomized, parallel-group, controlled trial. Arthritis Rheum 42(12):2646-2655
    • (1999) Arthritis Rheum , vol.42 , Issue.12 , pp. 2646-2655
    • Dziadzio, M.1    Denton, C.P.2    Smith, R.3
  • 52
    • 84860122263 scopus 로고    scopus 로고
    • Telmisartan improves endothelial function in scleroderma patients with pulmonary hypertension
    • Yatsyshyn N, Yatsyshyn R, Neyko YE (2010) Telmisartan improves endothelial function in scleroderma patients with pulmonary hypertension. J Hypertens 28:e550
    • (2010) J Hypertens , vol.28
    • Yatsyshyn, N.1    Yatsyshyn, R.2    Neyko, Y.E.3
  • 53
    • 84921430435 scopus 로고    scopus 로고
    • Prazosin for Raynaud's phenomenon in progressive systemic sclerosis
    • Pope J, Fenlon D, Thompson A et al (2000) Prazosin for Raynaud's phenomenon in progressive systemic sclerosis. Cochrane Database Syst Rev 2:CD000956
    • (2000) Cochrane Database Syst Rev , vol.2
    • Pope, J.1    Fenlon, D.2    Thompson, A.3
  • 54
    • 61649118817 scopus 로고    scopus 로고
    • MQX-503, a novel formulation of nitroglycerin, improves the severity of Raynaud's phenomenon
    • Chung L, Shapiro L, Fiorentino D et al (2009) MQX-503, a novel formulation of nitroglycerin, improves the severity of Raynaud's phenomenon. Random Control Trial Arthritis Rheumatism 60(3):870-877
    • (2009) Random Control Trial Arthritis Rheumatism , vol.60 , Issue.3 , pp. 870-877
    • Chung, L.1    Shapiro, L.2    Fiorentino, D.3
  • 55
    • 36849073290 scopus 로고    scopus 로고
    • Sildenafil for pulmonary arterial hypertension associated with connective tissue disease
    • 17985403
    • Badesch DB, Hill NS, Burgess G et al (2007) Sildenafil for pulmonary arterial hypertension associated with connective tissue disease. J Rheumatol 34:2417-2422
    • (2007) J Rheumatol , vol.34 , pp. 2417-2422
    • Badesch, D.B.1    Hill, N.S.2    Burgess, G.3
  • 56
    • 84860148526 scopus 로고    scopus 로고
    • Oral Sildenafil therapy for chinese patients with pulmonary arterial hypertension: A multicenter study
    • PMID 21415281
    • Xiong C-M, Lu X-L, Shan G-L et al (2011) Oral Sildenafil therapy for chinese patients with pulmonary arterial hypertension: a multicenter study. J Clin Pharm, PMID 21415281
    • (2011) J Clin Pharm
    • Xiong, C.-M.1    Lu, X.-L.2    Shan, G.-L.3
  • 57
    • 17644380962 scopus 로고    scopus 로고
    • Sildenafil for pulmonary hypertension
    • 15827074 1:CAS:528:DC%2BD2MXktlOjurY%3D
    • Lee AJ, Chiao TB, Tsang MP (2005) Sildenafil for pulmonary hypertension. Ann Pharmacother 39(5):869-884
    • (2005) Ann Pharmacother , vol.39 , Issue.5 , pp. 869-884
    • Lee, A.J.1    Chiao, T.B.2    Tsang, M.P.3
  • 58
    • 79953696248 scopus 로고    scopus 로고
    • Modified-release sildenafil reduces Raynaud's phenomenon attack frequency in limited cutaneous systemic sclerosis
    • Herrick AL, van den Hoogen F, Gabrielli A et al (2011) Modified-release sildenafil reduces Raynaud's phenomenon attack frequency in limited cutaneous systemic sclerosis. Arthritis Rheumatism 63(3):775-782
    • (2011) Arthritis Rheumatism , vol.63 , Issue.3 , pp. 775-782
    • Herrick, A.L.1    Van Den Hoogen, F.2    Gabrielli, A.3
  • 59
    • 77955460984 scopus 로고    scopus 로고
    • Effect of sildenafil on digital ulcers in systemic sclerosis: Analysis from a single centre pilot study
    • 19900936 1:CAS:528:DC%2BC3cXhtVykt7fE
    • Brueckner CS, Becker MO, Kroencke T (2010) Effect of sildenafil on digital ulcers in systemic sclerosis: analysis from a single centre pilot study. Ann Rheum Dis 69:1475-1478
    • (2010) Ann Rheum Dis , vol.69 , pp. 1475-1478
    • Brueckner, C.S.1    Becker, M.O.2    Kroencke, T.3
  • 60
    • 23044512051 scopus 로고    scopus 로고
    • Improvement in digital flexibility and dexterity following ingestion of sildenafil citrate in limited systemic sclerosis
    • Yung A, Reay N, Goodfield MD (2005) Improvement in digital flexibility and dexterity following ingestion of sildenafil citrate in limited systemic sclerosis. Arch Dermatol 141:831-883
    • (2005) Arch Dermatol , vol.141 , pp. 831-883
    • Yung, A.1    Reay, N.2    Goodfield, M.D.3
  • 61
    • 70450206009 scopus 로고    scopus 로고
    • Efficacy of tadalafil in secondary Raynaud's phenomenon resistant to vasodilator therapy: A double-blind randomized cross-over trial [abstract]
    • Shenoy P, Agarwal V, Kumar S et al (2008) Efficacy of tadalafil in secondary Raynaud's phenomenon resistant to vasodilator therapy: a double-blind randomized cross-over trial [abstract]. Arthritis Rheum 58(9 Suppl):S402
    • (2008) Arthritis Rheum , vol.58 , Issue.9 SUPPL. , pp. 402
    • Shenoy, P.1    Agarwal, V.2    Kumar, S.3
  • 62
    • 67649523052 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension and response to tadalafil (PHIRST) study group. Tadalafil therapy for pulmonary arterial hypertension
    • 19470885 [PubMed]
    • Galiè N, Brundage BH, Ghofrani HA et al (2009) Pulmonary arterial hypertension and response to tadalafil (PHIRST) study group. Tadalafil therapy for pulmonary arterial hypertension. Circulation 119:2894-2903 [PubMed]
    • (2009) Circulation , vol.119 , pp. 2894-2903
    • Galiè, N.1    Brundage, B.H.2    Ghofrani, H.A.3
  • 63
    • 4644232338 scopus 로고    scopus 로고
    • Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: A randomized prospective study
    • Ghofrani HA, Voswinckel R, Reichenberger F et al (2004) Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study. J Am Coll Cardiol 44:1488-1496
    • (2004) J Am Coll Cardiol , vol.44 , pp. 1488-1496
    • Ghofrani, H.A.1    Voswinckel, R.2    Reichenberger, F.3
  • 64
    • 44949156264 scopus 로고    scopus 로고
    • Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets
    • Toque HA, Teixeira CE, Priviero FB (2008) Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets. Br J Pharmacol 154(4):787-796
    • (2008) Br J Pharmacol , vol.154 , Issue.4 , pp. 787-796
    • Toque, H.A.1    Teixeira, C.E.2    Priviero, F.B.3
  • 65
    • 31344445685 scopus 로고    scopus 로고
    • Phosphodiesterase Type 5 inhibition is a novel therapeutic option in Raynaud disease
    • Caglayan E, Huntgeburth M, Karasch T (2006) Phosphodiesterase Type 5 inhibition is a novel therapeutic option in Raynaud disease. Arch Intern Med 166:231-233
