메뉴 건너뛰기




Volumn 19, Issue 5, 2010, Pages 393-400

Scleroderma: From pathophysiology to novel therapeutic approaches

Author keywords

Connective tissue; Fibrosis; Growth factor; Hypoxia

Indexed keywords

BOSENTAN; CONNECTIVE TISSUE GROWTH FACTOR; GROWTH FACTOR; IMATINIB; PLATELET DERIVED GROWTH FACTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SILDENAFIL; TRANSFORMING GROWTH FACTOR BETA;

EID: 77953142653     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2010.01082.x     Document Type: Review
Times cited : (37)

References (115)
  • 1
    • 0028920576 scopus 로고
    • Guidelines for clinical trials in systemic sclerosis (scleroderma). I. disease modifying interventions. The American College of Rheumatology Committee on Design and Outcomes in Clinical Trials in Systemic sclerosis
    • White B, Bauer E A, Goldsmith L A. Guidelines for clinical trials in systemic sclerosis (scleroderma). I. disease modifying interventions. The American College of Rheumatology Committee on Design and Outcomes in Clinical Trials in Systemic sclerosis. Arthritis Rheum 1995, 38:351-360.
    • (1995) Arthritis Rheum , vol.38 , pp. 351-360
    • White, B.1    Bauer, E.A.2    Goldsmith, L.A.3
  • 3
    • 34248379222 scopus 로고    scopus 로고
    • Clinical risk assessment of organ manifestations in systemic sclerosis: a report from the EULAR Scleroderma Trials And Research group database
    • Walker U A, Tyndall A, Czirják L. Clinical risk assessment of organ manifestations in systemic sclerosis: a report from the EULAR Scleroderma Trials And Research group database. Ann Rheum Dis 2007, 66:754-763.
    • (2007) Ann Rheum Dis , vol.66 , pp. 754-763
    • Walker, U.A.1    Tyndall, A.2    Czirják, L.3
  • 4
    • 47849097487 scopus 로고    scopus 로고
    • The registry of the German Network for Systemic Scleroderma: frequency of disease subsets and patterns of organ involvement
    • Hunzelmann N, Genth E, Krieg T. The registry of the German Network for Systemic Scleroderma: frequency of disease subsets and patterns of organ involvement. Rheumatology (Oxford) 2008, 47:1185-1192.
    • (2008) Rheumatology (Oxford) , vol.47 , pp. 1185-1192
    • Hunzelmann, N.1    Genth, E.2    Krieg, T.3
  • 5
    • 3242723418 scopus 로고    scopus 로고
    • Scleroderma - clinical and pathological advances
    • Denton C P, Black C M. Scleroderma - clinical and pathological advances. Best Pract Res Clin Rheumatol 2004, 18:271-290.
    • (2004) Best Pract Res Clin Rheumatol , vol.18 , pp. 271-290
    • Denton, C.P.1    Black, C.M.2
  • 6
    • 66149112569 scopus 로고    scopus 로고
    • European League Against Rheumatism (EULAR) Scleroderma Trial and Research group (EUSTAR) recommendations for the treatment of systemic sclerosis: methods of elaboration and results of systematic literature research
    • Avouac J, Kowal-Bielecka O, Landewe R. European League Against Rheumatism (EULAR) Scleroderma Trial and Research group (EUSTAR) recommendations for the treatment of systemic sclerosis: methods of elaboration and results of systematic literature research. Ann Rheum Dis 2009, 68:629-634.
    • (2009) Ann Rheum Dis , vol.68 , pp. 629-634
    • Avouac, J.1    Kowal-Bielecka, O.2    Landewe, R.3
  • 7
    • 66149100618 scopus 로고    scopus 로고
    • EULAR recommendations for the treatment of systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group (EUSTAR)
    • Kowal-Bielecka O, Landewé R, Avouac J. EULAR recommendations for the treatment of systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group (EUSTAR). Ann Rheum Dis 2009, 68:620-628.
    • (2009) Ann Rheum Dis , vol.68 , pp. 620-628
    • Kowal-Bielecka, O.1    Landewé, R.2    Avouac, J.3
  • 9
    • 62849100599 scopus 로고    scopus 로고
    • High frequency of corticosteroid and immunosuppressive therapy in patients with systemic sclerosis despite limited evidence for efficacy
    • Hunzelmann N, Moinzadeh P, Genth E. High frequency of corticosteroid and immunosuppressive therapy in patients with systemic sclerosis despite limited evidence for efficacy. Arthritis Res Ther 2009, 11:R30.
    • (2009) Arthritis Res Ther , vol.11
    • Hunzelmann, N.1    Moinzadeh, P.2    Genth, E.3
  • 10
    • 33745227399 scopus 로고    scopus 로고
    • Cyclophosphamide versus placebo in scleroderma lung disease
    • Tashkin D P, Elashoff R, Clements P J. Cyclophosphamide versus placebo in scleroderma lung disease. N Engl J Med 2006, 354:2655-2666.
    • (2006) N Engl J Med , vol.354 , pp. 2655-2666
    • Tashkin, D.P.1    Elashoff, R.2    Clements, P.J.3
  • 11
    • 34347266509 scopus 로고    scopus 로고
    • Changes in causes of death in systemic sclerosis, 1972-2002
    • Steen V D, Medsger T A. Changes in causes of death in systemic sclerosis, 1972-2002. Ann Rheum Dis 2007, 66:940-944.
    • (2007) Ann Rheum Dis , vol.66 , pp. 940-944
    • Steen, V.D.1    Medsger, T.A.2
  • 12
    • 0036124419 scopus 로고    scopus 로고
    • Systemic sclerosis: demographic, clinical, and serologic features and survival in 1,012 Italian patients
    • Ferri C, Valentini G, Cozzi F. Systemic sclerosis: demographic, clinical, and serologic features and survival in 1,012 Italian patients. Medicine (Baltimore) 2002, 81:139-153.
    • (2002) Medicine (Baltimore) , vol.81 , pp. 139-153
    • Ferri, C.1    Valentini, G.2    Cozzi, F.3
  • 13
    • 74449085877 scopus 로고    scopus 로고
    • Determinants of Morbidity and Mortality of Systemic Sclerosis in Canada
    • Al-Dhaher F F, Pope J E, Ouimet J M. Determinants of Morbidity and Mortality of Systemic Sclerosis in Canada. Semin Arthritis Rheum 2010, 39:269-277.
