Epitope mapping and reactivity of autoantibodies to the E2 component of 2-oxoglutarate dehydrogenase complex in primary biliary cirrhosis using recombinant 2-oxoglutarate dehydrogenase complex

Hepatology

Volumn 23, Issue 3, 1996, Pages 436-444

  Moteki, Sekio ^a   Leung, Patrick S C ^a   Rolland Dickson, E ^b   Van Thiel, David H ^c   Galperin, Claudio ^a   Buch, Thorsten ^a   Alarcon Segovia, Donato ^d   Kershenobich, David ^d   Kawano, Kinya ^e   Coppel, Ross L ^f   Matuda, Sadayuki ^g   Eric Gershwin, M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MAYO CLINIC   (United States)

^c INTEGRIS BAPTIST MEDICAL CENTER   (United States)

^d Institut Nal De Nutricion

^e NIHON UNIVERSITY   (Japan)

^f MONASH UNIVERSITY   (Australia)

^g NATIONAL INSTITUTE OF FITNESS AND SPORTS IN KANOYA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; HYBRID PROTEIN; OXOGLUTARATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE;

AMINO ACID SEQUENCE; ANTIGENICITY; ARTICLE; BILIARY CIRRHOSIS; EPITOPE MAPPING; HEART MITOCHONDRION; HUMAN; MAJOR CLINICAL STUDY; PATHOGENESIS; PRIORITY JOURNAL;

ANIMALS; ANTIGEN-ANTIBODY REACTIONS; AUTOANTIBODIES; AUTOANTIGENS; BASE SEQUENCE; EPITOPES; HUMANS; IMMUNOBLOTTING; KETOGLUTARATE DEHYDROGENASE COMPLEX; LIVER CIRRHOSIS, BILIARY; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; RATS; RECOMBINANT FUSION PROTEINS;

EID: 0029929326     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510230307     Document Type: Article

References (6)

1. Kaplan MM. Primary biliary cirrhosis. Adv Intern Med 1987;32:359-377.
2. Walker JG, Doniach D, Roitt IM, Sherlock S. Serological tests in diagnosis of primary biliary cirrhosis. Lancet 1965;1:827-831.
3. Gershwin ME, Coppel RL, Mackay IR. Primary biliary cirrhosis and mitochondrial autoantigen-insights from molecular biology. HEPATOLOGY 1988;8:147-151.
4. Yeaman SJ, Fussey SPM, Danner DJ, James OFW, Mutimer DJ, Bassendine MF. Primary biliary cirrhosis: identification of two major M2 mitochondrial autoantigens. Lancet 1988;1:1067-1070.
5. Van de Water J, Fregeau D, Davis P, Ansari A, Danner D, Leung P, Coppel R, et al. Autoantibodies of primary biliary cirrhosis recognize dihydrolipoamide acetyltransferase and inhibit enzyme function. J Immunol 1988;141:2321-2324.
6. Fussey SPM, Guest JR, James OFW, Bassendine MF, Yeaman SJ. Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis. Proc Natl Acad Sci U S A 1988; 85:8654-8658.