    • (2006) Arch Intern Med , vol.166 , pp. 231-233
    • Caglayan, E.1    Huntgeburth, M.2    Karasch, T.3
  • 66
    • 0242488838 scopus 로고    scopus 로고
    • Effects of cilostazol in patients with Raynaud's syndrome
    • 14636909 1:CAS:528:DC%2BD3sXptVWntr4%3D
    • Rajagopalan S, Pfenninger D, Somers E et al (2003) Effects of cilostazol in patients with Raynaud's syndrome. Am J Cardiol 92(11):1310-1315
    • (2003) Am J Cardiol , vol.92 , Issue.11 , pp. 1310-1315
    • Rajagopalan, S.1    Pfenninger, D.2    Somers, E.3
  • 67
    • 10444270963 scopus 로고    scopus 로고
    • Digital ulcers in systemic sclerosis: Prevention by treatment with bosentan, an oral endothelin receptor antagonist
    • 15593188 1:CAS:528:DC%2BD2MXls1eguw%3D%3D
    • Korn JH, Mayes M, Matucci CM, Rainisio M, Pope J, Hachulla E et al (2004) Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist. Arthritis Rheum 50:3985-3993
    • (2004) Arthritis Rheum , vol.50 , pp. 3985-3993
    • Korn, J.H.1    Mayes, M.2    Matucci, C.M.3    Rainisio, M.4    Pope, J.5    Hachulla, E.6
  • 70
    • 4544383466 scopus 로고    scopus 로고
    • Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2
    • 15358690 1:CAS:528:DC%2BD2cXotlyrtL4%3D
    • Humbert M, Barst RJ, Robbins IM, Channick RN, Galie N, Boonstra A et al (2004) Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2. Eur Respir J 24:353-359
    • (2004) Eur Respir J , vol.24 , pp. 353-359
    • Humbert, M.1    Barst, R.J.2    Robbins, I.M.3    Channick, R.N.4    Galie, N.5    Boonstra, A.6
  • 71
    • 37849012578 scopus 로고    scopus 로고
    • BUILD-1: A randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis
    • King Jr. TE, Behr J, Brown KK et al (2008) BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis. Am J Respirat Crit Care Med 177:75-81
    • (2008) Am J Respirat Crit Care Med , vol.177 , pp. 75-81
    • King Jr., T.E.1    Behr, J.2    Brown, K.K.3
  • 72
    • 80051566676 scopus 로고    scopus 로고
    • BUILD-3: A randomized, controlled trial of Bosentan in idiopathic pulmonary fibrosis
    • Published ahead of print on April 7, 2011
    • King Jr. TE, Brown KK, Raghu G (2011) BUILD-3: a randomized, controlled trial of Bosentan in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (Published ahead of print on April 7, 2011)
    • (2011) Am J Respir Crit Care Med
    • King Jr., T.E.1    Brown, K.K.2    Raghu, G.3
  • 73
    • 65849500132 scopus 로고    scopus 로고
    • Endothelin and scleroderma lung disease
    • Silver RM (2008) Endothelin and scleroderma lung disease. Rheumatology 47:v25-v26
    • (2008) Rheumatology , vol.47
    • Silver, R.M.1
  • 75
    • 33646255654 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan
    • 16697324 1:CAS:528:DC%2BD28XksFalsbs%3D
    • Barst RJ, Langleben D, Badesch D, Frost A, Lawrence EC, Shapiro S et al (2006) Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan. J Am Coll Cardiol 47:2049-2056
    • (2006) J Am Coll Cardiol , vol.47 , pp. 2049-2056
    • Barst, R.J.1    Langleben, D.2    Badesch, D.3    Frost, A.4    Lawrence, E.C.5    Shapiro, S.6
  • 76
    • 46449124591 scopus 로고    scopus 로고
    • Ambrisentan for the treatment of pulmonary arterial hypertension: Results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2
    • 18506008 1:CAS:528:DC%2BD1cXmsFymu70%3D
    • Galie N, Olschewski H, Oudiz RJ, Torres F, Frost A, Ghofrani HA et al (2008) Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2. Circulation 117:3010-3019
    • (2008) Circulation , vol.117 , pp. 3010-3019
    • Galie, N.1    Olschewski, H.2    Oudiz, R.J.3    Torres, F.4    Frost, A.5    Ghofrani, H.A.6
  • 77
    • 33646201514 scopus 로고    scopus 로고
    • Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: Critical role for serotonin-induced smooth muscle hyperplasia
    • 16606791 1:CAS:528:DC%2BD28XjtlCjurY%3D
    • Eddahibi S, Guignabert C, Barlier-Mur AM et al (2006) Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia. Circulation 113:1857-1864
    • (2006) Circulation , vol.113 , pp. 1857-1864
    • Eddahibi, S.1    Guignabert, C.2    Barlier-Mur, A.M.3
  • 78
    • 0034794451 scopus 로고    scopus 로고
    • Treatment of Raynaud's phenomenon with the selective serotonin reuptake inhibitr fluoxetine
    • 1:CAS:528:DC%2BD3MXot1Ckur0%3D
    • Coleiro B, Marshall SE, Denton CP et al (2001) Treatment of Raynaud's phenomenon with the selective serotonin reuptake inhibitr fluoxetine. Rheumatology (Oxford) 40:1038-1043
    • (2001) Rheumatology (Oxford) , vol.40 , pp. 1038-1043
    • Coleiro, B.1    Marshall, S.E.2    Denton, C.P.3
  • 79
    • 0041326610 scopus 로고    scopus 로고
    • Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension
    • 12773327
    • Marcos E, Adnot S, Pham MH et al (2003) Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension. Am J Respir Crit Care Med 168:487-493
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 487-493
    • Marcos, E.1    Adnot, S.2    Pham, M.H.3
  • 80
    • 33745915236 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitor use and outcomes in pulmonary arterial hypertension
    • 16483811 1:CAS:528:DC%2BD28XntVWgs74%3D
    • Kawut SM, Horn EM, Berekashvili KK et al (2006) Selective serotonin reuptake inhibitor use and outcomes in pulmonary arterial hypertension. Pulm Pharmacol Ther 19:370-374
    • (2006) Pulm Pharmacol Ther , vol.19 , pp. 370-374
    • Kawut, S.M.1    Horn, E.M.2    Berekashvili, K.K.3
  • 81
    • 0034789303 scopus 로고    scopus 로고
    • Intravenous N-acetylcysteine for treatment of Raynaud's phenomenon secondary to systemic sclerosis: A pilot study
    • 11669166 1:CAS:528:DC%2BD3MXnvVCis7o%3D
    • Sambo P, Amico D, Giacomelli R et al (2001) Intravenous N-acetylcysteine for treatment of Raynaud's phenomenon secondary to systemic sclerosis: a pilot study. J Rheumatol 28:2257-2262
    • (2001) J Rheumatol , vol.28 , pp. 2257-2262
    • Sambo, P.1    Amico, D.2    Giacomelli, R.3
  • 82
    • 57349084998 scopus 로고    scopus 로고
    • Autologous progenitor cell implantation as a novel therapeutic intervention for ischaemic digits in systemic sclerosis
    • Nevskaya T, Ananieva L, Bykovskaia S et al. Autologous progenitor cell implantation as a novel therapeutic intervention for ischaemic digits in systemic sclerosis. Rheumatology 48(1):61-64
