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Volumn 43, Issue 3, 2012, Pages 230-241

The immunophysiology and apoptosis of biliary epithelial cells: Primary biliary cirrhosis and primary sclerosing cholangitis

Author keywords

Apoptosis; Autoimmunity; Biliary epithelial cells; Primary biliary cirrhosis; Primary sclerosing cholangitis

Indexed keywords

ALPHA DEFENSIN; BETA DEFENSIN; CATHELICIDIN; CD2 ANTIGEN; CD40 ANTIGEN; CX3C CHEMOKINE; FAS LIGAND; IMMUNOGLOBULIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 12; INTERLEUKIN 6; INTERLEUKIN 8; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; MITOCHONDRION ANTIBODY; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOID DIFFERENTIATION FACTOR 88; OXOGLUTARATE DEHYDROGENASE; PROTEIN P53; PYRUVATE DEHYDROGENASE; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; URSODEOXYCHOLIC ACID;

EID: 84871645959     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-012-8324-0     Document Type: Article
Times cited : (33)

References (114)
  • 1
    • 4644359523 scopus 로고    scopus 로고
    • Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree
    • DOI 10.1002/hep.20379
    • Harada K, Ohba K, Ozaki S et al (2004) Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree. Hepatology 40:925-932 (Pubitemid 39288126)
    • (2004) Hepatology , vol.40 , Issue.4 , pp. 925-932
    • Harada, K.1    Ohba, K.2    Ozaki, S.3    Isse, K.4    Hirayama, T.5    Wada, A.6    Nakanuma, Y.7
  • 2
    • 33645741989 scopus 로고    scopus 로고
    • Human intrahepatic biliary epithelial cells function in innate immunity by producing il-6 and il-8 via the tlr4-nf-kappab and -mapk signaling pathways
    • Yokoyama T, Komori A, Nakamura M et al (2006) Human intrahepatic biliary epithelial cells function in innate immunity by producing IL-6 and IL-8 via the TLR4-NF-kappaB and -MAPK signaling pathways. Liver Int 26:467-476
    • (2006) Liver Int , vol.26 , pp. 467-476
    • Yokoyama, T.1    Komori, A.2    Nakamura, M.3
  • 4
    • 0036884424 scopus 로고    scopus 로고
    • A blast from the past: Clearance of apoptotic cells regulates immune responses
    • DOI 10.1038/nri957
    • Savill J, Dransfield I, Gregory C, Haslett C (2002) A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol 2:965-975 (Pubitemid 37323217)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.12 , pp. 965-975
    • Savill, J.1    Dransfield, I.2    Gregory, C.3    Haslett, C.4
  • 5
    • 36448961645 scopus 로고    scopus 로고
    • Engulfment of apoptotic cells: Signals for a good meal
    • DOI 10.1038/nri2214, PII NRI2214
    • Ravichandran KS, Lorenz U (2007) Engulfment of apoptotic cells: signals for a good meal. Nat Rev Immunol 7:964-974 (Pubitemid 350166061)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.12 , pp. 964-974
    • Ravichandran, K.S.1    Lorenz, U.2
  • 9
    • 36348931523 scopus 로고    scopus 로고
    • Apoptotic cell death takes its toll
    • DOI 10.1002/hep.21968
    • Torok NJ (2007) Apoptotic cell death takes its toll. Hepatology 46:1323-1325 (Pubitemid 350155511)
    • (2007) Hepatology , vol.46 , Issue.5 , pp. 1323-1325
    • Torok, N.J.1
  • 10
    • 37349104035 scopus 로고    scopus 로고
    • Autoantigens are translocated into small apoptotic bodies during early stages of apoptosis
    • DOI 10.1038/sj.cdd.4402239, PII 4402239, Special issue on Tumor stress, cell death and the ensuing immune response
    • Schiller M, Bekeredjian-Ding I, Heyder P, Blank N, Ho AD, Lorenz HM (2008) Autoantigens are translocated into small apoptotic bodies during early stages of apoptosis. Cell Death Differ 15:183-191 (Pubitemid 350286186)
    • (2008) Cell Death and Differentiation , vol.15 , Issue.1 , pp. 183-191
    • Schiller, M.1    Bekeredjian-Ding, I.2    Heyder, P.3    Blank, N.4    Ho, A.D.5    Lorenz, H.-M.6
  • 11
    • 0041427760 scopus 로고    scopus 로고
    • Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion
    • Lucas M, Stuart LM, Savill J, Lacy-Hulbert A (2003) Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion. J Immunol 171:2610-2615 (Pubitemid 37025573)
    • (2003) Journal of Immunology , vol.171 , Issue.5 , pp. 2610-2615
    • Lucas, M.1    Stuart, L.M.2    Savill, J.3    Lacy-Hulbert, A.4
  • 12
    • 77649152255 scopus 로고    scopus 로고
    • Autoimmunity and the clearance of dead cells
    • Nagata S, Hanayama R, Kawane K (2010) Autoimmunity and the clearance of dead cells. Cell 140:619-630
    • (2010) Cell , vol.140 , pp. 619-630
    • Nagata, S.1    Hanayama, R.2    Kawane, K.3
  • 14
