Structural basis of the inhibition of Golgi α-mannosidase II by mannostatin A and the role of the thiomethyl moiety in ligand-protein interactions

Journal of the American Chemical Society

Volumn 128, Issue 25, 2006, Pages 8310-8319

  Kawatkar, Sameer P ^a   Kuntz, Douglas A ^b   Woods, Robert J ^a   Rose, David R ^b,c   Boons, Geert Jan ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; COMPUTER SIMULATION; CRYSTAL STRUCTURE; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; PROTEINS;

GOLGI Α-MANNOSIDASE II (DGMII); LIGAND-PROTEIN INTERACTIONS; N-BENZYL ANALOGUE;

ENZYME INHIBITION;

ALPHA MANNOSIDASE; BENZYL DERIVATIVE; LIGAND; MANNOSE; MANNOSTATIN A; PROTEIN;

ARTICLE; COVALENT BOND; CRYSTAL STRUCTURE; DROSOPHILA; DRUG CONFORMATION; GOLGI COMPLEX; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN PROTEIN INTERACTION; SIMULATION;

BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYCLOPENTANES; DRUG DESIGN; LIGANDS; MANNOSIDASES; METHYLATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEINS; SULFHYDRYL COMPOUNDS;

EID: 33745670361     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja061216p     Document Type: Article

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