Obesity and pulmonary disease: Unanswered questions

Obesity Reviews

Volumn 13, Issue 9, 2012, Pages 822-833

  Santamaria, F ^a   Montella, S ^a   Pietrobelli, A ^b,c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Adiposity; Asthma; Lung disease; Lung function; Overweight

Indexed keywords

BECLOMETASONE DIPROPIONATE; BUDESONIDE; CORTICOSTEROID; DEXAMETHASONE; FLUNISOLIDE; FLUTICASONE PROPIONATE; FLUTICASONE PROPIONATE PLUS SALMETEROL; GLUCOCORTICOID; MONTELUKAST; SALMETEROL; STEROID; THEOPHYLLINE; VITAMIN D;

AIRWAY RESISTANCE; ARTICLE; ASTHMA; AUTOIMMUNITY; BRONCHOSPASM; CHORIOAMNIONITIS; CHRONIC LUNG DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMORBIDITY; CORTICOSTEROID THERAPY; DISEASE ASSOCIATION; DISEASE CONTROL; DISEASE SEVERITY; DRUG MEGADOSE; EARLY LIFE STRESS; FETUS GROWTH; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GASTROESOPHAGEAL REFLUX; HEALTH CARE COST; HIGH RISK INFANT; HUMAN; INTRAUTERINE GROWTH RETARDATION; LIFE EXPECTANCY; LOW BIRTH WEIGHT; LUNG DISEASE; LUNG MECHANICS; LUNG VOLUME; MATERNAL SMOKING; MORBIDITY; MORTALITY; NONHUMAN; OBESITY; OXIDATIVE STRESS; PATHOGENESIS; PERINATAL DRUG EXPOSURE; PHENOTYPE; PLEIOTROPY; PREMATURITY; PRENATAL GROWTH; PREVALENCE; PUBLIC HEALTH; QUALITY OF LIFE; RESPIRATORY TRACT INFLAMMATION; SIDE EFFECT; SLEEP APNEA SYNDROME; TOTAL LUNG CAPACITY; TREATMENT RESPONSE; VERY LOW BIRTH WEIGHT; VITAMIN SUPPLEMENTATION; WEIGHT GAIN;

ASTHMA; COMORBIDITY; HUMANS; LUNG DISEASES; OBESITY; PREVALENCE; QUALITY OF LIFE; RISK FACTORS;

EID: 84865539087     PISSN: 14677881     EISSN: 1467789X     Source Type: Journal    
DOI: 10.1111/j.1467-789X.2012.01008.x     Document Type: Article

References (155)

1. McClean KM, Kee F, Young IS, Elborn JS. Obesity and the lung: 1. Epidemiology. Thorax 2008; 63: 649-654.
2. Pelone F, Specchia ML, Veneziano MA etal. Economic impact of childhood obesity on health systems: a systematic review. Obes Rev 2012; 13: 431-440.
3. Kelly T, Yang W, Chen CS, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. Int J Obes 2008; 32: 1431-1437.
4. Maziak W, Ward KD, Stockton MB. Childhood obesity: are we missing the big picture? Obes Rev 2008; 9: 35-42.
5. Peroni DG, Pietrobelli A, Boner AL. Asthma and obesity in childhood: on the road ahead. Int J Obes 2010; 34: 599-605.
6. Szefler SJ. Advancing asthma care: the glass is only half full! J Allergy Clin Immunol 2011; 128: 485-494.
7. Shore SA, Johnston RA. Obesity and asthma. Pharmacol Ther 2006; 110: 83-102.
8. Matricardi PM, Illi S, Grüber C etal. Wheezing in childhood: incidence, longitudinal patterns and factors predicting persistence. Eur Respir J 2008; 32: 585-592.