    • 0023267078 scopus 로고
    • Identification and specificity of a cDNA encoding the 70 KD mitochondrial antigen recognized in primary biliary cirrhosis
    • Gershwin ME, Mackay IR, Sturgess A, Coppel RL (1987) Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis. J Immunol 138:3525-3531 (Pubitemid 17071942)
    • (1987) Journal of Immunology , vol.138 , Issue.10 , pp. 3525-3531
    • Gershwin, M.E.1    Mackay, I.R.2    Sturgess, A.3    Coppel, R.L.4
  • 15
    • 63349090979 scopus 로고    scopus 로고
    • Apotopes and the biliary specificity of primary biliary cirrhosis
    • Lleo A, Selmi C, Invernizzi P et al (2009) Apotopes and the biliary specificity of primary biliary cirrhosis. Hepatology 49:871-879
    • (2009) Hepatology , vol.49 , pp. 871-879
    • Lleo, A.1    Selmi, C.2    Invernizzi, P.3
  • 16
    • 79959549320 scopus 로고    scopus 로고
    • Epithelial cell specificity and apotope recognition by serum autoantibodies in primary biliary cirrhosis
    • Rong G, Zhong R, Lleo A et al (2011) Epithelial cell specificity and apotope recognition by serum autoantibodies in primary biliary cirrhosis. Hepatology 54:196-203
    • (2011) Hepatology , vol.54 , pp. 196-203
    • Rong, G.1    Zhong, R.2    Lleo, A.3
  • 17
    • 77956627699 scopus 로고    scopus 로고
    • Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis
    • Lleo A, Bowlus CL, Yang GX et al (2010) Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis. Hepatology 52:987-998
    • (2010) Hepatology , vol.52 , pp. 987-998
    • Lleo, A.1    Bowlus, C.L.2    Yang, G.X.3
  • 18
    • 0035990949 scopus 로고    scopus 로고
    • Apoptosis of biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis
    • DOI 10.1046/j.0106-9543.2002.01595.x
    • Tinmouth J, Lee M,Wanless IR, Tsui FW, Inman R, Heathcote EJ (2002) Apoptosis of biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis. Liver 22:228-234 (Pubitemid 34846361)
    • (2002) Liver , vol.22 , Issue.3 , pp. 228-234
    • Tinmouth, J.1    Lee, M.2    Wanless, I.R.3    Tsui, F.W.L.4    Inman, R.5    Heathcote, E.J.6
  • 19
    • 0033966411 scopus 로고    scopus 로고
    • Toll signaling pathways in the innate immune response
    • DOI 10.1016/S0952-7915(99)00045-X
    • Anderson KV (2000) Toll signaling pathways in the innate immune response. Curr Opin Immunol 12:13-19 (Pubitemid 30093445)
    • (2000) Current Opinion in Immunology , vol.12 , Issue.1 , pp. 13-19
    • Anderson, K.V.1
  • 21
    • 32544446183 scopus 로고    scopus 로고
    • Interferon γ accelerates NF-κB activation of biliary epithelial cells induced by Toll-like receptor and ligand interaction
    • DOI 10.1136/jcp.2004.023507
    • Harada K, Isse K, Nakanuma Y (2006) Interferon gamma accelerates NF-kappaB activation of biliary epithelial cells induced by Toll-like receptor and ligand interaction. J Clin Pathol 59:184-190 (Pubitemid 43235585)
    • (2006) Journal of Clinical Pathology , vol.59 , Issue.2 , pp. 184-190
    • Harada, K.1    Isse, K.2    Nakanuma, Y.3
  • 24
    • 34247196579 scopus 로고    scopus 로고
    • Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis
    • DOI 10.1053/j.gastro.2007.01.039, PII S0016508507001783
    • Karrar A, Broome U, Sodergren T et al (2007) Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis. Gastroenterology 132:1504-1514 (Pubitemid 46627575)
    • (2007) Gastroenterology , vol.132 , Issue.4 , pp. 1504-1514
    • Karrar, A.1    Broome, U.2    Sodergren, T.3    Jaksch, M.4    Bergquist, A.5    Bjornstedt, M.6    Sumitran-Holgersson, S.7
  • 25
    • 0242413703 scopus 로고    scopus 로고
    • Lipopolysaccharide Activates Nuclear Factor-KappaB through Toll-Like Receptors and Related Molecules in Cultured Biliary Epithelial Cells
    • DOI 10.1097/01.LAB.0000097190.56734.FE
    • Harada K, Ohira S, Isse K et al (2003) Lipopolysaccharide activates nuclear factor-kappaB through toll-like receptors and related molecules in cultured biliary epithelial cells. Lab Invest 83:1657-1667 (Pubitemid 37421106)
    • (2003) Laboratory Investigation , vol.83 , Issue.11 , pp. 1657-1667
    • Harada, K.1    Ohira, S.2    Isse, K.3    Ozaki, S.4    Zen, Y.5    Sato, Y.6    Nakanuma, Y.7
  • 26
    • 36349035570 scopus 로고    scopus 로고
    • Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia
    • DOI 10.1002/hep.21797
    • Harada K, Sato Y, Itatsu K et al (2007) Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia. Hepatology 46:1146-1154 (Pubitemid 350144779)
    • (2007) Hepatology , vol.46 , Issue.4 , pp. 1146-1154
