메뉴 건너뛰기




Volumn 67, Issue 7, 2006, Pages 574-578

Today's challenges and tomorrow's opportunities: Ligands to peroxisome proliferator-activated receptors as therapies for type 2 diabetes and the metabolic syndrome

Author keywords

Metabolic syndrome; Peroxisome proliferator activated receptors; Type 2 diabetes

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 (2,4 DIOXO 5 THIAZOLIDINYLMETHYL) 2 METHOXY N [4 (TRIFLUOROMETHYL)BENZYL]BENZAMIDE; CREATININE; GLUCOSE; IMIGLITAZAR; INSULIN; LIPID; LIVER ENZYME; MURAGLITAZAR; PARTIAL AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; RAGAGLITAZAR; ROSIGLITAZONE; TESAGLITAZAR; TROGLITAZONE;

EID: 33845232611     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.20125     Document Type: Conference Paper
Times cited : (12)

References (32)
  • 1
    • 0344586732 scopus 로고    scopus 로고
    • The effects of K-111, a new insulin-sensitizer, on metabolic syndrome in obese prediabetic rhesus monkeys
    • Bodkin NL, Pill J, Meyer K, Hansen BC. 2003. The effects of K-111, a new insulin-sensitizer, on metabolic syndrome in obese prediabetic rhesus monkeys. Hormone Metab Res 35:617-624.
    • (2003) Hormone Metab Res , vol.35 , pp. 617-624
    • Bodkin, N.L.1    Pill, J.2    Meyer, K.3    Hansen, B.C.4
  • 2
    • 25844436624 scopus 로고    scopus 로고
    • Muraglitazar, a dual (α/γ) PPAR activator: A randomized, double-blind, placebo-controlled, 24-week monotherapy trial in adult patients with type 2 diabetes
    • Buse JB, Rubin CJ, Frederich R, Viraswami-Appanna K, Lin KC, Montoro R, Shockey G, Davidson JA. 2005. Muraglitazar, a dual (α/γ) PPAR activator: A randomized, double-blind, placebo-controlled, 24-week monotherapy trial in adult patients with type 2 diabetes. Clin Ther 27:1181-1195.
    • (2005) Clin Ther , vol.27 , pp. 1181-1195
    • Buse, J.B.1    Rubin, C.J.2    Frederich, R.3    Viraswami-Appanna, K.4    Lin, K.C.5    Montoro, R.6    Shockey, G.7    Davidson, J.A.8
  • 3
    • 0035431321 scopus 로고    scopus 로고
    • Structure of the PPARα and - γ ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family
    • Cronet P, Petersen JF, Folmer R, Blomberg N, Sjobolm K, Karlsson U, Lindstedt EL, Bamberg K. 2001. Structure of the PPARα and - γ ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family. Structure 9:699-706.
    • (2001) Structure , vol.9 , pp. 699-706
    • Cronet, P.1    Petersen, J.F.2    Folmer, R.3    Blomberg, N.4    Sjobolm, K.5    Karlsson, U.6    Lindstedt, E.L.7    Bamberg, K.8
  • 5
    • 1042286369 scopus 로고    scopus 로고
    • PPARα activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin II-infused rats
    • Diep QN, Benkirane K, Amiri F, Cohn JS, Endemann D, Schiffrin EL. 2004. PPARα activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin II-infused rats. J Mol Cell Cardiol 36:295-304.
    • (2004) J Mol Cell Cardiol , vol.36 , pp. 295-304
    • Diep, Q.N.1    Benkirane, K.2    Amiri, F.3    Cohn, J.S.4    Endemann, D.5    Schiffrin, E.L.6
  • 6
    • 24944588417 scopus 로고    scopus 로고
    • Leukopenia and thrombocytopenia caused by thiazolidinediones
    • Digman C, Klein AK, Pittas AG. 2005. Leukopenia and thrombocytopenia caused by thiazolidinediones. Ann Intern Med 143:465-466.
    • (2005) Ann Intern Med , vol.143 , pp. 465-466
    • Digman, C.1    Klein, A.K.2    Pittas, A.G.3
  • 7
    • 0346849699 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor β/δ agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells
    • Dressel U, Allen TL, Pippal JB, Allen TL, Pippal JB, Rohde PR, Lau P, Muscat GE. 2003. The peroxisome proliferator-activated receptor β/δ agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells. Mol Endocrinol 17:2477-2493.
