Development of an affinity-matured humanized anti-epidermal growth factor receptor antibody for cancer immunotherapy

Protein Engineering, Design and Selection

Volumn 26, Issue 2, 2013, Pages 113-122

  Nakanishi, Takeshi ^a,b   Maru, Takamitsu ^a   Tahara, Kazuhiro ^a   Sanada, Hideaki ^a   Umetsu, Mitsuo ^a   Asano, Ryutaro ^a   Kumagai, Izumi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b Osaka Prefecture University   (Japan)

Author keywords

affinity maturation; antibody; cancer immunotherapy; humanization; phage display

Indexed keywords

AFFINITY MATURATION; AFFINITY SELECTION; ANTI-TUMOR ACTIVITIES; ANTIGEN-ANTIBODY INTERACTION; CANCER IMMUNOTHERAPY; COMPLEMENTARITY-DETERMINING REGIONS; DIABODY; ENERGETIC BARRIERS; ENTROPY LOSS; EXTRACELLULAR DOMAINS; GROWTH FACTOR; GROWTH INHIBITION; HEAVY CHAIN; HUMANIZATION; HUMANIZED ANTIBODY; IN-VITRO; NEGATIVE ENTHALPY; PHAGE DISPLAY; PHAGE DISPLAY LIBRARIES; SINGLE MUTATION; THERMO DYNAMIC ANALYSIS; TUMOR CELLS; VARIABLE DOMAIN;

DISEASES; THERMOANALYSIS;

ANTIBODIES;

CD3 ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; H528FV ANTIBODY; HEX3 DIABODY; MUTANT PROTEIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIBODY AFFINITY; ANTIGEN ANTIBODY COMPLEX; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ANTINEOPLASTIC ACTIVITY; ARTICLE; BILE DUCT CARCINOMA; CANCER CELL CULTURE; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CARCINOMA CELL; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; ENTHALPY; ESCHERICHIA COLI; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR LIBRARY; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN TARGETING; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; ANTIBODY AFFINITY; CELL LINE, TUMOR; CELL PROLIFERATION; COCULTURE TECHNIQUES; COMPLEMENTARITY DETERMINING REGIONS; HUMANS; IMMUNOTHERAPY; INHIBITORY CONCENTRATION 50; KINETICS; MUTAGENESIS, SITE-DIRECTED; NEOPLASMS; PEPTIDE LIBRARY; PROTEIN BINDING; RECEPTOR, EPIDERMAL GROWTH FACTOR; SINGLE-CHAIN ANTIBODIES; THERMODYNAMICS;

MURINAE;

EID: 84872306863     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzs088     Document Type: Article

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