-
1
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC. The phosphoinositide 3-kinase pathway. Science, 296: 1655-1657, 2002.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
2
-
-
0035190026
-
Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer
-
Katso R, Okkenhaug K, Ahmadi K, et al. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol, 17: 615-675, 2001.
-
(2001)
Annu Rev Cell Dev Biol
, vol.17
, pp. 615-675
-
-
Katso, R.1
Okkenhaug, K.2
Ahmadi, K.3
-
3
-
-
0033604577
-
Signaling by distinct classes of phosphoinositide 3-kinases
-
Vanhaesebroeck B and Waterfield MD. Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res, 253: 239-254, 1999.
-
(1999)
Exp Cell Res
, vol.253
, pp. 239-254
-
-
Vanhaesebroeck, B.1
Waterfield, M.D.2
-
4
-
-
0034982825
-
Phosphoinositide 3-kinase inhibition in cancer treatment
-
Berrie CP. Phosphoinositide 3-kinase inhibition in cancer treatment. Expert Opin Investig Drugs, 10: 1085-1098, 2001.
-
(2001)
Expert Opin Investig Drugs
, vol.10
, pp. 1085-1098
-
-
Berrie, C.P.1
-
5
-
-
0032497832
-
Structure and function of phosphoinositide 3-kinases
-
Wymann MP and Pirola L. Structure and function of phosphoinositide 3-kinases. Biochim Biophys Acta, 1436: 127-150, 1998.
-
(1998)
Biochim Biophys Acta
, vol.1436
, pp. 127-150
-
-
Wymann, M.P.1
Pirola, L.2
-
6
-
-
0030805703
-
Phosphoinositide 3-kinases: A conserved family of signal transducers
-
Vanhaesebroeck B, Leevers SJ, Panayotou G, et al. Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem Sci, 22: 267-272, 1997.
-
(1997)
Trends Biochem Sci
, vol.22
, pp. 267-272
-
-
Vanhaesebroeck, B.1
Leevers, S.J.2
Panayotou, G.3
-
7
-
-
0032514801
-
Regulation of the p85/p110alpha phosphatidylinositol 3′-kinase. Distinct roles for the N-terminal and C-terminal SH2 domains
-
Yu J, Wjasow C, Backer JM. Regulation of the p85/p110alpha phosphatidylinositol 3′-kinase. Distinct roles for the N-terminal and C-terminal SH2 domains. J Biol Chem, 273: 30199-30203, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 30199-30203
-
-
Yu, J.1
Wjasow, C.2
Backer, J.M.3
-
8
-
-
0035920129
-
Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase
-
Cuevas BD, Lu Y, Mao M, et al. Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase. J Biol Chem, 276: 27455-27461, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 27455-27461
-
-
Cuevas, B.D.1
Lu, Y.2
Mao, M.3
-
9
-
-
0036490708
-
Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit
-
Chan TO, Rodeck U, Chan AM, et al. Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit. Cancer Cell, 1: 181-191, 2002.
-
(2002)
Cancer Cell
, vol.1
, pp. 181-191
-
-
Chan, T.O.1
Rodeck, U.2
Chan, A.M.3
-
10
-
-
0035886016
-
The phosphatidylinositol 3′-kinase p85alpha gene is an oncogene in human ovarian and colon tumors
-
Philp AJ, Campbell IG, Leet C, et al. The phosphatidylinositol 3′-kinase p85alpha gene is an oncogene in human ovarian and colon tumors. Cancer Res, 61: 7426-7429, 2001.
-
(2001)
Cancer Res
, vol.61
, pp. 7426-7429
-
-
Philp, A.J.1
Campbell, I.G.2
Leet, C.3
-
11
-
-
0029090212
-
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
-
Stoyanov B, Volinia S, Hanck T, et al. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science, 269: 690-693, 1995.
-
(1995)
Science
, vol.269
, pp. 690-693
-
-
Stoyanov, B.1
Volinia, S.2
Hanck, T.3
-
12
-
-
0031037296
-
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI3-kinase gamma
-
Lopez-Ilasaca M, Crespo P, Pellici PG, et al. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI3-kinase gamma. Science, 275: 394-397, 1997.
-
(1997)
Science
, vol.275
, pp. 394-397
-
-
Lopez-Ilasaca, M.1
Crespo, P.2
Pellici, P.G.3
-
13
-
-
0030887632
-
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101
-
Stephens LR, Eguinoa A, Erdjument-Bromage H, et al. The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell, 89: 105-114, 1997.
-
(1997)
Cell
, vol.89
, pp. 105-114
-
-
Stephens, L.R.1
Eguinoa, A.2
Erdjument-Bromage, H.3
-
14
-
-
0034624512
-
Cell biology. Moving in mysterious ways
-
Condliffe AM and Hawkins PT. Cell biology. Moving in mysterious ways. Nature, 404: 135, 137, 2000.
-
(2000)
Nature
, vol.404
, pp. 135-137
-
-
Condliffe, A.M.1
Hawkins, P.T.2
-
15
-
-
0036232933
-
Phosphoinositide 3-kinases in immunity: Lessons from knockout mice
-
Sasaki T, Suzuki A, Sasaki J, et al. Phosphoinositide 3-kinases in immunity: lessons from knockout mice. J Biochem (Tokyo), 131: 495-501, 2002.
