LAT regulates γδ T cell homeostasis and differentiation

Nature Immunology

Volumn 4, Issue 10, 2003, Pages 999-1008

  Nuñez Cruz, Selene ^a   Aguado, Enrique ^a,d   Richelme, Sylvie ^a   Chetaille, Bruno ^a,b   Mura, Anne Marie ^a   Richelme, Mireille ^a   Pouyet, Laurent ^a   Jouvin Marche, Evelyne ^c   Xerri, Luc ^b   Malissen, Bernard ^a   Malissen, Marie ^a  

^a INSERM   (France)

^b INSTITUT PAOLI CALMETTES   (France)

^c CEA GRENOBLE   (France)

^d UNIVERSITY OF MURCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; LAT PROTEIN; TYROSINE; UNCLASSIFIED DRUG; CARRIER PROTEIN; CYTOKINE; LAT PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LINEAGE; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE MUTATION; HELPER CELL; HOMEOSTASIS; HOMOZYGOSITY; IMMUNIZATION; LYMPH NODE; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMA CELL; PRIORITY JOURNAL; SPLEEN; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; ANIMAL; BAGG ALBINO MOUSE; CELL DIFFERENTIATION; FLOW CYTOMETRY; GENETICS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; MUTATION; PHENOTYPE; SIGNAL TRANSDUCTION; TH2 CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; CELL DIFFERENTIATION; CYTOKINES; FLOW CYTOMETRY; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; PHOSPHOPROTEINS; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTES; TH2 CELLS; TYROSINE;

EID: 0142124330     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni977     Document Type: Article

References (51)