    • (2010) Semin Arthritis Rheum , vol.39 , pp. 269-277
    • Al-Dhaher, F.F.1    Pope, J.E.2    Ouimet, J.M.3
  • 14
    • 19944427793 scopus 로고    scopus 로고
    • Mortality in systemic sclerosis: an international meta-analysis of individual patient data
    • Ioannidis J P, Vlachoyiannopoulos P G, Haidich A B. Mortality in systemic sclerosis: an international meta-analysis of individual patient data. Am J Med 2005, 118:2-10.
    • (2005) Am J Med , vol.118 , pp. 2-10
    • Ioannidis, J.P.1    Vlachoyiannopoulos, P.G.2    Haidich, A.B.3
  • 15
    • 42449112005 scopus 로고    scopus 로고
    • Scleroderma Clinical Trials Consortium co-authors. Development of a provisional core set of response measures for clinical trials of systemic sclerosis
    • Khanna D, Lovell D J, Giannini E. Scleroderma Clinical Trials Consortium co-authors. Development of a provisional core set of response measures for clinical trials of systemic sclerosis. Ann Rheum Dis 2008, 67:703-709.
    • (2008) Ann Rheum Dis , vol.67 , pp. 703-709
    • Khanna, D.1    Lovell, D.J.2    Giannini, E.3
  • 16
    • 0026604019 scopus 로고
    • Sequential dermal microvascular and perivascular changes in the development of scleroderma
    • Prescott R J, Freemont A, Jones C. Sequential dermal microvascular and perivascular changes in the development of scleroderma. J Pathol 1992, 166:255-263.
    • (1992) J Pathol , vol.166 , pp. 255-263
    • Prescott, R.J.1    Freemont, A.2    Jones, C.3
  • 17
    • 0018843919 scopus 로고
    • Diagnostic potential of in vivo capillary microscopy in scleroderma and related disorders
    • Maricq H, LeRoy E, Dangelo W. Diagnostic potential of in vivo capillary microscopy in scleroderma and related disorders. Arthritis Rheum 1980, 23:83-189.
    • (1980) Arthritis Rheum , vol.23 , pp. 83-189
    • Maricq, H.1    LeRoy, E.2    Dangelo, W.3
  • 18
    • 0029999963 scopus 로고    scopus 로고
    • Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma
    • Sgonc R, Gruschwitz M, Dietrich H. Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma. J Clin Invest 1996, 98:785-792.
    • (1996) J Clin Invest , vol.98 , pp. 785-792
    • Sgonc, R.1    Gruschwitz, M.2    Dietrich, H.3
  • 19
    • 0031127473 scopus 로고    scopus 로고
    • Mechanism of serum mediated endothelial injury in scleroderma: identification of a granular enzyme in scleroderma skin and sera
    • Kahaleh M, Fan P S. Mechanism of serum mediated endothelial injury in scleroderma: identification of a granular enzyme in scleroderma skin and sera. Clin Immunol Immunopathol 1997, 83:32-40.
    • (1997) Clin Immunol Immunopathol , vol.83 , pp. 32-40
    • Kahaleh, M.1    Fan, P.S.2
  • 20
    • 0033850755 scopus 로고    scopus 로고
    • Increased concentrations of the circulating angiogenesis inhibitor endostatin in patients with systemic sclerosis
    • Hebbar M, Peyrat J P, Hornez L, Hatron P Y, Hachulla E, Devulder B. Increased concentrations of the circulating angiogenesis inhibitor endostatin in patients with systemic sclerosis. Arthritis Rheum 2000, 43:889-893.
    • (2000) Arthritis Rheum , vol.43 , pp. 889-893
    • Hebbar, M.1    Peyrat, J.P.2    Hornez, L.3    Hatron, P.Y.4    Hachulla, E.5    Devulder, B.6
  • 21
    • 0033790892 scopus 로고    scopus 로고
    • Systemic sclerosis immunoglobulin G autoantibodies bind the human cytomegalovirus late protein UL94 and induce apoptosis in human endothelial cells
    • Lunardi C. Systemic sclerosis immunoglobulin G autoantibodies bind the human cytomegalovirus late protein UL94 and induce apoptosis in human endothelial cells. Nat Med 2000, 6:1183-1186.
    • (2000) Nat Med , vol.6 , pp. 1183-1186
    • Lunardi, C.1
  • 22
    • 32044456248 scopus 로고    scopus 로고
    • Antibodies against human cytomegalovirus in the pathogenesis of systemic sclerosis: a gene array approach
    • Lunardi C, Dolcino M, Peterlana D. Antibodies against human cytomegalovirus in the pathogenesis of systemic sclerosis: a gene array approach. PLoS Med 2006, 3:e2.
    • (2006) PLoS Med , vol.3
    • Lunardi, C.1    Dolcino, M.2    Peterlana, D.3
  • 23
    • 39049171830 scopus 로고    scopus 로고
    • Capillary regeneration in scleroderma: stem cell therapy reverses phenotype?
    • Fleming J N, Nash R A, McLeod D O. Capillary regeneration in scleroderma: stem cell therapy reverses phenotype? PLoS ONE 2008, 16:3.
    • (2008) PLoS ONE , vol.16 , pp. 3
    • Fleming, J.N.1    Nash, R.A.2    McLeod, D.O.3
  • 26
    • 17544370003 scopus 로고    scopus 로고
    • Soluble adhesion molecules (sVCAM-1, sE-selectin), vascular endothelial growth factor (VEGF) and endothelin-1 in patients with systemic sclerosis: relationship to organ systemic involvement
    • Kuryliszyn-Moskal A, Klimiuk P A, Sierakowski S. Soluble adhesion molecules (sVCAM-1, sE-selectin), vascular endothelial growth factor (VEGF) and endothelin-1 in patients with systemic sclerosis: relationship to organ systemic involvement. Clin Rheumatol 2005, 24:111-116.
    • (2005) Clin Rheumatol , vol.24 , pp. 111-116
    • Kuryliszyn-Moskal, A.1    Klimiuk, P.A.2    Sierakowski, S.3
  • 28
    • 58849152850 scopus 로고    scopus 로고
    • EULAR Scleroderma Trials and Research group statement and recommendations on endothelial precursor cells
    • Distler J H, Allanore Y, Avouac J. EULAR Scleroderma Trials and Research group statement and recommendations on endothelial precursor cells. Ann Rheum Dis 2009, 68:163-168.