9. Tantisira KG, Weiss ST. Complex interactions in complex traits: obesity and asthma. Thorax 2001; 56: S64-S73.
10. Weiss ST. Obesity: insight into the origins of asthma. Nat Immunol 2005; 6: 537-539.
11. Shore SA. Obesity and asthma: possible mechanisms. J Allergy Clin Immunol 2008; 121: 1087-1093.
12. Beuther DA, Weiss ST, Sutherland ER. Obesity and asthma. Am J Respir Crit Care Med 2006; 174: 112-119.
13. Beuther DA. Recent insight into obesity and asthma. Curr Opin Pulm Med 2010; 16: 64-70.
14. Noal RB, Menezes AMB, Macedo SEC, Dumith SC. Childhood body mass index and risk of asthma in adolescence: a systematic review. Obes Rev 2011; 12: 93-104.
15. Santamaria F, Montella S, Greco L etal. Obesity duration is associated to pulmonary function impairment in obese subjects. Obesity (Silver Spring) 2011; 19: 1623-1628.
16. Eneli IU, Skybo T, Camargo CA Jr. Weight loss and asthma: a systematic review. Thorax 2008; 63: 671-676.
17. de Groot EP, Duiverman EJ, Brand PL. Comorbidities of asthma during childhood: possibly important, yet poorly studied. Eur Respir J 2010; 36: 671-678.
18. Barker DJ, Godfrey KM, Fall C, Osmond C, Winter PD, Shaheen SO. Relation of birth weight and childhood respiratory infection to adult lung function and death from chronic obstructive airways disease. BMJ 1991; 303: 671-675.
19. Newnham JP, Pennell CE, Lye SJ, Rampono J, Challis JR. Early life origins of obesity. Obstet Gynecol Clin North Am 2009; 36: 227-244.
20. Monasta L, Batty GD, Cattaneo A etal. Early-life determinants of overweight and obesity: a review of systematic reviews. Obes Rev 2010; 11: 695-708.
21. Rogers I, EURO-BLCS Study Group. The influence of birthweight and intrauterine environment on adiposity and fat distribution in later life. Int J Obes Relat Metab Disord 2003; 27: 755-777.
22. Wells JC. The thrifty phenotype: an adaptation in growth or metabolism? Am J Hum Biol 2011; 23: 65-75.
23. Lucas A, Fewtrell MS, Cole TJ. Fetal origins of adult disease - the hypothesis revisited. BMJ 1999; 319: 245-249.
24. Desai M, Gayle D, Babu J, Ross MG. Programmed obesity in intrauterine growth-restricted newborns: modulation by newborn nutrition. Am J Physiol Regul Integr Comp Physiol 2005; 288: 91-96.
25. Holzhauer S, Hokken Koelega AC, Ridder M etal. Effect of birth weight and postnatal weight gain on body composition in early infancy: the Generation R Study. Early Hum Dev 2009; 85: 285-290.
26. Mai XM, Gäddlin PO, Nilsson L, Leijon I. Early rapid weight gain and current overweight in relation to asthma in adolescents born with very low birth weight. Pediatr Allergy Immunol 2005; 16: 380-385.
27. Karaolis-Danckert N, Buyken AE, Bolzenius K, Perim de Faria C, Lentze MJ, Kroke A. Rapid growth among term children whose birth weight was appropriate for gestational age has a longer lasting effect on body fat percentage than on body mass index. Am J Clin Nutr 2006; 84: 1449-1455.
28. Stocks T, Renders CM, Bulk-Bunschoten AMW, Hirasing RA, van Buuren S, Seidell JC. Body size and growth in 0- to 4-year-old children and the relation to body size in primary school age. Obes Rev 2011; 12: 637-652.
29. Lødrup Carlsen KC, Magnus P, Carlsen KH. Lung function by tidal breathing in awake healthy newborn infants. Eur Respir J 1994; 7: 1660-1668.
30. Jaakkola JJ, Ahmed P, Ieromnimon A etal. Preterm delivery and asthma: a systematic review and meta-analysis. J Allergy Clin Immunol 2006; 118: 823-830.
