Improvement in digital flexibility and dexterity following ingestion of sildenafil citrate (Viagra) in limited systemic sclerosis

Archives of Dermatology

Volumn 141, Issue 7, 2005, Pages 831-833

  Yung, Anthony ^a   Reay, Naomi ^a   Goodfield, Mark D ^a  

^a LEEDS GENERAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLOBETASOL PROPIONATE; HYDROXYCHLOROQUINE; KETOCONAZOLE; OMEPRAZOLE; PROSTACYCLIN; SILDENAFIL;

AGED; ANAMNESIS; ARTICLE; CASE REPORT; CLINICAL FEATURE; DISCOID LUPUS ERYTHEMATOSUS; DRUG INFUSION; DRUG INTERMITTENT THERAPY; ERECTILE DYSFUNCTION; FINGER; FLEXOR REFLEX; FLUSHING; HEADACHE; HUMAN; LIMITED SCLERODERMA; MALE; MOTOR PERFORMANCE; PRIORITY JOURNAL; RAYNAUD PHENOMENON; SIDE EFFECT;

ADMINISTRATION, ORAL; AGED; DOSE-RESPONSE RELATIONSHIP, DRUG; FINGER JOINT; FOLLOW-UP STUDIES; HUMANS; MALE; PIPERAZINES; RANGE OF MOTION, ARTICULAR; RECOVERY OF FUNCTION; SCLERODERMA, SYSTEMIC; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 23044512051     PISSN: 0003987X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archderm.141.7.831     Document Type: Article

References (32)

1. LeRoy EC, Black C, Fleischmajer R, et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol. 1988;15:202-205.
2. LeRoy EC. Raynaud's phenomenon, scleroderma, overlap syndromes, and other fibrosing syndromes. Curr Opin Rheumatol. 1992;4:821-824.
3. Goodfield MJ, Hume A, Rowell NR. The effect of simple warming procedures on finger blood flow in systemic sclerosis. Br J Dermatol. 1988;118:661-668.
4. Engelhart M, Seibold JR. The effect of local temperature versus sympathetic tone on digital perfusion in Raynaud's phenomenon. Angiology. 1990;41:715-723.
5. Engelhart M, Kristensen JK. Raynaud's phenomenon: blood supply to fingers during indirect cooling, evaluated by laser Doppler flowmetry. Clin Physiol. 1986;6:481-488.
6. Engelhart M. The effect of sympathetic blockade and cooling in Raynaud's phenomenon. Clin Physiol. 1990;10:131-136.
7. Geirsson AJ, Jonsson GS, Asgeirsdottir LP. Functional study of the dermal microcirculation in systemic sclerosis. Scand J Rheumatol. 1994;23:73-76.
8. Block JA, Sequeira W. Raynaud's phenomenon. Lancet. 2001;357:2042-2048.
9. Kalis B, De Rigal J, Leonard F, et al. In vivo study of scleroderma by non-invasive techniques. Br J Dermatol. 1990;122:785-791.
10. Nikkels-Tassoudji N, Henry F, Pierard-Franchimont C, Pierard GE. Computerized evaluation of skin stiffening in scleroderma. Eur J Clin Invest. 1996;26:457-460.
11. Dobrev HP. In vivo study of skin mechanical properties in patients with systemic sclerosis. J Am Acad Dermatol. 1999;40:436-442.
12. Enomoto DN, Mekkes JR, Bossuyt PM, Hoekzema R, Bos JD. Quantification of cutaneous sclerosis with a skin elasticity meter in patients with generalized scleroderma. J Am Acad Dermatol. 1996;35:381-387.
13. Ishikawa T, Tamura T. Measurement of skin elastic properties with a new suction device (II): systemic sclerosis. J Dermatol. 1996;23:165-168.
14. Ballou SP, Mackiewicz A, Lysikiewicz A, Neuman MR. Direct quantitation of skin elasticity in systemic sclerosis. J Rheumatol. 1990;17:790-794.
15. Sapadin AN, Fleischmajer R. Treatment of scleroderma. Arch Dermatol. 2002;138:99-105.
16. Fink HA, Mac Donald R, Rutks IR, Nelson DB, Wilt TJ. Sildenafil for male erectile dysfunction: a systematic review and meta-analysis. Arch Intern Med. 2002;162:1349-1360.
17. Reffelmann T, Kloner RA. Therapeutic potential of phosphodiesterase 5 inhibition for cardiovascular disease. Circulation. 2003;108:239-244.
18. Lim PH, Moorthy P, Benton KG. The clinical safety of Viagra. Ann N Y Acad Sci. 2002;962:378-388.
19. Tracqui A, Miras A, Tabib A, Raul JS, Ludes B, Malicier D. Fatal overdosage with sildenafil citrate (Viagra): first report and review of the literature. Hum Exp Toxicol. 2002;21:623-629.
20. Matucci Cerinic M, Kahaleh MB. Beauty and the beast: the nitric oxide paradox in systemic sclerosis. Rheumatology (Oxford). 2002;41:843-847.
21. Anderson ME, Moore TL, Hollis S, Jayson MI, King TA, Herrick AL. Digital vascular response to topical glyceryl trinitrate, as measured by laser Doppler imaging, in primary Raynaud's phenomenon and systemic sclerosis. Rheumatology (Oxford). 2002;41:324-328.
22. Fatini C, Gensini F, Sticchi E, et al. High prevalence of polymorphisms of angiotensin-converting enzyme (I/D) and endothelial nitric oxide synthase (Glu298Asp) in patients with systemic sclerosis. Am J Med. 2002;112:540-544.
23. Schlez A, Kittel M, Braun S, Hafner HM, Junger M. Endothelium-dependent regulation of cutaneous microcirculation in patients with systemic scleroderma. J Invest Dermatol. 2003;120:332-334.
24. Freedman RR, Girgis R, Mayes MD. Acute effect of nitric oxide on Raynaud's phenomenon in scleroderma. Lancet. 1999;354:739.
25. Rembold CM, Ayers CR. Oral L-arginine can reverse digital necrosis in Raynaud's phenomenon. Mol Cell Biochem. 2003;244:139-141.
26. Agostoni A, Marasini B, Biondi ML, et al. L-arginine therapy in Raynaud's phenomenon? Int J Clin Lab Res. 1991;21:202-203.
27. Khan F, Litchfield SJ, McLaren M, Veale DJ, Littleford RC, Belch JJ. Oral L-arginine supplementation and cutaneous vascular responses in patients with primary Raynaud's phenomenon. Arthritis Rheum. 1997;40:352-357.
28. Khan F, Belch JJ. Skin blood flow in patients with systemic sclerosis and Raynaud's phenomenon: effects of oral L-arginine supplementation. J Rheumatol. 1999;26:2389-2394.
29. Lichtenstein JR. Use of sildenafil citrate in Raynaud's phenomenon: comment on the article by Thompson et al. Arthritis Rheum. 2003;48:282-283.
30. Furst DE, Clements PJ, Steen VD, et al. The modified Rodnan skin score is an accurate reflection of skin biopsy thickness in systemic sclerosis. J Rheumatol. 1998;25:84-88.
31. Falanga V, Bucalo B. Use of a durometer to assess skin hardness. J Am Acad Dermatol. 1993;29:47-51.
32. Ryan TJ. Vibration: good or bad? Clin Exp Dermatol. 1981;6:179-189.