    • (2009) Ann Rheum Dis , vol.68 , pp. 163-168
    • Distler, J.H.1    Allanore, Y.2    Avouac, J.3
  • 29
    • 55849130694 scopus 로고    scopus 로고
    • Angiogenesis in systemic sclerosis: impaired expression of vascular endothelial growth factor receptor 1 in endothelial progenitor-derived cells under hypoxic conditions
    • Avouac J, Wipff J, Goldman O. Angiogenesis in systemic sclerosis: impaired expression of vascular endothelial growth factor receptor 1 in endothelial progenitor-derived cells under hypoxic conditions. Arthritis Rheum 2008, 58:3550-3561.
    • (2008) Arthritis Rheum , vol.58 , pp. 3550-3561
    • Avouac, J.1    Wipff, J.2    Goldman, O.3
  • 30
    • 34247564964 scopus 로고    scopus 로고
    • Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers
    • Distler O, Del Rosso A, Giacomelli R. Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers. Arthritis Res 2002, 4:R11.
    • (2002) Arthritis Res , vol.4
    • Distler, O.1    Del Rosso, A.2    Giacomelli, R.3
  • 31
    • 77953141647 scopus 로고    scopus 로고
    • Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis
    • Distler O, Distler J H, Scheid A. Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis. Circ Res 2004, 9:95.
    • (2004) Circ Res , vol.9 , pp. 95
    • Distler, O.1    Distler, J.H.2    Scheid, A.3
  • 32
    • 30744438818 scopus 로고    scopus 로고
    • The differential expression of VEGF, VEGFR-2, and GLUT-1 proteins in disease subtypes of systemic sclerosis
    • Davies C A, Jeziorska M, Freemont A J, Herrick A L. The differential expression of VEGF, VEGFR-2, and GLUT-1 proteins in disease subtypes of systemic sclerosis. Hum Pathol 2006, 37:190-197.
    • (2006) Hum Pathol , vol.37 , pp. 190-197
    • Davies, C.A.1    Jeziorska, M.2    Freemont, A.J.3    Herrick, A.L.4
  • 33
    • 26644440414 scopus 로고    scopus 로고
    • Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: important pathogenetic steps in early and late stage of systemic scleroderma?
    • Brinckmann J, Kim S, Wu J. Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: important pathogenetic steps in early and late stage of systemic scleroderma? Matrix Biol 2005, 24:459-468.
    • (2005) Matrix Biol , vol.24 , pp. 459-468
    • Brinckmann, J.1    Kim, S.2    Wu, J.3
  • 34
    • 37149006718 scopus 로고    scopus 로고
    • Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis
    • Distler J H, Jüngel A, Pileckyte M. Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis. Arthritis Rheum 2007, 56:4203-4215.
    • (2007) Arthritis Rheum , vol.56 , pp. 4203-4215
    • Distler, J.H.1    Jüngel, A.2    Pileckyte, M.3
  • 35
    • 33750083588 scopus 로고    scopus 로고
    • Hypoxia induces expression of connective tissue growth factor in scleroderma skin fibroblasts
    • Hong K H, Yoo S A, Kang S S, Choi J J, Kim W U, Cho C S. Hypoxia induces expression of connective tissue growth factor in scleroderma skin fibroblasts. Clin Exp Immunol 2006, 146:362-370.
    • (2006) Clin Exp Immunol , vol.146 , pp. 362-370
    • Hong, K.H.1    Yoo, S.A.2    Kang, S.S.3    Choi, J.J.4    Kim, W.U.5    Cho, C.S.6
  • 36
    • 36849021771 scopus 로고    scopus 로고
    • Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
    • Higgins D F, Kimura K, Bernhardt W M. Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest 2007, 117:3810-3820.
    • (2007) J Clin Invest , vol.117 , pp. 3810-3820
    • Higgins, D.F.1    Kimura, K.2    Bernhardt, W.M.3
  • 37
    • 59449090107 scopus 로고    scopus 로고
    • TGF-beta-induced epithelial to mesenchymal transition
    • Xu J, Lamouille S, Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res 2009, 19:156-172.
    • (2009) Cell Res , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 38
    • 0034837756 scopus 로고    scopus 로고
    • Effects of long-term cyclic iloprost therapy in systemic sclerosis with Raynaud's phenomenon. A randomized, controlled study
    • Scorza R, Caronni M, Mascagni B. Effects of long-term cyclic iloprost therapy in systemic sclerosis with Raynaud's phenomenon. A randomized, controlled study. Clin Exp Rheumatol 2001, 19:503-508.
    • (2001) Clin Exp Rheumatol , vol.19 , pp. 503-508
    • Scorza, R.1    Caronni, M.2    Mascagni, B.3
  • 39
    • 62649152815 scopus 로고    scopus 로고
    • Comparison of patients with and without digital ulcers in systemic sclerosis: detection of possible risk factors
    • Sunderkötter C, Herrgott I, Brückner C. Comparison of patients with and without digital ulcers in systemic sclerosis: detection of possible risk factors. Br J Dermatol 2009, 160:835-843.
    • (2009) Br J Dermatol , vol.160 , pp. 835-843
    • Sunderkötter, C.1    Herrgott, I.2    Brückner, C.3
  • 40
    • 37849012578 scopus 로고    scopus 로고
    • BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis
    • King T E, Behr J, Brown K K. BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2008, 1:177.
    • (2008) Am J Respir Crit Care Med , vol.1 , pp. 177
    • King, T.E.1    Behr, J.2    Brown, K.K.3
  • 41
    • 18344396051 scopus 로고    scopus 로고
    • Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans
    • Zuo F, Kaminski N, Eugui E. Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. Proc Natl Acad Sci USA 2002, 99:6292-6297.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 6292-6297
    • Zuo, F.1    Kaminski, N.2    Eugui, E.3
  • 42
    • 72549108357 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha processing inhibitor-1 inhibits skin fibrosis in a bleomycin-induced murine model of scleroderma
    • Terao M, Murota H, Kitaba S, Katayama I. Tumor necrosis factor-alpha processing inhibitor-1 inhibits skin fibrosis in a bleomycin-induced murine model of scleroderma. Exp Dermatol 2010, 18:38-43.
    • (2010) Exp Dermatol , vol.18 , pp. 38-43
    • Terao, M.1    Murota, H.2    Kitaba, S.3    Katayama, I.4
  • 43
    • 2442694270 scopus 로고    scopus 로고
    • Pivotal role of cathepsin K in lung fibrosis
    • Buhling F, Rocken C, Brasch F. Pivotal role of cathepsin K in lung fibrosis. Am J Pathol 2004, 164:2203-2216.
