Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells

Cancer Letters

Volumn 241, Issue 1, 2006, Pages 31-41

  Wan, Chi Keung ^a   Wang, Cheng ^a   Cheung, Hon Yeung ^a   Yang, Mengsu ^a   Fong, Wang Fun ^a  

^a CITY UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Apoptosis; Bcl 2; Caspases; Cytochrome c; Triptolide (PG490)

Indexed keywords

CASPASE; CYTOCHROME C; DITERPENE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHENANTHRENE DERIVATIVE; PROTEIN BCL 2; PROTEIN P53; TRIPTOLIDE;

ARTICLE; CELL CYCLE; CELL STRAIN HL 60; DRUG ANTAGONISM; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; HUMAN; HYDROLYSIS; METABOLISM; MITOCHONDRION;

CASPASES; CELL CYCLE; CYTOCHROMES C; DITERPENES; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HL-60 CELLS; HUMANS; HYDROLYSIS; MITOCHONDRIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENANTHRENES; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34250869896     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.10.001     Document Type: Article

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