-
(2002)
J Biochem (Tokyo)
, vol.131
, pp. 495-501
-
-
Sasaki, T.1
Suzuki, A.2
Sasaki, J.3
-
16
-
-
0031026639
-
Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150. Ptdins 3-kinase complex
-
Panaretou C, Domin J, Cockcroft S, et al. Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150. Ptdins 3-kinase complex. J Biol Chem, 272: 2477-2485, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 2477-2485
-
-
Panaretou, C.1
Domin, J.2
Cockcroft, S.3
-
17
-
-
0033574429
-
Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase
-
Bi L, Okabe I, Bernard DJ, et al. Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase. J Biol Chem, 274: 10963-10968, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 10963-10968
-
-
Bi, L.1
Okabe, I.2
Bernard, D.J.3
-
18
-
-
0033555829
-
Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase
-
Suzuki H, Terauchi Y, Fujiwara M, et al. Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. Science, 283: 390-392, 1999.
-
(1999)
Science
, vol.283
, pp. 390-392
-
-
Suzuki, H.1
Terauchi, Y.2
Fujiwara, M.3
-
19
-
-
0033556333
-
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha
-
Fruman DA, Snapper SB, Yballe CM, et al. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science, 283: 393-397, 1999.
-
(1999)
Science
, vol.283
, pp. 393-397
-
-
Fruman, D.A.1
Snapper, S.B.2
Yballe, C.M.3
-
20
-
-
0031725052
-
A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: Requirement for insulin- and lysophosphatidic acid-mediated signal transduction
-
Roche S, Downward J, Raynal P, et al. A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction. Mol Cell Biol, 18: 7119-7129, 1998.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 7119-7129
-
-
Roche, S.1
Downward, J.2
Raynal, P.3
-
21
-
-
0028795721
-
DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases
-
Roche S, Koegl M, Barone MV, et al. DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases. Mol Cell Biol, 15: 1162-1109, 1995.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 1162-1109
-
-
Roche, S.1
Koegl, M.2
Barone, M.V.3
-
22
-
-
0033128166
-
Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages
-
Vanhaesebroeck B, Jones GE, Allen WE, et al. Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages. Nat Cell Biol, 1: 69-71, 1999.
-
(1999)
Nat Cell Biol
, vol.1
, pp. 69-71
-
-
Vanhaesebroeck, B.1
Jones, G.E.2
Allen, W.E.3
-
23
-
-
0031001041
-
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
-
Li DM and Sun H. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res, 57: 2124-2129, 1997.
-
(1997)
Cancer Res
, vol.57
, pp. 2124-2129
-
-
Li, D.M.1
Sun, H.2
-
24
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science, 275: 1943-1947, 1997.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
-
25
-
-
17144436629
-
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
-
Steck PA, Pershouse MA, Jasser SA, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet, 15: 356-362, 1997.
-
(1997)
Nat Genet
, vol.15
, pp. 356-362
-
-
Steck, P.A.1
Pershouse, M.A.2
Jasser, S.A.3
-
26
-
-
0032577699
-
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci USA dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Myers MP, Stolarov JP, Eng C, et al. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci USA dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem, 273: 13375-13378, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Myers, M.P.1
Stolarov, J.P.2
Eng, C.3
-
27
-
-
0033615538
-
Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
-
Lee JO, Yang H, Georgescu MM, et al. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell, 99: 323-334, 1999.
-
(1999)
Cell
, vol.99
, pp. 323-334
-
-
Lee, J.O.1
Yang, H.2
Georgescu, M.M.3
-
28
-
-
0033852872
-
Mutations of the human PTEN gene
-
Bonneau D and Longy M. Mutations of the human PTEN gene. Hum Mutat, 16: 109-122, 2000.
-
(2000)
Hum Mutat
, vol.16
, pp. 109-122
-
-
Bonneau, D.1
Longy, M.2
-
29
-
-
85047698214
-
Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity
-
Koul D, Jasser SA, Lu Y, et al. Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity. Oncogene, 21: 2357-2364, 2002.
-
(2002)
Oncogene
, vol.21
, pp. 2357-2364
-
-
Koul, D.1
Jasser, S.A.2
Lu, Y.3
-
30
-
-
6844252284
-
Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation
-
Marsh DJ, Coulon V, Lunetta KL, et al. Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation. Hum Mol Genet, 7: 507-515, 1998.
-
(1998)
Hum Mol Genet
, vol.7
, pp. 507-515
-
-
Marsh, D.J.1
Coulon, V.2
Lunetta, K.L.3
-
31
-
-
0034654298
-
Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: Differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase
-
Leslie NR, Gray A, Pass I, et al. Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase. Biochem J, 346 Pt 3: 827-833, 2000.
-
(2000)
Biochem J
, vol.346
, Issue.PART 3
, pp. 827-833
-
-
Leslie, N.R.1
Gray, A.2
Pass, I.3
-
32
-
-
0032506011
-
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
-
Myers MP, Pass I, Batty IH, et al. The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci USA, 95: 13513-13518, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 13513-13518
-
-
Myers, M.P.1
Pass, I.2
Batty, I.H.3
-
33
-
-
0032486198
-
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
-
Tamura M, Gu J, Matsumoto K, et al. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science, 280: 1614-1617, 1998.
-
(1998)
Science
, vol.280
, pp. 1614-1617
-
-
Tamura, M.1
Gu, J.2
Matsumoto, K.3
-
34
-
-
0041450058
-
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms
-
Freeman DJ, Li AG, Wei G, et al. PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell, 3: 117-130, 2003.