31. Hack M, Taylor HG, Drotar D etal. Chronic conditions, functional limitations, and special health care needs of school-aged children born with extremely low-birth-weight in the 1990s. JAMA 2005; 294: 318-325.
32. Ortqvist AK, Lundholm C, Carlström E, Lichtenstein P, Cnattingius S, Almqvist C. Familial factors do not confound the association between birth weight and childhood asthma. Pediatrics 2009; 124: 737-743.
33. Jobe AH. Glucocorticoids, inflammation and the perinatal lung. Semin Neonatol 2001; 6: 331-342.
34. Baraldi E, Filippone M. Chronic lung disease after premature birth. N Engl J Med 2007; 357: 1946-1955.
35. Kiechl-Kohlendorfer U, Horak E, Mueller W etal. Neonatal characteristics and risk of atopic asthma in schoolchildren: results from a large prospective birth-cohort study. Acta Paediatr 2007; 96: 1606-1610.
36. Mai XM, Gäddlin PO, Nilsson L etal. Asthma, lung function and allergy in 12-year-old children with very low birth weight: a prospective study. Pediatr Allergy Immunol 2003; 14: 184-192.
37. Crump C, Winkleby MA, Sundquist J, Sundquist K. Risk of asthma in young adults who were born preterm: a Swedish national cohort study. Pediatrics 2011; 127: 913-920.
38. Getahun D, Strickland D, Zeiger RS etal. Effect of chorioamnionitis on early childhood asthma. Arch Pediatr Adolesc Med 2010; 164: 187-192.
39. Greenough A, Yuksel B, Cheeseman P. Effect of in utero growth retardation on lung function at follow-up of prematurely born infants. Eur Respir J 2004; 24: 731-733.
40. Filippone M, Carraro S, Baraldi E. From BPD to COPD? The hypothesis is intriguing but we lack lung pathology data in humans. Eur Respir J 2010; 35: 1419-1420.
41. Shaheen SO, Sterne JA, Montgomery SM, Azima H. Birth weight, body mass index and asthma in young adults. Thorax 1999; 54: 396-402.
42. Boezen HM, Vonk JM, van Aalderen WM etal. Perinatal predictors of respiratory symptoms and lung function at a young adult age. Eur Respir J 2002; 20: 383-390.
43. Thyagarajan B, Jacobs DR Jr, Apostol GG etal. Longitudinal association of body mass index with lung function: the CARDIA study. Respir Res 2008; 9: 31.
44. Tennant PW, Gibson GJ, Parker L, Pearce MS. Childhood respiratory illness and lung function at ages 14 and 50 years: childhood respiratory illness and lung function. Chest 2010; 137: 146-155.
45. Pei L, Chen G, Mi J etal. Low birth weight and lung function in adulthood: retrospective cohort study in China, 1948-1996. Pediatrics 2010; 125: 899-905.
46. Jaakkola JJ, Gissler M. Maternal smoking in pregnancy, fetal development, and childhood asthma. Am J Public Health 2004; 94: 136-140.
47. Caudri D, Wijga A, Gehring U etal. Respiratory symptoms in the first 7 years of life and birth weight at term: the PIAMA Birth Cohort. Am J Respir Crit Care Med 2007; 175: 1078-1085.
48. Metsälä J, Kilkkinen A, Kaila M etal. Perinatal factors and the risk of asthma in childhood - a population-based register study in Finland. Am J Epidemiol 2008; 168: 170-178.
49. Villamor E, Iliadou A, Cnattingius S. Is the association between low birth weight and asthma independent of genetic and shared environmental factors? Am J Epidemiol 2009; 169: 1337-1343.
50. Leadbitter P, Pearce N, Cheng S etal. Relationship between fetal growth and the development of asthma and atopy in childhood. Thorax 1999; 54: 905-910.
51. Sin DD, Spier S, Svenson LW etal. The relationship between birth weight and childhood asthma: a population-based cohort study. Arch Pediatr Adolesc Med 2004; 158: 60-64.
