Macrophages and inflammation

Adipose Tissue Biology

Volumn , Issue , 2012, Pages 167-193

  Dalmas, Elise ^a,b,c,d   Tordjman, Joan ^a,b,c,d   Guerre Millo, Michèle ^a,b,c,d   Clément, Karine ^a,b,c,d  

^a INSERM   (France)

^b CENTRE DE RECHERCHE DES CORDELIERS   (France)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^d CENTRE MAURICE HALBWACHS   (France)

Author keywords

Inflammation; Macrophages; Obesity; Weight loss

Indexed keywords

EID: 84871795294     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-0965-6_6     Document Type: Chapter

References (119)

1. Ahima RS, Osei SY (2008) Adipokines in obesity. Front Horm Res 36:182-197
2. Andersson CX, Gustafson B, Hammarstedt A et al (2008) Inflamed adipose tissue, insulin resistance and vascular injury. Diabetes Metab Res Rev 24:595-603
3. Apovian CM, Bigornia S, Mott M et al (2008) Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects. Arterioscler Thromb Vasc Biol 28:1654-1659
4. Aron-Wisnewsky J, Tordjman J, Poitou C et al (2009) Human adipose tissue macrophages: m1 and m2 cell surface markers in subcutaneous and omental depots and after weight loss. J Clin Endocrinol Metab 94:4619-4623
5. Bourlier V, Zakaroff-Girard A, Miranville A et al (2008) Remodeling phenotype of human subcutaneous adipose tissue macrophages. Circulation 117:806-815
6. Bradshaw AD, Graves DC, Motamed K et al (2003) SPARC-null mice exhibit increased adiposity without significant differences in overall body weight. Proc Natl Acad Sci USA 100: 6045-6050
7. Bruun JM, Lihn AS, Pedersen SB et al (2005) Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT. J Clin Endocrinol Metab 90:2282-2289
8. Buchwald H, Avidor Y, Braunwald E et al (2004) Bariatric surgery: a systematic review and metaanalysis. JAMA 292:1724-1737
9. Cancello R, Henegar C, Viguerie N et al (2005) Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes 54:2277-2286
10. Cancello R, Tordjman J, Poitou C et al (2006) Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. Diabetes 55:1554-1561
11. Cani PD, Amar J, Iglesias MA et al (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56:1761-1772
12. Capel F, Klimcakova E, Viguerie N et al (2009) Macrophages and adipocytes in human obesity: adipose tissue gene expression and insulin sensitivity during calorie restriction and weight stabilization. Diabetes 58:1558-1567
13. Chen GY, Nunez G (2010) Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol 10:826-837
14. Chen A, Mumick S, Zhang C et al (2005) Diet induction of monocyte chemoattractant protein-1 and its impact on obesity. Obes Res 13:1311-1320
15. Chun TH, Hotary KB, Sabeh F et al (2006) A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell 125:577-591
16. Cinti S, Mitchell G, Barbatelli G et al (2005) Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 46:2347-2355
17. Clement K, Viguerie N, Poitou C et al (2004) Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB J 18:1657-1669
18. Cottam DR, Schaefer PA, Shaftan GW et al (2002) Effect of surgically-induced weight loss on leukocyte indicators of chronic inflammation in morbid obesity. Obes Surg 12:335-342
19. Cottam DR, Mattar SG, Barinas-Mitchell E et al (2004) The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss. Obes Surg 14:589-600
20. Cros J, Cagnard N, Woollard K et al (2010) Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity 33:375-386
21. Curat CA, Miranville A, Sengenes C et al (2004) From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes 53:1285-1292
22. Dahlman I, Kaaman M, Olsson T et al (2005) A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjects. J Clin Endocrinol Metab 90:5834-5840
23. Davis JE, Gabler NK, Walker-Daniels J et al (2008) Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity (Silver Spring) 16:1248-1255
24. Di Gregorio GB, Yao-Borengasser A, Rasouli N et al (2005) Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes 54:2305-2313
25. Divoux A, Tordjman J, Lacasa D et al (2010) Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss. Diabetes 59:2817-2825
26. Dixon JB, O’Brien PE, Playfair J et al (2008) Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. JAMA 299:316-323
27. Esposito K, Pontillo A, Di Palo C et al (2003) Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 289:1799-1804
