Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax

Life Sciences

Volumn 92, Issue 1, 2013, Pages 55-62

  Zhang, Meng ^a   Liu, Li Ping ^a   Chen, Yuling ^b,c   Tian, Xiao Ying ^d   Qin, Jian ^a   Wang, Dongmei ^a   Li, Zhi ^a   Mo, Sui Lin ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b UNIVERSITY OF SYDNEY   (Australia)

^c Macao Special Administrative Region of the People's Republic of China   (Macao)

^d HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

Akt signaling pathway; Apoptosis; Bax; Multiple myeloma; Wogonin

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; WOGONIN;

ALGORITHM; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CANCER GROWTH; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIGAND BINDING; MOLECULAR DOCKING; MYELOMA CELL; NICK END LABELING; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FLAVANONES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU NICK-END LABELING; MOLECULAR DOCKING SIMULATION; MULTIPLE MYELOMA; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; SCUTELLARIA BAICALENSIS;

SCUTELLARIA BAICALENSIS;

EID: 84871926836     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.10.023     Document Type: Article

References (48)

1. D.R. Alessi, F.B. Caudwell, M. Andjelkovic, B.A. Hemmings, and P. Cohen Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase FEBS Lett 399 1996 333 338
2. K.C. Anderson Clinical update: novel targets in multiple myeloma Semin Oncol 31 6 Suppl. 16 2004 27 32 [discussion 33]
3. S.F. Barnett, D. Defeo-Jones, S. Fu, P.J. Hancock, K.M. Haskell, and R.E. Jones Identification and characterization of pleckstrin-homology-domain- dependent and isoenzyme-specific Akt inhibitors Biochem J 385 2005 399 408
4. S. Baumann, S.C. Fas, M. Giaisi, W.W. Müller, A. Merling, and K. Gülow Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis Blood 111 2008 2354 2363
5. M. Bonham, J. Posakony, I. Coleman, B. Montgomery, J. Simon, and P.S. Nelson Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma Clin Cancer Res 11 2005 3905 3914
6. D.P. Brazil, J. Park, and B.A. Hemmings PKB binding proteins. Getting in on the Akt Cell 111 2002 293 303
7. J.K. Brunelle, and A. Letai Control of mitochondrial apoptosis by the Bcl-2 family J Cell Sci 122 2009 437 441
8. Y.L. Chang, J.J. Shen, B.S. Wung, J.J. Cheng, and D.L. Wang Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells Mol Pharmacol 60 2001 507 513
9. Y.C. Chen, S.C. Shen, W.R. Lee, H.Y. Lin, C.H. Ko, and C.M. Shih Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1 Arch Toxicol 76 2002 351 359
10. Y.S. Chi, B.S. Cheon, and H.P. Kim Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells Biochem Pharmacol 61 2001 1195 1203
11. S.E. Chow, Y.L. Chang, S.F. Chuang, and J.S. Wang Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting GSK-3β and ΔNp63 Cancer Chemother Pharmacol 68 2011 835 845
12. H. Chung, Y.M. Jung, D.H. Shin, J.Y. Lee, M.Y. Oh, and H.J. Kim Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts Int J Cancer 122 2008 816 822
13. G. Descamps, C. Pellat-Deceunynck, Y. Szpak, R. Bataille, N. Robillard, and M. Amiot The magnitude of Akt/phosphatidylinositol 3-kinase proliferating signaling is related to CD45 expression in human myeloma cells J Immunol 173 2004 4953 4959
14. J. Downward PI3-kinase, Akt and cell survival Semin Cell Dev Biol 15 2004 177 182
15. R. Enomoto, C. Koshiba, C. Suzuki, and E. Lee Wogonin potentiates the antitumor action of etoposide and a meliorates its adverse effects Cancer Chemother Pharmacol 67 2011 1063 1072
16. T.F. Franke, C.P. Hornik, L. Segev, G.A. Shostak, and C. Sugimoto PI3K/Akt and apoptosis: size matters Oncogene 22 2003 8983 8998
17. J.A. Fresno Vara, E. Casado, J. de Castro, P. Cejas, C. Belda-Iniesta, and M. Gonzalez-Baron PI3K/Akt signalling pathway and cancer Cancer Treat Rev 30 2004 193 204
18. I.M. Ghobrial, T.E. Witzig, and A.A. Adjei Targeting apoptosis pathways in cancer therapy CA Cancer J Clin 55 2005 178 194
19. M. Hanada, J. Feng, and B.A. Hemmings Structure, regulation and function of PKB/AKT - a major therapeutic target Biochim Biophys Acta 1697 2004 3 16