    • Harada, K.1    Sato, Y.2    Itatsu, K.3    Isse, K.4    Ikeda, H.5    Yasoshima, M.6    Zen, Y.7    Matsui, A.8    Nakanuma, Y.9
  • 28
    • 33748309351 scopus 로고    scopus 로고
    • Endotoxin tolerance in human intrahepatic biliary epithelial cells is induced by upregulation of IRAK-M
    • DOI 10.1111/j.1478-3231.2006.01325.x
    • Harada K, Isse K, Sato Y, Ozaki S, Nakanuma Y (2006) Endotoxin tolerance in human intrahepatic biliary epithelial cells is induced by upregulation of IRAK-M. Liver Int 26:935-942 (Pubitemid 44323411)
    • (2006) Liver International , vol.26 , Issue.8 , pp. 935-942
    • Harada, K.1    Isse, K.2    Sato, Y.3    Ozaki, S.4    Nakanuma, Y.5
  • 30
    • 39149127361 scopus 로고    scopus 로고
    • Structure-Activity relationships in beta-defensin peptides
    • Taylor K, Barran PE, Dorin JR (2008) Structure-Activity relationships in beta-defensin peptides. Biopolymers 90:1-7
    • (2008) Biopolymers , vol.90 , pp. 1-7
    • Taylor, K.1    Barran, P.E.2    Dorin, J.R.3
  • 32
    • 62949244071 scopus 로고    scopus 로고
    • Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium
    • D'Aldebert E, Biyeyeme Bi Mve MJ, Mergey M et al (2009) Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium. Gastroenterology 136:1435-1443
    • (2009) Gastroenterology , vol.136 , pp. 1435-1443
    • D'Aldebert, E.1    Biyeyeme Bi Mve, M.J.2    Mergey, M.3
  • 33
  • 34
    • 14244261439 scopus 로고    scopus 로고
    • Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts
    • DOI 10.1002/hep.20582
    • Isse K, Harada K, Zen Y et al (2005) Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts. Hepatology 41:506-516 (Pubitemid 40289497)
    • (2005) Hepatology , vol.41 , Issue.3 , pp. 506-516
    • Isse, K.1    Harada, K.2    Zen, Y.3    Kamihira, T.4    Shimoda, S.5    Harada, M.6    Nakanuma, Y.7
  • 35
    • 75449089682 scopus 로고    scopus 로고
    • Cx3cl1 (fractalkine): A signpost for biliary inflammation in primary biliary cirrhosis
    • Shimoda S, Harada K, Niiro H et al (2010) CX3CL1 (fractalkine): a signpost for biliary inflammation in primary biliary cirrhosis. Hepatology 51:567-575
    • (2010) Hepatology , vol.51 , pp. 567-575
    • Shimoda, S.1    Harada, K.2    Niiro, H.3
  • 36
    • 34249888774 scopus 로고    scopus 로고
    • The immunological milieu of the liver
    • DOI 10.1055/s-2007-979466
    • Selmi C, Mackay IR, Gershwin ME (2007) The immunological milieu of the liver. Semin Liver Dis 27:129-139 (Pubitemid 46871659)
    • (2007) Seminars in Liver Disease , vol.27 , Issue.2 , pp. 129-139
    • Selmi, C.1    Mackay, I.R.2    Gershwin, M.E.3
  • 38
    • 22144446042 scopus 로고    scopus 로고
    • ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-α-activated vascular endothelium under flow
    • DOI 10.1182/blood-2004-12-4942
    • Yang L, Froio RM, Sciuto TE, Dvorak AM, Alon R, Luscinskas FW (2005) ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-Alpha-Activated vascular endothelium under flow. Blood 106:584-592 (Pubitemid 40981255)
    • (2005) Blood , vol.106 , Issue.2 , pp. 584-592
    • Yang, L.1    Froio, R.M.2    Sciuto, T.E.3    Dvorak, A.M.4    Alon, R.5    Luscinskas, F.W.6
  • 39
    • 0031048591 scopus 로고    scopus 로고
    • Immunogenicity of biliary epithelium: Study of the adhesive interaction with lymphocytes
    • DOI 10.1053/gast.1997.v112.pm9041260
    • Leon MP, Bassendine MF, Gibbs P, Thick M, Kirby JA (1997) Immunogenicity of biliary epithelium: study of the adhesive interaction with lymphocytes. Gastroenterology 112:968-977 (Pubitemid 27113824)
    • (1997) Gastroenterology , vol.112 , Issue.3 , pp. 968-977
    • Leon, M.P.1    Bassendine, M.F.2    Gibbs, P.3    Thick, M.4    Kirby, J.A.5
  • 40
    • 0032192339 scopus 로고    scopus 로고
    • Expression and cytokine regulation of immune recognition elements by normal human biliary epithelial and established liver cell lines in vitro
    • DOI 10.1016/S0168-8278(98)80149-9
    • Cruickshank SM, Southgate J, Selby PJ, Trejdosiewicz LK (1998) Expression and cytokine regulation of immune recognition elements by normal human biliary epithelial and established liver cell lines in vitro. J Hepatol 29:550-558 (Pubitemid 28484943)
    • (1998) Journal of Hepatology , vol.29 , Issue.4 , pp. 550-558
    • Cruickshank, S.M.1    Southgate, J.2    Selby, P.J.3    Trejdosiewicz, L.K.4
  • 41
    • 0036634816 scopus 로고    scopus 로고
    • The role of cholangiocytes in the development of chronic inflammatory liver disease