28. Fain JN (2010) Release of inflammatory mediators by human adipose tissue is enhanced in obesity and primarily by the nonfat cells: a review. Mediators Inflamm 2010:513-948
29. Fontana L, Eagon JC, Trujillo ME et al (2007) Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 56:1010-1013
30. Fujisaka S, Usui I, Bukhari A et al (2009) Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes 58:2574-2582
31. Fujita K, Maeda N, Sonoda M et al (2008) Adiponectin protects against angiotensin Il-induced cardiac fibrosis through activation of PPAR-alpha. Arterioscler Thromb Vasc Biol 28:863-870
32. Geissmann F, Manz MG, Jung S et al (2010) Development of monocytes, macrophages, and dendritic cells. Science 327:656-661
33. Ghanim H, Aljada A, Hofmeyer D et al (2004) Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation 110:1564-1571
34. Gordon S (2003) Alternative activation of macrophages. Nat Rev Immunol 3:23-35
35. Gordon S, Taylor PR (2005) Monocyte and macrophage heterogeneity. Nat Rev Immunol 5:953-964
36. Halberg N, Khan T, Trujillo ME et al (2009) Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol 29:4467-4483
37. Harman-Boehm I, Bluher M, Redel H et al (2007) Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity. J Clin Endocrinol Metab 92:2240-2247
38. Heilbronn LK, de Jonge L, Frisard MI et al (2006) Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA 295:1539-1548
39. Henegar C, Tordjman J, Achard V et al (2008) Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol 9:R14
40. Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444:860-867
41. Hotamisligil GS, Arner P, Caro JF et al (1995) Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 95:2409-2415
42. Huber J, Kiefer FW, Zeyda M et al (2008) CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity. J Clin Endocrinol Metab 93:3215-3221
43. Hui JM, Hodge A, Farrell GC et al (2004) Beyond insulin resistance in NASH: TNF-alpha or adiponectin? Hepatology 40:46-54
44. Hummasti S, Hotamisligil GS (2010) Endoplasmic reticulum stress and inflammation in obesity and diabetes. Circ Res 107:579-591
45. Inouye KE, Shi H, Howard JK et al (2007) Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes 56:2242-2250
46. Ito A, Suganami T, Yamauchi A et al (2008) Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue. J Biol Chem 283:35715-35723
47. Kamada Y, Tamura S, Kiso S et al (2003) Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin. Gastroenterology 125:1796-1807
48. Kamei M, Carman CV (2010) New observations on the trafficking and diapedesis of monocytes. Curr Opin Hematol 17:43-52
49. Kamei N, Tobe K, Suzuki R et al (2006) Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem 281:26602-26614
50. Kanda H, Tateya S, Tamori Y et al (2006) MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 116:1494-1505
51. Keophiphath M, Achard V, Henegar C et al (2009) Macrophage-secreted factors promote a profi- brotic phenotype in human preadipocytes. Mol Endocrinol 23:11-24
52. Keophiphath M, Rouault C, Divoux A et al (2010) CCL5 promotes macrophage recruitment and survival in human adipose tissue. Arterioscler Thromb Vasc Biol 30:39-45
53. Khallou-Laschet J, Varthaman A, Fornasa G et al (2010) Macrophage plasticity in experimental atherosclerosis. PLoS One 5:e8852
54. Kirk EA, Sagawa ZK, McDonald TO et al (2008) Monocyte chemoattractant protein deficiency fails to restrain macrophage infiltration into adipose tissue [corrected]. Diabetes 57:1254-1261
55. Kishore P, Li W, Tonelli J et al (2010) Adipocyte-derived factors potentiate nutrient-induced production of plasminogen activator inhibitor-1 by macrophages. Sci Transl Med 24(20):20
56. Kobashi C, Urakaze M, Kishida M et al (2005) Adiponectin inhibits endothelial synthesis of interleukin-8. Circ Res 97:1245-1252
57. Koliwad SK, Streeper RS, Monetti M et al (2010) DGATl-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation. J Clin Invest 120:756-767
58. Kos K, Wong S, Tan B et al (2009) Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose. Diabetes 58:1780-1788
59. Kosteli A, Sugaru E, Haemmerle G et al (2010) Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest 120:3466-3479
60. Kovacikova M, Sengenes C, Kovacova Z et al (2011) Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women. Int J Obes (Lond) 35:91-98
