Dendritic cell depletion exacerbates acetaminophen hepatotoxicity

Hepatology

Volumn 54, Issue 3, 2011, Pages 959-968

  Connolly, Michael K ^a   Ayo, Diego ^a   Malhotra, Ashim ^a   Hackman, Michael ^a   Bedrosian, Andrea S ^a   Ibrahim, Junaid ^a   Cieza Rubio, Napoleon E ^a   Nguyen, Andrew H ^a   Henning, Justin R ^a   Dorvil Castro, Monica ^a   Pachter, H Leon ^a   Miller, George ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; FLT3 LIGAND; INTERLEUKIN 6; MACROPHAGE CHEMOATTRACTANT PROTEIN 1; PARACETAMOL; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CHRONIC LIVER DISEASE; CONTROLLED STUDY; DENDRITIC CELL; DISEASE EXACERBATION; IMMUNOMODULATION; IN VIVO STUDY; LIVER INJURY; LIVER TOXICITY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MALE; MORTALITY; MOUSE; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SYSTEMATIC REVIEW;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; DENDRITIC CELLS; IMMUNOPHENOTYPING; INFLAMMATION MEDIATORS; KILLER CELLS, NATURAL; LIVER; MALE; MICE; MICE, INBRED C57BL; NEUTROPHILS;

EID: 80052037842     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24429     Document Type: Article

References (41)