-
(2003)
Cancer Cell
, vol.3
, pp. 117-130
-
-
Freeman, D.J.1
Li, A.G.2
Wei, G.3
-
35
-
-
0036181869
-
PTEN: The down side of PI 3-kinase signalling
-
Leslie NR and Downes CP. PTEN: The down side of PI 3-kinase signalling. Cell Signal, 14: 285-295, 2002.
-
(2002)
Cell Signal
, vol.14
, pp. 285-295
-
-
Leslie, N.R.1
Downes, C.P.2
-
36
-
-
0033604468
-
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells
-
Lu Y, Lin YZ, LaPushin R, et al. The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene, 18: 7034-7045, 1999.
-
(1999)
Oncogene
, vol.18
, pp. 7034-7045
-
-
Lu, Y.1
Lin, Y.Z.2
LaPushin, R.3
-
37
-
-
0034921007
-
Tumor suppressor PTEN: Modulator of cell signaling, growth, migration and apoptosis
-
Yamada KM and Araki M. Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. J Cell Sci, 114: 2375-2382, 2001.
-
(2001)
J Cell Sci
, vol.114
, pp. 2375-2382
-
-
Yamada, K.M.1
Araki, M.2
-
38
-
-
0035196043
-
PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma
-
Salvesen HB, MacDonald N, Ryan A, et al. PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma. Int J Cancer, 91: 22-26, 2001.
-
(2001)
Int J Cancer
, vol.91
, pp. 22-26
-
-
Salvesen, H.B.1
MacDonald, N.2
Ryan, A.3
-
39
-
-
0035847102
-
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation
-
Torres J and Pulido R. The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J Biol Chem, 276: 993-998, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 993-998
-
-
Torres, J.1
Pulido, R.2
-
40
-
-
0033946740
-
Phosphorylation of the PTEN tail regulates protein stability and function
-
Vazquez F, Ramaswamy S, Nakamura N, et al. W. R. Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol, 20: 5010-5018, 2000.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 5010-5018
-
-
Vazquez, F.1
Ramaswamy, S.2
Nakamura, N.3
-
41
-
-
0033958869
-
Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding
-
Adey NB, Huang L, Ormonde PA, et al. Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding. Cancer Res, 60:35-37, 2000.
-
(2000)
Cancer Res
, vol.60
, pp. 35-37
-
-
Adey, N.B.1
Huang, L.2
Ormonde, P.A.3
-
42
-
-
0035966127
-
Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex
-
Vazquez F, Grossman SR, Takahashi Y, et al. Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J Biol Chem, 276: 48627-48630, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 48627-48630
-
-
Vazquez, F.1
Grossman, S.R.2
Takahashi, Y.3
-
43
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivanco I. and Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer, 2: 489-501, 2002.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
44
-
-
85047681190
-
Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture
-
Alessi DR. Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture. Biochem Soc Trans, 29: 1-14, 2001.
-
(2001)
Biochem Soc Trans
, vol.29
, pp. 1-14
-
-
Alessi, D.R.1
-
45
-
-
0036185848
-
The protein kinase B/Akt signalling pathway in human malignancy
-
Nicholson KM and Anderson NG. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal, 14: 381-395, 2002.
-
(2002)
Cell Signal
, vol.14
, pp. 381-395
-
-
Nicholson, K.M.1
Anderson, N.G.2
-
46
-
-
0035990924
-
Inhibition of protein kinase B/Akt implications for cancer therapy
-
Hill MM and Hemmings BA. Inhibition of protein kinase B/Akt. implications for cancer therapy. Pharmacol Ther, 93: 243-251, 2002.
-
(2002)
Pharmacol Ther
, vol.93
, pp. 243-251
-
-
Hill, M.M.1
Hemmings, B.A.2
-
47
-
-
0035850916
-
Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane
-
Maira SM, Galetic I, Brazil DP, et al. Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. Science, 294: 374-380, 2001.
-
(2001)
Science
, vol.294
, pp. 374-380
-
-
Maira, S.M.1
Galetic, I.2
Brazil, D.P.3
-
48
-
-
0033636528
-
The protooncogene TCL1 is an Akt kinase coactivator
-
Laine J, Kunstle G, Obata T, et al. The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell, 6: 395-407, 2000.
-
(2000)
Mol Cell
, vol.6
, pp. 395-407
-
-
Laine, J.1
Kunstle, G.2
Obata, T.3
-
49
-
-
0034724199
-
Tcl1 enhances Akt kinase activity and mediates its nuclear translocation
-
Pekarsky Y, Koval A, Hallas C, et al. Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. Proc Natl Acad Sci USA, 97: 3028-3033, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 3028-3033
-
-
Pekarsky, Y.1
Koval, A.2
Hallas, C.3
-
50
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell, 96: 857-868, 1999.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
-
51
-
-
0034609737
-
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
-
Dijkers PF, Medema RH, Lammers JW, et al. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol, 10: 1201-1204, 2000.
-
(2000)
Curr Biol
, vol.10
, pp. 1201-1204
-
-
Dijkers, P.F.1
Medema, R.H.2
Lammers, J.W.3
-
52
-
-
0030710188
-
Transformation of hematopoietic cells by BCR/ABL requires activation of a PI3k/Akt-dependent pathway
-
Skorski T, Bellacosa A, Nieborowska-Skorska M, et al. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI3k/Akt-dependent pathway. Embo J, 16: 6151-6161, 1997.
