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Volumn 128, Issue 4, 2008, Pages 871-881

Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: Role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; DAPPER HOMOLOG ANTAGONIST OF BETA CATENIN 1; DAPPER HOMOLOG ANTAGONIST OF BETA CATENIN 2; FIBRILLIN; FIBRILLIN 1; MESSENGER RNA; RIBONUCLEASE; SECRETED FRIZZLED RELATED PROTEIN 2; SECRETED FRIZZLED RELATED PROTEIN 4; UNCLASSIFIED DRUG; WNT 10B PROTEIN; WNT 9A PROTEIN; WNT PROTEIN; WNT11 PROTEIN; WNT2 PROTEIN; WNT3A PROTEIN;

EID: 40649105572     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5701101     Document Type: Article
Times cited : (116)

References (53)
  • 1
    • 0032948879 scopus 로고    scopus 로고
    • Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy
    • G. Abu-Jawdeh N. Comella Y. Tomita L.F. Brown K. Tognazzi S.Y. Sokol Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy Lab Invest 79 1999 439 447
    • (1999) Lab Invest , vol.79 , pp. 439-447
    • Abu-Jawdeh, G.1    Comella, N.2    Tomita, Y.3    Brown, L.F.4    Tognazzi, K.5    Sokol, S.Y.6
  • 2
    • 0036113510 scopus 로고    scopus 로고
    • WNT signals are required for the initiation of hair follicle development
    • T. Andl S.T. Reddy T. Gaddapara S.E. Millar WNT signals are required for the initiation of hair follicle development Dev Cell 2 2002 643 653
    • (2002) Dev Cell , vol.2 , pp. 643-653
    • Andl, T.1    Reddy, S.T.2    Gaddapara, T.3    Millar, S.E.4
  • 4
    • 1642324456 scopus 로고    scopus 로고
    • Distinct Wnt members regulate the hierarchical morphogenesis of skin regions (spinal tract) and individual feathers
    • C.H. Chang T.X. Jiang C.M. Lin L.W. Burrus C.M. Chuong R. Widelitz Distinct Wnt members regulate the hierarchical morphogenesis of skin regions (spinal tract) and individual feathers Mech Dev 121 2004 157 171
    • (2004) Mech Dev , vol.121 , pp. 157-171
    • Chang, C.H.1    Jiang, T.X.2    Lin, C.M.3    Burrus, L.W.4    Chuong, C.M.5    Widelitz, R.6
  • 5
    • 33646346588 scopus 로고    scopus 로고
    • Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts
    • Y. Chen X. Shi-wen M. Eastwood C.M. Black C.P. Denton A. Leask Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts Arthritis Rheum 54 2006 1309 1316
    • (2006) Arthritis Rheum , vol.54 , pp. 1309-1316
    • Chen, Y.1    Shi-wen, X.2    Eastwood, M.3    Black, C.M.4    Denton, C.P.5    Leask, A.6
  • 6
    • 0036181393 scopus 로고    scopus 로고
    • Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing
    • T.J. Cho L.C. Gerstenfeld T.A. Einhorn Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing J Bone Miner Res 17 2002 513 520
    • (2002) J Bone Miner Res , vol.17 , pp. 513-520
    • Cho, T.J.1    Gerstenfeld, L.C.2    Einhorn, T.A.3
  • 7
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • H. Clevers Wnt/beta-catenin signaling in development and disease Cell 127 2006 469 480
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 8
    • 33646830969 scopus 로고    scopus 로고
    • Mechanisms and consequences of fibrosis in systemic sclerosis
    • C.P. Denton C.M. Black D.J. Abraham Mechanisms and consequences of fibrosis in systemic sclerosis Nat Clin Pract Rheumatol 2 2006 134 144
    • (2006) Nat Clin Pract Rheumatol , vol.2 , pp. 134-144
    • Denton, C.P.1    Black, C.M.2    Abraham, D.J.3
  • 10
    • 0025916022 scopus 로고
    • Extracellular microfibrils are increased in localized and systemic scleroderma skin