    • Rheumatology , vol.48 , Issue.1 , pp. 61-64
    • Nevskaya, T.1    Ananieva, L.2    Bykovskaia, S.3
  • 83
    • 70349814390 scopus 로고    scopus 로고
    • Disease-modifying treatment in systemic sclerosis: Current status
    • 19726995
    • Quillinan NP, Denton CP (2009) Disease-modifying treatment in systemic sclerosis: current status. Curr Opin Rheumatol 21:636-641
    • (2009) Curr Opin Rheumatol , vol.21 , pp. 636-641
    • Quillinan, N.P.1    Denton, C.P.2
  • 84
    • 18444416057 scopus 로고    scopus 로고
    • Placebo controlled trial of methotrexate in systemic sclerosis
    • 15695960 1:STN:280:DC%2BD2M%2FmslWqtw%3D%3D
    • Das SN, Alam MR, Islam N et al (2005) Placebo controlled trial of methotrexate in systemic sclerosis. Mymensingh Med J: MMJ 14:71-74
    • (2005) Mymensingh Med J: MMJ , vol.14 , pp. 71-74
    • Das, S.N.1    Alam, M.R.2    Islam, N.3
  • 85
    • 0029867337 scopus 로고    scopus 로고
    • Comparison of methotrexate with placebo in the treatment of systemic sclerosis: A 24 week randomized double-blind trial, followed by a 24 week observational trial
    • 8624641
    • van den Hoogen FH, Boerbooms AM, Swaak AJ, Rasker JJ, van Lier HJ, van de Putte LB (1996) Comparison of methotrexate with placebo in the treatment of systemic sclerosis: a 24 week randomized double-blind trial, followed by a 24 week observational trial. Br J Rheumatol 35:364-372
    • (1996) Br J Rheumatol , vol.35 , pp. 364-372
    • Van Den Hoogen, F.H.1    Boerbooms, A.M.2    Swaak, A.J.3    Rasker, J.J.4    Van Lier, H.J.5    Van De Putte, L.B.6
  • 86
    • 0034970031 scopus 로고    scopus 로고
    • A randomized, controlled trial of methotrexate versus placebo in early diffuse scleroderma
    • 11407694 1:CAS:528:DC%2BD38XpsFA%3D
    • Pope JE, Bellamy N, Seibold JR, Baron M, Ellman M, Carette S et al (2001) A randomized, controlled trial of methotrexate versus placebo in early diffuse scleroderma. Arthritis Rheum 44:1351-1358
    • (2001) Arthritis Rheum , vol.44 , pp. 1351-1358
    • Pope, J.E.1    Bellamy, N.2    Seibold, J.R.3    Baron, M.4    Ellman, M.5    Carette, S.6
  • 87
    • 34948902222 scopus 로고    scopus 로고
    • Current drug therapy for scleroderma and secondary Raynaud's phenomenon: Evidence-based review
    • Hennessa S, Wigley FM (2007) Current drug therapy for scleroderma and secondary Raynaud's phenomenon: evidence-based review. Curr Opin Rheumatol 19:611-618
    • (2007) Curr Opin Rheumatol , vol.19 , pp. 611-618
    • Hennessa, S.1    Wigley, F.M.2
  • 88
    • 33745227399 scopus 로고    scopus 로고
    • Cyclophosphamide versus placebo in scleroderma lung disease
    • 16790698 1:CAS:528:DC%2BD28XmtFSgtLs%3D
    • Tashkin DP, Elashoff R, Clements PJ et al (2006) Cyclophosphamide versus placebo in scleroderma lung disease. N Engl J Med 354:2655-2666
    • (2006) N Engl J Med , vol.354 , pp. 2655-2666
    • Tashkin, D.P.1    Elashoff, R.2    Clements, P.J.3
  • 89
    • 33845643063 scopus 로고    scopus 로고
    • A multicenter prospective, randomised, double-blind, placebo controlled trial of corticosteroids and intravenous cyclophosphamide, followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma
    • 17133610 1:CAS:528:DC%2BD2sXktlalug%3D%3D
    • Hoyles RK, Ellis RW, Wellsbury J et al (2006) A multicenter prospective, randomised, double-blind, placebo controlled trial of corticosteroids and intravenous cyclophosphamide, followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma. Arthritis Rheum 54:3962-3970
    • (2006) Arthritis Rheum , vol.54 , pp. 3962-3970
    • Hoyles, R.K.1    Ellis, R.W.2    Wellsbury, J.3
  • 90
    • 36249001195 scopus 로고    scopus 로고
    • Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease
    • 17717203 1:CAS:528:DC%2BD2sXhsVekt7%2FN
    • Tashkin DP, Elashoff R, Clements PJ et al (2007) Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease. Am J Respir Crit Care Med 176:1026-1034
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 1026-1034
    • Tashkin, D.P.1    Elashoff, R.2    Clements, P.J.3
  • 91
    • 44949238111 scopus 로고    scopus 로고
    • Therapeutic strategy combining intravenous cyclophosphamide followed by oral azathioprine to treat worsening interstitial lung disease associated with systemic sclerosis: A retrospective multicenter open-label study
    • 18464307 1:CAS:528:DC%2BD1cXotlWmsL4%3D
    • Berezne A, Ranque B, Valeyre D et al (2008) Therapeutic strategy combining intravenous cyclophosphamide followed by oral azathioprine to treat worsening interstitial lung disease associated with systemic sclerosis: a retrospective multicenter open-label study. J Rheumatol 35:1064-1072
    • (2008) J Rheumatol , vol.35 , pp. 1064-1072
    • Berezne, A.1    Ranque, B.2    Valeyre, D.3
  • 92
    • 33847394965 scopus 로고    scopus 로고
    • Mycophenolate mofetil in diffuse cutaneous systemic sclerosis: A retrospective analysis
    • 16899504 1:CAS:528:DC%2BD2sXhvFWltbg%3D
    • Nihtyanova SI, Brough GM, Black CM et al (2007) Mycophenolate mofetil in diffuse cutaneous systemic sclerosis: a retrospective analysis. Rheumatology 46:442-445
    • (2007) Rheumatology , vol.46 , pp. 442-445
    • Nihtyanova, S.I.1    Brough, G.M.2    Black, C.M.3
  • 93
    • 33746372441 scopus 로고    scopus 로고
    • Mycophenolate mofetil is safe, well tolerated and preserves lung function in patients with connective tissue disease related interstitial lung disease
    • 16840379 1:CAS:528:DC%2BD28Xot1KjtL8%3D
    • Swigris JJ, Olson AL, Fischer A et al (2006) Mycophenolate mofetil is safe, well tolerated and preserves lung function in patients with connective tissue disease related interstitial lung disease. Chest 130:30-36
    • (2006) Chest , vol.130 , pp. 30-36
    • Swigris, J.J.1    Olson, A.L.2    Fischer, A.3
  • 94
    • 0027403879 scopus 로고
    • Cyclosporine in systemic sclerosis. Results of a forty-eight-week open safety study in ten patients
    • 8424841 1:STN:280:DyaK3s7ktlOqsQ%3D%3D
    • Clements PJ, Lachenbruch PA, Sterz M et al (1993) Cyclosporine in systemic sclerosis. Results of a forty-eight-week open safety study in ten patients. Arthritis Rheum 36(1):75-83
    • (1993) Arthritis Rheum , vol.36 , Issue.1 , pp. 75-83