-
(1997)
Embo J
, vol.16
, pp. 6151-6161
-
-
Skorski, T.1
Bellacosa, A.2
Nieborowska-Skorska, M.3
-
53
-
-
0034646644
-
Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein
-
Pugazhenthi S, Nesterova A, Sable C, et al. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J Biol Chem, 275: 10761-10766, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 10761-10766
-
-
Pugazhenthi, S.1
Nesterova, A.2
Sable, C.3
-
54
-
-
0032484019
-
CREB is a regulatory target for the protein kinase Akt/PKB
-
Du K and Montminy M. CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem, 273: 32377-32379, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 32377-32379
-
-
Du, K.1
Montminy, M.2
-
55
-
-
0032772367
-
The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB
-
Wang JM, Chao JR, Chen W, et al. The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB. Mol Cell Biol, 19: 6195-6206, 1999.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 6195-6206
-
-
Wang, J.M.1
Chao, J.R.2
Chen, W.3
-
56
-
-
0033517190
-
NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
-
Romashkova JA and Makarov SS. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature, 401: 86-90, 1999.
-
(1999)
Nature
, vol.401
, pp. 86-90
-
-
Romashkova, J.A.1
Makarov, S.S.2
-
57
-
-
0033517189
-
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
-
Ozes ON, Mayo LD, Gustin JA, et al. D. B. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature, 401: 82-85, 1999.
-
(1999)
Nature
, vol.401
, pp. 82-85
-
-
Ozes, O.N.1
Mayo, L.D.2
Gustin, J.A.3
-
58
-
-
0033596127
-
Control of apoptosis by Rel/NF-kappaB transcription factors
-
Barkett M and Gilmore TD. Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene, 18: 6910-6924, 1999.
-
(1999)
Oncogene
, vol.18
, pp. 6910-6924
-
-
Barkett, M.1
Gilmore, T.D.2
-
59
-
-
0034898707
-
c-Myb transcription is activated by protein kinase B (PKB) following interleukin 2 stimulation of T cells and is required for PKB-mediated protection from apoptosis
-
Lauder A, Castellanos A and Weston K. c-Myb transcription is activated by protein kinase B (PKB) following interleukin 2 stimulation of T cells and is required for PKB-mediated protection from apoptosis. Mol Cell Biol, 21: 5797-5805, 2001.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 5797-5805
-
-
Lauder, A.1
Castellanos, A.2
Weston, K.3
-
60
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR, Dudek H, Tao X, et al, M. E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 91: 231-241, 1997.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
-
61
-
-
0032752063
-
Cellular survival: A play in three Akts
-
Datta SR, Brunet A and Greenberg ME. Cellular survival: a play in three Akts. Genes Dev, 13: 2905-2927, 1999.
-
(1999)
Genes Dev
, vol.13
, pp. 2905-2927
-
-
Datta, S.R.1
Brunet, A.2
Greenberg, M.E.3
-
62
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone MH, Roy N, Stennicke HR, et al. Regulation of cell death protease caspase-9 by phosphorylation. Science, 282: 1318-1321, 1998.
-
(1998)
Science
, vol.282
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
-
63
-
-
0033595720
-
Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9
-
Fujita E, Jinbo A, Matuzaki H, et al. Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9. Biochem Biophys Res Commun, 264: 550-555, 1999.
-
(1999)
Biochem Biophys Res Commun
, vol.264
, pp. 550-555
-
-
Fujita, E.1
Jinbo, A.2
Matuzaki, H.3
-
64
-
-
0035133227
-
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1
-
Kim AH, Khursigara G, Sun X, et al. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol, 21: 893-901, 2001.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 893-901
-
-
Kim, A.H.1
Khursigara, G.2
Sun, X.3
-
65
-
-
14444281569
-
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
-
Ichijo H, Nishida E, Irie K, et al. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science, 275: 90-94, 1997.
-
(1997)
Science
, vol.275
, pp. 90-94
-
-
Ichijo, H.1
Nishida, E.2
Irie, K.3
-
66
-
-
0035949588
-
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
-
Mayo LD and Donner DB. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci USA, 98: 11598-11603, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 11598-11603
-
-
Mayo, L.D.1
Donner, D.B.2
-
67
-
-
0035736487
-
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
-
Zhou BP, Liao Y, Xia W, et al. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol, 3: 973-982, 2001.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 973-982
-
-
Zhou, B.P.1
Liao, Y.2
Xia, W.3
-
68
-
-
0034745353
-
Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
-
Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol, 3: 245-252, 2001.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 245-252
-
-
Zhou, B.P.1
Liao, Y.2
Xia, W.3
-
69
-
-
18644370396
-
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer
-
Viglietto G, Motti ML, Bruni P, et al. Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nat Med, 8: 1136-1144, 2002.
-
(2002)
Nat Med
, vol.8
, pp. 1136-1144
-
-
Viglietto, G.1
Motti, M.L.2
Bruni, P.3
-
70
-
-
0036799377
-
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization
-
Shin I, Yakes FM, Rojo F, et al. PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med, 8: 1145-1152, 2002.
-
(2002)
Nat Med
, vol.8
, pp. 1145-1152
-
-
Shin, I.1
Yakes, F.M.2
Rojo, F.3
-
71
-
-
18644376449
-
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
-
Liang J, Zubovitz J, Petrocelli T, et al. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med, 8: 1153-1160, 2002.
