Increased protein expression of the PTEN tumor suppressor in the presence of constitutively active notch-1

Cell Cycle

Volumn 4, Issue 10, 2005, Pages 1389-1395

  Chappell, William H ^a   Green, Thomas D ^a   Spengeman, Justin D ^a   McCubrey, James A ^a   Akula, Shaw M ^a   Bertrand, Fred E ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

CBF 1; Experimental therapeutics; FAK; Notch; PTEN; RBP J

Indexed keywords

FOCAL ADHESION KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; NOTCH1 RECEPTOR; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAF PROTEIN; RAS PROTEIN;

ARTICLE; CANCER INHIBITION; CELL LINEAGE; CELL STRAIN HEK293; CELL ULTRASTRUCTURE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST CULTURE; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS REGULATION; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 26444467062     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.4.10.2028     Document Type: Article

References (48)

1. Mumm J, Kopan R. Notch signaling: From the outside in. Dev Biol 2000; 228:151-65.
2. Allman D, Aster J, Pear W. Notch signaling in hematopoiesis and early lymphocyte development. Immunol Rev 2002; 187:75-86.
3. Logeat F, Bessia C, Brou C, LeBail O, Jarriault S, Seidah NG, Israel Alain. The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci USA 1998; 95:8108-12.
4. Mumm JS, Schroeter EH, Saxena MT, Griesemer A, Tain X, Pan DJ, Ray WJ, Kopan R. A ligand induced-extracellular cleavage regulates γ-secretase- like proteolytic activation of Notch1. Mol Cell 2000; 5:207-16.
5. Brou C, Logeat F, Gupta N, Bessia C, LeBail O, Doedens JR, Cumano A, Roux P, Black RA, Israel A. A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE. Mol Cell 2000; 5:207-16.
6. Struhl G, Adachi A. Nuclear access and activation of Notch in vivo. Cell 1998; 93:649-60.
7. Furukawa T, Maruyama S, Kawiachi M, Honjo T. The drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system develoment. Cell 1992; 69:1191-7.
8. Kao HY, Ordentlich P, Koyano-Nakagawa N, Tang Z, Downes M, Kintner C, Evans R, Kadesch T. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev 1998; 12:2269-77.
9. Wu L, Griffin JD. Modulation of Notch signaling by mastermind-like (MAML) transcriptional coactivators and their involvement in tumorigensis. Semin Cancer Biol 2004; 14:248-56.
10. Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, Sklar J. TAN-1, the homolog of the Drosophila notch gene, is broken by chromosomal translocation in T lymphoblastic neoplasms. Cell 1991; 66:649-61.
11. Weng AP, Ferrando AA, Lee W, Morris IVth JP, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 30:269-71.
12. Weng AP, Aster JC. Multiple niches for Notch in cancer: Context is everything. Curr Opin Genet Dev 2004; 14:48-54.
13. Politi K, Feirt N, Kitajewski J. Notch in mammary gland development and breast cancer. Semin Cancer Biol 2004; 14:341-47.
14. Nicolas M, Wolfer A, Raj K, Kummer JA, Mill P, Noort M, Hui C, Clevers H, Dotto GP, Radtke F. Notch1 functions as a tumor suppressor in mouse skin. Nature Gen 2003; 33:416-21.
15. Cheng P, Zlobin A, Volgina V, Gottipati S, Osborne B, Simel EJ, Miele L, Gabrilovich DI. Notch-1 regulates NF-κB Activity in hemopoietic progenitor cells. J Immunol 2001; 167:4458-67.
16. Wang J, Shelly L, Miele L, Boykins R, Norcross MA, Guan E. Human Notch-1 inhibits NF-κB activity in the nucleus through a direct interaction involving a novel domain. J Immunol 2001; 167:289-95.
17. lck-dependent Akt/PKB-mediated signaling in T cells. J Biol Chem 2004; 279:2937-44.
18. Nair P, Somasundaram K, Krishna S. Activated Notch 1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway. J Virol 2003; 77:7106-12.
19. Berset T, Hoier EF, Battu G, Canevascini S, Hajnal A. Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development. Science 2001; 291:1055-8.
20. Tomlinson A, Struhl G. Delta/Notch and Boss/Sevenless signals act combinatorially to specify the Drosophila R7 photoreceptor. Mol Cell 2001; 7:487-95.
21. Cooper M, Bray S. R7 photoreceptor specification requires Notch activity. Curr Biol 2000; 10:1507-10.