    • Clements, P.J.1    Lachenbruch, P.A.2    Sterz, M.3
  • 95
    • 0035681336 scopus 로고    scopus 로고
    • Long-term treatment of patients affected by systemic sclerosis with cyclosporin A
    • 1:STN:280:DC%2BD38%2FmsFymtg%3D%3D
    • Filaci G, Cutolo M, Basso M et al (2001) Long-term treatment of patients affected by systemic sclerosis with cyclosporin A. Rheumatology (Oxford) 40:1431-1432
    • (2001) Rheumatology (Oxford) , vol.40 , pp. 1431-1432
    • Filaci, G.1    Cutolo, M.2    Basso, M.3
  • 97
    • 2542422760 scopus 로고    scopus 로고
    • Mammalian target of rapamycin positively regulates collagen Type i production via a phosphatidylinositol 3-kinase-independent pathway
    • 15047702 1:CAS:528:DC%2BD2cXkt1GisLs%3D
    • Shegogue D, Trojanowska M (2004) Mammalian target of rapamycin positively regulates collagen Type I production via a phosphatidylinositol 3-kinase-independent pathway. J Biol Chem 279:23166-23175
    • (2004) J Biol Chem , vol.279 , pp. 23166-23175
    • Shegogue, D.1    Trojanowska, M.2
  • 98
    • 73249139173 scopus 로고    scopus 로고
    • Rapamycin (rapa) vs methotrexate (mtx) in early diffuse systemic sclerosis (ssc): A 48-week randomized, single-blind pilot safety study
    • Karleen Su T-I, Khanna D, Furst DE et al (2009) Rapamycin (rapa) vs methotrexate (mtx) in early diffuse systemic sclerosis (ssc): a 48-week randomized, single-blind pilot safety study. Arthritis Rheum 60(12):3821-3830
    • (2009) Arthritis Rheum , vol.60 , Issue.12 , pp. 3821-3830
    • Karleen Su, T.-I.1    Khanna, D.2    Furst, D.E.3
  • 99
    • 3242810358 scopus 로고    scopus 로고
    • B lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse
    • 15277237 1:CAS:528:DC%2BD2cXmvFWjs70%3D
    • Asano N, Fujimoto M, Yazawa N et al (2004) B lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse. Am J Pathol 165:641-650
    • (2004) Am J Pathol , vol.165 , pp. 641-650
    • Asano, N.1    Fujimoto, M.2    Yazawa, N.3
  • 100
    • 0036262665 scopus 로고    scopus 로고
    • CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse
    • 12045259 1:CAS:528:DC%2BD38XktlWlu7s%3D
    • Saito E, Fujimoto M, Hasegawa M et al (2002) CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse. J Clin Invest 109:1453-1462
    • (2002) J Clin Invest , vol.109 , pp. 1453-1462
    • Saito, E.1    Fujimoto, M.2    Hasegawa, M.3
  • 101
    • 33748788266 scopus 로고    scopus 로고
    • B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis
    • 16936269 1:CAS:528:DC%2BD28XpvFWqsrg%3D
    • Hasegawa M, Hamaguchi Y, Yanaba K et al (2006) B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis. Am J Pathol 169:954-966
    • (2006) Am J Pathol , vol.169 , pp. 954-966
    • Hasegawa, M.1    Hamaguchi, Y.2    Yanaba, K.3
  • 102
    • 44849130732 scopus 로고    scopus 로고
    • CD19 regulates and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma
    • 18467694 1:CAS:528:DC%2BD1cXnslKjsL4%3D
    • Yoshizaki A, Iwata Y, Komura K et al (2008) CD19 regulates and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma. Am J Pathol 172:1650-1663
    • (2008) Am J Pathol , vol.172 , pp. 1650-1663
    • Yoshizaki, A.1    Iwata, Y.2    Komura, K.3
  • 103
    • 77956992383 scopus 로고    scopus 로고
    • B cell depletion in diff use progressive systemic sclerosis: Safety, skin score modification and IL-6 modulation in an up to thirty-six months follow up open-label trial
    • 20338043
    • Bosello S, De Santis M, Lama G et al (2010) B cell depletion in diff use progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow up open-label trial. Arthritis Res Ther 12:R54
    • (2010) Arthritis Res Ther , vol.12 , pp. 54
    • Bosello, S.1    De Santis, M.2    Lama, G.3
  • 105
    • 73449095775 scopus 로고    scopus 로고
    • Rituximab in diff use cutaneous systemic sclerosis: An open-label clinical and histopathological study
    • 19103636 1:CAS:528:DC%2BC3cXhtFOlsL4%3D
    • Smith V, Van Praet JT, Vandooren B et al (2010) Rituximab in diff use cutaneous systemic sclerosis: an open-label clinical and histopathological study. Ann Rheum Dis 69:193-197
    • (2010) Ann Rheum Dis , vol.69 , pp. 193-197
    • Smith, V.1    Van Praet, J.T.2    Vandooren, B.3
  • 106
    • 77950443096 scopus 로고    scopus 로고
    • Experience with rituximab in scleroderma: Results from a 1-year, proof-of-principle study
    • 19447770 1:CAS:528:DC%2BC3cXntlertw%3D%3D
    • Daoussis D, Liossis SC, Tsamandas AC et al (2010) Experience with rituximab in scleroderma: results from a 1-year, proof-of-principle study. Rheumatology 49:271-280
    • (2010) Rheumatology , vol.49 , pp. 271-280
    • Daoussis, D.1    Liossis, S.C.2    Tsamandas, A.C.3
  • 107
    • 0034856397 scopus 로고    scopus 로고
    • Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis
    • 11532378 1:CAS:528:DC%2BD3MXmt1yhtL0%3D
    • Sato S, Hasegawa M, Takehara K (2001) Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis. J Dermatol Sci 27:140-146
    • (2001) J Dermatol Sci , vol.27 , pp. 140-146
    • Sato, S.1    Hasegawa, M.2    Takehara, K.3
  • 108
    • 0027717313 scopus 로고
    • In situ expression of cytokines and cellular adhesion molecules in the skin of patients with systemic sclerosis. Their role in early and late disease
    • Koch AE, Kronfeld-Harrington LB, Szekanecz et al (1993) In situ expression of cytokines and cellular adhesion molecules in the skin of patients with systemic sclerosis. Their role in early and late disease. Pathobiology 61:239-246
    • (1993) Pathobiology , vol.61 , pp. 239-246
    • Koch, A.E.1    Kronfeld-Harrington, L.B.2    Szekanecz3
  • 109
    • 78049421175 scopus 로고    scopus 로고
    • The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab
    • 20819796 1:CAS:528:DC%2BC3cXhsVejsbzE
    • Shima Y, Kuwahara Y, Murota H et al (2010) The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab. Rheumatology 49:2408-2412
    • (2010) Rheumatology , vol.49 , pp. 2408-2412
    • Shima, Y.1    Kuwahara, Y.2    Murota, H.3
  • 110
    • 49449088182 scopus 로고    scopus 로고
    • The controversial role of tumour necrosis factor a in fibrotic diseases
    • 1:CAS:528:DC%2BD1cXhtVCjtbbI
    • Distler JHW, Schett G, Gay S, Distler O (2008) The controversial role of tumour necrosis factor a in fibrotic diseases. Arth Rheum 58:2228-2235
