Clinical application of exhaled nitric oxide measurement in pediatric lung diseases

Italian Journal of Pediatrics

Volumn 38, Issue 1, 2012, Pages

  Manna, Angelo ^a   Caffarelli, Carlo ^b   Varini, Margherita ^b   Dascola, Carlotta Povesi ^b   Montella, Silvia ^a   Maglione, Marco ^a   Sperlì, Francesco ^a   Santamaria, Francesca ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY HOSPITAL OF PARMA   (Italy)

Author keywords

Airway diseases; Asthma; Bronchiectasis; Bronchiolitis; Children; Community acquired pneumonia; Diffuse lung disease; Exhaled nitric oxide

Indexed keywords

CORTICOSTEROID; NITRIC OXIDE;

ASTHMA; BODY MASS; BRONCHIECTASIS; BRONCHIOLITIS; BRONCHIOLITIS OBLITERANS; BRONCHOSPASM; CLINICAL ASSESSMENT TOOL; CLINICAL PRACTICE; COMMUNITY ACQUIRED PNEUMONIA; DIAGNOSTIC ACCURACY; FOLLOW UP; FRACTIONAL EXHALED NITRIC OXIDE; HUMAN; LUNG DISEASE; LUNG FUNCTION; LUNG LAVAGE; LUNG SARCOIDOSIS; OBESITY; PATIENT CARE; REVIEW; SYSTEMIC SCLEROSIS; TREATMENT RESPONSE; WAIST HIP RATIO;

ASTHMA; BIOLOGICAL MARKERS; CHILD; FORCED EXPIRATORY VOLUME; HUMANS; LUNG DISEASES; NITRIC OXIDE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX;

EID: 84871692445     PISSN: 17208424     EISSN: 18247288     Source Type: Journal    
DOI: 10.1186/1824-7288-38-74     Document Type: Review

References (161)

1. The L-arginine-nitric oxide pathway. Moncada S, Higgs A, N Engl J Med 1993 329 2002 2012 10.1056/NEJM199312303292706 7504210 (Pubitemid 24015045)
2. Nitric oxide in upper airways inflammatory diseases. Maniscalco M, Sofia M, Pelaia G, Inflamm Res 2007 56 58 69 10.1007/s00011-006-6111-1 17431742 (Pubitemid 46412015)
3. Exhaled markers of pulmonary disease. Kharitonov SA, Barnes PJ, Am J Respir Crit Care Med 2001 163 1693 1722 11401895 (Pubitemid 32578777)
4. High nitric oxide production in human paranasal sinuses. Lundberg JO, Farkas-Szallasi T, Weitzberg E, Rinder J, Lidholm J, Anggåard A, Hökfelt T, Lundberg JM, Alving K, Nat Med 1995 1 370 373 10.1038/nm0495-370 7585069
5. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. American Thoracic Society; European Respiratory Society, Am J Respir Crit Care Med 2005 171 912 930 15817806
6. Exhaled NO and breath condensate. Baraldi E, Carraro S, Paediatr Respir Rev 2006 7 Suppl 1 20 22
7. Measurement of nasal nitric oxide by hand-held and stationary devices. Montella S, Alving K, Maniscalco M, Sofia M, De Stefano S, Raia V, Santamaria F, Eur J Clin Invest 2011 41 1063 1070 10.1111/j.1365-2362.2011.02501.x 21413977
8. Nasal nitric oxide assessment in primary ciliary dyskinesia using aspiration, exhalation, and humming. Santamaria F, De Stefano S, Montella S, Barbarano F, Iacotucci P, Ciccarelli R, Sofia M, Maniscalco M, Med Sci Monit 2008 14 80 85
9. Asthma, atopy, and airway inflammation in obese children. Santamaria F, Montella S, De Stefano S, Sperlì F, Barbarano F, Spadaro R, Franzese A, J Allergy Clin Immunol 2007 120 965 967 10.1016/j.jaci.2007.06.002 17637474 (Pubitemid 47531838)
10. Exhaled breath biomarkers in asthmatic children. Corradi M, Zinelli C, Caffarelli C, Inflamm Allergy Drug Targets 2007 6 150 159 10.2174/ 187152807781696437 17897051 (Pubitemid 47455783)
11. Measurement of exhaled nitric oxide in children, 2001. Baraldi E, de Jongste JC, European Respiratory Society/American Thoracic Society (ERS/ATS) Task Force, Eur Respir J 2002 20 223 237 10.1183/09031936.02.00293102 12166573 (Pubitemid 34822946)
12. FeNO measured at fixed exhalation flow rate during controlled tidal breathing in children from the age of 2 yr. Buchvald F, Bisgaard H, Am J Respir Crit Care Med 2001 163 699 704 11254527 (Pubitemid 32230832)
13. A comparison of exhaled nitric oxide measurements performed using three different analysers. Borrill Z, Clough D, Truman N, Morris J, Langley S, Singh D, Respir Med 2006 100 1392 1396 10.1016/j.rmed.2005.11.018 16431095 (Pubitemid 43964493)
14. Performance of a new hand-held device for exhaled nitric oxide measurement in adults and children. Alving K, Janson C, Nordvall L, Respir Res 2006 7 67 10.1186/1465-9921-7-67 16626491 (Pubitemid 43744581)
15. Comparison of exhaled nitric oxide measurements between NIOX MINO electrochemical and Ecomedics chemiluminescence analyzer. Boot JD, de Ridder L, de Kam ML, Calderon C, Mascelli MA, Diamant Z, Respir Med 2008 102 1667 1671 10.1016/j.rmed.2008.06.021 18694637
16. Portable exhaled nitric oxide measurement: Comparison with the «gold standard» technique. Menzies D, Nair A, Lipworth BJ, Chest 2007 131 410 414 10.1378/chest.06-1335 17296641 (Pubitemid 46280400)
17. Measurement of exhaled nitric oxide: comparison of different analysers. Korn S, Telke I, Kornmann O, Buhl R, Respirology 2010 15 1203 1208 10.1111/j.1440-1843.2010.01847.x 20920124
18. Reference values of exhaled nitric oxide for healthy children 6-15 years old. Baraldi E, Azzolin NM, Cracco A, Zacchello F, Pediatr Pulmonol 1999 27 54 58 10023792 (Pubitemid 29063802)
19. Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years. Buchvald F, Baraldi E, Carraro S, Gaston B, De Jongste J, Pijnenburg MW, Silkoff PE, Bisgaard H, J Allergy Clin Immunol 2005 115 1130 1136 10.1016/j.jaci.2005.03.020 15940124 (Pubitemid 40824579)
20. Exhaled nitric oxide concentration is affected by age, height, and race in healthy 9- to 12-year-old children. Kovesi T, Kulka R, Dales R, Chest 2008 133 169 175 10.1378/chest.07-1177 17925422
21. High levels and gender difference of exhaled nitric oxide in Chinese schoolchildren. Wong GW, Liu EK, Leung TF, Yung E, Ko FW, Hui DS, Fok TF, Lai CK, Clin Exp Allergy 2005 35 889 893 10.1111/j.1365-2222.2005.02263.x 16008675 (Pubitemid 41032537)
22. Exhaled nitric oxide in healthy nonatopic school-age children: determinants and height-adjusted reference values. Malmberg LP, Petäys T, Haahtela T, Laatikainen T, Jousilahti P, Vartiainen E, Mäkelä MJ, Pediatr Pulmonol 2006 41 635 642 10.1002/ppul.20417 16703576
23. Reference values of exhaled nitric oxide in healthy Asian children aged 5 to 18 years. Yao TC, Lee WI, Ou LS, Chen LC, Yeh KW, Huang JL, PATCH Study Group, Eur Respir J 2012 39 378 384 10.1183/09031936.00013911 21622584
24. Airway nitric oxide in asthmatic children and patients with cystic fibrosis. Dötsch J, Demirakça S, Terbrack HG, Hüls G, Rascher W, Kühl PG, Eur Respir J 1996 9 2537 2540 10.1183/09031936.96.09122537 8980966 (Pubitemid 26407905)
25. Orally exhaled nitric oxide levels are related to the degree of blood eosinophilia in atopic children with mild-intermittent asthma. Silvestri M, Spallarossa D, Frangova Yourukova V, Battistini E, Fregonese B, Rossi GA, Eur Respir J 1999 13 321 326 10.1034/j.1399-3003.1999.13b17.x 10065675 (Pubitemid 29086827)
26. A community study of exhaled nitric oxide in healthy children. Franklin PJ, Taplin R, Stick SM, Am J Respir Crit Care Med 1999 159 69 73 9872820 (Pubitemid 29036505)
27. Exhaled nitric oxide in healthy children: variability and a lack of correlation with atopy. Latzin P, Beck J, Griese M, Pediatr Allergy Immunol 2002 13 37 46 10.1034/j.1399-3038.2002.00066.x 12000497 (Pubitemid 34453879)
28. Interrelationships among asthma, atopy, rhinitis and exhaled nitric oxide in a population-based sample of children. Jouaville LF, Annesi-Maesano I, Nguyen LT, Bocage AS, Bedu M, Caillaud D, Clin Exp Allergy 2003 33 1506 1511 10.1046/j.1365-2222.2003.01800.x 14616861 (Pubitemid 37421627)
29. Exhaled nitric oxide in asthma. From diagnosis, to monitoring, to screening: are we there yet? Grob NM, Dweik RA, Chest 2008 133 837 839 10.1378/chest.07-2743 18398112 (Pubitemid 351536854)
30. Fraction of exhaled nitric oxide at 50 mL/s: reference values for adult lifelong never-smokers. Olin AC, Bake B, Torén K, Chest 2007 131 1852 1856 10.1378/chest.06-2928 17565022 (Pubitemid 46981645)
31. Reference ranges for exhaled nitric oxide derived from a random community survey of adults. Travers J, Marsh S, Aldington S, Williams M, Shirtcliffe P, Pritchard A, Weatherall M, Beasley R, Am J Respir Crit Care Med 2007 176 238 242 10.1164/rccm.200609-1346OC 17478616 (Pubitemid 47195873)
32. Factors affecting exhaled nitric oxide measurements: the effect of sex. Taylor DR, Mandhane P, Greene JM, Hancox RJ, Filsell S, McLachlan CR, Williamson AJ, Cowan JO, Smith AD, Sears MR, Respir Res 2007 8 82 10.1186/1465-9921-8-82 18005450
33. Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma (GINA) http://www.ginasthma.org/
34. British Guideline on the Management of Asthma. British Thoracic Society Scottish Intercollegiate Guidelines Network, Thorax 2008 63 Suppl 4 1 121 18156562
35. The role of inflammation in childhood asthma. Chedevergne F, Le Bourgeois M, de Blic J, Scheinmann P, Arch Dis Child 2000 82 Suppl 2 6 9
36. Hydrogen peroxide in exhaled breath condensate in asthmatic children during acute exacerbation and after treatment. Caffarelli C, Calcinai E, Rinaldi L, Povesi Dascola C, Terracciano L, Corradi M, Respiration 2012 84 291 298 10.1159/000341969 23018317
37. Increased amount of nitric oxide in exhaled air of asthmatics. Alving K, Weitzberg E, Lundberg JM, Eur Respir J 1993 6 1368 1370 7507065 (Pubitemid 23329557)
38. Increased nitric oxide in exhaled air of asthmatic patients. Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne EA, Barnes PJ, Lancet 1994 343 133 135 10.1016/S0140-6736(94)90931-8 7904001 (Pubitemid 24028638)
39. Induction of nitric oxide synthase in asthma. Hamid Q, Springall DR, Riveros-Moreno V, Chanez P, Howarth P, Redington A, Bousquet J, Godard P, Holgate S, Polak JM, Lancet 1993 342 1510 1513 10.1016/S0140-6736(05)80083-2 7504773 (Pubitemid 23362167)
40. Corticosteroids decrease exhaled nitric oxide in children with acute asthma. Baraldi E, Azzolin NM, Zanconato S, Dario C, Zacchello F, J Pediatr 1997 131 381 385 10.1016/S0022-3476(97)80062-5 9329413 (Pubitemid 27495197)