61. Lacasa D, Taleb S, Keophiphath M et al (2007) Macrophage-secreted factors impair human adipo- genesis: involvement of proinflammatory state in preadipocytes. Endocrinology 148:868-877
62. Lee MJ, Wu Y, Fried SK (2010) Adipose tissue remodeling in pathophysiology of obesity. Curr Opin Clin Nutr Metab Care 13:371-376
63. Liu J, Divoux A, Sun J et al (2009) Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med 15:940-945
64. Lumeng CN, Bodzin JL, Saltiel AR (2007a) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117:175-184
65. Lumeng CN, Deyoung SM, Bodzin JL et al (2007b) Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 56:16-23
66. Lumeng CN, DelProposto JB, Westcott DJ et al (2008) Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 57:3239-3246
67. Makkonen J, Westerbacka J, Kolak M et al (2007) Increased expression of the macrophage markers and of 11beta-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity. Int J Obes (Lond) 31:1617-1625
68. Marra F, Aleffi S, Bertolani C et al (2005) Review article: the pathogenesis of fibrosis in nonalcoholic steatohepatitis. Aliment Pharmacol Ther 22(Suppl 2):44-47
69. Martinez FO, Sica A, Mantovani A et al (2008) Macrophage activation and polarization. Front Biosci 13:453-461
70. Matsuda M, Shimomura I, Sata M et al (2002) Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem 277:37487-37491
71. Medzhitov R (2008) Origin and physiological roles of inflammation. Nature 454:428-435
72. Mosser DM, Edwards JP (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8:958-969
73. Musso G, Gambino R, Biroli G et al (2005) Hypoadiponectinemia predicts the severity of hepatic fibrosis and pancreatic Beta-cell dysfunction in nondiabetic nonobese patients with nonalcoholic steatohepatitis. Am J Gastroenterol 100:2438-2446
74. Nara N, Nakayama Y, Okamoto S et al (2007) Disruption of CXC motif chemokine ligand-14 in mice ameliorates obesity-induced insulin resistance. J Biol Chem 282:30794-30803
75. Nijhuis J, Rensen SS, Slaats Y et al (2009) Neutrophil activation in morbid obesity, chronic activation of acute inflammation. Obesity (Silver Spring) 17:2014-2018
76. Nishimura S, Manabe I, Nagasaki M et al (2009) CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 15:914-920
77. Ohashi K, Parker JL, Ouchi N et al (2010) Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem 285:6153-6160
78. Ohman MK, Eitzman DT (2009) Targeting MCP-1 to reduce vascular complications of obesity. Recent Pat Cardiovasc Drug Discov 4:164-176
79. Pandzic Jaksic V, Gizdic B, Miletic Z et al (2010) Monocytes in metabolic disorders-opportunities for flow cytometry contributions. Coll Antropol 34:319-325
80. Pang C, Gao Z, Yin J et al (2008) Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity. Am J Physiol Endocrinol Metab 295:E313-E322
81. Pasarica M, Gowronska-Kozak B, Burk D et al (2009) Adipose tissue collagen VI in obesity. J Clin Endocrinol Metab 94:5155-5162
82. Poitou C, Divoux A, Faty A et al (2009) Role of serum amyloid a in adipocyte-macrophage cross talk and adipocyte cholesterol efflux. J Clin Endocrinol Metab 94:1810-1817
83. Rogacev KS, Ulrich C, Blomer L et al (2010) Monocyte heterogeneity in obesity and subclinical atherosclerosis. Eur Heart J 31:369-376
84. Roncon-Albuquerque R Jr., Moreira-Rodrigues M, Faria B et al (2008) Attenuation of the cardiovascular and metabolic complications of obesity in CD14 knockout mice. Life Sci 83:502-510
85. Scherer PE (2006) Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes 55:1537-1545
86. Shaul ME, Bennett G, Strissel KJ et al (2010) Dynamic, M2-like remodeling phenotypes of CD11c + adipose tissue macrophages during high-fat diet-induced obesity in mice. Diabetes 59:1171-1181
87. Shi H, Kokoeva MV, Inouye K et al (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116:3015-3025
88. Shoelson SE, Lee J, Goldfine AB (2006) Inflammation and insulin resistance. J Clin Invest 116:1793-1801
89. Sica A, Larghi P, Mancino A et al (2008) Macrophage polarization in tumour progression. Semin Cancer Biol 18:349-355
90. Sjostrom L, Lindroos AK, Peltonen M et al (2004) Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 351:2683-2693
91. Skilton MR, Boussel L, Bonnet F et al (2011) Carotid intima-media and adventitial thickening: comparison of new and established ultrasound and magnetic resonance imaging techniques. Atherosclerosis 215(2):405-410