    • Adams DH, Afford SC (2002) The role of cholangiocytes in the development of chronic inflammatory liver disease. Front Biosci 7:e276-e285
    • (2002) Front Biosci , vol.7
    • Adams, D.H.1    Afford, S.C.2
  • 42
    • 0029997091 scopus 로고    scopus 로고
    • Intestinal immunisation with Escherichia coli protects rats against Escherichia coli induced cholangitis
    • Aagaard BD, Heyworth MF, Oesterle AL, Jones AL, Way LW (1996) Intestinal immunisation with Escherichia coli protects rats against Escherichia coli induced cholangitis. Gut 39:136-140 (Pubitemid 26239121)
    • (1996) Gut , vol.39 , Issue.1 , pp. 136-140
    • Aagaard, B.D.L.1    Heyworth, M.F.2    Oesterle, A.L.3    Jones, A.L.4    Way, L.W.5
  • 43
    • 0028202474 scopus 로고
    • Transepithelial transport of immunoglobulins
    • Mostov KE (1994) Transepithelial transport of immunoglobulins. Annu Rev Immunol 12:63-84 (Pubitemid 24140409)
    • (1994) Annual Review of Immunology , vol.12 , pp. 63-84
    • Mostov, K.E.1
  • 44
    • 0034610743 scopus 로고    scopus 로고
    • Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
    • DOI 10.1038/47513
    • Nakagawa T, Zhu H, Morishima N et al (2000) Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403:98-103 (Pubitemid 30038529)
    • (2000) Nature , vol.403 , Issue.6765 , pp. 98-103
    • Nakagawa, T.1    Zhu, H.2    Morishima, N.3    Li, E.4    Xu, J.5    Yankner, B.A.6    Yuan, J.7
  • 45
    • 0036598992 scopus 로고    scopus 로고
    • Targeting death and decoy receptors of the tumour-necrosis factor superfamily
    • Ashkenazi A (2002) Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat Rev Cancer 2:420-430 (Pubitemid 37328939)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.6 , pp. 420-430
    • Ashkenazi, A.1
  • 46
    • 49449097533 scopus 로고    scopus 로고
    • Death receptor 5 mediated-Apoptosis contributes to cholestatic liver disease
    • Takeda K, Kojima Y, Ikejima K et al (2008) Death receptor 5 mediated-Apoptosis contributes to cholestatic liver disease. Proc Natl Acad Sci U S A 105:10895-10900
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 10895-10900
    • Takeda, K.1    Kojima, Y.2    Ikejima, K.3
  • 47
    • 0041880709 scopus 로고    scopus 로고
    • Apoptosis and the liver: Relation to autoimmunity and related conditions
    • DOI 10.1016/S1568-9972(02)00125-8, PII S1568997202001258
    • Bai J, Odin JA (2003) Apoptosis and the liver: relation to autoimmunity and related conditions. Autoimmun Rev 2:36-42 (Pubitemid 37443870)
    • (2003) Autoimmunity Reviews , vol.2 , Issue.1 , pp. 36-42
    • Bai, J.1    Odin, J.A.2
  • 49
    • 80755180853 scopus 로고    scopus 로고
    • Beginnings of a good apoptotic meal: The find-me and eat-me signaling pathways
    • Ravichandran KS (2011) Beginnings of a good apoptotic meal: the find-me and eat-me signaling pathways. Immunity 35:445-455
    • (2011) Immunity , vol.35 , pp. 445-455
    • Ravichandran, K.S.1
  • 50
    • 34447092921 scopus 로고    scopus 로고
    • Intrahepatic expression of the co-stimulatory molecules programmed death-1, and its ligands in autoimmune liver disease
    • DOI 10.1111/j.1440-1827.2007.02129.x
    • Oikawa T, Takahashi H, Ishikawa T et al (2007) Intrahepatic expression of the co-stimulatory molecules programmed death-1, and its ligands in autoimmune liver disease. Pathol Int 57:485-492 (Pubitemid 47030132)
    • (2007) Pathology International , vol.57 , Issue.8 , pp. 485-492
    • Oikawa, T.1    Takahashi, H.2    Ishikawa, T.3    Hokari, A.4    Otsuki, N.5    Azuma, M.6    Zeniya, M.7    Tajiri, H.8
  • 54
    • 0036143018 scopus 로고    scopus 로고
    • Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation
    • DOI 10.1172/JCI200211638
    • Huynh ML, Fadok VA, Henson PM (2002) Phosphatidylserinedependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J Clin Invest 109:41-50 (Pubitemid 34052540)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.1 , pp. 41-50
    • Huynh, M.-L.N.1    Fadok, V.A.2    Henson, P.M.3
  • 55
    • 0032519925 scopus 로고    scopus 로고
    • Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF
    • Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, Henson PM (1998) Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest 101:890-898 (Pubitemid 28096086)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.4 , pp. 890-898
    • Fadok, V.A.1    Bratton, D.L.2    Konowal, A.3    Freed, P.W.4    Westcott, J.Y.5    Henson, P.M.6
  • 56
    • 30044438392 scopus 로고    scopus 로고
    • Dampening inflammation
    • DOI 10.1038/ni1205-1179, PII N12051179
