The Use of Exhaled Nitric Oxide in the Diagnosis of Asthma in School Children

Journal of Pediatrics

Volumn 155, Issue 2, 2009, Pages 211-216

  Sivan, Yakov ^a   Gadish, Tali ^a   Fireman, Elizabeth ^b   Soferman, Ruth ^a  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE;

ARTICLE; ASTHMA; CHILD; CONTROLLED STUDY; CYTOLOGY; EXPIRATORY RESERVE VOLUME; EXPIRED AIR; FORCED EXPIRATORY VOLUME; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; SPIROMETRY; SPUTUM ANALYSIS;

ADOLESCENT; ASTHMA; BREATH TESTS; CHILD; CHILD, PRESCHOOL; EARLY DIAGNOSIS; EOSINOPHILS; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; LEUKOCYTE COUNT; MALE; NITRIC OXIDE; PREDICTIVE VALUE OF TESTS; ROC CURVE; SENSITIVITY AND SPECIFICITY; SPIROMETRY; SPUTUM;

EID: 67749145147     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpeds.2009.02.034     Document Type: Article

References (36)

1. Zacharasiewicz A. Fractional exhaled nitric oxide and induced sputum. Paediatr Respir Rev 8 (2007) 94-96
2. Asher M.I., and Grant C. Epidemiology of asthma. In: Chernick V., Boat T.F., Wilmott R.W., and Bush A. (Eds). Kendig's disorders of the respiratory tract in children. 7th ed (2006), Elsevier, St. Louis 762-765
3. National Asthma Education and Prevention Program. Expert panel report 2: guidelines for the diagnosis and management of asthma (1997), National Institutes of Health, Bethesda publication No. 97-4051
4. Bukstein D., Kraft K., Liu A.H., and Peters S.P. Asthma end points and outcomes: what have we learned?. J Allergy Clin Immunol 118 (2006) S1-S15
5. Franklin P.J., and Stick S.M. The value of FeNO measurement in asthma management: the motion against FeNO to help manage childhood asthma-reality bites. Paediatr Respir Rev 9 (2008) 122-126
6. Smith A.D., Cowan J.O., Filsell S., McLachlan C., Monti-Sheehan G., Jackson P., et al. Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests. Am J Respir Crit Care Med 169 (2004) 473-478
7. Lieberman P. Objective measures of asthma control: sputum eosinophils, nitric oxide, and other inflammatory mediators. Allergy Asthma Proc 28 (2007) 510-513
8. Siersted H.C., Mostgaard G., Hyldebrandt N., Hansen H.S., Boldsen J., and Oxhøj H. Interrelationships between diagnosed asthma, asthma-like symptoms, and abnormal airway behavior in adolescence: the Odense Schoolchild Study. Thorax 51 (1996) 503-509
9. Narang I., Ersu R., Wilson N.M., and Bush A. Nitric oxide in chronic airway inflammation in children: diagnostic use and pathophysiological significance. Thorax 57 (2002) 586-589
10. Lex C., Ferreira F., Zacharasiewicz A., Nicholson A.G., Haslam P.L., Wilson N.M., et al. Airway eosinophilia in children with severe asthma: predictive values of non-invasive tests. Am J Respir Crit Care Med 174 (2006) 1286-1291
11. Warke T.J., Fitch P.S., Brown V., Taylor R., Lyons J.D., Ennis M., et al. Exhaled nitric oxide correlates with airway eosinophils in childhood asthma. Thorax 57 (2002) 383-387
12. Baraldi E., and de Jongste J.C. European Respiratory Society; American Thoracic Society. Measurement of exhaled nitric oxide in children, 2001. Eur Respir J 20 (2002) 223-237
13. Paraskakis E., Brindicci C., Fleming L., Krol R., Kharitonov S.A., Wilson N.M., Barnes P.J., and Bush A. Measurement of bronchial and alveolar nitric oxide production in normal children and children with asthma. Am J Respir Crit Care Med 174 (2006) 260-267
14. Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med 152 (1995) 1107-1136
15. Lex C., Payne D.N., Li A.M., Zacharasiewicz A., Wilson N.M., Hansel T., et al. Sputum induction in children with difficult asthma: safety, feasibility, and inflammatory cell pattern. Pediatr Pulmonol 39 (2005) 318-324