52. Svanes C, Omenaas E, Heuch JM, Irgens LM, Gulsvik A. Birth characteristics and asthma symptoms in young adults: results from a population-based cohort study in Norway. Eur Respir J 1998; 12: 1366-1370.
53. Taveras EM, Camargo CA Jr, Rifas-Shiman SL etal. Association of birth weight with asthma-related outcomes at age 2 years. Pediatr Pulmonol 2006; 41: 643-648.
54. Raby BA, Celedón JC, Litonjua AA etal. Low-normal gestational age as a predictor of asthma at 6 years of age. Pediatrics 2004; 114: 327-332.
55. Lucas JS, Inskip HM, Godfrey KM etal. Small size at birth and greater postnatal weight gain: relationships to diminished infant lung function. Am J Respir Crit Care Med 2004; 170: 534-540.
56. Turner S, Zhang G, Young S etal. Associations between postnatal weight gain, change in postnatal pulmonary function, formula feeding and early asthma. Thorax 2008; 63: 234-239.
57. Paul IM, Camera L, Zeiger RS etal. Relationship between infant weight gain and later asthma. Pediatr Allergy Immunol 2010; 21: 82-89.
58. Flexeder C, Thiering E, Brüske I etal. Growth velocity during infancy and onset of asthma in school-aged children. Allergy 2012; 67: 257-264.
59. Sherrill DL, Guerra S, Wright AL, Morgan WJ, Martinez FD. Relation of early childhood growth and wheezing phenotypes to adult lung function. Pediatr Pulmonol 2011; 46: 956-963.
60. Abbasi S, Oxford C, Gerdes J, Sehdev H, Ludmir J. Antenatal corticosteroids prior to 24 weeks' gestation and neonatal outcome of extremely low birth weight infants. Am J Perinatol 2010; 27: 61-66.
61. Khan AA, Rodriguez A, Kaakinen M, Pouta A, Hartikainen AL, Jarvelin MR. Does in utero exposure to synthetic glucocorticoids influence birthweight, head circumference and birth length? A systematic review of current evidence in humans. Paediatr Perinat Epidemiol 2011; 25: 20-36.
62. Cole TJ, Blendy JA, Monaghan AP etal. Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev 1995; 9: 1608-1621.
63. Remesal A, San Feliciano L, Isidoro-García M, Ludeña D. Effects of antenatal betamethasone and dexamethasone on the lung expression of vascular endothelial growth factor and alveolarization in newborn rats exposed to acute hypoxia and recovered in normoxia or hyperoxia. Neonatology 2010; 98: 313-320.
64. Miracle X, Di Renzo GC, Stark A etal. Guideline for the use of antenatal corticosteroids for fetal maturation. J Perinat Med 2008; 36: 191-196.
65. Sugden MC, Langdown ML, Munns MJ, Holness MJ. Maternal glucocorticoid treatment modulates placental leptin and leptin receptor expression and materno-fetal leptin physiology during late pregnancy, and elicits hypertension associated with hyperleptinaemia in the early-growth-retarded adult offspring. Eur J Endocrinol 2001; 145: 529-539.
66. McDonough AK, Curtis JR, Saag KG. The epidemiology of glucocorticoid-associated adverse events. Curr Opin Rheumatol 2008; 20: 131-137.
67. Watterberg KL, American Academy of Pediatrics, Committee on Fetus and Newborn. Policy statement - postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia. Pediatrics 2010; 126: 800-888.
68. Karemaker R, Kavelaars A, ter Wolbeek M etal. Neonatal dexamethasone treatment for chronic lung disease of prematurity alters the hypothalamus-pituitary-adrenal axis and immune system activity at school age. Pediatrics 2008; 121: e870-e878.
69. Lumeng CN, Maillard I, Saltiel AR. T-ing up inflammation in fat. Nat Med 2009; 15: 846-847.
70. Matarese G, Procaccini C, De Rosa V, Horvath TL, La Cava A. Regulatory T cells in obesity: the leptin connection. Trends Mol Med 2010; 16: 247-256.