1. Chun LJ, Tong MJ, Busuttil RW, Hiatt JR. Acetaminophen hepatotoxicity and acute liver failure. J Clin Gastroenterol 2009; 43: 342-349.
2. Hinson JA, Roberts DW, James LP. Mechanisms of acetaminophen-induced liver necrosis. Handb Exp Pharmacol 2010; 369-405.
3. Lee WM. Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure. HEPATOLOGY 2004; 40: 6-9.
4. Lee WM. The case for limiting acetaminophen-related deaths: smaller doses and unbundling the opioid-acetaminophen compounds. Clin Pharmacol Ther 2010; 88: 289-292.
5. Han D, Shinohara M, Ybanez MD, Saberi B, Kaplowitz N. Signal transduction pathways involved in drug-induced liver injury. Handb Exp Pharmacol 2010; 267-310.
6. James LP, Mayeux PR, Hinson JA. Acetaminophen-induced hepatotoxicity. Drug Metab Dispos 2003; 31: 1499-1506.
7. Larson AM. Acetaminophen hepatotoxicity. Clin Liver Dis 2007; 11: 525-548, vi.
8. Jaeschke H, Bait ML. Intracellular signaling mechanisms of acetaminophen-induced liver cell death. Toxicol Sci 2006; 89: 31-41.
9. Lee WM. Drug-induced hepatotoxicity. N Engl J Med 2003; 349: 474-485.
10. Gardner CR, Laskin JD, Dambach DM, Sacco M, Durham SK, Bruno MK, et al. Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10. Toxicol Appl Pharmacol 2002; 184: 27-36.
11. Ishida Y, Kondo T, Ohshima T, Fujiwara H, Iwakura Y, Mukaida N. A pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injury. FASEB J 2002; 16: 1227-1236.
12. Liu ZX, Govindarajan S, Kaplowitz N. Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology 2004; 127: 1760-1774.
13. Ju C, Reilly TP, Bourdi M, Radonovich MF, Brady JN, George JW, et al. Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice. Chem Res Toxicol 2002; 15: 1504-1513.
14. Lawson JA, Farhood A, Hopper RD, Bajt ML, Jaeschke H. The hepatic inflammatory response after acetaminophen overdose: role of neutrophils. Toxicol Sci 2000; 54: 509-516.
15. Masson MJ, Carpenter LD, Graf ML, Pohl LR. Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide. HEPATOLOGY 2008; 48: 889-897.
16. Michael SL, Pumford NR, Mayeux PR, Niesman MR, Hinson JA. Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species. HEPATOLOGY 1999; 30: 186-195.
17. Liu ZX, Han D, Gunawan B, Kaplowitz N. Neutrophil depletion protects against murine acetaminophen hepatotoxicity. HEPATOLOGY 2006; 43: 1220-1230.
18. Liu ZX, Kaplowitz N. Role of innate immunity in acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol 2006; 2: 493-503.
19. Plitas G, Burt BM, Stableford JA, Nguyen HM, Welles AP, DeMatteo RP. Dendritic cells are required for effective cross-presentation in the murine liver. HEPATOLOGY 2008; 47: 1343-1351.
20. Steinman RM. Dendritic cells in vivo: a key target for a new vaccine science. Immunity 2008; 29: 319-324.
21. Pillarisetty VG, Shah AB, Miller G, Bleier JI, Dematteo RP. Liver dendritic cells are less immunogenic than spleen dendritic cells because of differences in subtype composition. J Immunol 2004; 172: 1009-1017.
22. Goubier A, Dubois B, Gheit H, Joubert G, Villard-Truc F, Asselin-Paturel C, et al. Plasmacytoid dendritic cells mediate oral tolerance. Immunity 2008; 29: 464-475.
23. Xia S, Guo Z, Xu X, Yi H, Wang Q, Cao X. Hepatic microenvironment programs hematopoietic progenitor differentiation into regulatory dendritic cells, maintaining liver tolerance. Blood 2008; 112: 3175-3185.
24. Crispe IN, Giannandrea M, Klein I, John B, Sampson B, Wuensch S. Cellular and molecular mechanisms of liver tolerance. Immunol Rev 2006; 213: 101-118.
25. Connolly MK, Bedrosian AS, Malhotra A, Henning JR, Ibrahim J, Vera V, et al. In hepatic fibrosis, liver sinusoidal endothelial cells acquire enhanced immunogenicity. J Immunol 2010; 185: 2200-2208.
26. Asselin-Paturel C, Brizard G, Pin JJ, Briere F, Trinchieri G. Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J Immunol 2003; 171: 6466-6477.
27. Hauben E, Gregori S, Draghici E, Migliavacca B, Olivieri S, Woisetschlager M et al. Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell-mediated effects on regulatory T cells. Blood 2008; 112: 1214-1222.
28. Ettmayer P, Mayer P, Kalthoff F, Neruda W, Harrer N, Hartmann G, et al. A novel low molecular weight inhibitor of dendritic cells and B cells blocks allergic inflammation. Am J Respir Crit Care Med 2005; 173: 599-606.
29. Xu Y, Malhotra A, Ren, Schlame M. The enzymatic function of tafazzin. The enzymatic function of tafazzin. J Biol Chem 2006; 281: 39217-24.
30. Matsuda H, Suda T, Hashizume H, Yokomura K, Asada K, Suzuki K, et al. Alteration of balance between myeloid dendritic cells and plasmacytoid dendritic cells in peripheral blood of patients with asthma. Am J Respir Crit Care Med 2002; 166: 1050-1054.
31. Kingham TP, Chaudhry UI, Plitas G, Katz SC, Raab J, Dematteo RP. Murine liver plasmacytoid dendritic cells become potent immunostimulatory cells after Flt-3 ligand expansion. HEPATOLOGY 2007; 45: 445-454.
32. Miller G, Pillarisetty VG, Shah AB, Lahrs S, Dematteo RP. Murine Flt3 ligand expands distinct dendritic cells with both tolerogenic and immunogenic properties. J Immunol 2003; 170: 3554-3564.
33. Krug A, Rothenfusser S, Hornung V, Jahrsdörfer B, Blackwell S, Ballas ZK, et al. Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells. Eur J Immunol 2001; 31: 2154-2163.
34. Bamboat ZM, Ocuin LM, Balachandran VP, Obaid H, Plitas G, Dematteo RP. Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion. J Clin Invest 2010; 120: 559-569.
35. Oberholzer A, Oberholzer C, Moldawer LL. Sepsis syndromes: understanding the role of innate and acquired immunity. Shock 2001; 16: 83-86.
36. Efron P, Moldawer LL. Sepsis and the dendritic cell. Shock 2003; 20: 386-401.
37. Huang X, Venet F, Chung-Shiang C, Lomas-Neira J, Ayala A. Changes in dendritic cell function in the immune response to sepsis. Expert Opin Biol Ther 2007: 929-938.
38. Tinsley KW, Grayson MH, Swanson PE, Drewry AM, Chang KC, Karl IE, et al. Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells. J Immunol 2003; 171: 909-914.
39. Scumpia PO, McAuliffe PF, O'Malley KA, Ungaro R, Uchida T, Matsumoto T, et al. CD 11c+ dendritic cells are required for survival in murine polymicrobial sepsis. J Immunol 2005; 175: 3282-3286.
40. Rock KL, Latz E, Ontiveros F, Kono H. The sterile inflammatory response. Annu Rev Immunol 2010; 28: 321-342.
41. Yang D, La Rosa G, Tewary P, Oppenheim JJ. Alarmins link neutrophils and dendritic cells. Trends Immunol 2009; 30: 531-537.