    • R. Fleischmajer L. Jacobs E. Schwartz L.Y. Sakai Extracellular microfibrils are increased in localized and systemic scleroderma skin Lab Invest 64 1991 791 798
    • (1991) Lab Invest , vol.64 , pp. 791-798
    • Fleischmajer, R.1    Jacobs, L.2    Schwartz, E.3    Sakai, L.Y.4
  • 12
    • 33745042859 scopus 로고    scopus 로고
    • Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts
    • H. Gardner J.R. Shearstone R. Bandaru T. Crowell M. Lynes M. Trojanowska Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts Arthritis Rheum 54 2006 1961 1973
    • (2006) Arthritis Rheum , vol.54 , pp. 1961-1973
    • Gardner, H.1    Shearstone, J.R.2    Bandaru, R.3    Crowell, T.4    Lynes, M.5    Trojanowska, M.6
  • 13
    • 33747339465 scopus 로고    scopus 로고
    • Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors
    • M.D. Gordon R. Nusse Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors J Biol Chem 281 2006 22429 22433
    • (2006) J Biol Chem , vol.281 , pp. 22429-22433
    • Gordon, M.D.1    Nusse, R.2
  • 14
    • 0017250167 scopus 로고
    • Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton
    • M.C. Green H.O. Sweet L.E. Bunker Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton Am J Pathol 82 1976 493 512
    • (1976) Am J Pathol , vol.82 , pp. 493-512
    • Green, M.C.1    Sweet, H.O.2    Bunker, L.E.3
  • 16
    • 10744233346 scopus 로고    scopus 로고
    • Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro
    • L.G. Horvath S.M. Henshall J.G. Kench D.N. Saunders C.S. Lee D. Golovsky Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro Clin Cancer Res 10 2004 615 625
    • (2004) Clin Cancer Res , vol.10 , pp. 615-625
    • Horvath, L.G.1    Henshall, S.M.2    Kench, J.G.3    Saunders, D.N.4    Lee, C.S.5    Golovsky, D.6
  • 17
    • 0029154782 scopus 로고
    • Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis
    • A. Igarashi K. Nashiro K. Kikuchi S. Sato H. Ihn G.R. Grotendorst Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis J Invest Dermatol 105 1995 280 284
    • (1995) J Invest Dermatol , vol.105 , pp. 280-284
    • Igarashi, A.1    Nashiro, K.2    Kikuchi, K.3    Sato, S.4    Ihn, H.5    Grotendorst, G.R.6
  • 18
    • 0034535637 scopus 로고    scopus 로고
    • FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis
    • I.E. James S. Kumar M.R. Barnes C.J. Gress A.T. Hand R.A. Dodds FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis Osteoarthr Cartil 8 2000 452 463
    • (2000) Osteoarthr Cartil , vol.8 , pp. 452-463
    • James, I.E.1    Kumar, S.2    Barnes, M.R.3    Gress, C.J.4    Hand, A.T.5    Dodds, R.A.6
  • 19
    • 0036714307 scopus 로고    scopus 로고
    • Secreted Frizzled-related proteins: searching for relationships and patterns
    • S.E. Jones C. Jomary Secreted Frizzled-related proteins: searching for relationships and patterns Bioessays 24 2002 811 820
    • (2002) Bioessays , vol.24 , pp. 811-820
    • Jones, S.E.1    Jomary, C.2
  • 21
    • 33644813850 scopus 로고    scopus 로고
    • Regulation of Wnt signaling by protein-protein interaction and post-translational modifications
    • A. Kikuchi S. Kishida H. Yamamoto Regulation of Wnt signaling by protein-protein interaction and post-translational modifications Exp Mol Med 38 2006 1 10
    • (2006) Exp Mol Med , vol.38 , pp. 1-10
    • Kikuchi, A.1    Kishida, S.2    Yamamoto, H.3
  • 23
    • 0036847101 scopus 로고    scopus 로고
    • Transforming growth factor beta induces fibroblast fibrillin-1 matrix formation
    • E.Y. Kissin R. Lemaire J.H. Korn R. Lafyatis Transforming growth factor beta induces fibroblast fibrillin-1 matrix formation Arthritis Rheum 46 2002 3000 3009