    • Henson PM (2005) Dampening inflammation. Nat Immunol 6:1179-1181 (Pubitemid 43045625)
    • (2005) Nature Immunology , vol.6 , Issue.12 , pp. 1179-1181
    • Henson, P.M.1
  • 57
    • 0028288510 scopus 로고
    • Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
    • Casciola-Rosen LA, Anhalt G, Rosen A (1994) Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 179:1317-1330 (Pubitemid 24091790)
    • (1994) Journal of Experimental Medicine , vol.179 , Issue.4 , pp. 1317-1330
    • Casciola-Rosen, L.A.1    Anhalt, G.2    Rosen, A.3
  • 58
    • 0029789073 scopus 로고    scopus 로고
    • Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)- mediated T cell apoptosis
    • Casiano CA, Martin SJ, Green DR, Tan EM (1996) Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis. J Exp Med 184:765-770 (Pubitemid 26324132)
    • (1996) Journal of Experimental Medicine , vol.184 , Issue.2 , pp. 765-770
    • Casiano, C.A.1    Martin, S.J.2    Green, D.R.3    Tan, E.M.4
  • 59
    • 0028881847 scopus 로고
    • Dna-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis
    • Casciola-Rosen LA, Anhalt GJ, Rosen A (1995) DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J Exp Med 182:1625-1634
    • (1995) J Exp Med , vol.182 , pp. 1625-1634
    • Casciola-Rosen, L.A.1    Anhalt, G.J.2    Rosen, A.3
  • 60
    • 0034614894 scopus 로고    scopus 로고
    • A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to t cell areas of mesenteric lymph nodes
    • Huang FP, Platt N, Wykes M et al (2000) A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J Exp Med 191: 435-444
    • (2000) J Exp Med , vol.191 , pp. 435-444
    • Huang, F.P.1    Platt, N.2    Wykes, M.3
  • 61
    • 0034614897 scopus 로고    scopus 로고
    • Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
    • Sauter B, Albert ML, Francisco L, Larsson M, Somersan S, Bhardwaj N (2000) Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med 191:423-434
    • (2000) J Exp Med , vol.191 , pp. 423-434
    • Sauter, B.1    Albert, M.L.2    Francisco, L.3    Larsson, M.4    Somersan, S.5    Bhardwaj, N.6
  • 62
    • 34548654130 scopus 로고    scopus 로고
    • Triggering of dendritic cell responses after exposure to activated, but not resting, apoptotic pbmcs
    • Johansson U, Walther-Jallow L, Smed-Sorensen A, Spetz AL (2007) Triggering of dendritic cell responses after exposure to activated, but not resting, apoptotic PBMCs. J Immunol 179:1711-1720
    • (2007) J Immunol , vol.179 , pp. 1711-1720
    • Johansson, U.1    Walther-Jallow, L.2    Smed-Sorensen, A.3    Spetz, A.L.4
  • 64
    • 23444461619 scopus 로고    scopus 로고
    • Nuclear autoantigen translocation and autoantibody opsonization lead to increased dendritic cell phagocytosis and presentation of nuclear antigens: A novel pathogenic pathway for autoimmunity?
    • Frisoni L, McPhie L, Colonna L et al (2005) Nuclear autoantigen translocation and autoantibody opsonization lead to increased dendritic cell phagocytosis and presentation of nuclear antigens: a novel pathogenic pathway for autoimmunity? J Immunol 175: 2692-2701 (Pubitemid 41113885)
    • (2005) Journal of Immunology , vol.175 , Issue.4 , pp. 2692-2701
    • Frisoni, L.1    Mcphie, L.2    Colonna, L.3    Sriram, U.4    Monestier, M.5    Gallucci, S.6    Caricchio, R.7
  • 65
    • 33747380587 scopus 로고    scopus 로고
    • Dendritic cells pulsed with apoptotic cells activate self-reactive t-cells of lupus mice both in vitro and in vivo
    • Tzeng TC, Suen JL, Chiang BL (2006) Dendritic cells pulsed with apoptotic cells activate self-reactive T-cells of lupus mice both in vitro and in vivo. Rheumatology (Oxford) 45:1230-1237
    • (2006) Rheumatology (Oxford , vol.45 , pp. 1230-1237
    • Tzeng, T.C.1    Suen, J.L.2    Chiang, B.L.3
  • 66
    • 39549115685 scopus 로고    scopus 로고
    • The causes of primary biliary cirrhosis: Convenient and inconvenient truths
    • DOI 10.1002/hep.22042
    • Gershwin ME, Mackay IR (2008) The causes of primary biliary cirrhosis: convenient and inconvenient truths. Hepatology 47:737-745 (Pubitemid 351280742)
    • (2008) Hepatology , vol.47 , Issue.2 , pp. 737-745
    • Gershwin, M.E.1    Mackay, I.R.2
  • 67
    • 10644262224 scopus 로고    scopus 로고
    • Sidechain biology and the immunogenicity of PDC-E2, the major autoantigen of primary biliary cirrhosis
    • DOI 10.1002/hep.20491
    • Mao TK, Davis PA, Odin JA, Coppel RL, Gershwin ME (2004) Sidechain biology and the immunogenicity of PDC-E2, the major autoantigen of primary biliary cirrhosis. Hepatology 40:1241-1248 (Pubitemid 39656995)