20. M. Hellek, P.L. Bergsagel, and K.C. Anderson Multiple myeloma: increasing evidence for a multistep transformation process Blood 91 1998 3 21
21. T. Hideshima, N. Nakamura, D. Chauhan, and K.C. Anderson Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma Oncogene 20 2001 5991 6000
22. M. Himeji, T. Ohtsuki, H. Fukazawa, M. Tanaka, S. Yazaki, and S. Ui Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell Cancer Lett 245 2007 269 274
23. S. Ikemoto, K. Sugimura, N. Yoshida, R. Yasumoto, S. Wada, and K. Yamamoto Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines Urology 55 2000 951 955
24. A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, and T. Murray Cancer statistics, 2008 CA Cancer J Clin 58 2008 71 96
25. R.W. Johnstone, A.J. Frew, and M.J. Smyth The TRAIL apoptotic pathway in cancer onset progression and therapy Nat Rev Cancer 8 2008 782 798
26. S.J. Korsmeyer BCL-2 gene family and the regulation of programmed cell death Cancer Res 59 1999 1693s 1700s
27. D.H. Lee, C. Kim, L. Zhang, and Y.J. Lee Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells Biochem Pharmacol 75 2008 2020 2033
28. C.W. Lindsley, Z. Zhao, W.H. Leister, R.G. Robinson, S.F. Barnett, and D. Defeo-Jones Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors Bioorg Med Chem Lett 15 2005 761 764
29. Y.M. Liu, X. Wang, A. Nawaz, Z.H. Kong, Y. Hong, and C.H. Wang Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway Acta Pharmacol Sin 32 2011 1475 1482
30. M. Li-Weber New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin Cancer Treat Rev 35 2009 57 68
31. M. Li-Weber Targeting apoptosis pathways in cancer by Chinese medicine Cancer Lett 2010 [Epub ahead of print, PMID: 20685036 ]
32. Y. Lu, H. Wang, and G.B. Mills Targeting PI3K-AKT pathway for cancer therapy Rev Clin Exp Hematol 7 2003 205 228
33. Z. Ma, K. Otsuyama, S. Liu, S. Abroun, H. Ishikawa, and N. Tsuyama Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells Blood 105 2005 3312 3318
34. A. Ozmen, S. Madlener, S. Bauer, S. Krasteva, C. Vonach, and B. Giessrigl In vitro anti-leukemic activity of the ethno-pharmacological plant Scutellaria orientalis ssp. carica endemic to western Turkey Phytomedicine 17 1 2010 55 62
35. P. Parajuli, N. Joshee, S.R. Chinni, A.M. Rimando, S. Mittal, and S. Sethi Delayed growth of glioma by Scutellaria flavonoids involve inhibition of Akt, GSK-3 and NF-κB signaling J Neurooncol 101 2011 15 24
36. F. Pene, Y.E. Claessens, O. Muller, F. Viguié, P. Mayeux, and F. Dreyfus Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma Oncogene 21 2002 6587 6597
37. J.C. Reed Dysregulation of apoptosis in cancer J Clin Oncol 17 1999 2941 2953
38. H.L. Roderick, and S.J. Cook Ca2 + signalling checkpoints in cancer: remodelling Ca2 + for cancer cell proliferation and survival Nat Rev Cancer 8 2008 361 375
39. I. Shiojima, and K. Walsh Role of Akt signaling in vascular homeostasis and angiogenesis Circ Res 90 2002 1243 1250
40. J.P. Steinbach, and M. Weller Apoptosis in gliomas: molecular mechanisms and therapeutic implications J Neurooncol 70 2004 245 254
41. J.E. Thompson, and C.B. Thompson Putting the wrap on Akt J Clin Oncol 22 2004 4217 4226
42. A. Toker, and M. Yoeli-Lerner Akt signaling and cancer: surviving but not moving on Cancer Res 66 2006 3963 3966
43. F. Tsuruta, N. Masuyama, and Y. Gotoh The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria J Biol Chem 277 2002 14040 14047
44. I. Vivanco, and C.L. Sawyers The phosphatidylinositol 3-kinase AKT pathway in human cancer Nat Rev Cancer 2 2002 489 501
45. W. Wang, Q. Guo, Q. You, K. Zhang, Y. Yang, and J. Yu Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721 Anticancer Drugs 17 2006 797 805
46. W. Wang, Q.L. Guo, Q.D. You, K. Zhang, Y. Yang, and J. Yu The anticancer activities of wogonin in murine sarcoma S180 both in vitro and in vivo Biol Pharm Bull 29 2006 1132 1137
47. W.I. Wu, W.C. Voegtli, H.L. Sturgis, F.P. Dizon, G.P. Vigers, and B.J. Brandhuber Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition PLoS One 5 2010 12913
48. J.Q. Yu, H.B. Liu, D.Z. Tian, Y.W. Liu, J.C. Lei, and G.L. Zou Changes in mitochondrial membrane potential and reactive oxygen species during wogonin-induced cell death in human hepatoma cells Hepatol Res 37 2007 68 76