    • (2004) Am J Pathol , vol.164 , pp. 2203-2216
    • Buhling, F.1    Rocken, C.2    Brasch, F.3
  • 44
    • 17044454221 scopus 로고    scopus 로고
    • Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis
    • van der Slot A J, Zuurmond A M, Bardoel A F. Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis. J Biol Chem 2003, 278:40967-40972.
    • (2003) J Biol Chem , vol.278 , pp. 40967-40972
    • van der Slot, A.J.1    Zuurmond, A.M.2    Bardoel, A.F.3
  • 45
    • 0032406845 scopus 로고    scopus 로고
    • Increased circulating concentrations of the type I collagen specific degradation product ICTP in systemic sclerosis reflect the extent of skin involvement: a new serum marker for clinical severity in SSc patients
    • Hunzelmann N, Risteli J, Risteli L, Sacher C, Black C M, Krieg T. Increased circulating concentrations of the type I collagen specific degradation product ICTP in systemic sclerosis reflect the extent of skin involvement: a new serum marker for clinical severity in SSc patients. Br J Dermatol 1998, 139:1020-1025.
    • (1998) Br J Dermatol , vol.139 , pp. 1020-1025
    • Hunzelmann, N.1    Risteli, J.2    Risteli, L.3    Sacher, C.4    Black, C.M.5    Krieg, T.6
  • 46
    • 12244264813 scopus 로고    scopus 로고
    • Correlation of serum collagen I carboxyterminal telopeptide concentrations with cutaneous and pulmonary involvement in systemic sclerosis
    • Allanore Y, Borderie D, Lemaréchal H, Cherruau B, Ekindjian O G, Kahan A. Correlation of serum collagen I carboxyterminal telopeptide concentrations with cutaneous and pulmonary involvement in systemic sclerosis. J Rheumatol 2003, 30:68-73.
    • (2003) J Rheumatol , vol.30 , pp. 68-73
    • Allanore, Y.1    Borderie, D.2    Lemaréchal, H.3    Cherruau, B.4    Ekindjian, O.G.5    Kahan, A.6
  • 47
    • 77953170845 scopus 로고    scopus 로고
    • Autologous peripheral blood stem cell transplantation for systemic sclerosis - C-terminal collagen telopeptide serum levels as a biomarker for reduction of fibrosis and clinical improvement
    • Kötter I, Henes J, Koch S, Kanz L, Hunzelmann N. Autologous peripheral blood stem cell transplantation for systemic sclerosis - C-terminal collagen telopeptide serum levels as a biomarker for reduction of fibrosis and clinical improvement. Ann Rheum Dis 2007, 66(Suppl. II):213.
    • (2007) Ann Rheum Dis , vol.66 , Issue.2 SUPPL. , pp. 213
    • Kötter, I.1    Henes, J.2    Koch, S.3    Kanz, L.4    Hunzelmann, N.5
  • 48
    • 33745042859 scopus 로고    scopus 로고
    • Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts
    • Gardner H, Shearstone J R, Bandaru R. Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts. Arthritis Rheum 2006, 54:1961-1973.
    • (2006) Arthritis Rheum , vol.54 , pp. 1961-1973
    • Gardner, H.1    Shearstone, J.R.2    Bandaru, R.3
  • 49
    • 49949114547 scopus 로고    scopus 로고
    • Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin
    • Milano A, Pendergrass S A, Sargent J L. Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin. PLoS ONE 2008, 3:e2696.
    • (2008) PLoS ONE , vol.3
    • Milano, A.1    Pendergrass, S.A.2    Sargent, J.L.3
  • 50
    • 0028040486 scopus 로고    scopus 로고
    • Localization of endothelin-1 and its binding sites in scleroderma skin
    • Vancheeswaran R, Azam A, Black C, Dashwood M R. Localization of endothelin-1 and its binding sites in scleroderma skin. J Rheumatol 2004, 21:1268-1276.
    • (2004) J Rheumatol , vol.21 , pp. 1268-1276
    • Vancheeswaran, R.1    Azam, A.2    Black, C.3    Dashwood, M.R.4
  • 51
    • 77953173150 scopus 로고    scopus 로고
    • Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK
    • Xu S W, Howat S L, Renzoni E A. Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK. J Biol Chem 2004, 28:279.
    • (2004) J Biol Chem , vol.28 , pp. 279
    • Xu, S.W.1    Howat, S.L.2    Renzoni, E.A.3
  • 52
    • 29144492719 scopus 로고    scopus 로고
    • Signalling and regulation of collagen I synthesis by ET-1 and TGF-beta 1
    • Horstmeyer A, Licht C, Scherr G, Eckes G, Krieg T. Signalling and regulation of collagen I synthesis by ET-1 and TGF-beta 1. FEBS J 2005, 272:6297-6309.
    • (2005) FEBS J , vol.272 , pp. 6297-6309
    • Horstmeyer, A.1    Licht, C.2    Scherr, G.3    Eckes, G.4    Krieg, T.5
  • 53
    • 59649083980 scopus 로고    scopus 로고
    • Alpha-melanocyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: melanocortin peptides as a novel treatment strategy for scleroderma?
    • Kokot A, Sindrilaru A, Schiller M. alpha-melanocyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: melanocortin peptides as a novel treatment strategy for scleroderma? Arthritis Rheum 2009, 60:592-603.
    • (2009) Arthritis Rheum , vol.60 , pp. 592-603
    • Kokot, A.1    Sindrilaru, A.2    Schiller, M.3
  • 55
    • 34547676391 scopus 로고    scopus 로고
    • Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
    • Zeisberg E M, Tarnavaski O, Zeisberg M. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med 2007, 13:952-961.
    • (2007) Nat Med , vol.13 , pp. 952-961
    • Zeisberg, E.M.1    Tarnavaski, O.2    Zeisberg, M.3
  • 56
    • 34247533369 scopus 로고    scopus 로고
    • Phenotypic transitions and fibrosis in diabetic nephropathy
    • Simonson M S. Phenotypic transitions and fibrosis in diabetic nephropathy. Kidney Int 2007, 71:846-854.
    • (2007) Kidney Int , vol.71 , pp. 846-854
    • Simonson, M.S.1
  • 57
    • 34547960749 scopus 로고    scopus 로고
    • The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses
    • Bellini A, Mattoli S. The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses. Lab Invest 2007, 87:858-870.
    • (2007) Lab Invest , vol.87 , pp. 858-870
    • Bellini, A.1    Mattoli, S.2
  • 58
    • 33846086980 scopus 로고    scopus 로고
    • Transforming growth factor-beta: innately bipolar
    • Wahl S M. Transforming growth factor-beta: innately bipolar. Curr Opin Immunol 2007, 19:55-62.