16. ATS/ERS recommendations for standardized procedures for the online and offline Measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med 171 (2005) 912-930
17. Sackett D.L., Straus S.E., Richardson W.S., Rosenberg W., and Haynes W. Evidence-Based Medicine - how to practice and teach EBM. 2nd edition (2000), Churchill Livingtone p.67-93
18. Hanley J.A., and McNeil B.J. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 143 (1982) 29-36
19. Altman D.G., and Bland J.M. Diagnostic tests. 1: Sensitivity and specificity. BMJ 308 (1994) 1552
20. Altman D.G., and Bland J.M. Diagnostic tests 2: Predictive values. BMJ 309 (1994) 102
21. Altman D.G., and Bland J.M. Statistics Notes: Diagnostic tests 3: receiver operating characteristic plots. BMJ 309 (1994) 188
22. Deykin A., Massaro A.F., Drazen J.M., and Israel E. Exhaled nitric oxide as a diagnostic test for asthma: online versus offline techniques and effect of flow rate. Am J Respir Crit Care Med 165 (2002) 1597-1601
23. Dupont L.J., Demedts M.G., and Verleden G.M. Prospective evaluation of the validity of exhaled nitric oxide for the diagnosis of asthma. Chest 123 (2003) 751-756
24. Franklin P.J., Turner S.W., Le Souef P.N., and Stick S.M. Exhaled nitric oxide and asthma: complex interactions between atopy, airway responsiveness, and symptoms in a community population of children. Thorax 58 (2003) 1048-1052
25. Avital A., Uwyyed K., Berkman N., Godfrey S., Bar-Yishay E., and Springer C. Exhaled nitric oxide and asthma in young children. Pediatr Pulmonol 32 (2001) 308-313
26. Berkman N., Avital A., Breuer R., Bardach E., Springer C., and Godfrey S. Exhaled nitric oxide in the diagnosis of asthma: comparison with bronchial provocation tests. Thorax 60 (2005) 383-388
27. Thomas P.S., Gibson P.G., Wang H., Shah S., and Henry R.L. The relationship of exhaled nitric oxide to airway inflammation and responsiveness in children. J Asthma 42 (2005) 291-295
28. Prasad A., Langford B., Stradling J.R., and Ho L.P. Exhaled nitric oxide as a screening tool for asthma in school children. Respir Med 100 (2006) 167-173
29. Malmberg L.P., Pelkonen A.S., Haahtela T., and Turpeinen M. Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma. Thorax 58 (2003) 494-499
30. Bush A., and Eber E. The value of FeNO measurement in asthma management: the motion for Yes, it's NO - or, the wrong end of the Stick!. Paediatric Respiratory Reviews 9 (2008) 127-131
31. Fortuna A.M., Feixas T., Gonzalez M., and Casan P. Diagnostic utility of inflammatory biomarkers in asthma: Exhaled nitric oxide and induced sputum eosinophil count. Respir Med 101 (2007) 2416-2421
32. van den Toorn L.M., Overbeek S.E., de Jongste J.C., Leman K., Hoogsteden H.C., and Prins J.B. Airway inflammation is present during clinical remission of atopic asthma. Am J Respir Crit Care Med 164 (2001) 2107-2113
33. Green R.H., Brightling C.E., McKenna S., Hargadon B., Parker D., Bradding P., et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 360 (2002) 1715-1721
34. Piacentini G.L., Bodini A., Costella S., Vicentini L., Mazzi P., Sperandio S., et al. Exhaled nitric oxide and sputum eosinophil markers of inflammation in asthmatic children. Eur Respir J 13 (1999) 1386-1390
35. Toelle B.G., Peat J.K., Salome C.M., Mellis C.M., and Woolcock A.J. Toward a definition of asthma for epidemiology. Am Rev Respir Dis 146 (1992) 633-637
36. Buchvald F., Baraldi E., Carraro S., Gaston B., De Jongste J., Pijnenburg M.W.H., et al. Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years. J Allergy Clin Immunol 115 (2005) 1130-1136