    • (2008) Arth Rheum , vol.58 , pp. 2228-2235
    • Distler, J.H.W.1    Schett, G.2    Gay, S.3    Distler, O.4
  • 111
    • 34447503592 scopus 로고    scopus 로고
    • Efficacy and safety of etanercept in the treatment of scleroderma-associated joint disease
    • 17611970
    • Lam GK, Hummers LK, Woods A et al (2007) Efficacy and safety of etanercept in the treatment of scleroderma-associated joint disease. J Rheumatol 34:1636-1637
    • (2007) J Rheumatol , vol.34 , pp. 1636-1637
    • Lam, G.K.1    Hummers, L.K.2    Woods, A.3
  • 112
    • 69949138488 scopus 로고    scopus 로고
    • An open-label pilot study of infliximab therapy in diffuse cutaneous systemic sclerosis
    • 18782794
    • Denton CP, Engelhart M, Tvede N et al (2008) An open-label pilot study of infliximab therapy in diffuse cutaneous systemic sclerosis. Ann Rheum Dis 68(9):1433-1439
    • (2008) Ann Rheum Dis , vol.68 , Issue.9 , pp. 1433-1439
    • Denton, C.P.1    Engelhart, M.2    Tvede, N.3
  • 113
    • 79551704329 scopus 로고    scopus 로고
    • Biologic therapy for systemic sclerosis: A systematic review
    • Phumethum V, Jamal S, Johnson SR (2011) Biologic therapy for systemic sclerosis: a systematic review. J Rheumatol 38(2):289-296
    • (2011) J Rheumatol , vol.38 , Issue.2 , pp. 289-296
    • Phumethum, V.1    Jamal, S.2    Johnson, S.R.3
  • 114
    • 0034038720 scopus 로고    scopus 로고
    • Skin score decrease in systemic sclerosis patients treated with intravenous immunoglobulin: A preliminary report
    • 10870656 1:STN:280:DC%2BD3M%2Fhs1CktQ%3D%3D
    • Levy Y, Sherer Y, Langevitz P et al (2000) Skin score decrease in systemic sclerosis patients treated with intravenous immunoglobulin: a preliminary report. Clin Rheumatol 19:207-211
    • (2000) Clin Rheumatol , vol.19 , pp. 207-211
    • Levy, Y.1    Sherer, Y.2    Langevitz, P.3
  • 115
    • 1542343965 scopus 로고    scopus 로고
    • Intravenous immunoglobulin modulates cutaneous involvement and reduces skin fibrosis in systemic sclerosis: An open-label study
    • 15022346
    • Levy Y, Amital H, Langevitz P et al (2004) Intravenous immunoglobulin modulates cutaneous involvement and reduces skin fibrosis in systemic sclerosis: an open-label study. Arthritis Rheum 50:1005-1007
    • (2004) Arthritis Rheum , vol.50 , pp. 1005-1007
    • Levy, Y.1    Amital, H.2    Langevitz, P.3
  • 116
    • 34347263723 scopus 로고    scopus 로고
    • Intravenous immunoglobulins improve the function and ameliorate joint involvement in systemic sclerosis: A pilot study
    • 17344244 1:CAS:528:DC%2BD2sXotlSitbk%3D
    • Nacci F, Righi A, Conforti ML et al (2007) Intravenous immunoglobulins improve the function and ameliorate joint involvement in systemic sclerosis: a pilot study. Ann Rheum Dis 66:977-979
    • (2007) Ann Rheum Dis , vol.66 , pp. 977-979
    • Nacci, F.1    Righi, A.2    Conforti, M.L.3
  • 117
    • 34247335464 scopus 로고    scopus 로고
    • High-dose intravenous immunoglobulin infusion as treatment for diffuse scleroderma
    • 17381465 1:STN:280:DC%2BD2s3kvFGhtQ%3D%3D
    • Ihn H, Mimura Y, Yazawa N et al (2007) High-dose intravenous immunoglobulin infusion as treatment for diffuse scleroderma. Br J Dermatol 156:1058-1060
    • (2007) Br J Dermatol , vol.156 , pp. 1058-1060
    • Ihn, H.1    Mimura, Y.2    Yazawa, N.3
  • 118
    • 0036277168 scopus 로고    scopus 로고
    • The role of intravenous immunoglobulin therapy in mediating skin fibrosis in tight skin mice
    • 12115202 1:CAS:528:DC%2BD38XltlamsLc%3D
    • Blank M, Levy Y, Amital H, Shoenfeld Y, Pines M, Genina O (2002) The role of intravenous immunoglobulin therapy in mediating skin fibrosis in tight skin mice. Arthritis Rheum 46:1689-1690
    • (2002) Arthritis Rheum , vol.46 , pp. 1689-1690
    • Blank, M.1    Levy, Y.2    Amital, H.3    Shoenfeld, Y.4    Pines, M.5    Genina, O.6
  • 119
    • 0344341646 scopus 로고    scopus 로고
    • Fibrosis regression induced by intravenous gammaglobulin treatment
    • Amital H, Rewald E, Levy Y et al (2003) Fibrosis regression induced by intravenous gammaglobulin treatment. Ann Rheum Dis 62:175-177
    • (2003) Ann Rheum Dis , vol.62 , pp. 175-177
    • Amital, H.1    Rewald, E.2    Levy, Y.3
  • 120
    • 45349109299 scopus 로고    scopus 로고
    • A multicenter, randomized, double-blind, placebo-controlled trial of oral type i collagen treatment in patients with diffuse cutaneous systemic sclerosis: I. Oral type i collagen does not improve skin in all patients, but may improve skin in late-phase disease
    • 18512816 1:CAS:528:DC%2BD1cXotVOnt7g%3D
    • Postlethwaite AE, Wong WK, Clements P et al (2008) A multicenter, randomized, double-blind, placebo-controlled trial of oral type I collagen treatment in patients with diffuse cutaneous systemic sclerosis: I. Oral type I collagen does not improve skin in all patients, but may improve skin in late-phase disease. Arthritis Rheum 58:1810-1822
    • (2008) Arthritis Rheum , vol.58 , pp. 1810-1822
    • Postlethwaite, A.E.1    Wong, W.K.2    Clements, P.3
  • 121
    • 0035815696 scopus 로고    scopus 로고
    • Antagonistic regulation of type i collagen gene expression by interferon-gamma and transforming growth factor-beta. Integration at the level of p300/CBP transcriptional coactivators
    • 11134049 1:CAS:528:DC%2BD3MXjvFGjsro%3D
    • Ghosh AK, Yuan W, Mori Y, Chen S, Varga J (2001) Antagonistic regulation of type I collagen gene expression by interferon-gamma and transforming growth factor-beta. Integration at the level of p300/CBP transcriptional coactivators. J Biol Chem 276:11041-11048
    • (2001) J Biol Chem , vol.276 , pp. 11041-11048
    • Ghosh, A.K.1    Yuan, W.2    Mori, Y.3    Chen, S.4    Varga, J.5
  • 122
    • 0025197676 scopus 로고
    • Interferon-gamma reverses the stimulation of collagen but not fibronectin gene expression by transforming growth factor-beta in normal human fibroblasts
    • 2124978 1:CAS:528:DyaK3MXit1Wmtw%3D%3D
    • Varga J, Olsen A, Herhal J, Constantine G, Rosenbloom J, Jimenez SA (1990) Interferon-gamma reverses the stimulation of collagen but not fibronectin gene expression by transforming growth factor-beta in normal human fibroblasts. Eur J Clin Invest 20:487-493