    • (2007) Curr Opin Immunol , vol.19 , pp. 55-62
    • Wahl, S.M.1
  • 59
    • 2142646426 scopus 로고    scopus 로고
    • TGF-beta signaling and the fibrotic response
    • Leask A, Abraham D J. TGF-beta signaling and the fibrotic response. FASEB J 2004, 18:816-827.
    • (2004) FASEB J , vol.18 , pp. 816-827
    • Leask, A.1    Abraham, D.J.2
  • 60
    • 34948826895 scopus 로고    scopus 로고
    • Molecular pathways as novel therapeutic targets in systemic sclerosis
    • Trojanowska M, Varga J. Molecular pathways as novel therapeutic targets in systemic sclerosis. Curr Opin Rheumatol 2007, 19:568-573.
    • (2007) Curr Opin Rheumatol , vol.19 , pp. 568-573
    • Trojanowska, M.1    Varga, J.2
  • 61
    • 0035089825 scopus 로고    scopus 로고
    • Blockade of endogenous transforming growth factor beta signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor beta receptors
    • Ihn H, Yamane K, Kubo M, Tamaki K. Blockade of endogenous transforming growth factor beta signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor beta receptors. Arthritis Rheum 2001, 44:474-480.
    • (2001) Arthritis Rheum , vol.44 , pp. 474-480
    • Ihn, H.1    Yamane, K.2    Kubo, M.3    Tamaki, K.4
  • 62
    • 0031886413 scopus 로고    scopus 로고
    • Increased expression of TGF-beta receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype
    • Kawakami T, Ihn H, Xu W, Smith E, LeRoy C, Trojanowska M. Increased expression of TGF-beta receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype. J Invest Dermatol 1998, 110:47-51.
    • (1998) J Invest Dermatol , vol.110 , pp. 47-51
    • Kawakami, T.1    Ihn, H.2    Xu, W.3    Smith, E.4    LeRoy, C.5    Trojanowska, M.6
  • 63
    • 0029905441 scopus 로고    scopus 로고
    • Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney
    • Isaka Y, Brees D K, Ikegaya K. Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nat Med 1996, 2:418-423.
    • (1996) Nat Med , vol.2 , pp. 418-423
    • Isaka, Y.1    Brees, D.K.2    Ikegaya, K.3
  • 64
    • 0033571072 scopus 로고    scopus 로고
    • Anti-TGF-beta treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma
    • McCormick L L, Zhang Y, Tootell E, Gilliam A C. Anti-TGF-beta treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma. J Immunol 1999, 163:5693-5699.
    • (1999) J Immunol , vol.163 , pp. 5693-5699
    • McCormick, L.L.1    Zhang, Y.2    Tootell, E.3    Gilliam, A.C.4
  • 65
    • 27144458232 scopus 로고    scopus 로고
    • Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis
    • Santiago B, Gutierrez-Canas I, Dotor J. Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis. J Invest Dermatol 2005, 125:450-455.
    • (2005) J Invest Dermatol , vol.125 , pp. 450-455
    • Santiago, B.1    Gutierrez-Canas, I.2    Dotor, J.3
  • 66
    • 77953150350 scopus 로고    scopus 로고
    • A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats
    • Hermida N, López B, González A. A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats. Cardiovasc Res 2009, 15:81.
    • (2009) Cardiovasc Res , vol.15 , pp. 81
    • Hermida, N.1    López, B.2    González, A.3
  • 67
    • 3042550759 scopus 로고    scopus 로고
    • Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma
    • Lakos G, Takagawa S, Chen S J. Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. Am J Pathol 2004, 165:203-217.
    • (2004) Am J Pathol , vol.165 , pp. 203-217
    • Lakos, G.1    Takagawa, S.2    Chen, S.J.3
  • 68
    • 0041342109 scopus 로고    scopus 로고
    • Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery
    • Mead A L, Wong T T, Cordeiro M F, Anderson I K, Khaw P T. Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery. Invest Ophthalmol Vis Sci 2003, 44:3394-3401.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 3394-3401
    • Mead, A.L.1    Wong, T.T.2    Cordeiro, M.F.3    Anderson, I.K.4    Khaw, P.T.5
  • 69
    • 34748861947 scopus 로고    scopus 로고
    • A phase III study of subconjunctival human anti-transforming growth factor beta (2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy
    • Khaw P, Grehn F. A phase III study of subconjunctival human anti-transforming growth factor beta (2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy. Ophthalmology 2007, 114:1822-1830.
    • (2007) Ophthalmology , vol.114 , pp. 1822-1830
    • Khaw, P.1    Grehn, F.2
  • 70
    • 33846250366 scopus 로고    scopus 로고
    • Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192
    • Denton C P, Merkel P A, Furst D E. Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum 2007, 56:323-333.
    • (2007) Arthritis Rheum , vol.56 , pp. 323-333
    • Denton, C.P.1    Merkel, P.A.2    Furst, D.E.3    et al4
  • 71
    • 0032875460 scopus 로고    scopus 로고
    • Mechanism of action and in vivo role of platelet-derived growth factor
    • Heldin C-H, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 1999, 79:1283-1316.
    • (1999) Physiol Rev , vol.79 , pp. 1283-1316
    • Heldin, C.-H.1    Westermark, B.2
  • 72
    • 0032462002 scopus 로고    scopus 로고
    • Evidence for distinct signaling properties and biological responses induced by the PDGF receptor α and β subtypes
    • Rosenkranz S, Kazlauskas A. Evidence for distinct signaling properties and biological responses induced by the PDGF receptor α and β subtypes. Growth Factors 1999, 16:201-216.
    • (1999) Growth Factors , vol.16 , pp. 201-216
    • Rosenkranz, S.1    Kazlauskas, A.2
  • 73
    • 17144386566 scopus 로고    scopus 로고
    • Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells: only phosphatidylinositol 3′-kinase is important
    • Vantler M, Caglayan E, Zimmermann W H, Bäumer A T, Rosenkranz S. Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells: only phosphatidylinositol 3′-kinase is important. J Biol Chem 2005, 280:14168-14176.
    • (2005) J Biol Chem , vol.280 , pp. 14168-14176
    • Vantler, M.1    Caglayan, E.2    Zimmermann, W.H.3    Bäumer, A.T.4    Rosenkranz, S.5
  • 74
    • 26444540768 scopus 로고    scopus 로고
    • Reversal of experimental pulmonary hypertension by PDGF inhibition
    • Schermuly R T, Dony E, Ghofrani H A. Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 2005, 115:2811-2821.
