Solvation and the hidden thermodynamics of a zinc finger probed by nonstandard repair of a protein crevice

Protein Science

Volumn 13, Issue 12, 2004, Pages 3115-3126

  Lachenmann, Marcel J ^a,b   Ladbury, John E ^a,c   Qian, Xiuqi ^a,d   Huang, Kun ^a   Singh, Rupinder ^a   Weiss, Michael A ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d SHIONOGI AND CO LTD   (Japan)

Author keywords

Isothermal titration calorimetry; NMR spectroscopy; Nonstandard mutagenesis; Protein design; Structural water

Indexed keywords

LEUCINE; PHENYLALANINE; SOLVENT; ZINC FINGER PROTEIN; ZINC ION;

ARTICLE; BINDING AFFINITY; BINDING SITE; CALORIMETRY; CHEMICAL INTERACTION; CONFORMATIONAL TRANSITION; DNA BINDING; ENTHALPY; ENTROPY; HUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; SOLVATION; THERMODYNAMICS;

AMINO ACID SEQUENCE; BINDING SITES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHENYLALANINE; PROTEINS; SOLVENTS; THERMODYNAMICS; ZINC FINGERS;

EID: 8344249515     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.04866404     Document Type: Article

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