    • (2002) Arthritis Rheum , vol.46 , pp. 3000-3009
    • Kissin, E.Y.1    Lemaire, R.2    Korn, J.H.3    Lafyatis, R.4
  • 24
    • 0036545885 scopus 로고    scopus 로고
    • Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis
    • A. Leask A. Holmes D.J. Abraham Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis Curr Rheumatol Rep 4 2002 136 142
    • (2002) Curr Rheumatol Rep , vol.4 , pp. 136-142
    • Leask, A.1    Holmes, A.2    Abraham, D.J.3
  • 25
    • 2442597995 scopus 로고    scopus 로고
    • Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: a possible mechanism of mammary tumorigenesis
    • J.L. Lee C.T. Lin L.L. Chueh C.J. Chang Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: a possible mechanism of mammary tumorigenesis J Biol Chem 279 2004 14602 14609
    • (2004) J Biol Chem , vol.279 , pp. 14602-14609
    • Lee, J.L.1    Lin, C.T.2    Chueh, L.L.3    Chang, C.J.4
  • 26
    • 0032122460 scopus 로고    scopus 로고
    • Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family
    • C. Leimeister A. Bach M. Gessler Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family Mech Dev 75 1998 29 42
    • (1998) Mech Dev , vol.75 , pp. 29-42
    • Leimeister, C.1    Bach, A.2    Gessler, M.3
  • 27
    • 33750208100 scopus 로고    scopus 로고
    • Fibrillin in Marfan syndrome and tight skin mice provides new insights into transforming growth factor-beta regulation and systemic sclerosis
    • R. Lemaire J. Bayle R. Lafyatis Fibrillin in Marfan syndrome and tight skin mice provides new insights into transforming growth factor-beta regulation and systemic sclerosis Curr Opin Rheumatol 18 2006 582 587
    • (2006) Curr Opin Rheumatol , vol.18 , pp. 582-587
    • Lemaire, R.1    Bayle, J.2    Lafyatis, R.3
  • 28
    • 33846978751 scopus 로고    scopus 로고
    • Microfibril-associated MAGP-2 stimulates elastic fiber assembly
    • R. Lemaire J. Bayle R.P. Mecham R. Lafyatis Microfibril-associated MAGP-2 stimulates elastic fiber assembly J Biol Chem 282 2007 800 808
    • (2007) J Biol Chem , vol.282 , pp. 800-808
    • Lemaire, R.1    Bayle, J.2    Mecham, R.P.3    Lafyatis, R.4
  • 29
    • 1542313925 scopus 로고    scopus 로고
    • Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril-associated glycoprotein 2 and type I collagen
    • R. Lemaire G. Farina E. Kissin J.M. Shipley C. Bona J.H. Korn Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril-associated glycoprotein 2 and type I collagen Arthritis Rheum 50 2004 915 926
    • (2004) Arthritis Rheum , vol.50 , pp. 915-926
    • Lemaire, R.1    Farina, G.2    Kissin, E.3    Shipley, J.M.4    Bona, C.5    Korn, J.H.6
  • 30
    • 9744241690 scopus 로고    scopus 로고
    • Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering
    • R. Lemaire J.H. Korn W.P. Schiemann R. Lafyatis Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering J Invest Dermatol 123 2004 1063 1069
    • (2004) J Invest Dermatol , vol.123 , pp. 1063-1069
    • Lemaire, R.1    Korn, J.H.2    Schiemann, W.P.3    Lafyatis, R.4
  • 31
    • 20744434416 scopus 로고    scopus 로고
    • Increased expression of type I collagen induced by microfibril-associated glycoprotein 2: novel mechanistic insights into the molecular basis of dermal fibrosis in scleroderma
    • R. Lemaire J.H. Korn J.M. Shipley R. Lafyatis Increased expression of type I collagen induced by microfibril-associated glycoprotein 2: novel mechanistic insights into the molecular basis of dermal fibrosis in scleroderma Arthritis Rheum 52 2005 1812 1823