    • (2005) J Clin Invest , vol.115 , pp. 2811-2821
    • Schermuly, R.T.1    Dony, E.2    Ghofrani, H.A.3
  • 75
    • 59649093844 scopus 로고    scopus 로고
    • Increased PDGFRα Activation Disrupts Connective Tissue Development and Drives Systemic Fibrosis
    • Olson L E, Soriano P. Increased PDGFRα Activation Disrupts Connective Tissue Development and Drives Systemic Fibrosis. Dev Cell 2009, 16:303-313.
    • (2009) Dev Cell , vol.16 , pp. 303-313
    • Olson, L.E.1    Soriano, P.2
  • 76
    • 33745277147 scopus 로고    scopus 로고
    • Stimulatory Autoantibodies to the PDGF Receptor in Systemic Sclerosis
    • Baroni S S, Santillo M, Bevilacqua F. Stimulatory Autoantibodies to the PDGF Receptor in Systemic Sclerosis. N Engl J Med 2006, 354:2667-2676.
    • (2006) N Engl J Med , vol.354 , pp. 2667-2676
    • Baroni, S.S.1    Santillo, M.2    Bevilacqua, F.3
  • 77
    • 34347386226 scopus 로고    scopus 로고
    • Stimulatory autoantibodies to PDGF receptor in patients with extensive chronic graft-versus-host disease
    • Svegliati S, Olivieri A, Campelli N. Stimulatory autoantibodies to PDGF receptor in patients with extensive chronic graft-versus-host disease. Blood 2007, 1:110.
    • (2007) Blood , vol.1 , pp. 110
    • Svegliati, S.1    Olivieri, A.2    Campelli, N.3
  • 78
    • 65249166538 scopus 로고    scopus 로고
    • Stimulatory autoantibodies to platelet-derived growth factor receptors in systemic sclerosis: what functional autoimmunity could learn from receptor biology
    • Dragun D, Distler J H, Riemekasten G, Distler O. Stimulatory autoantibodies to platelet-derived growth factor receptors in systemic sclerosis: what functional autoimmunity could learn from receptor biology. Arthritis Rheum 2009, 60:907-911.
    • (2009) Arthritis Rheum , vol.60 , pp. 907-911
    • Dragun, D.1    Distler, J.H.2    Riemekasten, G.3    Distler, O.4
  • 79
    • 0035064803 scopus 로고    scopus 로고
    • The CCN family of genes: a brief history
    • Perbal B. The CCN family of genes: a brief history. Mol Pathol 2001, 54:103-104.
    • (2001) Mol Pathol , vol.54 , pp. 103-104
    • Perbal, B.1
  • 80
    • 0029816069 scopus 로고    scopus 로고
    • Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor
    • Frazier K, Williams S, Kothapalli D, Klapper H, Grotendorst G R. Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J Invest Dermatol 1996, 107:404-411.
    • (1996) J Invest Dermatol , vol.107 , pp. 404-411
    • Frazier, K.1    Williams, S.2    Kothapalli, D.3    Klapper, H.4    Grotendorst, G.R.5
  • 81
    • 0029996247 scopus 로고    scopus 로고
    • Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders
    • Igarashi A, Nashiro K, Kikuchi K. Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. J Invest Dermatol 1996, 106:729-733.
    • (1996) J Invest Dermatol , vol.106 , pp. 729-733
    • Igarashi, A.1    Nashiro, K.2    Kikuchi, K.3
  • 82
    • 0035161153 scopus 로고    scopus 로고
    • Transforming growth factor-beta and connective tissue growth factor: key cytokines in scleroderma pathogenesis
    • Denton C P, Abraham D J. Transforming growth factor-beta and connective tissue growth factor: key cytokines in scleroderma pathogenesis. Curr Opin Rheumatol 2001, 13:505-511.
    • (2001) Curr Opin Rheumatol , vol.13 , pp. 505-511
    • Denton, C.P.1    Abraham, D.J.2
  • 83
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • Wynn T A. Cellular and molecular mechanisms of fibrosis. J Pathol 2008, 214:199-210.
    • (2008) J Pathol , vol.214 , pp. 199-210
    • Wynn, T.A.1
  • 85
    • 77953173512 scopus 로고    scopus 로고
    • Imatinib for the treatment of pulmonary arterial hypertension
    • Ghofrani H A, Seeger W, Grimminger F. Imatinib for the treatment of pulmonary arterial hypertension. N Engl J Med 2005, 29:353.
    • (2005) N Engl J Med , vol.29 , pp. 353
    • Ghofrani, H.A.1    Seeger, W.2    Grimminger, F.3
  • 86
    • 36348930435 scopus 로고    scopus 로고
    • Marrow fibrosis and its relevance during imatinib treatment of chronic myeloid leukemia
    • Buesche G, Ganser A, Schlegelberger B. Marrow fibrosis and its relevance during imatinib treatment of chronic myeloid leukemia. Leukemia 2007, 21:2420-2427.
    • (2007) Leukemia , vol.21 , pp. 2420-2427
    • Buesche, G.1    Ganser, A.2    Schlegelberger, B.3
  • 87
    • 33846209989 scopus 로고    scopus 로고
    • Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis
    • Distler J H, Jüngel A, Huber L C. Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis. Arthritis Rheum 2007, 56:311-322.
    • (2007) Arthritis Rheum , vol.56 , pp. 311-322
    • Distler, J.H.1    Jüngel, A.2    Huber, L.C.3
  • 88
    • 46749154199 scopus 로고    scopus 로고
    • Dual inhibition of c-abl and PDGF receptor signaling by datatinib and nilotinib for the treatment of dermal fibrosis
    • Akhmetshina A, Dees C, Pileckyte M. Dual inhibition of c-abl and PDGF receptor signaling by datatinib and nilotinib for the treatment of dermal fibrosis. FASEB J 2008, 22:2214-2222.
    • (2008) FASEB J , vol.22 , pp. 2214-2222
    • Akhmetshina, A.1    Dees, C.2    Pileckyte, M.3
  • 89
    • 58249120518 scopus 로고    scopus 로고
    • Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of fibrosis
    • Akhmetshina A, Venalis P, Dees C. Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of fibrosis. Arthritis Rheum 2009, 60:219-224.
    • (2009) Arthritis Rheum , vol.60 , pp. 219-224
    • Akhmetshina, A.1    Venalis, P.2    Dees, C.3
  • 90
    • 42949167686 scopus 로고    scopus 로고
    • Imatinib for the treatment of refractory, diffuse systemic sclerosis
    • Sfikakis P P, Gorgoulis V G, Katsiari C G. Imatinib for the treatment of refractory, diffuse systemic sclerosis. Rheumatology (Oxford) 2008, 47:735-737.