-
(2002)
Nat Med
, vol.8
, pp. 1153-1160
-
-
Liang, J.1
Zubovitz, J.2
Petrocelli, T.3
-
72
-
-
0034643331
-
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
-
Medema RH, Kops GJ, Bos JL, et al. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature, 404: 782-787, 2000.
-
(2000)
Nature
, vol.404
, pp. 782-787
-
-
Medema, R.H.1
Kops, G.J.2
Bos, J.L.3
-
73
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P and Hunter T. Oncogenic kinase signalling. Nature, 411: 355-365, 2001.
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
74
-
-
0037018847
-
A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle
-
Shtivelman E, Sussman J and Stokoe D. A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle. Curr Biol, 12: 919-924, 2002.
-
(2002)
Curr Biol
, vol.12
, pp. 919-924
-
-
Shtivelman, E.1
Sussman, J.2
Stokoe, D.3
-
75
-
-
0033429554
-
Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
-
Nave BT, Ouwens M, Withers DJ, et al. Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J, 344 Pt 2: 427-431, 1999.
-
(1999)
Biochem J
, vol.344
, Issue.PART 2
, pp. 427-431
-
-
Nave, B.T.1
Ouwens, M.2
Withers, D.J.3
-
76
-
-
0034234924
-
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
-
Sekulic A, Hudson CC, Homme JL, et al. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res, 60: 3504-3513, 2000.
-
(2000)
Cancer Res
, vol.60
, pp. 3504-3513
-
-
Sekulic, A.1
Hudson, C.C.2
Homme, J.L.3
-
77
-
-
0029831167
-
Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002
-
Brunn GJ, Williams J, Sabers C, et al. Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. Embo J, 15: 5256-5267, 1996.
-
(1996)
Embo J
, vol.15
, pp. 5256-5267
-
-
Brunn, G.J.1
Williams, J.2
Sabers, C.3
-
78
-
-
0036776168
-
A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling
-
Chen J and Fang Y. A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling. Biochem Pharmacol, 64: 1071-1077, 2002.
-
(2002)
Biochem Pharmacol
, vol.64
, pp. 1071-1077
-
-
Chen, J.1
Fang, Y.2
-
79
-
-
0032929762
-
Signalling through phosphoinositide 3-kinases: The lipids take centre stage
-
Leevers SJ, Vanhaesebroeck B and Waterfield MD. Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr Opin Cell Biol, 11: 219-225, 1999.
-
(1999)
Curr Opin Cell Biol
, vol.11
, pp. 219-225
-
-
Leevers, S.J.1
Vanhaesebroeck, B.2
Waterfield, M.D.3
-
80
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle T and Hall MN. TOR, a central controller of cell growth. Cell, 103: 253-262, 2000.
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
81
-
-
0032881288
-
AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation
-
Chan TO, Rittenhouse SE and Tsichlis PN. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem, 68:965-1014, 1999.
-
(1999)
Annu Rev Biochem
, vol.68
, pp. 965-1014
-
-
Chan, T.O.1
Rittenhouse, S.E.2
Tsichlis, P.N.3
-
82
-
-
0035168724
-
The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy
-
Mills GB, Lu Y, Fang X, et al. The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy. Semin Oncol, 28: 125-141, 2001.
-
(2001)
Semin Oncol
, vol.28
, pp. 125-141
-
-
Mills, G.B.1
Lu, Y.2
Fang, X.3
-
83
-
-
0035008874
-
Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression
-
Hutchinson J, Jin J, Cardiff RD, et al. Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol, 21: 2203-2212, 2001.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 2203-2212
-
-
Hutchinson, J.1
Jin, J.2
Cardiff, R.D.3
-
84
-
-
0037882244
-
Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells
-
Klingler-Hoffmann M, Bukczynska P and Tiganis T. Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells. Int J Cancer, 105: 331-339, 2003.
-
(2003)
Int J Cancer
, vol.105
, pp. 331-339
-
-
Klingler-Hoffmann, M.1
Bukczynska, P.2
Tiganis, T.3
-
85
-
-
0000440912
-
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
-
Chang HW, Aoki M, Fruman D, et al. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science, 276: 1848-1850, 1997.
-
(1997)
Science
, vol.276
, pp. 1848-1850
-
-
Chang, H.W.1
Aoki, M.2
Fruman, D.3
-
86
-
-
0031708412
-
Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
-
Klippel A, Escobedo MA, Wachowicz MS, et al. Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation. Mol Cell Biol, 18: 5699-5711, 1998.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 5699-5711
-
-
Klippel, A.1
Escobedo, M.A.2
Wachowicz, M.S.3
-
87
-
-
14444269482
-
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines
-
Teng DH, Hu R, Lin H, et al. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res, 57: 5221-5225, 1997.
-
(1997)
Cancer Res
, vol.57
, pp. 5221-5225
-
-
Teng, D.H.1
Hu, R.2
Lin, H.3
-
88
-
-
13144249184
-
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
-
Suzuki A, de la Pompa JL, Stambolic V, et al. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol, 8: 1169-1178, 1998.
