Exhaled nitric oxide in 4-year-old children: Relationship with asthma and atopy

European Respiratory Journal

Volumn 25, Issue 3, 2005, Pages 455-461

  Brussee, J E ^a,b   Smit, H A ^a,b   Kerkhof, M ^d   Koopman, L P ^e   Wijga, A H ^a   Postma, D S ^d   Gerritsen, J ^d   Grobbee, D E ^b   Brunekreef, B ^c   de Jongste, J C ^e  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Allergy; Asthma; Cohort studies; Nitric oxide; Pre school child

Indexed keywords

CORTICOSTEROID; NITRIC OXIDE;

ALLERGIC ASTHMA; ANALYZER; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHILDHOOD DISEASE; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; EARLY DIAGNOSIS; EOSINOPHILIA; EPIDEMIOLOGICAL DATA; EXHALATION; FEMALE; HIGH RISK PATIENT; HOUSE DUST ALLERGY; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; NETHERLANDS; NON INVASIVE MEASUREMENT; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; SYMPTOMATOLOGY; WHEEZING;

ASTHMA; BIOLOGICAL MARKERS; BREATH TESTS; CHILD, PRESCHOOL; COMORBIDITY; EOSINOPHILIA; FEMALE; HUMANS; HYPERSENSITIVITY; INFLAMMATION; MALE; NETHERLANDS; NITRIC OXIDE; PHENOTYPE; RESPIRATORY SOUNDS; RISK FACTORS; SOCIOECONOMIC FACTORS;

EID: 20044370627     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.05.00079604     Document Type: Article

References (29)

1. Warner JO, Marguet C, Rao R, Roche WR, Pohunek P. Inflammatory mechanisms in childhood asthma. Clin Exp Allergy 1998; 28: 71-75.
2. Pedersen S, Szefler S. Pharmacological interventions. Eur Respir J 194; 12: Suppl. 12, 40s-45s.
3. Pijnenburg MW, Lissenberg ET, Hofhuis W, et al. Exhaled nitric oxide measurements with dynamic flow restriction in children aged 4-8 yrs. Eur Respir J 2002; 20: 919-924.
4. Bodini A, Pijnenburg MW, Boner AL, De Jongste JC. Exhaled nitric oxide in mylar balloons: influence of storage time, humidity and temperature. Mediators Inflamm 2003; 12: 47-49.
5. Dotsch J, Demirakca S, Terbrack HG, Huls G, Rascher W, Kuhl PG. Airway nitric oxide in asthmatic children and patients with cystic fibrosis. Eur Respir J 1996; 9: 2537-2540.
6. Lundberg JO, Nordvall SL, Weitzberg E, Kollberg H, Alving K. Exhaled nitric oxide in paediatric asthma and cystic fibrosis. Arch Dis Child 1996; 75: 323-326.
7. Franklin PJ, Taplin R, Stick SM. A community study of exhaled nitric oxide in healthy children. Am J Respir Crit Care Med 1999; 159: 69-73.
8. Gratziou C, Lignos M, Dassiou M, Roussos C. Influence of atopy on exhaled nitric oxide in patients with stable asthma and rhinitis. Eur Respir J 1999; 14: 897-901.
9. Silvestri M, Sabatini F, Spallarossa D, et al. Exhaled nitric oxide levels in non-allergic and allergic mono- or poly-sensitised children with asthma. Thorax 2001; 56: 857-862.
10. Silvestri M, Sabatini F, Sale R, et al. Correlations between exhaled nitric oxide levels, blood eosinophilia, and airway obstruction reversibility in childhood asthma are detectable only in atopic individuals. Pediatr Pulmonol 2003; 35: 358-363.
11. Warke TJ, Fitch PS, Brown V, et al. Exhaled nitric oxide correlates with airway eosinophils in childhood asthma. Thorax 2002; 57: 383-387.
12. Malmberg LP, Pelkonen AS, Haahtela T, Turpeinen M. Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma. Thorax 2003; 58: 494-499.
13. Baraldi E, Dario C, Ongaro R, et al. Exhaled nitric oxide concentrations during treatment of wheezing exacerbation in infants and young children. Am J Respir Crit Care Med 1999; 159: 1284-1288.
14. Avital A, Uwyyed K, Berkman N, Godfrey S, Bar Yishay E, Springer C. Exhaled nitric oxide and asthma in young children. Pediatr Pulmonol 2001; 32: 308-313.
15. Jouaville LF, Annesi-Maesano I, Nguyen LT, Bocage AS, Bedu M, Caillaud D. Interrelationships among asthma, atopy, rhinitis and exhaled nitric oxide in a population-based sample of children. Clin Exp Allergy 2003; 33: 1506-1511.
16. Franklin PJ, Turner SW, Le Souef PN, Stick SM. Exhaled nitric oxide and asthma: complex interactions between atopy, airway responsiveness, and symptoms in a community population of children. Thorax 2003; 58: 1048-1052.
17. Lakwijk N, Van Strien RT, Doekes G, Brunekreef B, Gerritsen J. Validation of a screening questionnaire for atopy with serum IgE tests in a population of pregnant Dutch women. Clin Exp Allergy 1998; 28: 454-458.
18. Brunekreef B, Smit J, de jongste J, et al. The prevention and incidence of asthma and mite allergy (PIAMA) birth cohort study: design and first results. Pediatr Allergy Immunol 2002; 13: 55-60.
19. Baraldi E, de Jongste JC. Measurement of exhaled nitric oxide in children, 2001. Eur Respir J 2002; 20: 223-237.
20. Asher MI, Keil U, Anderson HR, et al. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J 1995; 8: 483-491.
21. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995; 332: 133-138.
22. Baldacci S, Omenaas E, Oryszczyn MP. Allergy markers in respiratory epidemiology. Eur Respir J 2001; 17: 773-790.
23. Frank TL, Adisesh A, Pickering AC, et al. Relationship between exhaled nitric oxide and childhood asthma. Am J Respir Crit Care Med 1998; 158: 1032-1036.
24. Langley SJ, Goldthorpe S, Custovic A, Woodcock A. Relationship among pulmonary function, bronchial reactivity, and exhaled nitric oxide in a large group of asthmatic patients. Ann Allergy Asthma Immunol 2003; 91: 398-404.
25. Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD. Tucson Children's Respiratory Study: 1980 to present. J Allergy Clin Immunol 2003; 111: 661-675.
26. Strunk RC, Szefler SJ, Phillips BR, et al. Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children. J Allergy Clin Immunol 2003; 112: 883-892.
27. Berlyne GS, Parameswaran K, Kamada D, Efthimiadis A, Hargreave FE. A comparison of exhaled nitric oxide and induced sputum as markers of airway inflammation. J Allergy Clin Immunol 2000; 106: 638-644.
28. Payne DN, Adcock IM, Wilson NM, Oates T, Scallan M, Bush A. Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone. Am J Respir Crit Care Med 2001; 164: 1376-1381.
29. Lim S, Jatakanon A, Meah S, Oates T, Chung KF, Barnes PJ. Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in mild to moderately severe asthma. Thorax 2000; 55: 184-188.