    • (2004) Hepatology , vol.40 , Issue.6 , pp. 1241-1248
    • Mao, T.K.1    Davis, P.A.2    Odin, J.A.3    Coppel, R.L.4    Gershwin, M.E.5
  • 68
    • 0029892610 scopus 로고    scopus 로고
    • Use of a designer triple expression hybrid clone for three different lipoyl domains for the detection of antimitochondrial autoantibodies
    • DOI 10.1053/jhep.1996.v24.pm0008707289
    • Moteki S, Leung PS, Coppel RL et al (1996) Use of a designer triple expression hybrid clone for three different lipoyl domain for the detection of antimitochondrial autoantibodies. Hepatology 24:97-103 (Pubitemid 26249419)
    • (1996) Hepatology , vol.24 , Issue.1 , pp. 97-103
    • Moteki, S.1    Leung, P.S.C.2    Coppel, R.L.3    Dickson, E.R.4    Kaplan, M.M.5    Munoz, S.6    Gershwin, M.E.7
  • 69
    • 0029929326 scopus 로고    scopus 로고
    • Epitope mapping and reactivity of autoantibodies to the e2 component of 2-oxoglutarate dehydrogenase complex in primary biliary cirrhosisusing recombinant 2-oxoglutarate dehydrogenase complex
    • Moteki S, Leung PS, Dickson ER et al (1996) Epitope mapping and reactivity of autoantibodies to the E2 component of 2-oxoglutarate dehydrogenase complex in primary biliary cirrhosisusing recombinant 2-oxoglutarate dehydrogenase complex. Hepatology 23:436-444
    • (1996) Hepatology , vol.23 , pp. 436-444
    • Moteki, S.1    Leung, P.S.2    Dickson, E.R.3
  • 70
    • 0034927079 scopus 로고    scopus 로고
    • Detection of antimitochondrial autoantibodies in immunofluorescent AMA-negative patients with primary biliary cirrhosis using recombinant autoantigens
    • DOI 10.1053/jhep.2001.26514
    • Miyakawa H, Tanaka A, Kikuchi K et al (2001) Detection of antimitochondrial autoantibodies in immunofluorescent AMAnegative patients with primary biliary cirrhosis using recombinant autoantigens. Hepatology 34:243-248 (Pubitemid 32702335)
    • (2001) Hepatology , vol.34 , Issue.2 , pp. 243-248
    • Miyakawa, H.1    Tanaka, A.2    Kikuchi, K.3    Matsushita, M.4    Kitazawa, E.5    Kawaguchi, N.6    Fujikawa, H.7    Gershwin, M.E.8
  • 73
    • 77958150189 scopus 로고    scopus 로고
    • Pbc screen: An igg/iga dual isotype elisa detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis
    • Liu H, Norman GL, Shums Z et al (2010) PBC screen: an IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis. J Autoimmun 35:436-442
    • (2010) J Autoimmun , vol.35 , pp. 436-442
    • Liu, H.1    Norman, G.L.2    Shums, Z.3
  • 74
    • 75149135547 scopus 로고    scopus 로고
    • A comprehensive evaluation of serum autoantibodies in primary biliary cirrhosis
    • Agmon-Levin N, Shapira Y, Selmi C et al (2010) A comprehensive evaluation of serum autoantibodies in primary biliary cirrhosis. J Autoimmun 34:55-58
    • (2010) J Autoimmun , vol.34 , pp. 55-58
    • Agmon-Levin, N.1    Shapira, Y.2    Selmi, C.3
  • 75
    • 77955761951 scopus 로고    scopus 로고
    • Primary biliary cirrhosis: What do autoantibodies tell us?
    • Hu CJ, Zhang FC, Li YZ, Zhang X (2010) Primary biliary cirrhosis: what do autoantibodies tell us? World J Gastroenterol 16:3616-3629
    • (2010) World J Gastroenterol , vol.16 , pp. 3616-3629
    • Hu, C.J.1    Zhang, F.C.2    Li, Y.Z.3    Zhang, X.4
  • 77
    • 37749042361 scopus 로고    scopus 로고
    • Quality of life and everyday activities in patients with primary biliary cirrhosis
    • Selmi C, Gershwin ME, Lindor KD et al (2007) Quality of life and everyday activities in patients with primary biliary cirrhosis. Hepatology 46:1836-1843
    • (2007) Hepatology , vol.46 , pp. 1836-1843
    • Selmi, C.1    Gershwin, M.E.2    Lindor, K.D.3
  • 78
    • 67149095289 scopus 로고    scopus 로고
    • Primary biliary cirrhosis associated with hla, il12a, and il12rb2 variants
    • Hirschfield GM, Liu X, Xu C et al (2009) Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N Engl J Med 360:2544-2555
    • (2009) N Engl J Med , vol.360 , pp. 2544-2555
    • Hirschfield, G.M.1    Liu, X.2    Xu, C.3
  • 79
    • 77955088582 scopus 로고    scopus 로고
    • Genome-wide metaanalyses identify three loci associated with primary biliary cirrhosis
    • Liu X, Invernizzi P, Lu Y et al (2010) Genome-wide metaanalyses identify three loci associated with primary biliary cirrhosis. Nat Genet 42:658-660
    • (2010) Nat Genet , vol.42 , pp. 658-660
    • Liu, X.1    Invernizzi, P.2    Lu, Y.3
  • 81
    • 77954886757 scopus 로고    scopus 로고
    • Il12a, mphosph9/cdk2ap1 and rgs1 are novel multiple sclerosis susceptibility loci
