Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARα and PPARδ in liver cells

Biochimica et Biophysica Acta - General Subjects

Volumn 1790, Issue 10, 2009, Pages 1206-1216

  Gutgesell, Anke ^a   Wen, Gaiping ^a   König, Bettina ^a   Koch, Alexander ^a   Spielmann, Julia ^a   Stangl, Gabriele I ^a   Eder, Klaus ^b   Ringseis, Robert ^b  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Carnitine acylcarnitine translocase (CACT); Fasting; Liver; Peroxisome proliferator activated receptor (PPAR )

Indexed keywords

[4 [2 (3 FLUORO 4 TRIFLUOROMETHYLPHENYL) 4 METHYL 5 THIAZOLYLMETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; ACYLCARNITINE CARNITINE TRANSLOCASE; CARRIER PROTEIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PIRINIXIC ACID; TROGLITAZONE; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE ACTIVATION; GENE FUNCTION; GENE MUTATION; HUMAN; HUMAN CELL; LIVER CELL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; BASE SEQUENCE; BODY WEIGHT; CARNITINE ACYLTRANSFERASES; CARNITINE O-PALMITOYLTRANSFERASE; CELL LINE, TUMOR; CYTOCHROME P-450 ENZYME SYSTEM; FASTING; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LIVER; LUCIFERASES; MALE; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTATION; PPAR ALPHA; PPAR DELTA; PROMOTER REGIONS, GENETIC; PYRIMIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THIAZOLES; TRANSCRIPTION, GENETIC;

MUS;

EID: 69949098108     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2009.06.012     Document Type: Article

References (35)