-
(1998)
Curr Biol
, vol.8
, pp. 1169-1178
-
-
Suzuki, A.1
De La Pompa, J.L.2
Stambolic, V.3
-
89
-
-
13044250465
-
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
-
Podsypanina K, Ellenson LH, Nemes A, et al. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci USA, 96: 1563-1568, 1999.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 1563-1568
-
-
Podsypanina, K.1
Ellenson, L.H.2
Nemes, A.3
-
90
-
-
0032590011
-
PIK3CA is implicated as an oncogene in ovarian cancer
-
Shayesteh L, Lu Y, Kuo WL, et al. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet, 21: 99-102, 1999.
-
(1999)
Nat Genet
, vol.21
, pp. 99-102
-
-
Shayesteh, L.1
Lu, Y.2
Kuo, W.L.3
-
91
-
-
0034713390
-
PIK3CA as an oncogene in cervical cancer
-
Ma YY, Wei SJ, Lin YC, et al. PIK3CA as an oncogene in cervical cancer. Oncogene, 19: 2739-2744, 2000.
-
(2000)
Oncogene
, vol.19
, pp. 2739-2744
-
-
Ma, Y.Y.1
Wei, S.J.2
Lin, Y.C.3
-
92
-
-
0035964367
-
Linking molecular therapeutics to molecular diagnostics: Inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo
-
Mills GB, Lu Y and Kohn EC. Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo. Proc Natl Acad Sci USA, 98: 10031-10033, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10031-10033
-
-
Mills, G.B.1
Lu, Y.2
Kohn, E.C.3
-
93
-
-
0034306970
-
Multiple genes at 17q23 undergo amplification and overexpression in breast cancer
-
Barlund M, Monni O, Kononen J, et al. Multiple genes at 17q23 undergo amplification and overexpression in breast cancer. Cancer Res, 60: 5340-5344, 2000.
-
(2000)
Cancer Res
, vol.60
, pp. 5340-5344
-
-
Barlund, M.1
Monni, O.2
Kononen, J.3
-
94
-
-
0028338545
-
Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85
-
Zheng Y, Bagrodia S, Cerione RA. Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85. J Biol Chem, 269: 18727-18730, 1994.
-
(1994)
J Biol Chem
, vol.269
, pp. 18727-18730
-
-
Zheng, Y.1
Bagrodia, S.2
Cerione, R.A.3
-
95
-
-
0032498231
-
LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
-
Zhang W, Sloan-Lancaster J, Kitchen J, et al. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell, 92: 83-92, 1998.
-
(1998)
Cell
, vol.92
, pp. 83-92
-
-
Zhang, W.1
Sloan-Lancaster, J.2
Kitchen, J.3
-
96
-
-
0032479864
-
T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane
-
Bruyns E, Marie-Cardine A, Kirchgessner H, et al. B. T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane. J Exp Med, 188: 561-575, 1998.
-
(1998)
J Exp Med
, vol.188
, pp. 561-575
-
-
Bruyns, E.1
Marie-Cardine, A.2
Kirchgessner, H.3
-
97
-
-
0033912699
-
The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase
-
Genot EM, Arrieumerlou C, Ku G, et al. The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase. Mol Cell Biol, 20: 5469-5478, 2000.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 5469-5478
-
-
Genot, E.M.1
Arrieumerlou, C.2
Ku, G.3
-
98
-
-
0032516873
-
Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction
-
Okkenhaug K and Rottapel R. Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction. J Biol Chem, 273: 21194-21202, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 21194-21202
-
-
Okkenhaug, K.1
Rottapel, R.2
-
99
-
-
0033826512
-
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
-
Gu H, Maeda H, Moon JJ, et al. New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway. Mol Cell Biol, 20: 7109-7120, 2000.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 7109-7120
-
-
Gu, H.1
Maeda, H.2
Moon, J.J.3
-
100
-
-
0034282897
-
The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines
-
Gadina M, Sudarshan C, Visconti R, et al. The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines. J Biol Chem, 275: 26959-26966, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 26959-26966
-
-
Gadina, M.1
Sudarshan, C.2
Visconti, R.3
-
101
-
-
0033647242
-
Phosphoinositide 3-kinase: A key biochemical signal for cell migration in response to chemokines
-
Sotsios Y and Ward SG. Phosphoinositide 3-kinase: a key biochemical signal for cell migration in response to chemokines. Immunol Rev, 177: 217-235, 2000.
-
(2000)
Immunol Rev
, vol.177
, pp. 217-235
-
-
Sotsios, Y.1
Ward, S.G.2
-
102
-
-
0034107671
-
Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo
-
Borlado LR, Redondo C, Alvarez B, et al. Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo. FASEB J, 14: 895-903, 2000.
-
(2000)
FASEB J
, vol.14
, pp. 895-903
-
-
Borlado, L.R.1
Redondo, C.2
Alvarez, B.3
-
103
-
-
0034995242
-
T cell-specific loss of PTEN leads to defects in central and peripheral tolerance
-
Suzuki A, Yamaguchi MT, Ohteki T, et al. T cell-specific loss of PTEN leads to defects in central and peripheral tolerance. Immunity, 14: 523-534, 2001.
-
(2001)
Immunity
, vol.14
, pp. 523-534
-
-
Suzuki, A.1
Yamaguchi, M.T.2
Ohteki, T.3
-
104
-
-
0035869402
-
Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo
-
Harada Y, Tokushima M, Matsumoto Y, et al. Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo. J Immunol, 166: 3797-3803, 2001.