1. Malissen, B., Ardouin, L., Lin, S.Y., Gillet, A. & Malissen, M. Function of the CD3 subunits of the pre-TCR and TCR complexes during T cell development. Adv. Immunol. 72, 103-148 (1999).
2. Von Boehmer, H. et al. Thymic selection revisited: how essential is it? Immunol. Rev. 191, 62-78 (2003).
3. Wilson, A., Capone, M. & MacDonald, H.R. Unexpectedly late expression of intracellular CD3E and TCRγδ proteins during adult thymus development. Int. Immunol. 11, 1641-1650 (1999).
4. Passoni, L. et al. Intrathymic δ selection events in γδ cell development. Immunity 7, 83-95 (1997).
5. Ferrero, I., Wilson, A., Beermann, F., Held, W. & MacDonald, H.R. T cell receptor specificity is critical for the development of epidermal γδ T cells. J. Exp. Med. 194, 1473-1483 (2001).
6. Jordan, M.S., Singer, A.L. & Koretzky, G.A. Adaptors as central mediators of signal transduction in immune cells. Nat. Immunol. 4, 110-116 (2003).
7. Lin, J. & Weiss, A. Identification of the minimal tyrosine residues required for linker for activation of T cell function. J. Biol. Chem. 276, 29588-29595 (2001).
8. Paz, P.E. et al. Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells. Biochem. J. 356, 461-471 (2001).
9. Zhang, W. et al. Association of Grb2, Gads, and phospholipase C-γ 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling. J. Biol. Chem. 275, 23355-23361 (2000).
10. Zhu, M., Janssen, E. & Zhang, W. Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development. J. Immunol. 170, 325-333 (2003).
11. Hartgroves, L.C. et al. Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains. J. Biol. Chem. 278, 20389-20394 (2003).
12. Yablonski, D., Kadlecek, T. & Weiss, A. Identification of a phospholipase C-γ1 (PLC-γ1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-γ1 and NFAT. Mol. Cell. Biol. 21, 4208-4218 (2001).
13. Zhang, W. et al. Essential role of LAT in T cell development. Immunity 10, 323-332 (1999).
14. Sommers, C.L. et al. Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development. J. Exp. Med. 194, 135-142 (2001).
15. Sommers, C.L. et al. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science 296, 2040-2043 (2002).
16. Aguado, E. et al. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 296, 2036-2040 (2002).
17. Pivniouk, V. et al. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell 94, 229-238 (1998).
18. Zorbas, M. & Scollay, R. Development of γδ T cells in the adult murine thymus. Eur. J. Immunol. 23, 1655-1660 (1993).
19. Mombaerts, P. et al. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 360, 225-231 (1992).
20. Leduc, I. et al. T cell development in TCRβ enhancer-deleted mice: implications for αβ T cell lineage commitment and differentiation. J. Immunol. 165, 1364-1673 (2000).
21. Pereira, P., Gerber, D., Huang, S.Y. & Tonegawa, S. Ontogenic development and tissue distribution of Vγ1-expressing γδ T lymphocytes in normal mice. J. Exp. Med. 182, 1921-1930 (1995).
22. Hayes, S.M. & Love, P.E. Distinct structure and signaling potential of the γδ TCR complex. Immunity 16, 827-838 (2002).
23. Kadlecek, T.A. et al. Differential requirements for ZAP-70 in TCR signaling and T cell development. J. Immunol. 161, 4688-4694 (1998).
24. Swat, W. et al. Essential role for Vav1 in activation, but not development, of γδ T cells. Int. Immunol. 15, 215-221 (2003).
25. Jaffe, S., Harris, N.L., Stein, H. & Vardiman, J.W. World Health Organisation Classification of Tumors. Pathology, and Genetics of Tumours of Hematopoietic and Lymphoid Tissues (IARC Press, Lyon, 2001).
26. Morse, H.C., 3rd. et al. Bethesda proposals for classification of lymphoid neoplasms in mice. Blood 100, 246-258 (2002).
27. Arnulf, B. et al. Nonhepatosplenic γδ T-cell lymphoma: a subset of cytotoxic lymphomas with mucosal or skin localization. Blood 91, 1723-1731 (1998).
28. Ferrick, D.A. et al. Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo. Nature 373, 255-257 (1995).
29. Wen, L. et al. Primary γδ cell clones can be defined phenotypically and functionally as Th1/Th2 cells and illustrate the association of CD4 with Th2 differentiation. J. Immunol. 160, 1965-1974 (1998).
30. Murphy, K.M. & Reiner, S.L. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2, 933-944 (2002).
31. Grogan, J.L. & Locksley, R.M. T helper cell differentiation: on again, off again. Curr. Opin. Immunol. 14, 366-372 (2002).
32. Ho, I.C. & Glimcher, L.H. Transcription: tantalizing times for T cells. Cell 109, S109-120 (2002).
33. Yin, Z. et al. Dominance of IL-12 over IL-4 in γδ T cell differentiation leads to default production of IFN-γ: failure to down-regulate IL-12 receptor β2-chain expression. J. Immunol. 164, 3056-3064 (2000).
34. Yin, Z. et al. T-Bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-γ by γδ T cells. J. Immunol. 168, 1566-1571 (2002).
35. Egan, P.J. & Carding, S.R. Downmodulation of the inflammatory response to bacterial infection by γδ T cells cytotoxic for activated macrophages. J. Exp. Med. 191, 2145-2158 (2000).
36. Azuara, V., Levraud, J.P., Lembezat, M.P. & Pereira, P. A novel subset of adult γδ thymocytes that secretes a distinct pattern of cytokines and expresses a very restricted T cell receptor repertoire. Eur. J. Immunol. 27, 544-553 (1997).
37. Wen, L. et al. Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non α/β" T cells. J. Exp. Med. 183, 2271-2282 (1996).
38. Bhan, A.K., Mizoguchi, E., Smith, R.N. & Mizoguchi, A. Spontaneous chronic colitis in TCRα-mutant mice; an experimental model of human ulcerative colitis. Int. Rev. Immunol. 19, 123-138 (2000).
39. Munk, M.E., Fazioli, R.A., Calich, V.L. & Kaufmann, S.H. Paracoccidioides brasiliensis-stimulated human γδ T cells support antibody production by B cells. Infect. Immun. 63, 1608-1610 (1995).
40. Horner, A.A., Jabara, H., Ramesh, N. & Geha, R.S. γδ T lymphocytes express CD40 ligand and induce isotype switching in B lymphocytes. J. Exp. Med. 181, 1239-1244 (1995).
41. Yamasaki, S. et al. Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells. Mol. Cell. Biol. 23, 2515-2529 (2003).
42. Sallusto, F. & Lanzavecchia, A. The instructive role of dendritic cells on T-cell responses. Arthritis Res. 4, S127-132 (2002).
43. Rogers, P.R. & Croft, M. CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen. J. Immunol. 164, 2955-2963 (2000).
44. + T cells. J. Immunol. 270, 2427-2434 (2003).
45. Boonstra, A. et al. Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation. J. Exp. Med. 197, 101-109 (2003).
46. Spanopoulou, E. et al. Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev. 8, 1030-1042 (1994).
47. Kress, C., Vandormael-Pournin, S., Baldacci, P., Cohen-Tannoudji, M. & Babinet, C. Nonpermissiveness for mouse embryonic stem (ES) cell derivation circumvented by a single backcross to 129/Sv strain: establishment of ES cell lines bearing the Omd conditional lethal mutation. Mamm. Genome 9, 998-1001 (1998).
48. Schwenk, F., Baron, U. & Rajewsky, K. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23, 5080-5081 (1995).
49. Pannetier, C., Even, J. & Kourilsky, P. T-cell repertoire diversity and clonal expansions in normal and clinical samples. Immunol. Today 16, 176-181 (1995).
50. Perron, H. et al. Multiple sclerosis retrovirus particles and recombinant envelope trigger an abnormal immune response in vitro, by inducing polyclonal Vβ16 T-lymphocyte activation. Virology 287, 321-332 (2001).
51. Garman, R.D., Doherty, P.J. & Raulet, D.H. Diversity, rearrangement, and expression of murine T cell γ genes. Cell 45, 733-742 (1986).