41. Exhaled nitric oxide measurements in normal and asthmatic children. Byrnes CA, Dinarevic S, Shinebourne EA, Barnes PJ, Bush A, Pediatr Pulmonol 1997 24 312 318 10.1002/(SICI)1099-0496(199711)24:5<312::AID-PPUL2>3.0.CO;2-K 9407563 (Pubitemid 27522974)
42. Exhaled nitric oxide in paediatric asthma and cystic fibrosis. Lundberg JO, Nordvall SL, Weitzberg E, Kollberg H, Alving K, Arch Dis Child 1996 75 323 326 10.1136/adc.75.4.323 8984919 (Pubitemid 26354604)
43. Exhaled nitric oxide correlates with airway eosinophils in childhood asthma. Warke TJ, Fitch PS, Brown V, Taylor R, Lyons JD, Ennis M, Shields MD, Thorax 2002 57 383 387 10.1136/thorax.57.5.383 11978911 (Pubitemid 34494145)
44. Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone. Payne DN, Adcock IM, Wilson NM, Oates T, Scallan M, Bush A, Am J Respir Crit Care Med 2001 164 1376 1381 11704581 (Pubitemid 33124013)
45. Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in mild to moderately severe asthma. Lim S, Jatakanon A, Meah S, Oates T, Chung KF, Barnes PJ, Thorax 2000 55 184 188 10.1136/thorax.55.3.184 10679535 (Pubitemid 30245966)
46. Correlations between exhaled nitric oxide levels, blood eosinophilia, and airway obstruction reversibility in childhood asthma are detectable only in atopic individuals. Silvestri M, Sabatini F, Sale R, Defilippi AC, Fregonese L, Battistini E, Biraghi MG, Rossi GA, Pediatr Pulmonol 2003 35 358 363 10.1002/ppul.10264 12687592 (Pubitemid 36529974)
47. Airway eosinophilia in children with severe asthma: predictive values of noninvasive tests. Lex C, Ferreira F, Zacharasiewicz A, Nicholson AG, Haslam PL, Wilson NM, Hansel TT, Payne DN, Bush A, Am J Respir Crit Care Med 2006 174 1286 1291 10.1164/rccm.200603-352OC 16973985 (Pubitemid 44913029)
48. Asthma: defining of the persistent adult phenotypes. Wenzel SE, Lancet 2006 368 804 813 10.1016/S0140-6736(06)69290-8 16935691 (Pubitemid 44279058)
49. Exhaled nitric oxide in 4-year-old children: relationship with asthma and atopy. Brussee JE, Smit HA, Kerkhof M, Koopman LP, Wijga AH, Postma DS, Gerritsen J, Grobbee DE, Brunekreef B, de Jongste JC, Eur Respir J 2005 25 455 461 10.1183/09031936.05.00079604 15738288 (Pubitemid 40331175)
50. Prospective evaluation of the validity of exhaled nitric oxide for the diagnosis of asthma. Dupont LJ, Demedts MG, Verleden GM, Chest 2003 123 751 756 10.1378/chest.123.3.751 12628874 (Pubitemid 36315489)
51. The use of exhaled nitric oxide in the diagnosis of asthma in school children. Sivan Y, Gadish T, Fireman E, Soferman R, J Pediatr 2009 155 211 216 10.1016/j.jpeds.2009.02.034 19394049
52. Diagnostic value of exhaled nitric oxide in childhood asthma and allergy. Sachs-Olsen C, Lødrup Carlsen KC, Mowinckel P, Håland G, Devulapalli CS, Munthe-Kaas MC, Carlsen KH, Pediatr Allergy Immunol 2010 21 1 Pt 2 213 221
53. Diagnostic value of exhaled nitric oxide measurement in mild asthma. Pérez Tarazona S, Martínez Camacho RM, Alfonso Diego J, Escolano Serrano S, Talens Gandía J, An Pediatr (Barc) 2011 75 320 328 10.1016/j.anpedi.2011.05.008
54. Exhaled nitric oxide discriminates children with and without allergic sensitization in a population-based study. Yao TC, Ou LS, Lee WI, Yeh KW, Chen LC, Huang JL, PATCH study group, Clin Exp Allergy 2011 41 556 564 10.1111/j.1365-2222.2010.03687.x 21338427
55. Utility of nitric oxide for the diagnosis of asthma in an allergy clinic population. Cordeiro D, Rudolphus A, Snoey E, Braunstahl GJ, Allergy Asthma Proc 2011 32 119 126 10.2500/aap.2011.32.3419 21439165
56. Utility of fractional exhaled nitric oxide (F(E)NO) measurements in diagnosing asthma. Woo SI, Lee JH, Kim H, Kang JW, Sun YH, Hahn YS, Respir Med 2012 106 1103 1109 10.1016/j.rmed.2012.03.022 22534041
57. Exhaled nitric oxide in the diagnosis of asthma: comparison with bronchial provocation tests. Berkman N, Avital A, Breuer R, Bardach E, Springer C, Godfrey S, Thorax 2005 60 383 388 10.1136/thx.2004.031104 15860713 (Pubitemid 40685820)
58. Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma. Malmberg LP, Pelkonen AS, Haahtela T, Turpeinen M, Thorax 2003 58 494 499 10.1136/thorax.58.6.494 12775859 (Pubitemid 36714010)
59. Relationship between exhaled nitric oxide and childhood asthma. Frank TL, Adisesh A, Pickering AC, Morrison JF, Wright T, Francis H, Fletcher A, Frank PI, Hannaford P, Am J Respir Crit Care Med 1998 158 1032 1036 9769256 (Pubitemid 28488997)
60. Exhaled nitric oxide and its relationship to airway responsiveness and atopy in asthma. BHR-Study Group. Lúdvíksdóttir D, Janson C, Högman M, Hedenström H, Björnsson E, Boman G, Respir Med 1999 93 552 556 10.1016/S0954-6111(99)90154-3 10542988 (Pubitemid 29476264)