71. Gessner BD, Chimonas MA. Asthma is associated with preterm birth but not with small for gestational age status among a population-based cohort of Medicaid-enrolled children <10 years of age. Thorax 2007; 62: 231-236.
72. ACOG Committee on Obstetric Practice. ACOG Committee Opinion No. 475: antenatal corticosteroid therapy for fetal maturation. Obstet Gynecol 2011; 117: 422-424.
73. Devereux G. Early life events in asthma - diet. Pediatr Pulmonol 2007; 42: 663-673.
74. Olsen SF, Østerdal ML, Salvig JD etal. Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial. Am J Clin Nutr 2008; 88: 167-175.
75. Paul G, Brehm JM, Alcorn JF, Holguin F, Aujla SJ, Celedon JC. Vitamin D and asthma. Am J Respir Crit Care Med 2012; 185: 124-132.
76. Erkkola M, Kaila M, Nwaru BI etal. Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. Clin Exp Allergy 2009; 39: 875-882.
77. Miyake Y, Sasaki S, Tanaka K, Hirota Y. Dairy food, calcium and vitamin D intake in pregnancy, and wheeze and eczema in infants. Eur Respir J 2010; 35: 1228-1234.
78. Gilliland FD, Li YF, Peters JM. Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med 2001; 163: 429-436.
79. Dixon AE, Holguin F, Sood A etal. An official American Thoracic Society Workshop report: obesity and asthma. Proc Am Thorac Soc 2010; 7: 325-335.
80. Lugogo NL, Kraft M, Dixon AE. Does obesity produce a distinct asthma phenotype? J Appl Physiol 2010; 108: 729-734.
81. Stream AR, Sutherland ER. Obesity and asthma disease phenotypes. Curr Opin Allergy Clin Immunol 2012; 12: 76-81.
82. Farah CS, Kermode JA, Downie SR etal. Obesity is a determinant of asthma control, independent of inflammation and lung mechanics. Chest 2011; 140: 659-666.
83. Moore WC, Meyers DA, Wenzel SE etal. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010; 181: 315-323.
84. Holguin F, Bleecker ER, Busse WW etal. Obesity and asthma: an association modified by age of asthma onset. J Allergy Clin Immunol 2011; 127: 1486-1493.
85. von Mutius E, Schwartz J, Neas LM, Dockery D, Weiss ST. Relation of body mass index to asthma and atopy in children: the National Health and Nutrition Examination Study III. Thorax 2001; 56: 835-838.
86. Chen Y, Dales R, Jiang Y. The association between obesity and asthma is stronger in nonallergic than allergic adults. Chest 2006; 130: 890-895.
87. Kazaks A, Uriu-Adams JY, Stern JS, Albertson TE. No significant relationship between exhaled nitric oxide and body mass index in people with asthma. J Allergy Clin Immunol 2005; 116: 929-930.
88. Santamaria F, Montella S, De Stefano S, Sperlì F, Barbarano F, Valerio G. Relationship between exhaled nitric oxide and body mass index in children and adolescents. J Allergy Clin Immunol 2005; 116: 1163-1164.
89. McLachlan CR, Poulton R, Car G etal. Adiposity, asthma, and airway inflammation. J Allergy Clin Immunol 2007; 119: 634-639.
90. Lessard A, Turcotte H, Cormier Y, Boulet LP. Obesity and asthma: a specific phenotype? Chest 2008; 134: 317-323.
91. Todd DC, Armstrong S, D'Silva L, Allen CJ, Hargreave FE, Parameswaran K. Effect of obesity on airway inflammation: a cross-sectional analysis of body mass index and sputum cell counts. Clin Exp Allergy 2007; 37: 1049-1054.
92. Santamaria F, Montella S, De Stefano S etal. Asthma, atopy, and airway inflammation in obese children. J Allergy Clin Immunol 2007; 120: 965-967.