    • (2008) Rheumatology (Oxford) , vol.47 , pp. 735-737
    • Sfikakis, P.P.1    Gorgoulis, V.G.2    Katsiari, C.G.3
  • 91
    • 49449090687 scopus 로고    scopus 로고
    • Treatment of pulmonary fibrosis for twenty weeks with imatinib mesylate in a patient with mixed connective tissue disease
    • Distler J H, Manger B, Spriewald B M, Schett G, Distler O. Treatment of pulmonary fibrosis for twenty weeks with imatinib mesylate in a patient with mixed connective tissue disease. Arthritis Rheum 2008, 58:2538-2542.
    • (2008) Arthritis Rheum , vol.58 , pp. 2538-2542
    • Distler, J.H.1    Manger, B.2    Spriewald, B.M.3    Schett, G.4    Distler, O.5
  • 92
    • 77953157458 scopus 로고    scopus 로고
    • Imatinib mesylate as salvage therapy for refractory sclerotic chronic graft-versus-host disease
    • Magro L, Mohty M, Catteau B. Imatinib mesylate as salvage therapy for refractory sclerotic chronic graft-versus-host disease. Blood 2009, 16:114.
    • (2009) Blood , vol.16 , pp. 114
    • Magro, L.1    Mohty, M.2    Catteau, B.3
  • 93
    • 0034881149 scopus 로고    scopus 로고
    • D-penicillamine is not an effective treatment in systemic sclerosis
    • Furst D E, Clements P J. D-penicillamine is not an effective treatment in systemic sclerosis. Scand J Rheumatol 2001, 30:189-191.
    • (2001) Scand J Rheumatol , vol.30 , pp. 189-191
    • Furst, D.E.1    Clements, P.J.2
  • 94
    • 0034970031 scopus 로고    scopus 로고
    • A randomized controlled trial of methotrexate versus placebo in early diffuse scleroderma
    • Pope J, Bellamy N, Seibold J. A randomized controlled trial of methotrexate versus placebo in early diffuse scleroderma. Arthritis Rheum 2001, 44:1351-1358.
    • (2001) Arthritis Rheum , vol.44 , pp. 1351-1358
    • Pope, J.1    Bellamy, N.2    Seibold, J.3
  • 95
    • 77953146389 scopus 로고    scopus 로고
    • Alternate trafficking of cathepsin L in dermal fibroblasts induced by UVA radiation
    • DOI: 10.1111/j.1600-0625.2009.01014.x, (Epub ahead of print)
    • Klose A, Wilbrand-Hennes A, Brinckmann J, Hunzelmann N. Alternate trafficking of cathepsin L in dermal fibroblasts induced by UVA radiation. Exp Dermatol 2010, 10.1111/j.1600-0625.2009.01014.x, DOI, (Epub ahead of print)
    • (2010) Exp Dermatol
    • Klose, A.1    Wilbrand-Hennes, A.2    Brinckmann, J.3    Hunzelmann, N.4
  • 96
    • 0035723147 scopus 로고    scopus 로고
    • Different patterns of collagen cross-links in two sclerotic skin diseases: lipodermatosclerosis and circumscribed scleroderma
    • Brinckmann J, Neess C M, Gaber Y. Different patterns of collagen cross-links in two sclerotic skin diseases: lipodermatosclerosis and circumscribed scleroderma. J Invest Dermatol 2001, 117:269-273.
    • (2001) J Invest Dermatol , vol.117 , pp. 269-273
    • Brinckmann, J.1    Neess, C.M.2    Gaber, Y.3
  • 97
    • 33748998739 scopus 로고    scopus 로고
    • Phototherapy: a promising treatment option for skin sclerosis in scleroderma?
    • Sunderkötter C, Kuhn A, Hunzelmann N, Beissert S. Phototherapy: a promising treatment option for skin sclerosis in scleroderma? Rheumatology 2006, 45:iii52-iii54.
    • (2006) Rheumatology , vol.45
    • Sunderkötter, C.1    Kuhn, A.2    Hunzelmann, N.3    Beissert, S.4
  • 98
    • 22544456889 scopus 로고    scopus 로고
    • Anti-B- cell-directed immunotherapy (rituximab) in the treatment of refractory pemphigus--an update
    • Arin M J, Hunzelmann N. Anti-B- cell-directed immunotherapy (rituximab) in the treatment of refractory pemphigus--an update. Eur J Dermatol 2005, 15:224-230.
    • (2005) Eur J Dermatol , vol.15 , pp. 224-230
    • Arin, M.J.1    Hunzelmann, N.2
  • 99
    • 47249144728 scopus 로고    scopus 로고
    • Induction of interferon-a by scleroderma sera containing autoantibodies to topoisomerase I
    • Kim D, Peck A, Santer D. Induction of interferon-a by scleroderma sera containing autoantibodies to topoisomerase I. Arthritis Rheum 2008, 58:2163-2173.
    • (2008) Arthritis Rheum , vol.58 , pp. 2163-2173
    • Kim, D.1    Peck, A.2    Santer, D.3
  • 100
    • 77953168209 scopus 로고    scopus 로고
    • Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection
    • Dragun D, Müller D N, Bräsen J H. Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection. N Engl J Med 2005, 10:352.
    • (2005) N Engl J Med , vol.10 , pp. 352
    • Dragun, D.1    Müller, D.N.2    Bräsen, J.H.3
  • 101
    • 49149112861 scopus 로고    scopus 로고
    • Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice
    • Zhou C C, Zhang Y, Irani R A. Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice. Nat Med 2008, 14:855-862.
    • (2008) Nat Med , vol.14 , pp. 855-862
    • Zhou, C.C.1    Zhang, Y.2    Irani, R.A.3
  • 102
    • 69949164465 scopus 로고    scopus 로고
    • Is preeclampsia an autoimmune disease?
    • Xia Y, Kellems R E. Is preeclampsia an autoimmune disease? Clin Immunol 2009, 133:1-12.
    • (2009) Clin Immunol , vol.133 , pp. 1-12
    • Xia, Y.1    Kellems, R.E.2
  • 103
    • 35148878346 scopus 로고    scopus 로고
    • Elevated serum APRIL levels in patients with systemic sclerosis: distinct profiles of systemic sclerosis categorized by APRIL and BAFF
    • Matsushita T, Fujimoto M, Hasegawa M. Elevated serum APRIL levels in patients with systemic sclerosis: distinct profiles of systemic sclerosis categorized by APRIL and BAFF. J Rheumatol 2007, 34:2056-2062.