61. Influence of atopy on exhaled nitric oxide in patients with stable asthma and rhinitis. Gratziou C, Lignos M, Dassiou M, Roussos C, Eur Respir J 1999 14 897 901 10.1034/j.1399-3003.1999.14d28.x 10573239 (Pubitemid 29519355)
62. Exhaled nitric oxide levels in non-allergic and allergic mono- or polysensitised children with asthma. Silvestri M, Sabatini F, Spallarossa D, Fregonese L, Battistini E, Biraghi MG, Rossi GA, Thorax 2001 56 857 862 10.1136/thorax.56.11.857 11641510 (Pubitemid 32999833)
63. Exhaled nitric oxide in a population-based study of southern California schoolchildren. Linn WS, Rappaport EB, Berhane KT, Bastain TM, Avol EL, Gilliland FD, Respir Res 2009 10 28 10.1186/1465-9921-10-28 19379527
64. Daily home measurements of exhaled nitric oxide in asthmatic children during natural birch pollen exposure. Vahlkvist S, Sinding M, Skamstrup K, Bisgaard H, J Allergy Clin Immunol 2006 117 1272 1276 10.1016/j.jaci.2006.03.018 16750986 (Pubitemid 43795757)
65. Measurement of nitric oxide and 8-isoprostane in exhaled breath of children with atopic eczema. Zinelli C, Caffarelli C, Strid J, Jaffe A, Atherton DJ, Clin Exp Dermatol 2009 34 607 612 10.1111/j.1365-2230.2008.03142.x 19508477
66. Complex interactions in complex traits: obesity and asthma. Tantisira KG, Weiss ST, Thorax 2001 56 Suppl 2 64 73
67. Obesity and pulmonary disease: unanswered questions. Santamaria F, Montella S, Pietrobelli A, Obes Rev 2012 13 822 833 10.1111/j.1467-789X.2012. 01008.x 22646804
68. Obesity duration is associated to pulmonary function impairment in obese subjects. Santamaria F, Montella S, Greco L, Valerio G, Franzese A, Maniscalco M, Fiorentino G, Peroni D, Pietrobelli A, De Stefano S, Sperlì F, Boner AL, Obesity (Silver Spring) 2011 19 1623 1628 10.1038/oby.2011.1
69. Relationship between exhaled nitric oxide and body mass index in children and adolescents. Santamaria F, Montella S, De Stefano S, Sperlì F, Barbarano F, Valerio G, J Allergy Clin Immunol 2005 116 1163 1164 10.1016/j.jaci.2005.07.018 16275394 (Pubitemid 41571806)
70. Decreased fraction of exhaled nitric oxide in obese subjects with asthma symptoms: data from the population study INTERGENE/ADONIX. Berg CM, Thelle DS, Rosengren A, Lissner L, Torén K, Olin AC, Chest 2011 139 1109 1116 10.1378/chest.10-1299 21183611
71. The relation between obesity and asthmatic airway inflammation. Leung TF, Li CY, Lam CW, Au CS, Yung E, Chan IH, Wong GW, Fok TF, Pediatr Allergy Immunol 2004 15 344 350 10.1111/j.1399-3038.2004.00164.x 15305944 (Pubitemid 39093493)
72. Asthma and obesity in childhood: on the road ahead. Peroni DG, Pietrobelli A, Boner AL, Int J Obes (Lond) 2010 34 599 605 10.1038/ijo.2009.273
73. Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests. Smith AD, Cowan JO, Filsell S, McLachlan C, Monti-Sheehan G, Jackson P, Taylor DR, Am J Respir Crit Care Med 2004 169 473 478 14644933 (Pubitemid 38187119)
74. Exhaled nitric oxide in children with allergic rhinitis and/or asthma: a relationship with bronchial hyperreactivity. Ciprandi G, Tosca MA, Capasso M, J Asthma 2010 47 1142 1147 10.3109/02770903.2010.527026 20950134
75. Relationship between exhaled NO, respiratory symptoms, lung function, bronchial hyperresponsiveness, and blood eosinophilia in school children. Steerenberg PA, Janssen NA, de Meer G, Fischer PH, Nierkens S, van Loveren H, Opperhuizen A, Brunekreef B, van Amsterdam JG, Thorax 2003 58 242 245 10.1136/thorax.58.3.242 12612304 (Pubitemid 36308004)
76. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. Jatakanon A, Lim S, Kharitonov SA, Chung KF, Barnes PJ, Thorax 1998 53 91 95 10.1136/thx.53.2.91 9624291 (Pubitemid 28212132)
77. Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children. Strunk RC, Szefler SJ, Phillips BR, Zeiger RS, Chinchilli VM, Larsen G, Hodgdon K, Morgan W, Sorkness CA, Lemanske RF Jr, Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute, J Allergy Clin Immunol 2003 112 883 892 10.1016/j.jaci.2003. 08.014 14610474 (Pubitemid 37412055)
78. Fractional exhaled nitric oxide (FeNO) may predict exercise-induced bronchoconstriction (EIB) in schoolchildren with atopic asthma. Grzelewski T, Grzelewska A, Majak P, Stelmach W, Kowalska A, Stelmach R, Janas A, Stelmach I, Nitric Oxide 2012 27 82 87 10.1016/j.niox.2012.05.002 22584259
79. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, Olin AC, Plummer AL, Taylor DR, American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications, Am J Respir Crit Care Med 2011 184 602 615 10.1164/rccm.9120-11ST 21885636
80. Nitric oxide in chronic airway inflammation in children: diagnostic use and pathophysiological significance. Narang I, Ersu R, Wilson NM, Bush A, Thorax 2002 57 586 589 10.1136/thorax.57.7.586 12096200 (Pubitemid 34761759)
81. Exhaled nitric oxide in relation to the clinical features of childhood asthma. Warke TJ, Mairs V, Fitch PS, McGovern V, Ennis M, Shields MD, J Asthma 2004 41 751 757 10.1081/JAS-200027838 15584635 (Pubitemid 39546321)