    • (1990) Eur J Clin Invest , vol.20 , pp. 487-493
    • Varga, J.1    Olsen, A.2    Herhal, J.3    Constantine, G.4    Rosenbloom, J.5    Jimenez, S.A.6
  • 123
    • 33750848526 scopus 로고    scopus 로고
    • Pamidronate infusion in patients with systemic sclerosis results in changes in blood mononuclear cell cytokine profiles
    • 17100755 1:CAS:528:DC%2BD2sXmslKgtw%3D%3D
    • Carbone LD, Warrington KJ, Barrow KD, Pugazhenthi M, Watsky MA, Somes G et al (2006) Pamidronate infusion in patients with systemic sclerosis results in changes in blood mononuclear cell cytokine profiles. Clin Exp Immunol 146:371-380
    • (2006) Clin Exp Immunol , vol.146 , pp. 371-380
    • Carbone, L.D.1    Warrington, K.J.2    Barrow, K.D.3    Pugazhenthi, M.4    Watsky, M.A.5    Somes, G.6
  • 124
    • 37749001089 scopus 로고    scopus 로고
    • Long-term follow-up results after autologous haematopoietic stem cell transplantation for severe systemic sclerosis
    • 17526554 1:STN:280:DC%2BD2sjjslKnug%3D%3D
    • Vonk MC, Marjanovic Z, van den Hoogen FHJ et al (2008) Long-term follow-up results after autologous haematopoietic stem cell transplantation for severe systemic sclerosis. Ann Rheum Dis 67:98-104
    • (2008) Ann Rheum Dis , vol.67 , pp. 98-104
    • Vonk, M.C.1    Marjanovic, Z.2    Van Den Hoogen, F.H.J.3
  • 125
    • 34548013337 scopus 로고    scopus 로고
    • High-dose immunosuppressive therapy and autologous hematopoietic stem cell transplantation for severe systemic sclerosis: Long-term follow-up of the US multicenter pilot study
    • 17452515 1:CAS:528:DC%2BD2sXptFKlsLs%3D
    • Nash RA, McSweeney PA, Corfford LJ et al (2007) High-dose immunosuppressive therapy and autologous hematopoietic stem cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study. Blood 110:1388-1396
    • (2007) Blood , vol.110 , pp. 1388-1396
    • Nash, R.A.1    McSweeney, P.A.2    Corfford, L.J.3
  • 126
    • 0033064099 scopus 로고    scopus 로고
    • High-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis: Analysis of a two-year, double-blind, randomized, controlled clinical trial
    • 10366112 1:CAS:528:DyaK1MXktVegtLw%3D
    • Clements PJ, Furst DE, Wong WK, Mayes M, White B, Wigley F et al (1999) High-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis: analysis of a two-year, double-blind, randomized, controlled clinical trial. Arthritis Rheum 42:1194-1203
    • (1999) Arthritis Rheum , vol.42 , pp. 1194-1203
    • Clements, P.J.1    Furst, D.E.2    Wong, W.K.3    Mayes, M.4    White, B.5    Wigley, F.6
  • 127
    • 42049114498 scopus 로고    scopus 로고
    • A retrospective randomly selected cohort study of D-penicillamine treatment in rapidly progressive diffuse cutaneous systemic sclerosis of recent onset
    • Derk CT, Huaman G, Jimenez SA (2008) A retrospective randomly selected cohort study of D-penicillamine treatment in rapidly progressive diffuse cutaneous systemic sclerosis of recent onset. Br J Dermatol 158(5):1063-1068
    • (2008) Br J Dermatol , vol.158 , Issue.5 , pp. 1063-1068
    • Derk, C.T.1    Huaman, G.2    Jimenez, S.A.3
  • 128
    • 7844237877 scopus 로고    scopus 로고
    • Interferon-gamma in the treatment of systemic sclerosis: A randomized controlled multicentre trial
    • 9892907 1:CAS:528:DyaK1cXntlCktb4%3D
    • Grassegger A, Schuler G, Hessenberger G et al (1998) Interferon-gamma in the treatment of systemic sclerosis: a randomized controlled multicentre trial. Br J Dermatol 139:639-648
    • (1998) Br J Dermatol , vol.139 , pp. 639-648
    • Grassegger, A.1    Schuler, G.2    Hessenberger, G.3
  • 129
    • 0032588623 scopus 로고    scopus 로고
    • Interferon-alpha does not improve outcome at one year in patients with diffuse cutaneous scleroderma: Results of a randomized, double-blind, placebo-controlled trial
    • 10025924 1:CAS:528:DyaK1MXhtlarsL4%3D
    • Black CM, Silman AJ, Herrick AI et al (1999) Interferon-alpha does not improve outcome at one year in patients with diffuse cutaneous scleroderma: results of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum 42:299-305
    • (1999) Arthritis Rheum , vol.42 , pp. 299-305
    • Black, C.M.1    Silman, A.J.2    Herrick, A.I.3
  • 130
    • 2342649549 scopus 로고    scopus 로고
    • Low dose UVA1 phototherapy in systemic sclerosis: Effects on acrosclerosis
    • 15097958
    • Kreuter A, Breuckmann F, Uhle A et al (2004) Low dose UVA1 phototherapy in systemic sclerosis: effects on acrosclerosis. J Am Acad Dermatol 50(5):740-747
    • (2004) J Am Acad Dermatol , vol.50 , Issue.5 , pp. 740-747
    • Kreuter, A.1    Breuckmann, F.2    Uhle, A.3
  • 131
    • 0029777347 scopus 로고    scopus 로고
    • Successful treatment of scleroderma with PUVA therapy
    • 8772023 1:STN:280:DyaK28zmsl2juw%3D%3D
    • Kanekura T, Fukumaru S, Matsushita S et al (1996) Successful treatment of scleroderma with PUVA therapy. J Dermatol 23:455-459
    • (1996) J Dermatol , vol.23 , pp. 455-459
    • Kanekura, T.1    Fukumaru, S.2    Matsushita, S.3
  • 132
    • 0032955588 scopus 로고    scopus 로고
    • Oral psoralen-UV-A for systemic scleroderma
    • 10328211 1:STN:280:DyaK1M3lvVOlsQ%3D%3D
    • Hofer A, Soyer HP (1999) Oral psoralen-UV-A for systemic scleroderma. Arch Dermatol 135:603-604
    • (1999) Arch Dermatol , vol.135 , pp. 603-604
    • Hofer, A.1    Soyer, H.P.2
  • 133
    • 0038545409 scopus 로고    scopus 로고
    • Phototherapy in pediatric patients
    • 12558852
    • Pasic A, Ceovic R, Lipozencic J et al (2003) Phototherapy in pediatric patients. Pediatr Dermatol 20(1):71-77
    • (2003) Pediatr Dermatol , vol.20 , Issue.1 , pp. 71-77
    • Pasic, A.1    Ceovic, R.2    Lipozencic, J.3
  • 134
    • 33646093984 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of photopheresis in systemic sclerosis
    • 16635659
    • Knobler RM, French LE, Kim Y, Bisaccia E, Graninger W (2006) A randomized, double-blind, placebo-controlled trial of photopheresis in systemic sclerosis. J Am Acad Dermatol 54(5):793-799
    • (2006) J Am Acad Dermatol , vol.54 , Issue.5 , pp. 793-799
    • Knobler, R.M.1    French, L.E.2    Kim, Y.3    Bisaccia, E.4    Graninger, W.5
  • 135
    • 33748998739 scopus 로고    scopus 로고
    • Phototherapy: A promising treatment option for skin sclerosis in scleroderma?