93. Sutherland TJ, Cowan JO, Young S etal. The association between obesity and asthma: interactions between systemic and airway inflammation. Am J Respir Crit Care Med 2008; 178: 469-475.
94. Berg CM, Thelle DS, Rosengren A, Lissner L, Torén K, Olin AC. Decreased fraction of exhaled nitric oxide in obese subjects with asthma symptoms: data from the population study INTERGENE/ADONIX. Chest 2011; 139: 1109-1116.
95. Rastogi D, Canfield SM, Andrade A etal. Obesity-associated asthma in children - a distinct entity. Chest 2012; 14: 895-905.
96. Haldar P, Pavord ID, Shaw DE etal. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008; 178: 218-224.
97. Scott HA, Gibson PG, Garg ML, Wood LG. Airway inflammation is augmented by obesity and fatty acids in asthma. Eur Respir J 2011; 38: 594-602.
98. Mosen DM, Schatz M, Magid DJ, Camargo CA Jr. The relationship between obesity and asthma severity and control in adults. J Allergy Clin Immunol 2008; 122: 507-511.
99. Rodrigo GJ, Plaza V. Body mass index and response to emergency department treatment in adults with severe asthma exacerbations: a prospective cohort study. Chest 2007; 132: 1513-1519.
100. Carroll CL, Bhandari A, Zucker AR, Schramm CM. Childhood obesity increases duration of therapy during severe asthma exacerbations. Pediatr Crit Care Med 2006; 7: 527-531.
101. Peters-Golden M, Swern A, Bird SS, Hustad CM, Grant E, Edelman JM. Influence of body mass index on the response to asthma controller agents. Eur Respir J 2006; 27: 495-503.
102. Sutherland ER, Lehman EB, Teodorescu M, Wechsler ME. Body mass index and phenotype in subjects with mild-to-moderate persistent asthma. J Allergy Clin Immunol 2009; 123: 1328-1334.
103. Dixon AE, Shade DM, Cohen RI etal. Effect of obesity on clinical presentation and response to treatment in asthma. J Asthma 2006; 43: 553-558.
104. Quinto KB, Zuraw BL, Poon KY, Chen W, Schatz M, Christiansen SC. The association of obesity and asthma severity and control in children. J Allergy Clin Immunol 2011; 128: 964-969.
105. Hallstrand TS, Fischer ME, Wurfel MM, Afari N, Buchwald D, Goldberg J. Genetic pleiotropy between asthma and obesity in a community-based sample of twins. J Allergy Clin Immunol 2005; 116: 1235-1241.
106. Tesse R, Schieck M, Kabesch M. Asthma and endocrine disorders: shared mechanisms and genetic pleiotropy. Mol Cell Endocrinol 2011; 333: 103-111.
107. Gunnbjörnsdóttir MI, Omenaas E, Gíslason T etal. Obesity and nocturnal gastro-oesophageal reflux are related to onset of asthma and respiratory symptoms. Eur Respir J 2004; 24: 116-121.
108. Holguin F, Cribbs S, Fitzpatrick AM, Ingram RH Jr, Jackson AC. A deep breath bronchoconstricts obese asthmatics. J Asthma 2010; 47: 55-60.
109. Maniscalco M, Zedda A, Faraone S etal. Weight loss and asthma control in severely obese asthmatic females. Respir Med 2008; 102: 102-108.
110. Dixon AE, Pratley RE, Forgione PM etal. Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation. J Allergy Clin Immunol 2011; 128: 508-515.
111. Holguin F, Fitzpatrick A. Obesity, asthma, and oxidative stress. J Appl Physiol 2010; 108: 754-759.
112. Behazin N, Jones SB, Cohen RI, Loring SH. Respiratory restriction and elevated pleural and esophageal pressures in morbid obesity. J Appl Physiol 2010; 108: 212-218.