    • International Multiple Sclerosis Genetics Consortium (IMSGC
    • International Multiple Sclerosis Genetics Consortium (IMSGC) (2010) IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. Genes Immun 11:397-405
    • (2010) Genes Immun , vol.11 , pp. 397-405
  • 86
    • 0028905099 scopus 로고
    • Hla drb4 0101-restricted immunodominant t cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: Evidence of molecular mimicry in human autoimmune diseases
    • Shimoda S, Nakamura M, Ishibashi H, Hayashida K, Niho Y (1995) HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases. J Exp Med 181:1835-1845
    • (1995) J Exp Med , vol.181 , pp. 1835-1845
    • Shimoda, S.1    Nakamura, M.2    Ishibashi, H.3    Hayashida, K.4    Niho, Y.5
  • 87
    • 0028936405 scopus 로고
    • Heterogeneity of autoreactive t cell clones specific for the e2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis
    • Van de Water J, Ansari A, Prindiville T et al (1995) Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis. J Exp Med 181:723-733
    • (1995) J Exp Med , vol.181 , pp. 723-733
    • Van De Water, J.1    Ansari, A.2    Prindiville, T.3
  • 90
    • 46249110385 scopus 로고    scopus 로고
    • Adoptive transfer of cd8(+) t cells from transforming growth factor beta receptor type ii (dominant negative form) induces autoimmune cholangitis in mice
    • Yang GX, Lian ZX, Chuang YH et al (2008) Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice. Hepatology 47:1974-1982
    • (2008) Hepatology , vol.47 , pp. 1974-1982
    • Yang, G.X.1    Lian, Z.X.2    Chuang, Y.H.3
  • 93
    • 80053294958 scopus 로고    scopus 로고
    • Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive t cells in human patients with primary biliary cirrhosis
    • Tsuda M, Ambrosini YM, Zhang Wet al (2011) Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis. Hepatology 54:1293-1302
    • (2011) Hepatology , vol.54 , pp. 1293-1302
    • Tsuda, M.1    Ambrosini, Y.M.2    Zhang, W.3
  • 94
    • 0034953329 scopus 로고    scopus 로고
    • Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis
    • DOI 10.1172/JCI200110716
    • Odin JA, Huebert RC, Casciola-Rosen L, LaRusso NF, Rosen A (2001) Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis. J Clin Invest 108:223-232 (Pubitemid 32656246)
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.2 , pp. 223-232
    • Odin, J.A.1    Huebert, R.C.2    Casciola-Rosen, L.3    LaRusso, N.F.4    Rosen, A.5
  • 95
    • 0031005366 scopus 로고    scopus 로고
    • Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis
    • Koga H, Sakisaka S, Ohishi M, Sata M, Tanikawa K (1997) Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis. Hepatology 25:1077-1084 (Pubitemid 27199930)
    • (1997) Hepatology , vol.25 , Issue.5 , pp. 1077-1084
    • Koga, H.1    Sakisaka, S.2    Ohishi, M.3    Sata, M.4    Tanikawa, K.5
  • 96
    • 0030663215 scopus 로고    scopus 로고
    • Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis
    • Harada K, Ozaki S, Gershwin ME, Nakanuma Y (1997) Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis. Hepatology 26:1399-1405 (Pubitemid 27520002)
    • (1997) Hepatology , vol.26 , Issue.6 , pp. 1399-1405
    • Harada, K.1    Ozaki, S.2    Gershwin, M.E.3    Nakanuma, Y.4
  • 98
    • 0031725616 scopus 로고    scopus 로고
    • Cell-kinetic study of proliferating bile ductules in various hepatobiliary diseases
    • Harada K, Kono N, Tsuneyama K, Nakanuma Y (1998) Cellkinetic study of proliferating bile ductules in various hepatobiliary diseases. Liver 18:277-284 (Pubitemid 28438536)
    • (1998) Liver , vol.18 , Issue.4 , pp. 277-284
    • Harada, K.1    Kono, N.2    Tsuneyama, K.3    Nakanuma, Y.4
  • 99
    • 0035064187 scopus 로고    scopus 로고
    • Increased expression of WAF1 in intrahepatic bile ducts in primary biliary cirrhosis relates to apoptosis
    • DOI 10.1016/S0168-8278(00)00075-1, PII S0168827800000751
    • Harada K, Furubo S, Ozaki S, Hiramatsu K, Sudo Y, Nakanuma Y (2001) Increased expression of WAF1 in intrahepatic bile ducts in primary biliary cirrhosis relates to apoptosis. J Hepatol 34:500-506 (Pubitemid 32328505)
    • (2001) Journal of Hepatology , vol.34 , Issue.4 , pp. 500-506
    • Harada, K.1    Furubo, S.2    Ozaki, S.3    Hiramatsu, K.4    Sudo, Y.5    Nakanuma, Y.6
  • 100
    • 0038170271 scopus 로고    scopus 로고
    • Combined analysis of the effect of treatment with ursodeoxycholic acid on histologic progression in primary biliary cirrhosis