    • (2005) Arthritis Rheum , vol.52 , pp. 1812-1823
    • Lemaire, R.1    Korn, J.H.2    Shipley, J.M.3    Lafyatis, R.4
  • 34
    • 4444309488 scopus 로고    scopus 로고
    • The tight skin mouse: an animal model of systemic sclerosis
    • J.L. Pablos E.T. Everett J.S. Norris The tight skin mouse: an animal model of systemic sclerosis Clin Exp Rheumatol 22 2004 S81 S85
    • (2004) Clin Exp Rheumatol , vol.22 , pp. S81-S85
    • Pablos, J.L.1    Everett, E.T.2    Norris, J.S.3
  • 37
    • 0034880422 scopus 로고    scopus 로고
    • Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis
    • S. Reddy T. Andl A. Bagasra M.M. Lu D.J. Epstein E.E. Morrisey Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis Mech Dev 107 2001 69 82
    • (2001) Mech Dev , vol.107 , pp. 69-82
    • Reddy, S.1    Andl, T.2    Bagasra, A.3    Lu, M.M.4    Epstein, D.J.5    Morrisey, E.E.6
  • 38
    • 0033206743 scopus 로고    scopus 로고
    • Genetic and immunologic features associated with scleroderma-like syndrome of TSK mice
    • S. Saito K. Kasturi C. Bona Genetic and immunologic features associated with scleroderma-like syndrome of TSK mice Curr Rheumatol Rep 1 1999 34 37
    • (1999) Curr Rheumatol Rep , vol.1 , pp. 34-37
    • Saito, S.1    Kasturi, K.2    Bona, C.3
  • 39
    • 0033979271 scopus 로고    scopus 로고
    • Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression
    • H. Schumann J. Holtz H.R. Zerkowski M. Hatzfeld Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression Cardiovasc Res 45 2000 720 728
    • (2000) Cardiovasc Res , vol.45 , pp. 720-728
    • Schumann, H.1    Holtz, J.2    Zerkowski, H.R.3    Hatzfeld, M.4
  • 40
    • 0034714517 scopus 로고    scopus 로고
    • Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis
    • X. Shi-wen D. Pennington A. Holmes A. Leask D. Bradham J.R. Beauchamp Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis Exp Cell Res 259 2000 213 224
    • (2000) Exp Cell Res , vol.259 , pp. 213-224
    • Shi-wen, X.1    Pennington, D.2    Holmes, A.3    Leask, A.4    Bradham, D.5    Beauchamp, J.R.6
  • 41
    • 0029941445 scopus 로고    scopus 로고
    • A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation
    • L.D. Siracusa R. McGrath Q. Ma J.J. Moskow J. Manne P.J. Christner A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation Genome Res 6 1996 300 313
    • (1996) Genome Res , vol.6 , pp. 300-313
    • Siracusa, L.D.1    McGrath, R.2    Ma, Q.3    Moskow, J.J.4    Manne, J.5    Christner, P.J.6
  • 42
    • 28444468088 scopus 로고    scopus 로고
    • Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis
    • K. Surendran S. Schiavi K.A. Hruska Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis J Am Soc Nephrol 16 2005 2373 2384
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2373-2384
    • Surendran, K.1    Schiavi, S.2    Hruska, K.A.3
  • 43
    • 12144291274 scopus 로고    scopus 로고
    • Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
    • H. Suzuki D.N. Watkins K.W. Jair K.E. Schuebel S.D. Markowitz W.D. Chen Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer Nat Genet 36 2004 417 422
    • (2004) Nat Genet , vol.36 , pp. 417-422
    • Suzuki, H.1    Watkins, D.N.2    Jair, K.W.3    Schuebel, K.E.4    Markowitz, S.D.5    Chen, W.D.6
  • 44
    • 0035193613 scopus 로고    scopus 로고
    • Expression of Tcf/Lef and sFrp and localization of beta-catenin in the developing mouse lung