113. King GG, Brown NJ, Diba C etal. The effects of body weight on airway calibre. Eur Respir J 2005; 25: 896-901.
114. Chapman DG, Berend N, King GG, Salome CM. Increased airway closure is a determinant of airway hyperresponsiveness. Eur Respir J 2008; 32: 1563-1569.
115. Nicolacakis K, Skowronski ME, Coreno AJ etal. Observations on the physiological interactions between obesity and asthma. J Appl Physiol 2008; 105: 1533-1541.
116. Salome CM, King GG, Berend N. Physiology of obesity and effects on lung function. J Appl Physiol 2010; 108: 206-211.
117. Zerah F, Harf A, Perlemuter L, Lorino H, Lorino AM, Atlan G. Effects of obesity on respiratory resistance. Chest 1993; 103: 1470-1476.
118. Forno E, Lescher R, Strunk R etal. Decreased response to inhaled steroids in overweight and obese asthmatic children. J Allergy Clin Immunol 2011; 127: 741-749.
119. Tantisira KG, Litonjua AA, Weiss ST, Fuhlbrigge AL, Childhood Asthma Management Program Research Group. Association of body mass with pulmonary function in the Childhood Asthma Management Program (CAMP). Thorax 2003; 58: 1036-1041.
120. Bergeron C, Boulet LP, Hamid Q. Obesity, allergy and immunology. J Allergy Clin Immunol 2005; 115: 1102-1104.
121. D'Angelo E, Pecchiari M, Della Valle P, Koutsoukou A, Milic-Emili J. Effects of mechanical ventilation at low lung volume on respiratory mechanics and nitric oxide exhalation in normal rabbits. J Appl Physiol 2005; 99: 433-444.
122. Inselman LS, Chander A, Spitzer AR. Diminished lung compliance and elevated surfactant lipids and proteins in nutritionally obese young rats. Lung 2004; 182: 101-117.
123. Ghadiali SN, Gaver DP. Biomechanics of liquid-epithelium interactions in pulmonary airways. Respir Physiol Neurobiol 2008; 163: 232-243.
124. Torchio R, Gulotta C, Ciacco C etal. Effects of chest wall strapping on mechanical response to methacholine in humans. J Appl Physiol 2006; 101: 430-438.
125. McClean MA, Matheson MJ, McKay K etal. Low lung volume alters contractile properties of airway smooth muscle in sheep. Eur Respir J 2003; 22: 50-56.
126. Hirst SJ. Airway smooth muscle cell culture: application to studies of airway wall remodelling and phenotype plasticity in asthma. Eur Respir J 1996; 9: 808-820.
127. Shore SA. Obesity, airway hyperresponsiveness, and inflammation. J Appl Physiol 2010; 108: 735-743.
128. Saraiva SA, Silva AL, Xisto DG etal. Impact of obesity on airway and lung parenchyma remodeling in experimental chronic allergic asthma. Respir Physiol Neurobiol 2011; 177: 141-148.
129. Sutherland ER, Goleva E, Strand M, Beuther DA, Leung DY. Body mass and glucocorticoid response in asthma. Am J Respir Crit Care Med 2008; 178: 682-687.
130. Boulet LP, Franssen E. Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma. Respir Med 2007; 101: 2240-2247.
131. Camargo CA Jr, Sutherland ER, Bailey W etal. Effect of increased body mass index on asthma risk, impairment and response to asthma controller therapy in African Americans. Curr Med Res Opin 2010; 26: 1629-1635.
132. Kassel O, Sancono A, Kratzschmar J, Kreft B, Stassen M, Cato AC. Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1. EMBO J 2001; 20: 7108-7116.
133. Zhao Q, Shepherd EG, Manson ME, Nelin LD, Sorokin A, Liu Y. The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38. J Biol Chem 2005; 280: 8101-8108.
134. Webster JC, Oakley RH, Jewell CM, Cidlowski JA. Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance. Proc Natl Acad Sci U S A 2001; 98: 6865-6870.