82. Exhaled nitric oxide, susceptibility and new-onset asthma in the Children's Health Study. Bastain TM, Islam T, Berhane KT, McConnell RS, Rappaport EB, Salam MT, Linn WS, Avol EL, Zhang Y, Gilliland FD, Eur Respir J 2011 37 523 531 10.1183/09031936.00021210 20634264
83. Increased exhaled nitric oxide predicts new-onset rhinitis and persistent rhinitis in adolescents without allergic symptoms. Malinovschi A, Alving K, Kalm-Stephens P, Janson C, Nordvall L, Clin Exp Allergy 2012 42 433 440 10.1111/j.1365-2222.2011.03947.x 22356144
84. Blocking induction of T helper type 2 responses prevents development of disease in a model of childhood asthma. Siegle JS, Hansbro N, Dong C, Angkasekwinai P, Foster PS, Kumar RK, Clin Exp Immunol 2011 165 19 28 10.1111/j.1365-2249.2011.04392.x 21501148
85. Exhaled nitric oxide and asthma: complex interactions between atopy, airway responsiveness, and symptoms in a community population of children. Franklin PJ, Turner SW, Le Souëf PN, Stick SM, Thorax 2003 58 1048 1052 10.1136/thorax.58.12.1048 14645971 (Pubitemid 37542109)
86. Increase in exhaled nitric oxide levels in patients with difficult asthma and correlation with symptoms and disease severity despite treatment with oral and inhaled corticosteroids.Asthma and Allergy Group. Stirling RG, Kharitonov SA, Campbell D, Robinson DS, Durham SR, Chung KF, Barnes PJ, Thorax 1998 53 1030 1034 10.1136/thx.53.12.1030 10195074 (Pubitemid 28567003)
87. Childhood asthma: exhaled nitric oxide in relation to clinical symptoms. Artlich A, Busch T, Lewandowski K, Jonas S, Gortner L, Falke KJ, Eur Respir J 1999 13 1396 1401 10.1183/09031936.99.13614029 10445618 (Pubitemid 29357159)
88. Longitudinal study of grass pollen exposure, symptoms, and exhaled nitric oxide in childhood seasonal allergic asthma. Roberts G, Hurley C, Bush A, Lack G, Thorax 2004 59 752 756 10.1136/thx.2003.008722 15333850 (Pubitemid 39215370)
89. Exhaled nitric oxide in a population-based study of asthma and allergy in schoolchildren. Nordvall SL, Janson C, Kalm-Stephens P, Foucard T, Torén K, Alving K, Allergy 2005 60 469 475 10.1111/j.1398-9995.2005.00735.x 15727578 (Pubitemid 40332972)
90. Fluctuation phenotyping based on daily fraction of exhaled nitric oxide values in asthmatic children. Stern G, de Jongste J, van der Valk R, Baraldi E, Carraro S, Thamrin C, Frey U, J Allergy Clin Immunol 2011 128 293 300 10.1016/j.jaci.2011.03.010 21489612
91. Exhaled nitric oxide, lung function, and exacerbations in wheezy infants and toddlers. Debley JS, Stamey DC, Cochrane ES, Gama KL, Redding GJ, J Allergy Clin Immunol 2010 125 1228 1234 10.1016/j.jaci.2010.03.023 20462633
92. Disagreement between common measures of asthma control in children. Green RJ, Klein M, Becker P, Halkas A, Lewis H, Kitchin O, Moodley T, Masekela R, Chest 2012 in press
93. Assessing asthma control: symptom scores, GINA levels of asthma control, lung function, and exhaled nitric oxide. Waibel V, Ulmer H, Horak E, Pediatr Pulmonol 2012 47 113 118 10.1002/ppul.21529 22241569
94. Childhood asthma: exhaled markers of airway inflammation, asthma control score, and lung function tests. Rosias PP, Dompeling E, Dentener MA, Pennings HJ, Hendriks HJ, Van Iersel MP, Jöbsis Q, Pediatr Pulmonol 2004 38 107 114 10.1002/ppul.20056 15211692 (Pubitemid 38989729)
95. Correlation between reversibility of airway obstruction and exhaled nitric oxide levels in children with stable bronchial asthma. Colon-Semidey AJ, Marshik P, Crowley M, Katz R, Kelly HW, Pediatr Pulmonol 2000 30 385 392 10.1002/1099-0496(200011)30:5<385::AID-PPUL4>3.0.CO;2-# 11064429
96. Airway nitrogen oxide measurements in asthma and other pediatric respiratory diseases. Hunt J, Gaston B, J Pediatr 2000 137 14 20 10.1067/mpd.2000.107526 10891815 (Pubitemid 30470916)
97. Exhaled nitric oxide, serum ECP and airway responsiveness in mild asthmatic children. Piacentini GL, Bodini A, Costella S, Suzuki Y, Zerman L, Peterson CG, Boner AL, Eur Respir J 2000 15 839 843 10.1034/j.1399-3003.2000. 15e05.x 10853846 (Pubitemid 30321838)
98. Fractional exhaled nitric oxide (FENO), lung function and airway hyperresponsiveness in naïve atopic asthmatic children. del Giudice MM, Brunese FP, Piacentini GL, Pedullà M, Capristo C, Decimo F, Capristo AF, J Asthma 2004 41 759 765 10.1081/JAS-200027862 15584636 (Pubitemid 39546322)
99. Effect of ciclesonide and fluticasone on exhaled nitric oxide in patients with mild allergic asthma. Zietkowski Z, Bodzenta-Lukaszyk A, Tomasiak MM, Szymanski W, Skiepko R, Respir Med 2006 100 1651 1656 10.1016/j.rmed.2005.12.004 16443353 (Pubitemid 44089354)
100. Effect of inhaled steroids on airway hyperresponsiveness, sputum eosinophils, and exhaled nitric oxide levels in patients with asthma. van Rensen EL, Straathof KC, Veselic-Charvat MA, Zwinderman AH, Bel EH, Sterk PJ, Thorax 1999 54 403 408 10.1136/thx.54.5.403 10212103 (Pubitemid 29199777)