    • DOI 10.1016/S0168-8278(03)00192-2
    • Poupon RE, Lindor KD, Pares A, Chazouilleres O, Poupon R, Heathcote EJ (2003) Combined analysis of the effect of treatment with ursodeoxycholic acid on histologic progression in primary biliary cirrhosis. J Hepatol 39:12-16 (Pubitemid 36724102)
    • (2003) Journal of Hepatology , vol.39 , Issue.1 , pp. 12-16
    • Poupon, R.E.1    Lindor, K.D.2    Pares, A.3    Chazouilleres, O.4    Poupon, R.5    Heathcote, E.J.6
  • 101
    • 14944361288 scopus 로고    scopus 로고
    • The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis
    • DOI 10.1053/j.gastro.2004.11.009
    • Corpechot C, Carrat F, Bahr A, Chretien Y, Poupon RE, Poupon R (2005) The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis. Gastroenterology 128:297-303 (Pubitemid 40431083)
    • (2005) Gastroenterology , vol.128 , Issue.2 , pp. 297-303
    • Corpechot, C.1    Carrat, F.2    Bahr, A.3    Chretien, Y.4    Poupon, R.-E.5    Poupon, R.6
  • 102
    • 0025876404 scopus 로고
    • A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. Udca-pbc study group
    • Poupon RE, Balkau B, Eschwege E, Poupon R (1991) A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC Study Group. N Engl J Med 324: 1548-1554
    • (1991) N Engl J Med , vol.324 , pp. 1548-1554
    • Poupon, R.E.1    Balkau, B.2    Eschwege, E.3    Poupon, R.4
  • 104
    • 0032525819 scopus 로고    scopus 로고
    • A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation
    • Rodrigues CM, Fan G, Ma X, Kren BT, Steer CJ (1998) A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. J Clin Invest 101:2790-2799 (Pubitemid 28294588)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.12 , pp. 2790-2799
    • Rodrigues, C.M.P.1    Fan, G.2    Ma, X.3    Kren, B.T.4    Steer, C.J.5
  • 106
    • 75449104123 scopus 로고    scopus 로고
    • Diagnosis and management of primary sclerosing cholangitis
    • Chapman R, Fevery J, Kalloo A et al (2010) Diagnosis and management of primary sclerosing cholangitis. Hepatology 51: 660-678
    • (2010) Hepatology , vol.51 , pp. 660-678
    • Chapman, R.1    Fevery, J.2    Kalloo, A.3
  • 107
    • 0025801192 scopus 로고
    • Relationship of inflammatory bowel disease and primary sclerosing cholangitis
    • Fausa O, Schrumpf E, Elgjo K (1991) Relationship of inflammatory bowel disease and primary sclerosing cholangitis. Semin Liver Dis 11:31-39
    • (1991) Semin Liver Dis , vol.11 , pp. 31-39
    • Fausa, O.1    Schrumpf, E.2    Elgjo, K.3
  • 109
    • 70349569615 scopus 로고    scopus 로고
    • The immunobiology of primary sclerosing cholangitis
    • Aron JH, Bowlus CL (2009) The immunobiology of primary sclerosing cholangitis. Semin Immunopathol 31:383-397
    • (2009) Semin Immunopathol , vol.31 , pp. 383-397
    • Aron, J.H.1    Bowlus, C.L.2
  • 110
    • 0029979464 scopus 로고    scopus 로고
    • Elevation of γdelta T lymphocytes in peripheral blood and livers of patients with primary sclerosing cholangitis and other autoimmune liver diseases
    • DOI 10.1053/jhep.1996.v23.pm0008621180
    • Martins EB, Graham AK, Chapman RW, Fleming KA (1996) Elevation of gamma delta T lymphocytes in peripheral blood and livers of patients with primary sclerosing cholangitis and other autoimmune liver diseases. Hepatology 23:988-993 (Pubitemid 26137037)
    • (1996) Hepatology , vol.23 , Issue.5 , pp. 988-993
    • Martins, E.B.G.1    Graham, A.K.2    Chapman, R.W.3    Fleming, K.A.4
  • 113
    • 0027191429 scopus 로고
    • In situ end-labelling detects DNA strand breaks in apoptosis and other physiological and pathological states
    • Ansari B, Coates PJ, Greenstein BD, Hall PA (1993) In situ end-labelling detects DNA strand breaks in apoptosis and other physiological and pathological states. J Pathol 170:1-8 (Pubitemid 23130577)
    • (1993) Journal of Pathology , vol.170 , Issue.1 , pp. 1-8
    • Ansari, B.1    Coates, P.J.2    Greenstein, B.D.3    Hall, P.A.4
  • 114
    • 0031942516 scopus 로고    scopus 로고
    • Characterization of the inflammatory infiltrate in autoimmune cholangitis. A morphological and immunhistochemical study
    • DOI 10.1007/s004280050158
    • Kaserer K et al (1998) Characterization of the inflammatory infiltrate autoimmune cholangitis. A morphological and immunhistochemical study. Virchows Arch 432(3):217-222 (Pubitemid 28134871)
    • (1998) Virchows Archiv , vol.432 , Issue.3 , pp. 217-222
    • Kaserer, K.1    Exner, M.2    Mosberger, I.3    Penner, E.4    Wrba, F.5


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