1. Kerner J., and Hoppel C. Fatty acid import into mitochondria. Biochim. Biophys. Acta 1486 (2000) 1-17
2. Pande S.V. A mitochondrial carnitine acylcarnitine translocase system. Proc. Natl. Acad. Sci. U. S. A. 72 (1975) 883-887
3. Ramsay R.R., and Tubbs P.K. The mechanism of fatty acid uptake by heart mitochondria: an acylcarnitine-carnitine exchange. FEBS Lett. 54 (1975) 21-25
4. Indiveri C., Tonazzi A., and Palmieri F. Identification and purification of the carnitine carrier from rat liver mitochondria. Biochim. Biophys. Acta 1020 (1990) 81-86
5. Desvergne B., and Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr. Rev. 20 (1999) 649-688
6. Leone T.C., Weinheimer C.J., and Kelly D.P. A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: the PPARα-null mouse as a model of fatty acid oxidation disorders. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 7473-7478
7. Kersten S., Seydoux J., Peters J.M., Gonzalez F.J., Desvergne B., and Wahli W. Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting. J. Clin. Invest. 103 (1999) 1489-1498
8. Mandard S., Müller M., and Kersten S. Peroxisome proliferator receptor α target genes. Cell. Mol. Life Sci. 61 (2004) 393-416
9. Luci S., Geissler S., König B., Koch A., Stangl G.I., Hirche F., and Eder K. PPARα agonists up-regulate organic cation transporters in rat liver cells. Biochem. Biophys. Res. Commun. 350 (2006) 704-708
10. van Vlies N., Ferdinandusse S., Turkenburg M., Wanders R.J., and Vaz F.M. PPARα-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation. Biochim. Biophys. Acta 1767 (2007) 1134-1142
11. Koch A., König B., Stangl G.I., and Eder K. PPARα mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis. Exp. Biol. Med. (Maywood) 233 (2008) 356-365
12. R. Ringseis, N. Wege, G. Wen, C. Rauer, F. Hirche, H. Kluge, K. Eder, Carnitine synthesis and uptake into cells are stimulated by fasting in pigs as a model of nonproliferating species, J. Nutr. Biochem. [Electronic publication ahead of print].
13. Rakhshandehroo M., Sanderson L.M., Matilainen M., Stienstra R., Carlberg C., de Groot P.J., Müller M., and Kersten S. Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling. PPAR Res. 2007 (2007) 26839
14. Tachibana K., Kobayashi Y., Tanaka T., et al. Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms. Nucl. Recept. 3 (2005) 3
15. Cabrero A., Cubero M., Llaverías G., et al. Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages. Metabolism 52 (2003) 652-657
16. Gilde A.J., van der Lee K.A., Willemsen P.H., et al. Peroxisome proliferator-activated receptor (PPAR) α and PPARβ/δ, but not PPARγ, modulate the expression of genes involved in cardiac lipid metabolism. Circ. Res. 92 (2003) 518-524
17. Senekeo-Effenberger K., Chen S., Brace-Sinnokrak E., et al. Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor α activation. Drug Metab. Dispos. 35 (2007) 419-427
18. Vistica D.T., Skehan P., Scudiero D., Monks A., Pittman A., and Boyd M.R. Tetrazolium-based assays for cellular viability: a critical examination of selected parameters affecting formazan production. Cancer Res. 51 (1991) 2515-2520
19. Ringseis R., Pösel S., Hirche F., and Eder K. Treatment with pharmacological peroxisome proliferator-activated receptor α agonist clofibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats. Pharmacol. Res. 56 (2007) 175-183
20. - ΔΔCT method. Methods 25 (2001) 402-408
21. Podvinec M., Kaufmann M.R., Handschin C., and Meyer U.A. NUBIScan, an in silico approach for prediction of nuclear receptor response elements. Mol. Endocrinol. 16 (2002) 1269-1279
22. Cartharius K., Frech K., Grote K., et al. MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics 21 (2005) 2933-2942
23. Ringseis R., König B., Leuner B., Schubert S., Nass N., Stangl G.I., and Eder K. LDL receptor gene transcription is selectively induced by t10c12-CLA but not by c9t11-CLA in the human hepatoma cell line HepG2. Biochim. Biophys. Acta 1761 (2006) 1235-1243
24. Ciana P., Biserni A., Tatangelo L., Tiveron C., Sciarroni A.F., Ottobrini L., and Maggi A. A novel peroxisome proliferator-activated receptor responsive element-luciferase reporter mouse reveals gender specificity of peroxisome proliferator-activated receptor activity in liver. Mol. Endocrinol. 21 (2007) 388-400
25. Zandbergen F., Mandard S., Escher P., et al. The G0/G1 switch gene 2 is a novel PPAR target gene. Biochem. J. 392 (2005) 313-324
26. Stienstra R., Mandard S., Tan N.S., et al. The Interleukin-1 receptor antagonist is a direct target gene of PPARα in liver. J. Hepatol. 46 (2007) 869-877
27. Van den Bosch H.M., Bünger M., de Groot P.J., van der Meijde J., Hooiveld G.J., and Müller M. Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting. BMC Genomics 8 (2007) 267
28. de Vogel-van den Bosch H.M., Bünger M., de Groot P.J., Bosch-Vermeulen H., Hooiveld G.J., and Müller M. PPARα-mediated effects of dietary lipids on intestinal barrier gene expression. BMC Genomics 9 (2008) 231
29. Holst D., Luquet S., Nogueira V., Kristiansen K., Leverve X., and Grimaldi P.A. Nutritional regulation and role of peroxisome proliferator-activated receptor δ in fatty acid catabolism in skeletal muscle. Biochim. Biophys. Acta 1633 (2003) 43-50
30. Rosen E.D., Walkey C.J., Puigserver P., and Spiegelman B.M. Transcriptional regulation of adipogenesis. Genes Dev. 14 (2000) 1293-1307
31. Kubota N., Terauchi Y., Miki H., et al. PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol. Cell. 4 (1999) 597-609
32. Tan N.S., Michalik L., Desvergne B., and Wahli W. Multiple expression control mechanisms of peroxisome proliferator-activated receptors and their target genes. J. Steroid Biochem. Mol. Biol. 93 (2005) 99-105
33. Qi C., Zhu Y., and Reddy J.K. Peroxisome proliferator-activated receptors, coactivators, and downstream targets. Cell. Biochem. Biophys. 32 (2000) 187-204
34. Johnson E.F., Palmer C.N., Griffin K.J., and Hsu M.H. Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation. FASEB J. 10 (1996) 1241-1248
35. Brandt J.M., Djouadi F., and Kelly D.P. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor α. J. Biol. Chem. 273 (1998) 23786-23792