101. Exhaled nitric oxide measurements: clinical application and interpretation. Taylor DR, Pijnenburg MW, Smith AD, De Jongste JC, Thorax 2006 61 817 827 10.1136/thx.2005.056093 16936238 (Pubitemid 44369409)
102. Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma. de Jongste JC, Carraro S, Hop WC, Baraldi E, CHARISM Study Group, Am J Respir Crit Care Med 2009 179 93 97 18931330
103. Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial. Pijnenburg MW, Bakker EM, Hop WC, De Jongste JC, Am J Respir Crit Care Med 2005 172 831 836 10.1164/rccm.200503-458OC 15976380 (Pubitemid 41369065)
104. Exhaled nitric oxide in the management of childhood asthma: a prospective 6-months study. Fritsch M, Uxa S, Horak F Jr, Putschoegl B, Dehlink E, Szepfalusi Z, Frischer T, Pediatr Pulmonol 2006 41 855 862 10.1002/ppul.20455 16850457 (Pubitemid 44300181)
105. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Szefler SJ, Mitchell H, Sorkness CA, Gergen PJ, O'Connor GT, Morgan WJ, Kattan M, Pongracic JA, Teach SJ, Bloomberg GR, Eggleston PA, Gruchalla RS, Kercsmar CM, Liu AH, Wildfire JJ, Curry MD, Busse WW, Lancet 2008 372 1065 1072 10.1016/S0140-6736(08)61448-8 18805335
106. A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils). Petsky HL, Cates CJ, Lasserson TJ, Li AM, Turner C, Kynaston JA, Chang AB, Thorax 2012 67 199 208 10.1136/thx.2010.135574 20937641
107. Daily ambulatory exhaled nitric oxide measurements in asthma. Pijnenburg MW, Floor SE, Hop WC, De Jongste JC, Pediatr Allergy Immunol 2006 17 189 193 10.1111/j.1399-3038.2006.00394.x 16672005
108. High fractional concentration of nitric oxide in exhaled air despite steroid treatment in asthmatic children. Pijnenburg MW, Bakker EM, Lever S, Hop WC, De Jongste JC, Clin Exp Allergy 2005 35 920 925 10.1111/j.1365-2222.2005. 02279.x 16008679 (Pubitemid 41032541)
109. Effect of fluticasone 250 microg/salmeterol 50 microg and montelukast on exhaled nitric oxide in asthmatic patients. Gelb AF, Taylor CF, Shinar CM, Gutierrez CA, Zamel N, Can Respir J 2008 15 193 198 18551200
110. Heterogeneity of FeNO response to inhaled steroid in asthmatic children. Buchvald F, Eiberg H, Bisgaard H, Clin Exp Allergy 2003 33 1735 1740 10.1111/j.1365-2222.2003.01822.x 14656363 (Pubitemid 38005396)
111. Exhaled nitric oxide and asthma control: a longitudinal study in unselected patients. Michils A, Baldassarre S, Van Muylem A, Eur Respir J 2008 31 539 546 10.1183/09031936.00020407 18057062
112. Monitoring asthma control in children with allergies by soft computing of lung function and exhaled nitric oxide. Pifferi M, Bush A, Pioggia G, Di Cicco M, Chinellato I, Bodini A, Macchia P, Boner AL, Chest 2011 139 319 327 10.1378/chest.10-0992 20930008
113. Daily exhaled nitric oxide measurements and asthma exacerbations in children. van der Valk RJ, Baraldi E, Stern G, Frey U, de Jongste JC, Allergy 2012 67 265 271 10.1111/j.1398-9995.2011.02734.x 21999328
114. NO in exhaled air of asthmatic children is reduced by the leukotriene receptor antagonist montelukast. Bisgaard H, Loland L, Oj JA, Am J Respir Crit Care Med 1999 160 1227 1231 10508811 (Pubitemid 29487463)
115. Effect of montelukast added to inhaled corticosteroids on fractional exhaled nitric oxide in asthmatic children. Ghiro L, Zanconato S, Rampon O, Piovan V, Pasquale MF, Baraldi E, Eur Respir J 2002 20 630 634 10.1183/09031936.02.01512002 12358339
116. The effect of montelukast on exhaled nitric oxide and lung function in asthmatic children 2 to 5 years old. Straub DA, Minocchieri S, Moeller A, Hamacher J, Wildhaber JH, Chest 2005 127 509 514 10.1378/chest.127.2.509 15705989 (Pubitemid 40229310)
117. Exhaled nitric oxide in children with asthma receiving Xolair (omalizumab), a monoclonal anti-immunoglobulin E antibody. Silkoff PE, Romero FA, Gupta N, Townley RG, Milgrom H, Pediatrics 2004 113 308 312 10.1542/peds.113.4.e308
118. Mechanisms of illness during respiratory syncytial virus infection: the lungs, the virus and the immune response. Hoffman SJ, Laham FR, Polack FP, Microb Infect 2004 6 767 772 10.1016/j.micinf.2004.03.010 (Pubitemid 38781189)
119. Immune and functional role of nitric oxide in a mouse model of respiratory syncytial virus infection. Stark JM, Khan AM, Chiappetta CL, Xue H, Alcorn JL, Colasurdo GN, J Infect Dis 2005 191 387 395 10.1086/427241 15633098 (Pubitemid 40139764)
120. Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthase. Song W, Liu G, Bosworth CA, Walker JR, Megaw GA, Lazrak A, Abraham E, Sullender WM, Matalon S, J Biol Chem 2009 284 7294 7306 19131335
121. Respiratory syncytial virus infection of human respiratory epithelial cells enhances inducible nitric oxide synthase gene expression. Tsutsumi H, Takeuchi R, Ohsaki M, Seki K, Chiba S, J Leukoc Biol 1999 66 99 104 10410996 (Pubitemid 29321376)