135. Camargo CA Jr, Boulet LP, Sutherland ER etal. Body mass index and response to asthma therapy: fluticasone propionate/salmeterol versus montelukast. J Asthma 2010; 47: 76-82.
136. Sutherland ER, Camargo CA Jr, Busse WW etal. Comparative effect of body mass index on response to asthma controller therapy. Allergy Asthma Proc 2010; 31: 20-25.
137. Horrillo R, González-Périz A, Martínez-Clemente M etal. 5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity. J Immunol 2010; 184: 3978-3987.
138. Chakrabarti SK, Wen Y, Dobrian AD etal. Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Am J Physiol Endocrinol Metab 2011; 300: E175-E187.
139. Mancuso P, Gottschalk A, Phare SM, Peters-Golden M, Lukacs NW, Huffnagle GB. Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol 2002; 168: 4018-4024.
140. Cederholm T, Lindgren JA, Palmblad J. Impaired leukotriene C4 generation in granulocytes from protein-energy malnourished chronically ill elderly. J Intern Med 2000; 247: 715-722.
141. Mancuso P, Canetti C, Gottschalk A, Tithof PK, Peters-Golden M. Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expression. Am J Physiol Lung Cell Mol Physiol 2004; 287: L497-L502.
142. Giouleka P, Papatheodorou G, Lyberopoulos P etal. Body mass index is associated with leukotriene inflammation in asthmatics. Eur J Clin Invest 2011; 41: 30-38.
143. Ratnovsky A, Mellema M, An SS, Fredberg JJ, Shore SA. Airway smooth muscle proliferation and mechanics: effects of AMP kinase agonists. Mol Cell Biochem 2007; 4: 143-157.
144. Cottrell L, Neal WA, Ice C, Perez MK, Piedimonte G. Metabolic abnormalities in children with asthma. Am J Respir Crit Care Med 2011; 183: 441-448.
145. Zhu M, Flynt L, Ghosh S etal. Anti-inflammatory effects of thiazolidinediones in human airway smooth muscle cells. Am J Respir Cell Mol Biol 2011; 45: 111-119.
146. Franssen FM, O'Donnell DE, Goossens GH, Blaak EE, Schols AM. Obesity and the lung: 5. Obesity and COPD. Thorax 2008; 63: 1110-1117.
147. Poulain M, Doucet M, Drapeau V etal. Metabolic and inflammatory profile in obese patients with chronic obstructive pulmonary disease. Chron Respir Dis 2008; 5: 35-41.
148. Wilson DO, Rogers RM, Wright EC, Anthonisen NR. Body weight in chronic obstructive pulmonary disease. The National Institutes of Health Intermittent Positive-Pressure Breathing Trial. Am Rev Respir Dis 1989; 139: 1435-1438.
149. Guerra S, Sherrill DL, Bobadilla A, Martinez FD, Barbee RA. The relation of body mass index to asthma, chronic bronchitis, and emphysema. Chest 2002; 122: 1256-1263.
150. Vestbo J, Prescott E, Almdal T etal. Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen city heart study. Am J Respir Crit Care Med 2006; 173: 79-83.
151. Curtis JP, Selter JG, Wang Y etal. The obesity paradox: body mass index and outcomes in patients with heart failure. Arch Intern Med 2005; 165: 55-61.
152. Poulain M, Doucet M, Major GC etal. The effect of obesity on chronic respiratory diseases: pathophysiology and therapeutic strategies. CMAJ 2006; 174: 1293-1299.
153. Despres JP, Lemieux I, Prud'homme D. Treatment of obesity: need to focus on high risk abdominally obese patients. BMJ 2001; 322: 716-720.
154. Sin DD, Man SF. Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease. Circulation 2003; 107: 1514-1519.
155. Schols AM, Soeters PB, Dingemans AM, Mostert R, Frantzen PJ, Wouters EF. Prevalence and characteristics of nutritional depletion in patients with stable COPD eligible for pulmonary rehabilitation. Am Rev Respir Dis 1993; 147: 1151-1156.