    • (2007) J Rheumatol , vol.34 , pp. 2056-2062
    • Matsushita, T.1    Fujimoto, M.2    Hasegawa, M.3
  • 104
    • 34848833579 scopus 로고    scopus 로고
    • B cell infiltration in systemic sclerosis-associated interstitial lung disease
    • Lafyatis R, O'Hara C, Feghali-Bostwick C A, Matteson E. B cell infiltration in systemic sclerosis-associated interstitial lung disease. Arthritis Rheum 2007, 56:3167-3168.
    • (2007) Arthritis Rheum , vol.56 , pp. 3167-3168
    • Lafyatis, R.1    O'Hara, C.2    Feghali-Bostwick, C.A.3    Matteson, E.4
  • 105
    • 0036262665 scopus 로고    scopus 로고
    • CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse
    • Saito E, Fujimoto M, Hasegawa M. CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse. J Clin Invest 2002, 109:1453-1462.
    • (2002) J Clin Invest , vol.109 , pp. 1453-1462
    • Saito, E.1    Fujimoto, M.2    Hasegawa, M.3
  • 106
    • 33748788266 scopus 로고    scopus 로고
    • B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis
    • Hasegawa M, Hamaguchi Y, Yanaba K. B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis. Am J Pathol 2006, 169:954-966.
    • (2006) Am J Pathol , vol.169 , pp. 954-966
    • Hasegawa, M.1    Hamaguchi, Y.2    Yanaba, K.3
  • 107
    • 41849147093 scopus 로고    scopus 로고
    • Discordant response to rituximab in a systemic sclerosis patient with associated myositis
    • Fabri M, Hunzelmann N, Krieg T, Rubbert A. Discordant response to rituximab in a systemic sclerosis patient with associated myositis. J Am Acad Dermatol 2008, 58(5 Suppl. 1):127-128.
    • (2008) J Am Acad Dermatol , vol.58 , Issue.5 SUPPL. 1 , pp. 127-128
    • Fabri, M.1    Hunzelmann, N.2    Krieg, T.3    Rubbert, A.4
  • 108
    • 59649109772 scopus 로고    scopus 로고
    • B Cell Depletion With Rituximab in Patients With Diffuse Cutaneous Systemic Sclerosis
    • Lafyatis R, Kissin E, York M. B Cell Depletion With Rituximab in Patients With Diffuse Cutaneous Systemic Sclerosis. Arthritis Rheum 2009, 60:578-583.
    • (2009) Arthritis Rheum , vol.60 , pp. 578-583
    • Lafyatis, R.1    Kissin, E.2    York, M.3
  • 109
    • 73449095775 scopus 로고    scopus 로고
    • Rituximab in diffuse cutaneous systemic sclerosis: an open-label clinical and histopathological study
    • Smith V, Van Praet J T, Vandooren B R. Rituximab in diffuse cutaneous systemic sclerosis: an open-label clinical and histopathological study. Ann Rheum Dis 2010, 69:193-197.
    • (2010) Ann Rheum Dis , vol.69 , pp. 193-197
    • Smith, V.1    Van Praet, J.T.2    Vandooren, B.R.3
  • 110
    • 56749098376 scopus 로고    scopus 로고
    • How to cope with pathogenic long-lived plasma cells in autoimmune diseases
    • Hoyer B F, Mumtaz I M, Yoshida T, Hiepe F, Radbruch A. How to cope with pathogenic long-lived plasma cells in autoimmune diseases. Ann Rheum Dis 2008, 67(Suppl. 3):iii87-iii89.
    • (2008) Ann Rheum Dis , vol.67 , Issue.3 SUPPL.
    • Hoyer, B.F.1    Mumtaz, I.M.2    Yoshida, T.3    Hiepe, F.4    Radbruch, A.5
  • 111
    • 34948847074 scopus 로고    scopus 로고
    • Adult stem cell treatment of scleroderma
    • Tyndall A, Furst D E. Adult stem cell treatment of scleroderma. Curr Opin Rheumatol 2007, 19:604-610.
    • (2007) Curr Opin Rheumatol , vol.19 , pp. 604-610
    • Tyndall, A.1    Furst, D.E.2
  • 112
    • 0035017415 scopus 로고    scopus 로고
    • Phase I/II trial of autologous stem cell transplantation in systemic sclerosis: procedure related mortality and impact on skin disease
    • Binks M, Passweg J R, Furst D. Phase I/II trial of autologous stem cell transplantation in systemic sclerosis: procedure related mortality and impact on skin disease. Ann Rheum Dis 2001, 60:577-584.
    • (2001) Ann Rheum Dis , vol.60 , pp. 577-584
    • Binks, M.1    Passweg, J.R.2    Furst, D.3
  • 113
    • 18744364686 scopus 로고    scopus 로고
    • Autologous bone marrow transplantation in the treatment of refractory systemic sclerosis: early results from a French multicentre phase I-II study
    • Farge D, Marolleau J P, Zohar S. Autologous bone marrow transplantation in the treatment of refractory systemic sclerosis: early results from a French multicentre phase I-II study. Br J Haematol 2002, 119:726-739.
    • (2002) Br J Haematol , vol.119 , pp. 726-739
    • Farge, D.1    Marolleau, J.P.2    Zohar, S.3
  • 114
    • 37749001089 scopus 로고    scopus 로고
    • Long-term follow-up results after autologous haematopoietic stem cell transplantation for severe systemic sclerosis
    • Vonk M C, Marjanovic Z, van den Hoogen F H. Long-term follow-up results after autologous haematopoietic stem cell transplantation for severe systemic sclerosis. Ann Rheum Dis 2008, 67:98-104.
    • (2008) Ann Rheum Dis , vol.67 , pp. 98-104
    • Vonk, M.C.1    Marjanovic, Z.2    van den Hoogen, F.H.3
  • 115
    • 33745040938 scopus 로고    scopus 로고
    • Allogeneic marrow transplantation in patients with severe systemic sclerosis: resolution of dermal fibrosis
    • Nash R A, McSweeney P A, Nelson J L. Allogeneic marrow transplantation in patients with severe systemic sclerosis: resolution of dermal fibrosis. Arthritis Rheum 2006, 54:1982-1986.
    • (2006) Arthritis Rheum , vol.54 , pp. 1982-1986
    • Nash, R.A.1    McSweeney, P.A.2    Nelson, J.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.