Intravenous immunoglobulins improve the function and ameliorate joint involvement in systemic sclerosis: A pilot study

Annals of the Rheumatic Diseases

Volumn 66, Issue 7, 2007, Pages 977-979

  Nacci, F ^a   Righi, A ^a   Conforti, M L ^a   Miniati, I ^a   Fiori, G ^a   Martinovic, D ^c   Melchiorre, D ^a   Sapir, T ^b,c   Blank, M ^b,c   Shoenfeld, Y ^b,c   Moggi Pignone, A ^a   Matucci Cerinic, M ^a,d  

^a UNIVERSITY OF FLORENCE   (Italy)

^b SHEBA MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

^d Section of Rheumatology   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; IMMUNOGLOBULIN; METHOTREXATE;

ADULT; AGED; ARTHRALGIA; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT TOOL; DREISER ALGO FUNCTIONAL INDEX; DRUG EFFICACY; DRUG RESPONSE; FEMALE; HAND FUNCTION; HEALTH ASSESSMENT QUESTIONNAIRE; HUMAN; JOINT CAVITY; JOINT FUNCTION; JOINT LIMITATION; JOINT SWELLING; PAIN ASSESSMENT; PAIN VISUAL ANALOG SCALE; PATIENT ASSESSMENT; PHYSICAL CAPACITY; PHYSICAL DISABILITY; PILOT STUDY; PRIORITY JOURNAL; RITCHIE INDEX; RODNAN SKIN SCORE; SCALE UP; SCORING SYSTEM; SYMPTOM; SYSTEMIC SCLEROSIS; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADULT; AGED; ARTHRALGIA; COHORT STUDIES; FEMALE; HAND JOINTS; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; MIDDLE AGED; PILOT PROJECTS; SCLERODERMA, DIFFUSE; SCLERODERMA, LIMITED; SCLERODERMA, SYSTEMIC; TREATMENT OUTCOME;

EID: 34347263723     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2006.060111     Document Type: Article

References (15)

1. Rodnan GP, Medsger TA. The rheumatic manifestation of progressive systemic sclerosis (scleroderma). Clin Orthop 1968;57:81-93.
2. Avouac J, Guerini H, Wipff J, Assous N, Chevrot A, Kahan A, et al. Radiological hand involvement in systemic sclerosis. Ann Rheum Dis 2006;65:1088-92.
3. Rodnan GP. The nature of joint involvement in progressive systemic sclerosis (diffuse scleroderma). Clinical study and pathologic examination of synovium in twenty-nine patients. Ann Intern Med 1962;56:422-39.
4. La Montagna G, Sodano A, Capurro V, Malesci D, Valentini G. The arthropathy of systemic sclerosis: a 12 month prospective clinical and imaging study. Skeletal Radiol 2005;34:35-41.
5. Rouzzaud S, Katz AL. Joint changes with progressive systemic sclerosis. Arthitis Rheum 1982;25:1026-8.
6. Shoenfeld Y, Krause I. IVIG for autoimmune, fibrosis and malignant conditions: our experience with 200 patients. J Clin Immunol 2004;24:107-14.
7. Tse SM, Silverman ED, McCrindle BW, Yeung RS. Early treatment with intravenous immunoglobulin in patients with Kawasaki disease. J Pediatr 2002;140:450-5.
8. Levy Y, Sherer Y, Ahmed A, Langevitz P, George J, Fabbrizzi F, et al. A study of 20 SLE patients with intravenous immunoglobulin - clinical and serologic response. Lupus 1999;8:705-12.
9. Cherin P, Pelletier S, Teixeira A, Laforet P, Genereau T, Simon A, et al. Results and long-term follow-up of intravenous immunoglobulin infusion in chronic, refractory polymyositis. Arthritis Rheum 2002;46:467-74.
10. Muscat C, Bertotto A, Ercolani R, Bistoni O, Agea E, Cesarotti M, et al. Long term treatment of rheumatoid arthritis with high doses of intravenous immunoglobulins: effects on disease activity and serum cytokines. Ann Rheum Dis 1995;54:382-5.
11. Levy Y, Amital H, Langevitz P, Shoenfeld Y, Nacci F, Righi A, et al. Intravenous immunoglobulin modulate cutaneous involvement and reduce skin fibrosis in systemic sclerosis. Arthritis Rheum 2004;50:1005-7.
12. Generini S, Steiner G, Pignone A, Skriner K, Del Rosso A, Giacomelli R, et al. Anti-hnRNP and other autoantibodies in systemic sclerosis with joint involvement. Rheumatology. In press.
13. Misra R, Darton K, Jewkes RF, Black CM, Maini RN. Arthritis in scleroderma. Br J Rheumatol 1995;34:831-7.
14. Allanore Y, Devos-Franois G, Caramella C, Boumier P, Jounieaux V, Kahan A. Fatal exacerbation of fibrosing alveolitis associated with systemic sclerosis in a patient treated with adalimumab. Ann Rheum Dis 2006;65:834-5.
15. Sapir T, Shoenfeld Y. Facing the enigma of immunomodulatory effects of intravenous immunoglobulin. Clin Rev Allergy Immunol 2005;29:185-99.