122. Induction and regulation of nitric oxide synthase in airway epithelial cells by respiratory syncytial virus. Kao YJ, Piedra PA, Larsen GL, Colasurdo GN, Am J Respir Crit Care Med 2001 163 532 539 11179135 (Pubitemid 32158541)
123. Exhaled nitric oxide in acute respiratory syncytial virus bronchiolitis. Gadish T, Soferman R, Merimovitch T, Fireman E, Sivan Y, Arch Pediatr Adolesc Med 2010 164 727 731 10.1001/archpediatrics.2010.128 20679163
124. Exhaled nitric oxide and respiratory symptoms in a community sample of school aged children. Kovesi T, Dales R, Pediatr Pulmonol 2008 43 1198 1205 10.1002/ppul.20927 19003883
125. Exhaled leukotriene B4 in children with community acquired pneumonia. Carraro S, Andreola B, Alinovi R, Corradi M, Freo L, Da Dalt L, Baraldi E, Pediatr Pulmonol 2008 43 982 986 10.1002/ppul.20889 18781641
126. British Thoracic Society guideline for non-CF bronchiectasis. Pasteur MC, Bilton D, Hill AT, British Thoracic Society Bronchiectasis non-CF Guideline Group, Thorax 2010 65 1 1 58 10.1136/thx.2009.118778 20029032
127. Structural and functional lung disease in primary ciliary dyskinesia. Santamaria F, Montella S, Tiddens HA, Guidi G, Casotti V, Maglione M, de Jong PA, Chest 2008 134 351 357 10.1378/chest.07-2812 18403663
128. A descriptive study of non-cystic fibrosis bronchiectasis in a pediatric population from central and southern Italy. Santamaria F, Montella S, Pifferi M, Ragazzo V, De Stefano S, De Paulis N, Maglione M, Boner AL, Respiration 2009 77 160 165 10.1159/000137510 18523381
129. Bronchiectasis, exacerbation indices, and inflammation in chronic obstructive pulmonary disease. Patel IS, Vlahos I, Wilkinson TM, Lloyd-Owen SJ, Donaldson GC, Wilks M, Reznek RH, Wedzicha JA, Am J Respir Crit Care Med 2004 170 400 407 10.1164/rccm.200305-648OC 15130905 (Pubitemid 39214614)
130. Post-infectious bronchiolitis obliterans: clinical, radiological and pulmonary function sequelae. Chang AB, Masel JP, Masters B, Pediatr Radiol 1998 28 23 29 10.1007/s002470050286 9426269 (Pubitemid 28055102)
131. Exacerbations in cystic fibrosis: 4-Non-cystic fibrosis bronchiectasis. Chang AB, Bilton D, Thorax 2008 63 269 276 10.1136/thx.2006.060913 18308962 (Pubitemid 351373725)
132. Lung structure abnormalities, but normal lung function in pediatric bronchiectasis. Santamaria F, Montella S, Camera L, Palumbo C, Greco L, Boner AL, Chest 2006 130 480 486 10.1378/chest.130.2.480 16899848 (Pubitemid 44267016)
133. Assessment of chest high-field magnetic resonance imaging in children and young adults with non-cystic fibrosis chronic lung disease: comparison to high-resolution computed tomography and correlation with pulmonary function. Montella S, Santamaria F, Salvatore M, Pignata C, Maglione M, Iacotucci P, Mollica C, Invest Radiol 2009 44 532 538 10.1097/RLI.0b013e3181b4c1ba 19652613
134. Magnetic resonance imaging is an accurate and reliable method to evaluate non-cystic fibrosis paediatric lung disease. Montella S, Maglione M, Bruzzese D, Mollica C, Pignata C, Aloj G, Manna A, Esposito A, Mirra V, Santamaria F, Respirology 2012 17 87 91 10.1111/j.1440-1843.2011.02067.x 21943039
135. Effect of sputum bacteriology on the quality of life of patients with bronchiectasis. Wilson CB, Jones PW, O'Leary CJ, Hansell DM, Cole PJ, Wilson R, Eur Respir J 1997 10 1754 1760 10.1183/09031936.97.10081754 9272915 (Pubitemid 27368366)
136. Elevated peripheral airway nitric oxide in bronchiectasis reflects disease severity. Shoemark A, Devaraj A, Meister M, Ozerovitch L, Hansell DM, Wilson R, Respir Med 2011 105 885 891 10.1016/j.rmed.2011.01.015 21398103
137. Elevated levels of exhaled nitric oxide in bronchiectasis. Kharitonov SA, Wells AU, O'Connor BJ, Cole PJ, Hansell DM, Logan-Sinclair RB, Barnes PJ, Am J Respir Crit Care Med 1995 151 1889 1893 7767536
138. Comparison of exhaled and nasal nitric oxide and exhaled carbon monoxide levels in bronchiectatic patients with and without primary ciliary dyskinesia. Horváth I, Loukides S, Wodehouse T, Csiszér E, Cole PJ, Kharitonov SA, Barnes PJ, Thorax 2003 58 68 72 10.1136/thorax.58.1.68 12511725 (Pubitemid 36135362)
139. Exhaled nitric oxide is not elevated in the inflammatory airways diseases of cystic fibrosis and bronchiectasis. Ho LP, Innes JA, Greening AP, Eur Respir J 1998 12 1290 1294 10.1183/09031936.98.12061290 9877479 (Pubitemid 29011417)
140. Exhaled and sputum nitric oxide in bronchiectasis: correlation with clinical parameters. Tsang KW, Leung R, Fung PC, Chan SL, Tipoe GL, Ooi GC, Lam WK, Chest 2002 121 88 94 10.1378/chest.121.1.88 11796436 (Pubitemid 34114232)
141. Correlation between cough frequency and airway inflammation in children with primary ciliary dyskinesia. Zihlif N, Paraskakis E, Lex C, Van de Pohl LA, Bush A, Pediatr Pulmonol 2005 39 551 557 10.1002/ppul.20202 15806596 (Pubitemid 40696327)
