Effect of inhaled steroids on airway hyperresponsiveness, sputum eosinophils, and exhaled nitric oxide levels in patients with asthma

Thorax

Volumn 54, Issue 5, 1999, Pages 403-408

  Van Rensen, Elizabeth L J ^a   Straathof, Karin C M ^a   Veselic Charvat, Maud A ^a   Zwinderman, Aeilko H ^a   Bel, Elisabeth H ^a   Sterk, Peter J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Airway hyperresponsiveness; Asthma; Fluticasone propionate; Induced sputum; Inhaled corticosteroids; Nitric oxide

Indexed keywords

FLUTICASONE PROPIONATE; HISTAMINE; NITRIC OXIDE; PLACEBO; SODIUM CHLORIDE; STEROID;

ADULT; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CELL COUNT; CHEMOLUMINESCENCE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EOSINOPHIL; EXHALATION; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MALE; PATIENT MONITORING; PRIORITY JOURNAL; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; SPUTUM ANALYSIS; SQUAMOUS CELL;

EID: 0032922825     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.54.5.403     Document Type: Article

References (31)

1. 1 National Institutes of Health, National Heart, Lung, and Blood Institute. Global initiative for asthma. Publication 95-3659, January 1995.
2. 2 Djukanovic R, Reiche WR, Wilson JW, et al. Mucosal inflammation in asthma. Am Rev Respir Dis 1990;142:434-57.
3. + T cells, cosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics. J Immunol 1997;158:3539-44.
4. 4 British Thoracic Society. The British guidelines on asthma management: 1995 review and position statement. Thorax 1997;52(Suppl 1):S1-S21.
5. 5 Sont JK, Van Krieken JHJM, Evertse CE, at al. Relationship between the inflammatory infiltrate in bronchial biopsy specimens and clinical severity of asthma in patients treated with inhaled steroids. Thorax 1996;51:496-502.
6. 6 In't Veen JCCM, De Gouw HWTM, Smits HH, et al. Repeatability of cellular and soluble markers of inflammation in induced sputum from patients with asthma. Eur Respir J 1996;9:2441-7.
7. 7 Kharitonov SA, Alving K, Barnes PJ. Exhaled and nasal NO measurements: recommendations. Eur Respir J 1997;10: 1683-93.
8. 8 Barnes PJ. Inhaled glucocorticoids for asthma. N Engl J Med 1995;332:868-75.
9. 9 Trigg CJ, Manolitsas ND, Wang J, et al. Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma. Am J Respir Crit Care Med 1994; 150:17-22.
10. 10 Pizzichini E, Pizzichini MMM, Efthimiadis A, et al. Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements. Am J Respir Crit Care Med 1996;154:308-17.
11. 11 Grootendorst DC, Sont JK, Willems LNA, et al. Comparison of inflammatory cell counts in asthma: induced sputum vs bronchoalveolar lavage and bronchial biopsies. Clin Exp Allergy 1997;27:769-79.
12. 12 Keatings VM, Jatakanon A, Worsdell M, et al. Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD. Am J Respir Crit Care Med 1997;155:542-8.
13. 13 Massaro AF, Gaston B, Kita D, et al. Expired nitric oxide levels during treatment of acute asthma. Am J Respir Crit Care Med 1995;152:800-3.
14. 14 Kharitonov SA, Yates DH, Barnes PJ. Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients. Am J Respir Crit Care Med 1996;153:454-7.
15. 15 Kharitonov SA, Yates DH, Chung KF, et al. Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients. Eur Respir J 1996;9:196-201.
16. 16 Quanjer PhH, Tammeling GJ, Cotes JE, et al. Lung volumes and forced ventilatory flows. Eur Respir J 1993;6:5-40.
17. 17 Sterk PJ, Fabbri LM, Quanjer PhH, et al. Airway responsiveness: standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Eur Respir J 1993;6:53-83.
18. 18 Fahy J, Lui J, Wong H, et al. Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects. Am Ref Respir Dis 1993;147:1126-31.
19. 19 De Gouw HWFM, Grünbcrg K, Schot R, et al. The relationship between exhaled nitric oxide and airway hyperresponsiveness following experimental rhinovirus infection in asthmatic subjects. Eur Respir J 1998;11:126-32.
20. 20 Kraan J, Koëter GH, Van der Mark ThW, et al. Changes in bronchial hyperreactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: a comparison between budesonide and terbutaline. J Allergy Clin Immunol 1985;76:628-36.
21. 21 Jatakanon A, Lim S, Chung KF, et al. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness. Am J Respir Crit Care Med 1997;155:A819.
22. 22 Baraldi E, Maestrelli P, Semenzato R, et al. Comparison of exhaled NO values, eosinophil counts in the induced sputum and eosinophil cationic protein (ECP) in asthmatic children. Eur Respir J 1997;10:158s.
23. 23 Wallen N, Kita H, Weiler D, et al. Glucocorticoids inhibit cytokine-mediated eosinophil survival. J Immunol 1991; 147:3490-5.
24. 24 Hallswoth MP, Litchfield TM, Lee TH. Glucocorticoids inhibit granulocyte-macrophage colony-stimulating factor-1 and interleukin-5 enhanced in vitro survival of human eosinophils. Immunology 1992;75:382-5.
25. 25 Corrigan CJ, Hamid Q, North J, et al. Peripheral blood CD4 but not CD 8 T-lymphocytes in patients with exacerbations of asthma transcribe and translate messenger RNA encoding cytokines which prolong eosinophil survival in the context of a Th2-type pattern: effect of glucocorticoid therapy. Am J Respir Cell Mol Biol 1995;12:567-78.
26. 26 Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: pathophysiology and pharmacology. Pharmacol Rev 1991; 42:109-42.
27. 27 Haley KJ, Drazen JM. Inflammation and airway function in asthma. What you see is not necessarily what you get. Am J Respir Crit Care Med 1998;157:1-3.
28. 28 Lange P, Parner J, Vestbo J, et al. A 15-years follow-up of ventilatory function in adults with asthma. N Engl J Med 1998;339:1194-200.
29. 29 Haahtela T, Järvinen M, Kava T, et al. Effects of reducing or discontinuing inhaled budesonide in patients with mild asthma. N Eng J Med 1994;331:700-5.
30. 30 Barnes PJ, Kharitonov SA. Exhaled nitric oxide: a new lung function test. Thorax 1996;51:233-7.
31. 31 Sont JK, Willems LNA, Bel EH, et al and the AMPUL Study Group. The clinical control and histopathological outcome of asthma using airway hyperresponsiveness as an additional guide of long-term treatment. Am J Respir Crit Care Med 1999 (in press).