92. Skurk T, Alberti-Huber C, Herder C et al (2007) Relationship between adipocyte size and adipokine expression and secretion. J Clin Endocrinol Metab 92:1023-1033
93. Spencer M, Yao-Borengasser A, Unal R et al (2010) Adipose tissue macrophages in insulin resistant subjects are associated with collagen VI, fibrosis and demonstrate alternative activation. Am J Physiol Endocrinol Metab 299:E1016-E1027
94. Strissel KJ, Stancheva Z, Miyoshi H et al (2007) Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes 56:2910-2918
95. Suganami T, Nishida J, Ogawa Y (2005) A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol 25:2062-2068
96. Surmi BK, Webb CD, Ristau AC et al (2010) Absence of macrophage inflammatory protein- 1 does not impact macrophage accumulation in adipose tissue of diet-induced obese mice. Am J Physiol Endocrinol Metab 299:E437-E445
97. Tam CS, Viardot A, Clement K et al (2010) Short-term overfeeding may induce peripheral insulin resistance without altering subcutaneous adipose tissue macrophages in humans. Diabetes 59:2164-2170
98. Tartare-Deckert S, Chavey C, Monthouel MN et al (2001) The matiicellular protein SPARC/osteonectin as a newly identified factor up-regulated in obesity. J Biol Chem 276:22231-22237
99. Tordjman J, Poitou C, Hugol D et al (2009) Association between omental adipose tissue macrophages and liver histopathology in morbid obesity: influence of glycemic status. J Hepatol 51:354-362
100. Tsou CL, Peters W, Si Y et al (2007) Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest 117:902-909
101. Tuomilehto J, Lindstrom J, Eriksson JG et al (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343-1350
102. Utzschneider KM, Kahn SE (2006) Review: The role of insulin resistance in nonalcoholic fatty liver disease. J Clin Endocrinol Metab 91:4753-4761
103. Van der Poorten D, Kenny DT, Butler T et al (2007) Liver disease in adolescents: a cohort study of high-risk individuals. Hepatology 46:1750-1758
104. Villaret A, Galitzky J, Decaunes P et al (2010) Adipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metbolic, and inflammatory gene expression and cellular senescence. Diabetes 59:2755-2763
105. Weisberg SP, McCann D, Desai M et al (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-1808
106. Weisberg SP, Hunter D, Huber R et al (2006) CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 116:115-124
107. Westcott DJ, Delproposto JB, Geletka LM et al (2009) MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity. J Exp Med 206:3143-3156
108. Westerbacka J, Corner A, Tiikkainen M et al (2004) Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk. Diabetologia 47:1360-1369
109. Wing RR, Koeske R, Epstein LH et al (1987) Long-term effects of modest weight loss in type II diabetic patients. Arch Intern Med 147:1749-1753
110. Wu H, Ghosh S, Perrard XD et al (2007) T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation 115:1029-1038
111. Xu H, Barnes GT, Yang Q et al (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821-1830
112. Yang RZ, Lee MJ, Hu H et al (2006) Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications. PLoS Med 3:e287
113. Ye J (2009) Emerging role of adipose tissue hypoxia in obesity and insulin resistance. Int J Obes (Lond) 33:54-66
114. Yokota T, Oritani K, Takahashi I et al (2000) Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 96:1723-1732
115. You T, Nicklas BJ (2006) Chronic inflammation: role of adipose tissue and modulation by weight loss. Curr Diabetes Rev 2:29-37
116. Yu R, Kim CS, Kwon BS et al (2006) Mesenteric adipose tissue-derived monocyte chemoattractant protein-1 plays a crucial role in adipose tissue macrophage migration and activation in obese mice. Obesity (Silver Spring) 14:1353-1362
117. Yudkin JS, Stehouwer CD, Emeis JJ et al (1999) C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 19:972-978
118. Zeyda M, Farmer D, Todoric J et al (2007) Human adipose tissue macrophages are of an antiinflammatory phenotype but capable of excessive pro-inflammatory mediator production. Int J Obes (Lond) 31:1420-1428
119. Ziegler-Heitbrock L (2007) The CD 14+ CD 16+ blood monocytes: their role in infection and inflammation. J Leukoc Biol 81:584-592