-
(2001)
J Immunol
, vol.166
, pp. 3797-3803
-
-
Harada, Y.1
Tokushima, M.2
Matsumoto, Y.3
-
105
-
-
0028157767
-
PI 3-kinase: Structural and functional analysis of intersubunit interactions
-
Dhand R, Hara K, Hiles I, et al. PI 3-kinase: structural and functional analysis of intersubunit interactions. Embo J, 13: 511-521, 1994.
-
(1994)
Embo J
, vol.13
, pp. 511-521
-
-
Dhand, R.1
Hara, K.2
Hiles, I.3
-
106
-
-
0034658320
-
Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo
-
Jones RG, Parsons M, Bonnard M, et al. Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo. J Exp Med, 191: 1721-1734, 2000.
-
(2000)
J Exp Med
, vol.191
, pp. 1721-1734
-
-
Jones, R.G.1
Parsons, M.2
Bonnard, M.3
-
107
-
-
0027242129
-
The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential
-
Ahmed NN, Franke TF, Bellacosa A, et al. The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential. Oncogene, 8: 1957-1963, 1993.
-
(1993)
Oncogene
, vol.8
, pp. 1957-1963
-
-
Ahmed, N.N.1
Franke, T.F.2
Bellacosa, A.3
-
108
-
-
0035913188
-
Oncogenic transformation induced by membrane-targeted Akt2 and Akt3
-
Mende I, Malstrom S, Tsichlis PN, et al. Oncogenic transformation induced by membrane-targeted Akt2 and Akt3. Oncogene, 20: 4419-4423, 2001.
-
(2001)
Oncogene
, vol.20
, pp. 4419-4423
-
-
Mende, I.1
Malstrom, S.2
Tsichlis, P.N.3
-
109
-
-
0036111802
-
Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO)
-
Jucker M, Sudel K, Horn S, et al. Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO). Leukemia, 16: 894-901, 2002.
-
(2002)
Leukemia
, vol.16
, pp. 894-901
-
-
Jucker, M.1
Sudel, K.2
Horn, S.3
-
110
-
-
0035266314
-
Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis
-
Slupianek A, Nieborowska-Skorska M, Hoser G, et al. Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis. Cancer Res, 61: 2194-2199, 2001.
-
(2001)
Cancer Res
, vol.61
, pp. 2194-2199
-
-
Slupianek, A.1
Nieborowska-Skorska, M.2
Hoser, G.3
-
111
-
-
0035861087
-
Molecular basis of mature T-cell leukemia
-
Pekarsky Y, Hallas C and Croce CM. Molecular basis of mature T-cell leukemia. Jama, 286: 2308-2314, 2001.
-
(2001)
Jama
, vol.286
, pp. 2308-2314
-
-
Pekarsky, Y.1
Hallas, C.2
Croce, C.M.3
-
112
-
-
0037195092
-
Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma
-
Hoyer KK, French SW, Turner DE, et al. Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma. Proc Natl Acad Sci USA, 99: 14392-14397, 2002.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 14392-14397
-
-
Hoyer, K.K.1
French, S.W.2
Turner, D.E.3
-
113
-
-
0037219339
-
Targeting mature T cell leukemia: New understanding of molecular pathways
-
Pekarsky Y, Hallas C and Croce CM. Targeting mature T cell leukemia: new understanding of molecular pathways. Am J Pharmacogenomics, 3: 31-36, 2003.
-
(2003)
Am J Pharmacogenomics
, vol.3
, pp. 31-36
-
-
Pekarsky, Y.1
Hallas, C.2
Croce, C.M.3
-
114
-
-
0037373706
-
Akt is TCL-ish: Implications for B-cell lymphoma
-
Gold MR. Akt is TCL-ish: implications for B-cell lymphoma. Trends Immunol, 24: 104-108, 2003.
-
(2003)
Trends Immunol
, vol.24
, pp. 104-108
-
-
Gold, M.R.1
-
115
-
-
0036968347
-
Activation of the PI3K/Akt pathway and chemotherapeutic resistance
-
West KA, Sianna Castillo S and Dennis PA. Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug Resist Updat, 5: 234-248, 2002.
-
(2002)
Drug Resist Updat
, vol.5
, pp. 234-248
-
-
West, K.A.1
Castillo, S.S.2
Dennis, P.A.3
-
116
-
-
0036168948
-
Inhibition of phosphatidylinositol 3′-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models
-
Hu L, Hofmann J, Lu Y, et al. Inhibition of phosphatidylinositol 3′-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. Cancer Res, 62: 1087-1092, 2002.
-
(2002)
Cancer Res
, vol.62
, pp. 1087-1092
-
-
Hu, L.1
Hofmann, J.2
Lu, Y.3
-
117
-
-
0042399368
-
Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy
-
Liang K, Jin W, Knuefermann C, et al. Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy. Mol Cancer Ther, 2: 353-360, 2003.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 353-360
-
-
Liang, K.1
Jin, W.2
Knuefermann, C.3
-
118
-
-
0034100051
-
In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002)
-
Hu L, Zaloudek C, Mills GB, et al. In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002). Clin Cancer Res, 6: 880-886, 2000.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 880-886
-
-
Hu, L.1
Zaloudek, C.2
Mills, G.B.3
-
119
-
-
0036490442
-
Smart drugs: Tyrosine kinase inhibitors in cancer therapy
-
Shawver LK, Slamon D and Ullrich A. Smart drugs: tyrosine kinase inhibitors in cancer therapy. Cancer Cell, 1: 117-123, 2002.