142. Biomarkers in exhaled breath condensate indicate presence and severity of cystic fibrosis in children. Robroeks CM, Rosias PP, van Vliet D, Jöbsis Q, Yntema JB, Brackel HJ, Damoiseaux JG, den Hartog GM, Wodzig WK, Dompeling E, Pediatr Allergy Immunol 2008 19 652 659 18312532
143. Decreased concentration of exhaled nitric oxide (NO) in patients with cystic fibrosis. Grasemann H, Michler E, Wallot M, Ratjen F, Pediatr Pulmonol 1997 24 173 177 10.1002/(SICI)1099-0496(199709)24:3<173::AID-PPUL2>3.0. CO;2-O 9330413 (Pubitemid 27431226)
144. A two-compartment model of pulmonary nitric oxide exchange dynamics. Tsoukias NM, George SC, J Appl Physiol 1998 85 653 666 9688744 (Pubitemid 28365835)
145. Low levels of exhaled nitric oxide are associated with impaired lung function in cystic fibrosis. Keen C, Gustafsson P, Lindblad A, Wennergren G, Olin AC, Pediatr Pulmonol 2010 45 241 248 20146368
146. Alveolar, but not bronchial nitric oxide production is elevated in cystic fibrosis. Suri R, Paraskakis E, Bush A, Pediatr Pulmonol 2007 42 1215 1221 10.1002/ppul.20730 17969001 (Pubitemid 350231874)
147. Nitric oxide production in PCD: possible evidence for differential nitric oxide synthase function. Paraskakis E, Zihlif N, Bush A, Pediatr Pulmonol 2007 42 876 880 10.1002/ppul.20670 17722051 (Pubitemid 47549793)
148. Diagnosis and management of diffuse lung disease in children. Vece TJ, Fan LL, Paediatr Respir Rev 2011 12 238 242 10.1016/j.prrv.2011.04.001 22018037
149. Clinical, radiological and pathological features of ABCA3 mutations in children. Doan ML, Guillerman RP, Dishop MK, Nogee LM, Langston C, Mallory GB, Sockrider MM, Fan LL, Thorax 2008 63 366 373 10.1136/thx.2007.083766 18024538 (Pubitemid 351497952)
150. Exhaled nitric oxide levels in systemic sclerosis with and without pulmonary involvement. Malerba M, Radaeli A, Ragnoli B, Airo' P, Corradi M, Ponticiello A, Zambruni A, Grassi V, Chest 2007 132 575 580 10.1378/chest.06- 2929 17550935 (Pubitemid 47282391)
151. Fractional exhaled nitric oxide concentration is increased in asbestosis and pleural plaques. Sandrini A, Johnson AR, Thomas PS, Yates DH, Respirology 2006 11 325 329 10.1111/j.1440-1843.2006.00852.x 16635093
152. Exhaled nitric oxide in sarcoidosis. Wilsher ML, Fergusson W, Milne D, Wells AU, Thorax 2005 60 967 970 10.1136/thx.2004.033852 16244094 (Pubitemid 41598214)
153. Bronchiolitis obliterans after human lung transplantation. Estenne M, Hertz MI, Am J Respir Crit Care Med 2002 166 440 444 10.1164/rccm.200201-003PP 12186817
154. Clinical course of postinfectious bronchiolitis obliterans. Zhang L, Irion K, Kozakewich H, Reid L, Camargo JJ, da Silva Porto N, Silva FA Ae, Pediatr Pulmonol 2000 29 341 350 10.1002/(SICI)1099-0496(200005)29:5<341:: AID-PPUL2>3.0.CO;2-4 10790245 (Pubitemid 30230421)
155. Cross sectional study of exhaled nitric oxide levels following lung transplantation. Fisher AJ, Gabbay E, Small T, Doig S, Dark JH, Corris PA, Thorax 1998 53 454 458 10.1136/thx.53.6.454 9713443 (Pubitemid 28308059)
156. Is there a role for measuring exhaled nitric oxide in lung transplant recipients with chronic rejection? Verleden GM, Dupont L, Lamont J, Buyse B, Delcroix M, Van Raemdonck D, Lerut T, Vanhaecke J, Demedts MG, J Heart Lung Transplant 1998 17 231 232 9513863
157. Usefulness of exhaled nitric oxide to guide risk stratification for bronchiolitis obliterans syndrome after lung transplantation. Neurohr C, Huppmann P, Leuschner S, von Wulffen W, Meis T, Leuchte H, Ihle F, Zimmermann G, Baezner C, Hatz R, Winter H, Frey L, Ueberfuhr P, Bittmann I, Behr J, Munich Lung Transplant Group, Am J Transplant 2011 11 129 137 10.1111/j.1600-6143.2010. 03327.x 21087415
158. Early detection of chronic pulmonary allograft dysfunction by exhaled biomarkers. Van Muylem A, Knoop C, Estenne M, Am J Respir Crit Care Med 2007 175 731 736 10.1164/rccm.200609-1301OC 17234904 (Pubitemid 46536490)
159. Exhaled NO may predict the decline in lung function in bronchiolitis obliterans syndrome. Brugière O, Thabut G, Mal H, Marceau A, Dauriat G, Marrash-Chahla R, Castier Y, Lesèche G, Colombat M, Fournier M, Eur Respir J 2005 25 813 819 10.1183/09031936.05.00057004 15863637 (Pubitemid 40667678)
160. Accuracy of exhaled nitric oxide measurements for the diagnosis of bronchiolitis obliterans syndrome after lung transplantation. Verleden GM, Dupont LJ, Van Raemdonck DE, Vanhaecke J, Leuven Lung Transplant Group, Transplantation 2004 78 730 733 15371677 (Pubitemid 39244737)
161. Post-lung transplant bronchiolitis obliterans syndrome (BOS) is characterized by increased exhaled nitric oxide levels and epithelial inducible nitric oxide synthase. Gabbay E, Walters EH, Orsida B, Whitford H, Ward C, Kotsimbos TC, Snell GI, Williams TJ, Am J Respir Crit Care Med 2000 162 2182 2187 11112135 (Pubitemid 32051684)