    • Sunderkotter C, Kuhn A, Hunzelmann N, Beissert S (2006) Phototherapy: a promising treatment option for skin sclerosis in scleroderma? Rheumatology 45:iii52-iii54
    • (2006) Rheumatology , vol.45
    • Sunderkotter, C.1    Kuhn, A.2    Hunzelmann, N.3    Beissert, S.4
  • 136
    • 0025302162 scopus 로고
    • Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts
    • 2162358 1:CAS:528:DyaK3cXksFaksL4%3D
    • Unemori EN, Amento EP (1990) Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts. J Biol Chem 265:10681-10685
    • (1990) J Biol Chem , vol.265 , pp. 10681-10685
    • Unemori, E.N.1    Amento, E.P.2
  • 137
    • 0034612234 scopus 로고    scopus 로고
    • Recombinant human relaxin in the treatment of scleroderma. A randomized, double-blind, placebo controlled trial
    • 10836913 1:CAS:528:DC%2BD3cXkt1Cnt7g%3D
    • Seibold JR, Korn JH, Simms R, Clements PJ, Moreland LW, Mayes MD et al (2000) Recombinant human relaxin in the treatment of scleroderma. A randomized, double-blind, placebo controlled trial. Ann Intern Med 132:871-879
    • (2000) Ann Intern Med , vol.132 , pp. 871-879
    • Seibold, J.R.1    Korn, J.H.2    Simms, R.3    Clements, P.J.4    Moreland, L.W.5    Mayes, M.D.6
  • 138
    • 0031028794 scopus 로고    scopus 로고
    • Inhibition of collagen synthesis, smooth muscle cell proliferation, and injury-induced intimal hyperplasia by halofuginone
    • 9012656 1:CAS:528:DyaK2sXhtFGmsro%3D
    • Nagler A, Miao HQ, Aingorn H et al (1997) Inhibition of collagen synthesis, smooth muscle cell proliferation, and injury-induced intimal hyperplasia by halofuginone. Arterioscler Thromb Vasc Biol 17:194-202
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 194-202
    • Nagler, A.1    Miao, H.Q.2    Aingorn, H.3
  • 139
    • 1442271244 scopus 로고    scopus 로고
    • Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma
    • 12869955 1:CAS:528:DC%2BD3sXmvFOhtrk%3D
    • Pines M, Snyder D, Yarkoni S, Nagler A (2003) Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma. Biol Blood Marrow Transplant 9:417-425
    • (2003) Biol Blood Marrow Transplant , vol.9 , pp. 417-425
    • Pines, M.1    Snyder, D.2    Yarkoni, S.3    Nagler, A.4
  • 141
    • 0036967820 scopus 로고    scopus 로고
    • Open-label compassionate use one year treatment with pirfenidone to patients with chronic pulmonary fibrosis
    • 12521199 1:CAS:528:DC%2BD3sXhslKqurs%3D
    • Nagai S, Hamada K, Shigematsu M, Taniyama M, Yamauchi S, Izumi T (2002) Open-label compassionate use one year treatment with pirfenidone to patients with chronic pulmonary fibrosis. Intern Med 41:1118-1123
    • (2002) Intern Med , vol.41 , pp. 1118-1123
    • Nagai, S.1    Hamada, K.2    Shigematsu, M.3    Taniyama, M.4    Yamauchi, S.5    Izumi, T.6
  • 142
    • 77951160564 scopus 로고    scopus 로고
    • Pirfenidone in idiopathic pulmonary fibrosis
    • Taniguchi H, Ebina M, Kondoh Y, Ogura T et al (2010) Pirfenidone in idiopathic pulmonary fibrosis. ERJ 35(4):821-829
    • (2010) ERJ , vol.35 , Issue.4 , pp. 821-829
    • Taniguchi, H.1    Ebina, M.2    Kondoh, Y.3    Ogura, T.4
  • 144
    • 0018597282 scopus 로고
    • Long-term evaluation of colchicine in the treatment of scleroderma
    • Alarcon-Segovia D, Ramos-Niembro F, Ibanez de Kasep G (1979) Long-term evaluation of colchicine in the treatment of scleroderma. J Rheumatol 6(6):705-712
    • (1979) J Rheumatol , vol.6 , Issue.6 , pp. 705-712
    • Alarcon-Segovia, D.1    Ramos-Niembro, F.2    Ibanez De Kasep, G.3
  • 145
    • 0017538477 scopus 로고
    • Colchicine in the treatment of scleroderma
    • Guttadauria M, Diamond H, Kaplan D (1977) Colchicine in the treatment of scleroderma. J Rheumatol 4(3):272-276
    • (1977) J Rheumatol , vol.4 , Issue.3 , pp. 272-276
    • Guttadauria, M.1    Diamond, H.2    Kaplan, D.3
  • 146
    • 0032576429 scopus 로고    scopus 로고
    • Minocycline in early diffuse scleroderma
    • 9848358 1:CAS:528:DyaK1cXotV2ktbY%3D
    • Le CH, Morales A, Trentham DEK (1998) Minocycline in early diffuse scleroderma. Lancet 352:1755-1756
    • (1998) Lancet , vol.352 , pp. 1755-1756
    • Le, C.H.1    Morales, A.2    Trentham, D.E.K.3
  • 147
    • 1042290310 scopus 로고    scopus 로고
    • Minocycline is not effective in systemic sclerosis: Results of an open-label multicenter trial
    • 14872498 1:CAS:528:DC%2BD2cXhvFeiuro%3D
    • Mayes MD, O'Donnell D, Rothfield NF, Csuka ME (2004) Minocycline is not effective in systemic sclerosis: results of an open-label multicenter trial. Arthritis Rheum 50(2):553-557
    • (2004) Arthritis Rheum , vol.50 , Issue.2 , pp. 553-557
    • Mayes, M.D.1    O'Donnell, D.2    Rothfield, N.F.3    Csuka, M.E.4
  • 148
    • 2142646426 scopus 로고    scopus 로고
    • TGF-beta signaling and the fibrotic response
    • 15117886 1:CAS:528:DC%2BD2cXjvVOnt70%3D
    • Leask A, Abraham DJ (2004) TGF-beta signaling and the fibrotic response. FASEB J 18:816-827
    • (2004) FASEB J , vol.18 , pp. 816-827
    • Leask, A.1    Abraham, D.J.2
  • 149
    • 34948826895 scopus 로고    scopus 로고
    • Molecular pathways as novel therapeutic targets in systemic sclerosis
    • 17917537 1:CAS:528:DC%2BD2sXhtFWqsrjO
    • Trojanowska M, Varga J (2007) Molecular pathways as novel therapeutic targets in systemic sclerosis. Curr Opin Rheumatol 19:568-573
    • (2007) Curr Opin Rheumatol , vol.19 , pp. 568-573
    • Trojanowska, M.1    Varga, J.2
  • 150
    • 0035089825 scopus 로고    scopus 로고
    • Blockade of endogenous transforming growth factor beta signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: Association with increased expression of transforming growth factor beta receptors
    • 11229480 1:CAS:528:DC%2BD3MXitlCgu74%3D
    • Ihn H, Yamane K, Kubo M, Tamaki K (2001) Blockade of endogenous transforming growth factor beta signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor beta receptors. Arthritis Rheum 44:474-480
    • (2001) Arthritis Rheum , vol.44 , pp. 474-480
    • Ihn, H.1    Yamane, K.2    Kubo, M.3    Tamaki, K.4
  • 151
    • 0031886413 scopus 로고    scopus 로고
    • Increased expression of TGF-beta receptors by scleroderma fibroblasts: Evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype
    • 9424086 1:CAS:528:DyaK1cXjslKhug%3D%3D
    • Kawakami T, Ihn H, Xu W, Smith E, LeRoy C, Trojanowska M (1998) Increased expression of TGF-beta receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype. J Invest Dermatol 110:47-51
    • (1998) J Invest Dermatol , vol.110 , pp. 47-51
    • Kawakami, T.1    Ihn, H.2    Xu, W.3    Smith, E.4    Leroy, C.5    Trojanowska, M.6
  • 152
    • 0033571072 scopus 로고    scopus 로고
    • Anti-TGF-ß treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: A model for human scleroderma
    • 10553100 1:CAS:528:DyaK1MXntlKqsbo%3D
    • McCormick LauraL, Zhang Yan et al (1999) Anti-TGF-ß treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma. J Immunol 163:5693-5699
    • (1999) J Immunol , vol.163 , pp. 5693-5699
    • McCormick, L.1    Zhang, Y.2
  • 153
    • 33846250366 scopus 로고    scopus 로고
    • Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: A multicenter, randomized, placebo-controlled phase I/II trial of CAT-192
    • 17195236 1:CAS:528:DC%2BD2sXhsFaisL8%3D
    • Denton CP, Merkel PA, Furst DE (2007) Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum 56(1):323-333