-
(2002)
Cancer Cell
, vol.1
, pp. 117-123
-
-
Shawver, L.K.1
Slamon, D.2
Ullrich, A.3
-
120
-
-
0037295398
-
Studies with ZD1839 in preclinical models
-
Sirotnak FM. Studies with ZD1839 in preclinical models. Semin Oncol, 30: 12-20, 2003.
-
(2003)
Semin Oncol
, vol.30
, pp. 12-20
-
-
Sirotnak, F.M.1
-
121
-
-
0037099532
-
Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
-
Yakes FM, Chinratanalab W, Ritter CA, et al. Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res, 62: 4132-4141, 2002.
-
(2002)
Cancer Res
, vol.62
, pp. 4132-4141
-
-
Yakes, F.M.1
Chinratanalab, W.2
Ritter, C.A.3
-
122
-
-
0035174127
-
Pharmacodynamic studies with the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839
-
Albanell J, Rojo F, Baselga J. Pharmacodynamic studies with the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839. Semin Oncol, 28: 56-66, 2001.
-
(2001)
Semin Oncol
, vol.28
, pp. 56-66
-
-
Albanell, J.1
Rojo, F.2
Baselga, J.3
-
123
-
-
0037648896
-
Molecular targeting therapy of cancer: Drug resistance, apoptosis and survival signal
-
Tsuruo T, Naito M, Tomida A, et al. Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal. Cancer Sci, 94: 15-21, 2003.
-
(2003)
Cancer Sci
, vol.94
, pp. 15-21
-
-
Tsuruo, T.1
Naito, M.2
Tomida, A.3
-
124
-
-
0034794639
-
Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment
-
Stein RC. Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment. Endocr Relat Cancer, 8: 237-248, 2001.
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 237-248
-
-
Stein, R.C.1
-
125
-
-
0033581886
-
Structural insights into phosphoinositide 3-kinase catalysis and signalling
-
Walker EH, Perisic O, Ried C, et al. Structural insights into phosphoinositide 3-kinase catalysis and signalling. Nature, 402: 313-320, 1999.
-
(1999)
Nature
, vol.402
, pp. 313-320
-
-
Walker, E.H.1
Perisic, O.2
Ried, C.3
-
126
-
-
0036683691
-
Structural insight into substrate specificity and regulatory mechanisms of phosphoinositide 3-kinases
-
Djordjevic S and Driscoll PC. Structural insight into substrate specificity and regulatory mechanisms of phosphoinositide 3-kinases. Trends Biochem Sci, 27: 426-432, 2002.
-
(2002)
Trends Biochem Sci
, vol.27
, pp. 426-432
-
-
Djordjevic, S.1
Driscoll, P.C.2
-
127
-
-
0036568378
-
Nuclear PTEN expression and clinico-pathologic features in a population-based series of primary cutaneous melanoma
-
Whiteman DC, Zhou XP, Cummings MC, et al. Nuclear PTEN expression and clinico-pathologic features in a population-based series of primary cutaneous melanoma. Int J Cancer, 99: 63-67, 2002.
-
(2002)
Int J Cancer
, vol.99
, pp. 63-67
-
-
Whiteman, D.C.1
Zhou, X.P.2
Cummings, M.C.3
-
128
-
-
0034676303
-
Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival
-
Flynn P, Wongdagger M, Zavar M, et al. D. Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival. Curr Biol 10: 1439-1442, 2000.
-
(2000)
Curr Biol
, vol.10
, pp. 1439-1442
-
-
Flynn, P.1
Wongdagger, M.2
Zavar, M.3
-
129
-
-
0034724443
-
Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells
-
Persad S, Attwell S, Gray V, et al. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc Natl Acad Sci USA, 97: 3207-3212, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 3207-3212
-
-
Persad, S.1
Attwell, S.2
Gray, V.3
-
130
-
-
0037419785
-
Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt
-
Kozikowski AP, Sun H, Brognard J, et al. Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt. J Am Chem Soc, 125: 1144-1145, 2003.
-
(2003)
J Am Chem Soc
, vol.125
, pp. 1144-1145
-
-
Kozikowski, A.P.1
Sun, H.2
Brognard, J.3
-
131
-
-
0345492814
-
Specific Inhibition of the Akt1 Pleckstrin Homology Domain by D-3-Deoxy-Phosphatidyl-myo-Inositol Analogues
-
Meuillet EJ, Mahadevan D, Vankayalapati H, et al. Specific Inhibition of the Akt1 Pleckstrin Homology Domain by D-3-Deoxy-Phosphatidyl-myo-Inositol Analogues. Mol Cancer Ther, 2: 389-399, 2003.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 389-399
-
-
Meuillet, E.J.1
Mahadevan, D.2
Vankayalapati, H.3
-
132
-
-
0034901515
-
Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition
-
Dudkin L, Dilling MB, Cheshire PJ, et al. Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition. Clin Cancer Res, 7: 1758-1764, 2001.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1758-1764
-
-
Dudkin, L.1
Dilling, M.B.2
Cheshire, P.J.3
-
133
-
-
0345492813
-
Src family protein tyrosine kinases alter the function of PTEN to regulate PI3K/AKT cascades
-
Epub ahead of print
-
Lu Y, Yu Q, Liu JH, et al. Src family protein tyrosine kinases alter the function of PTEN to regulate PI3K/AKT cascades. J Biol Chem. 2003 (Epub ahead of print).
-
(2003)
J Biol Chem
-
-
Lu, Y.1
Yu, Q.2
Liu, J.H.3
|