22. Fitzgerald K, Harrington A, Leder P. Ras pathway signals are required for notch-mediated oncogenes. Oncogene 2000; 19:4191-8.
23. Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, Iacobuzio-Donahue CA, Sriuranpong V, Iso T, Meszoely IM, Wolfe MS, Hruban RH, Ball DW, Schmid RM, Leach SD. Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 2003; 3:565-76.
24. Shelton JG, Blalock WL, White ER, Steelman LS, McCubrey JA. Ability of the activated PI3K/Akt oncoproteins to synergize with MEK1 and induce cell cycle progression and abrogate the cytokine-dependence of hematopoietic cells. Cell Cycle 2004; 3:503-12.
25. Bertrand FE, Spengemen JD, Shelton JG, McCubrey JA. Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support. Leukemia 2005; 19:98-102.
26. Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA. JAK/STAT, Raf/MEK/ERK-1,-2, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 2004; 18:189-18.
27. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang S, Puc J, Miliaresis C, Roders L, McCombie R, Bigner S, Giovanella B, Ittmann M, Tycko B, Hibshoosh H, Wigler M, Parsons R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997; 275:1943-7.
28. Myers M, Stalarov J, Eng C, Li J, Wang S, Wigler M, Parsons R, Tonks N. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci USA 1997; 94:9052-7.
29. Maehama T, Dixon J. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998; 273:13375-8.
30. Steelman LS, Bertrand FE, McCubrey JA. The complexity of PTEN: Mutation, marker and potential target for therapeutic intervention. Expert Opi Ther Targets 2004; 8:537-50.
31. Parsons R, Simpson L. PTEN and Cancer. Meth Mol Biol 2003; 222:147-66.
32. Eng C. PTEN: One gene, many syndromes. Hum Mutat 2003; 22:183-98.
33. Sheng X, Koul D, Liu JL, Liu TJ, Yung WK. Promoter analysis of tumor suppressor gene PTEN: Identification of minimum promoter region. Biochem Biophys Res 2002; 292:422-26.
34. Waite KA, Eng C. BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels. Hum Mol Genet 2003; 12:679-84.
35. Gu J, Tamura M, Pankov R, Danen E, Takino T, Matsumoto K, Yamada K. Sch and FAK differentially regulate cell motility and directionality modulated by PTEN. J Cell Biol 1999; 146:389-403.
36. Schaller MD. Biochemical signals and biological responses elicited by the focal adhesion kinase. Biochem Biophys ACTA 2001; 1540:1-21.
37. Pui JC, Allman D, Xu L, DeRocco S, Karnell FG, Bakkour S, Lee JY, Kadesch T, Hardy RR, Aster JC, Pear WS. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 1999; 11:299-308.
38. Naviaux RK, Costanzi E, Haas M, Verma IM. The pCL vector system: Rapid production of helper-free, high-titer, recombinant retroviruses. J Virol 1996; 70:5701-5.
39. Pear WS, Nolan GP, Scott ML, Baltimore D. Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci USA 1993; 90:8392-6.
40. Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israel A. Signaling downstream of activated mammalian Notch. Nature 1995; 377:355-8.
41. Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell 1997; 90:281-91.
42. Golubovskaya V, Kaur A, Cance W. Cloning and characterization of the promoter region of human focal adhesion kinase gene: Nuclear factor kappa B and p53 binding sites. Bioch Biophys Acta 2004; 1678:111-25.
43. Pear W, Aster J, Scott M, Hasserjian R, Soffer B, Sklar J, Baltimore D. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med 1996; 183:2283-91.
44. Zweidler-McKay PA, Pear WS. Notch and T cell malignancy. Semin Cancer Biol 2004; 14:329-40.
45. Weijzen S, Rizzo P, Braid M, Vaishnav R, Jonkheer S, Zlobin A, Osborne B, Gottipati S, Aster J, Hahn W, Rudolf M, Siziopikou K, Kast WM, Miele L. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nature Med 2002; 8:979-86.
46. Bertrand FE, Eckfeldt CE, Lysholm AS, LeBien TW. Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells. Leukemia 2000; 14:2095-102.
47. Blagosklonny MV. P53: An ubiquitous target of anticancer drugs. Int J Cancer 2002; 10:161-6.
48. Nickoloff BJ, Osborne BA, Miele L. Notch signaling as a therapeutic target in cancer: A new approach to the development of cell fate modifying agents. Oncogene 2003; 22:6598-608.