    • (2003) Mol Endocrinol , vol.17 , pp. 2477-2493
    • Dressel, U.1    Allen, T.L.2    Pippal, J.B.3    Allen, T.L.4    Pippal, J.B.5    Rohde, P.R.6    Lau, P.7    Muscat, G.E.8
  • 8
    • 3042630884 scopus 로고    scopus 로고
    • PPARα, fibrates, lipid metabolism and inflammation
    • Duval C, Fruchart JC, Staels B. 2004. PPARα, fibrates, lipid metabolism and inflammation. Arch Mal Coeur 97:665-672.
    • (2004) Arch Mal Coeur , vol.97 , pp. 665-672
    • Duval, C.1    Fruchart, J.C.2    Staels, B.3
  • 9
    • 24944505598 scopus 로고    scopus 로고
    • Tesaglitazar, a novel dual peroxisome proliferator-activated receptor α/γ agonist, dose-dependently improves the metabolic abnormalities associated with insulin resistance in a non-diabetic population
    • Fagerberg B, Edwards S, Halmos T, Lopatynski J, Schuster H, Stender S, Stoa-Birketvedt G, Tonstad S, Halldorsdottir S, Gause-Nilsson I. 2005. Tesaglitazar, a novel dual peroxisome proliferator-activated receptor α/γ agonist, dose-dependently improves the metabolic abnormalities associated with insulin resistance in a non-diabetic population. Diabetologia 48:1716-1725.
    • (2005) Diabetologia , vol.48 , pp. 1716-1725
    • Fagerberg, B.1    Edwards, S.2    Halmos, T.3    Lopatynski, J.4    Schuster, H.5    Stender, S.6    Stoa-Birketvedt, G.7    Tonstad, S.8    Halldorsdottir, S.9    Gause-Nilsson, I.10
  • 10
    • 0346219295 scopus 로고    scopus 로고
    • Effect of thiazolidinediones on body weight in patients with diabetes mellitus
    • Fonseca V. 2003. Effect of thiazolidinediones on body weight in patients with diabetes mellitus. Am J Med 115:42S-48S.
    • (2003) Am J Med , vol.115
    • Fonseca, V.1
  • 11
    • 0035832506 scopus 로고    scopus 로고
    • Lessons from the glitazones: A story of drug development
    • Gale EAM. 2001. Lessons from the glitazones: a story of drug development. The Lancet 357:1870-1875.
    • (2001) The Lancet , vol.357 , pp. 1870-1875
    • Gale, E.A.M.1
  • 12
    • 28044459737 scopus 로고    scopus 로고
    • Tesaglitazar improves glucose and lipid abnormalities in patients with type 2 diabetes
    • ABS 83-OR
    • Goldstein BJ, Rosenstock J, Anzalone D, Tou C, Ohman P. 2005. Tesaglitazar improves glucose and lipid abnormalities in patients with type 2 diabetes. Diabetes 54:ABS 83-OR, p A21.
    • (2005) Diabetes , vol.54
    • Goldstein, B.J.1    Rosenstock, J.2    Anzalone, D.3    Tou, C.4    Ohman, P.5
  • 14
    • 0037649053 scopus 로고    scopus 로고
    • Bezafibrate improves hypertension and insulin sensitivity in humans
    • Kim JI, Tsujino T, Fujioka Y, Saito K, Yokoyama M. 2003. Bezafibrate improves hypertension and insulin sensitivity in humans. Hypertens Res 26:307-313.
    • (2003) Hypertens Res , vol.26 , pp. 307-313
    • Kim, J.I.1    Tsujino, T.2    Fujioka, Y.3    Saito, K.4    Yokoyama, M.5
  • 15
    • 10644251916 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ calls for activation in moderation: Lessons from genetics and pharmacology
    • Knouff C, Auwerx J. 2005. Peroxisome proliferator-activated receptor-γ calls for activation in moderation: lessons from genetics and pharmacology. Endocrine Rev 25:899-918.
    • (2005) Endocrine Rev , vol.25 , pp. 899-918
    • Knouff, C.1    Auwerx, J.2
  • 17
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)
    • Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J Biol Chem 270:12953-12956.
    • (1995) J Biol Chem , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 19
    • 0036847135 scopus 로고    scopus 로고
    • AZ 242, a novel PPAR α/γ agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats
    • Ljung B, Bamberg K, Dahllof B, Kjellstadt A, Oakes ND, Ostling J, Svensson L, Camejo G. 2002. AZ 242, a novel PPAR α/γ agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats. J Lipid Res 43:1855-1863.