    • M. Tebar O. Destree W.J. de Vree A.A. Ten Have-Opbroek Expression of Tcf/Lef and sFrp and localization of beta-catenin in the developing mouse lung Mech Dev 109 2001 437 440
    • (2001) Mech Dev , vol.109 , pp. 437-440
    • Tebar, M.1    Destree, O.2    de Vree, W.J.3    Ten Have-Opbroek, A.A.4
  • 45
    • 0039174251 scopus 로고    scopus 로고
    • Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling
    • A. Uren F. Reichsman V. Anest W.G. Taylor K. Muraiso D.P. Bottaro Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling J Biol Chem 275 2000 4374 4382
    • (2000) J Biol Chem , vol.275 , pp. 4374-4382
    • Uren, A.1    Reichsman, F.2    Anest, V.3    Taylor, W.G.4    Muraiso, K.5    Bottaro, D.P.6
  • 46
    • 33847348491 scopus 로고    scopus 로고
    • Systemic sclerosis: a prototypic multisystem fibrotic disorder
    • J. Varga D. Abraham Systemic sclerosis: a prototypic multisystem fibrotic disorder J Clin Invest 117 2007 557 567
    • (2007) J Clin Invest , vol.117 , pp. 557-567
    • Varga, J.1    Abraham, D.2
  • 47
    • 0034881850 scopus 로고    scopus 로고
    • Abnormalities in fibrillin 1-containing microfibrils in dermal fibroblast cultures from patients with systemic sclerosis (scleroderma)
    • D.D. Wallis F.K. Tan C.M. Kielty M.D. Kimball F.C. Arnett D.M. Milewicz Abnormalities in fibrillin 1-containing microfibrils in dermal fibroblast cultures from patients with systemic sclerosis (scleroderma) Arthritis Rheum 44 2001 1855 1864
    • (2001) Arthritis Rheum , vol.44 , pp. 1855-1864
    • Wallis, D.D.1    Tan, F.K.2    Kielty, C.M.3    Kimball, M.D.4    Arnett, F.C.5    Milewicz, D.M.6
  • 48
    • 0030892061 scopus 로고    scopus 로고
    • Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8
    • S. Wang M. Krinks K. Lin F.P. Luyten M. Moos Jr Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8 Cell 88 1997 757 766
    • (1997) Cell , vol.88 , pp. 757-766
    • Wang, S.1    Krinks, M.2    Lin, K.3    Luyten, F.P.4    Moos, M.5
  • 51
    • 24644518100 scopus 로고    scopus 로고
    • Genomic structure, alternative splicing and tissue expression of rFrp/sFRP-4, the rat frizzled related protein gene
    • J.W. Yam K.W. Chan E.S. Ngan W.L. Hsiao Genomic structure, alternative splicing and tissue expression of rFrp/sFRP-4, the rat frizzled related protein gene Gene 357 2005 55 62
    • (2005) Gene , vol.357 , pp. 55-62
    • Yam, J.W.1    Chan, K.W.2    Ngan, E.S.3    Hsiao, W.L.4
  • 52
    • 33947154329 scopus 로고    scopus 로고
    • A macrophage marker, siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type i interferons and toll-like receptor agonists
    • M.R. York T. Nagai A.J. Mangini R. Lemaire J.M. van Seventer R. Lafyatis A macrophage marker, siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type i interferons and toll-like receptor agonists Arthritis Rheum 56 2007 1010 1020
    • (2007) Arthritis Rheum , vol.56 , pp. 1010-1020
    • York, M.R.1    Nagai, T.2    Mangini, A.J.3    Lemaire, R.4    van Seventer, J.M.5    Lafyatis, R.6
  • 53
    • 0035892875 scopus 로고    scopus 로고
    • Systemic sclerosis (scleroderma): specific autoantigen genes are selectively overexpressed in scleroderma fibroblasts
    • X. Zhou F.K. Tan M. Xiong D.M. Milewicz C.A. Feghali M.J. Fritzler Systemic sclerosis (scleroderma): specific autoantigen genes are selectively overexpressed in scleroderma fibroblasts J Immunol 167 2001 7126 7133
    • (2001) J Immunol , vol.167 , pp. 7126-7133
    • Zhou, X.1    Tan, F.K.2    Xiong, M.3    Milewicz, D.M.4    Feghali, C.A.5    Fritzler, M.J.6


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