Celastrol-induced apoptosis in human HaCaT keratinocytes involves the inhibition of NF-κB activity

European Journal of Pharmacology

Volumn 670, Issue 2-3, 2011, Pages 399-408

  Zhou, Lin Li ^a   Lin, Zhi Xiu ^a   Fung, Kwok Pui ^b   Cheng, Christopher H K ^b   Che, Chun Tao ^c   Zhao, Ming ^c   Wu, Shi Hua ^d   Zuo, Zhong ^b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d ZHEJIANG UNIVERSITY   (China)

Author keywords

Apoptosis; Celastrol; HaCaT cells; Mitochondrial membrane potential; NF B pathway; Psoriasis

Indexed keywords

ACTIN; CASPASE 3; CASPASE 8; CASPASE 8 INHIBITOR; CASPASE 9; CASPASE 9 INHIBITOR; CELASTROL; DEATH RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; PHOSPHATIDYLSERINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR REL;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; KERATINOCYTE; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANNEXIN A5; APOPTOSIS; CASPASES; CELL LINE; CELL PROLIFERATION; DRUGS, CHINESE HERBAL; ENZYME ACTIVATION; G1 PHASE; HUMANS; INHIBITORY CONCENTRATION 50; KERATINOCYTES; MEMBRANE POTENTIAL, MITOCHONDRIAL; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-BCL-2; TRITERPENES;

EID: 80755153117     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.09.014     Document Type: Article

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