New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator- activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression

Journal of Medicinal Chemistry

Volumn 56, Issue 1, 2013, Pages 60-72

  Laghezza, A ^a   Pochetti, G ^b   Lavecchia, A ^c   Fracchiolla, G ^a   Faliti, S ^a   Piemontese, L ^a   Di Giovanni, C ^c   Iacobazzi, V ^a,b   Infantino, V ^a,d   Montanari, R ^b   Capelli, D ^b   Tortorella, P ^a   Loiodice, F ^a  

^a UNIVERSITY OF BARI   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d UNIVERSITY OF BASILICATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLCARNITINE; CARNITINE; CARNITINE PALMITOYLTRANSFERASE I; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PROPIONIC ACID;

ARTICLE; CALORIMETRY; DRUG BINDING; DRUG STRUCTURE; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRION; MOLECULAR DOCKING; STEREOISOMERISM; UPREGULATION; X RAY;

CALORIMETRY; CARNITINE O-PALMITOYLTRANSFERASE; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; HUMANS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL PROTEINS; MOLECULAR DOCKING SIMULATION; PPAR ALPHA; PPAR GAMMA; PROPIONATES; PROTEIN CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84872318231     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301018z     Document Type: Article

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