    • (2007) Arthritis Rheum , vol.56 , Issue.1 , pp. 323-333
    • Denton, C.P.1    Merkel, P.A.2    Furst, D.E.3
  • 154
    • 0042846026 scopus 로고    scopus 로고
    • Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin
    • 12875977 1:CAS:528:DC%2BD3sXmslSnsLg%3D
    • Kubo M, Czuwara-Ladykowska J, Moussa O et al (2003) Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin. Am J Pathol 163:571-581
    • (2003) Am J Pathol , vol.163 , pp. 571-581
    • Kubo, M.1    Czuwara-Ladykowska, J.2    Moussa, O.3
  • 155
    • 77950560433 scopus 로고    scopus 로고
    • Faye Hant Endothelial Fli1 deficiency impairs vascular homeostasis: A role in scleroderma vasculopathy
    • Asano Y, Stawski L (2010) Faye Hant Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy. Am J Pathol 176(4):1983-1998
    • (2010) Am J Pathol , vol.176 , Issue.4 , pp. 1983-1998
    • Asano, Y.1    Stawski, L.2
  • 156
    • 0035877684 scopus 로고    scopus 로고
    • Fli-1 inhibits collagen type i production in dermal fibroblasts via an Sp1-dependent pathway
    • 11278621 1:CAS:528:DC%2BD3MXksFGlsrk%3D
    • Czuwara-Ladykowska J, Shirasaki F, Jackers P, Watson DK, Trojanowska M (2001) Fli-1 inhibits collagen type I production in dermal fibroblasts via an Sp1-dependent pathway. J Biol Chem 276:20839-20848
    • (2001) J Biol Chem , vol.276 , pp. 20839-20848
    • Czuwara-Ladykowska, J.1    Shirasaki, F.2    Jackers, P.3    Watson, D.K.4    Trojanowska, M.5
  • 157
    • 26444540768 scopus 로고    scopus 로고
    • Reversal of experimental pulmonary hypertension by PDGF inhibition
    • 16200212 1:CAS:528:DC%2BD2MXhtVygt7bN
    • Schermuly RT, Dony E, Ghofrani HA et al (2005) Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 115:2811-2821
    • (2005) J Clin Invest , vol.115 , pp. 2811-2821
    • Schermuly, R.T.1    Dony, E.2    Ghofrani, H.A.3
  • 158
    • 77953173512 scopus 로고    scopus 로고
    • Imatinib for the treatment of pulmonary arterial hypertension
    • Ghofrani HA, Seeger W, Grimminger F (2005) Imatinib for the treatment of pulmonary arterial hypertension. N Engl J Med 29:353
    • (2005) N Engl J Med , vol.29 , pp. 353
    • Ghofrani, H.A.1    Seeger, W.2    Grimminger, F.3
  • 159
    • 2642569161 scopus 로고    scopus 로고
    • Rho kinase mediates cold-induced constriction of Cutaneous Arteries role of α2C-adrenoceptor translocation
    • Bailey SR, Eid AH, Mitra S, Flavahan S et al (2004) Rho kinase mediates cold-induced constriction of Cutaneous Arteries role of α2C-adrenoceptor translocation Circul Res 94:1367
    • (2004) Circul Res , vol.94 , pp. 1367
    • Bailey, S.R.1    Eid, A.H.2    Mitra, S.3    Flavahan, S.4
  • 160
    • 49449087811 scopus 로고    scopus 로고
    • Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts
    • Dees C, Pileckyte M et al (2008) Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts. Arthritis Rheumatism 58(8):2553-2564
    • (2008) Arthritis Rheumatism , vol.58 , Issue.8 , pp. 2553-2564
    • Dees, C.1    Pileckyte, M.2
  • 161
    • 0031926840 scopus 로고    scopus 로고
    • Lovastatin modulates in vivo and in vitro the plasminogen activator/plasmin system of rat proximal tubular cells: Role of geranylgeranylation and Rho proteins
    • 9697659 1:CAS:528:DyaK1cXltleitb0%3D
    • Essig M, Vrtovsnik F, Nguyen G, Sraer JD, Friedlander G (1998) Lovastatin
    • (1998) J Am Soc Nephrol , vol.9 , pp. 1377-1388
    • Essig, M.1    Vrtovsnik, F.2    Nguyen, G.3    Sraer, J.D.4    Friedlander, G.5
  • 162
    • 54049086247 scopus 로고    scopus 로고
    • Statins: Potentially useful in therapy of systemic sclerosis-related Raynaud's phenomenon and digital ulcers
    • Abou-Raya A, Abou-Raya S, Helmii M (2008) Statins: potentially useful in therapy of systemic sclerosis-related Raynaud's phenomenon and digital ulcers. J Rheumatol 35(9):1801-1808
    • (2008) J Rheumatol , vol.35 , Issue.9 , pp. 1801-1808
    • Abou-Raya, A.1    Abou-Raya, S.2    Helmii, M.3
  • 163
    • 77958025377 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ: Innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis
    • 20693905 1:CAS:528:DC%2BC3cXht1ahu7jK
    • Wei J, Bhattacharyya S, Varga J (2010) Peroxisome proliferator-activated receptor γ: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis. Curr Opin Rheumatol 22(6):671-676
    • (2010) Curr Opin Rheumatol , vol.22 , Issue.6 , pp. 671-676
    • Wei, J.1    Bhattacharyya, S.2    Varga, J.3
  • 164
    • 1842733168 scopus 로고    scopus 로고
    • Disruption of transforming growth factor beta signaling and profibrotic responses in normal skin fibroblasts by peroxisome proliferator-activated receptor gamma
    • 15077315 1:CAS:528:DC%2BD2cXjslGqsLw%3D
    • Ghosh AK, Bhattacharyya S, Lakos G, Chen SJ, Mori Y, Varga J (2004) Disruption of transforming growth factor beta signaling and profibrotic responses in normal skin fibroblasts by peroxisome proliferator-activated receptor gamma. Arthritis Rheum 50:1305-1318
    • (2004) Arthritis Rheum , vol.50 , pp. 1305-1318
    • Ghosh, A.K.1    Bhattacharyya, S.2    Lakos, G.3    Chen, S.J.4    Mori, Y.5    Varga, J.6
  • 165
    • 70349331686 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator
    • 19395477 1:CAS:528:DC%2BD1MXhtFagsrjO
    • Ghosh AK, Bhattacharyya S, Wei J, Kim S, Barak Y, Mori Y et al (2009) Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator. FASEB J 23(9):2968-2977
    • (2009) FASEB J , vol.23 , Issue.9 , pp. 2968-2977
    • Ghosh, A.K.1    Bhattacharyya, S.2    Wei, J.3    Kim, S.4    Barak, Y.5    Mori, Y.6
  • 166
    • 77950433107 scopus 로고    scopus 로고
    • Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts
    • Shi-wen X, Eastwood M, Stratton RJ et al (2010) Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts. Rheumatology 49:259-263
    • (2010) Rheumatology , vol.49 , pp. 259-263
    • Shi-Wen, X.1    Eastwood, M.2    Stratton, R.J.3
  • 167
    • 0035149214 scopus 로고    scopus 로고
    • Oxidative stress in scleroderma: Maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway
    • 11710721 1:CAS:528:DC%2BD38Xpsl0%3D
    • Sambo P, Baroni SS, Luchetti M et al (2001) Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway. Arthritis Rheum 44(11):2653-2664
    • (2001) Arthritis Rheum , vol.44 , Issue.11 , pp. 2653-2664
    • Sambo, P.1    Baroni, S.S.2    Luchetti, M.3
  • 168
    • 0032723136 scopus 로고    scopus 로고
    • Probucol improves symptoms and reduces lipoprotein oxidation susceptibility in patients with Raynaud's phenomenon
    • 1:CAS:528:DyaK1MXjslOmtrg%3D
    • Denton CP, Bunce TD, Dorado MB et al (1999) Probucol improves symptoms and reduces lipoprotein oxidation susceptibility in patients with Raynaud's phenomenon. Rheumatology (Oxford) 38(4):309-315
    • (1999) Rheumatology (Oxford) , vol.38 , Issue.4 , pp. 309-315
    • Denton, C.P.1    Bunce, T.D.2    Dorado, M.B.3
  • 169
    • 0034086405 scopus 로고    scopus 로고
    • A double-blind placebo-controlled trial of antioxidant therapy in limited cutaneous systemic sclerosis
    • Herrick AL, Hollis S, Schofield D et al (2000) A double-blind placebo-controlled trial of antioxidant therapy in limited cutaneous systemic sclerosis. Clin Exp Rheumatol 18(3):349-356
    • (2000) Clin Exp Rheumatol , vol.18 , Issue.3 , pp. 349-356
    • Herrick, A.L.1    Hollis, S.2    Schofield, D.3


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