    • (2002) J Lipid Res , vol.43 , pp. 1855-1863
    • Ljung, B.1    Bamberg, K.2    Dahllof, B.3    Kjellstadt, A.4    Oakes, N.D.5    Ostling, J.6    Svensson, L.7    Camejo, G.8
  • 20
    • 1542652476 scopus 로고    scopus 로고
    • Thiazolidinediones, peripheral edema, and type 2 diabetes: Incidence, pathophysiology, and clinical implications
    • Mudaliar S, Chang AR, Henry RR. 2003. Thiazolidinediones, peripheral edema, and type 2 diabetes: incidence, pathophysiology, and clinical implications. Endocr Pract 9:406-416.
    • (2003) Endocr Pract , vol.9 , pp. 406-416
    • Mudaliar, S.1    Chang, A.R.2    Henry, R.R.3
  • 22
    • 28144451163 scopus 로고    scopus 로고
    • Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus
    • Nissen SE, Wolski K, Topol EJ. 2005. Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus. JAMA 294:2581-2586.
    • (2005) JAMA , vol.294 , pp. 2581-2586
    • Nissen, S.E.1    Wolski, K.2    Topol, E.J.3
  • 25
    • 15744392484 scopus 로고    scopus 로고
    • Risk reduction therapy of syndrome X: Comparison of several treatments
    • Oron-Herman M, Sela BA, Rosenthal T. 2005. Risk reduction therapy of syndrome X: comparison of several treatments. AJH 18:372-378.
    • (2005) AJH , vol.18 , pp. 372-378
    • Oron-Herman, M.1    Sela, B.A.2    Rosenthal, T.3
  • 26
    • 0038381739 scopus 로고    scopus 로고
    • Possible heart failure exacerbation associated with rosiglitazone: Case report and literature review
    • Page RLI, Gozansky WS, Ruscin JM. 2003. Possible heart failure exacerbation associated with rosiglitazone: case report and literature review. Pharmacotherapy 23:945-954.
    • (2003) Pharmacotherapy , vol.23 , pp. 945-954
    • Page, R.L.I.1    Gozansky, W.S.2    Ruscin, J.M.3
  • 29
    • 33845197073 scopus 로고    scopus 로고
    • Bristol Joins the Ranks: Firm Bags Pargluva Development. Prescription Pharmaceutical and Biotechnology
    • May 18th, 2006, Number 009, Rockville, MD: FDC Reports, Inc.
    • The Pink Sheet Daily. 2006. Bristol Joins The Ranks: Firm Bags Pargluva Development. Prescription Pharmaceutical and Biotechnology. May 18th, 2006, Number 009, Rockville, MD: FDC Reports, Inc.
    • (2006) The Pink Sheet Daily
  • 30
    • 3843076994 scopus 로고    scopus 로고
    • Single and multiple doses of MK-767 (KRP-297) reduce free fatty acids (FFA) and lipids in healthy subjects
    • ABS 588-P
    • Wagner JA, Chun X, Rippley RK, et al. 2003. Single and multiple doses of MK-767 (KRP-297) reduce free fatty acids (FFA) and lipids in healthy subjects. Diabetes 52:ABS 588-P.
    • (2003) Diabetes , vol.52
    • Wagner, J.A.1    Chun, X.2    Rippley, R.K.3
  • 31
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity
    • Wang Y-X, Lee C-H, Tiep S, Yu RT, Ham J, Kang H, Evans RM. 2003. Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity. Cell 113:159-170.
    • (2003) Cell , vol.113 , pp. 159-170
    • Wang, Y.-X.1    Lee, C.-H.2    Tiep, S.3    Yu, R.T.4    Ham, J.5    Kang, H.6    Evans, R.M.7
  • 32
    • 21544479710 scopus 로고    scopus 로고
    • Collecting duct-specific deletion of peroxisome proliferator-activated receptor γ blocks thiazolidine-dione-induced fluid retention
    • Zhang H, Zhang A, Kohan DE, Nelson RD, Gonzalez FJ, Yang T. 2005. Collecting duct-specific deletion of peroxisome proliferator-activated receptor γ blocks thiazolidine-dione-induced fluid retention. Proc Natl Acad Sci USA 102: 9406-9411.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 9406-9411
    • Zhang, H.1    Zhang, A.2    Kohan, D.E.3    Nelson, R.D.4    Gonzalez, F.J.5    Yang, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.