Bile duct epithelia as target cells in primary biliary cirrhosis and primary sclerosing cholangitis

Virchows Archiv

Volumn 431, Issue 2, 1997, Pages 119-124

  Dienes, H P ^a   Lohse, A W ^b   Gerken, G ^b   Schirmacher, P ^b   Gallati, H ^c   Lohr H F ^b   Meyer Zum Buschenfelde K H ^b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Epithelial cells as immune targets; Immunopathology of bile ducts; T lymphozyte subtyping

Indexed keywords

B7 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; FAS ANTIGEN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3;

ARTICLE; AUTOIMMUNITY; BASEMENT MEMBRANE; BILE DUCT; BILE DUCT ATRESIA; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; HELPER CELL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOLOGY; MALE; PRIMARY BILIARY CIRRHOSIS; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; T LYMPHOCYTE; TARGET CELL;

ANTIGENS, CD; AUTOIMMUNE DISEASES; BILE DUCTS; CHOLANGITIS, SCLEROSING; CYTOKINES; EPITHELIUM; FEMALE; HLA ANTIGENS; HUMANS; IMMUNITY, CELLULAR; LIVER CIRRHOSIS, BILIARY; MALE; T-LYMPHOCYTES;

EID: 0030825092     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004280050077     Document Type: Article

References (20)

1. Adams DH, Hubscher SG, Shaw J, Johnson GD, Babbs C, Rothlein R, Neuberger JM (1991) Increased expression of intercellular adhesion molecule 1 on bile ducts in primary biliary cirrhosis and primary sclerosing cholangitis. Hepatology 14:426-431
2. Autschbach F, Meuer SC, Moebius U, Manns M, Hess G, Meyer zum Büschenfelde K-H, Thoenes W, Dienes H-P (1991) Hepatocellular expression of lymphocyte function-associated antigen 3 in chronic hepatitis. Hepatology 14:223-230
3. Berke G (1994) The functions and mechanisms of action of cytolytic lymphocytes. In: Paul WE (ed) Fundamental immunology. Raven Press, New York
4. Björkland A, Festin R, Mendel-Hartvig I, Nyberg A, Lööf L, Totterman TH (1991) Blood and liver-infiltrating lymphocytes in primary biliary cirrhosis: increase in activated T and natural killer cells and recruitment of primed memory T cells. Hepatology 113:1106-1111
5. Bloom S, Fleming K, Chapman R (1995) Adhesion molecule expression in primary sclerosing cholangitis and primary biliary cirrhosis. Gut 36:604-609
6. Dienes HP, Hess G, Wörsdörfer M, Rossol S, Gallati H, Ramadori G, Meyer zum Büschenfelde KH (1991) Ultrastructural localization of Interferon producing cells in the liver of patients with chronic hepatitis B. Hepatology 13:321-326
7. Freilich BL, Hu K-Q, Vierling JM (1994) Immunopathogenesis of autoimmune hepatobiliary diseases. Liver 10:257-268
8. Hata K, Van Thiel DH, Herberman RB, Whiteside TL (1992) Phenotypic and functional characteristics of lymphocytes isolated from liver biopsy specimens from patients with active liver disease. Hepatology 15:816-823
9. Janeway CA Jr, Bottomly K (1994) Signals and signs for lymphocyte responses. Cell 76:275-285
10. Krams SM, Van de Water J, Coppel RL, Esquivel C, Roberts J, Ansari A, Gershwin ME (1990) Analysis of hepatic T lymphocyte and immunoglobulin deposits in patients with primary biliary cirrhosis. Hepatology 12:306-313
11. Leon MP, Kirby JA, Gibbs P, Burt AD, Bassendine MF (1995) Immunogenicity of biliary epithelial cells: study of the expression of B7 molecules. J Hepatol 22:591-595
12. Löhr H, Fleischer B, Gerken G, Yeamann SJ, Meyer zum Büschenfelde KH (1993) Autoreactive liver infiltrating T cells in primary biliary cirrhosis recognize inner mitochondrial epitopoes and the pyruvate dehydrogenase complex. J Hepatol 18:322-327
13. Löhr HF, Schlaak JF, Gerken F, Fleischer B, Dienes H-P, Meyer zum Büschenfelde K-H (1994) Phenotypical analysis and cytokine release of liver-infiltrating and peripheral blood T lymphocytes from patients with chronic hepatitis of different etiology. Liver 14:161-166
14. Nakanuma Y (1993) Distribution of B lymphocytes in nonsuppurative cholangitis in primary biliary cirrhosis. Hepatology 18:570-575
15. Okazaki M, Hino K, Fujii K, Hanada H, Nakanishi Y, Kanazawa S, Kobayashi N, Okita K (1995) Immunohistochemical study of Fas antigen in liver of patients with chronic hepatitis and autoimmune liver disease. Int Hepatol Comm 3:285
16. Scheuer PJ, Lefkowitch JH (1994) Liver biopsy interpretation. WB Saunders, London
17. Spengler U, Moller A, Jung M, Messer G, Weiss EH (1992) T lymphocytes from patients with primary biliary cirrhosis produce reduced amounts of lymphotoxin, tumor necrosis factor and interferon-γ upon mitogen stimulation. J Hepatol 15:129-135
18. Van de Water J, Turchany J, Leung PSC, Lake J, Munoz S, Surh CD, Coppel R, Ansari A, Nakanuma Y, Gershwin ME (1993) Molecular mimicry in primary biliary cirrhosis. J Clin Invest 91:2653-2664
19. Yamada G, Hyodo I, Tobe K, Mizuno M, Nishihara T, Kobayashi T, Nagashima H (1986) Ultrastructural immunocytochemical analysis of lymphocytes infiltrating bile duct epithelia in primary biliary cirrhosis. Hepatology 6:385-391
20. Yasoshima M, Nakanuma Y, Tsuneyama K, Van de Water J, Gershwin ME (1995) Immunohistochemical analysis of adhesion molecules in the micro-environment of portal tracts in relation to aberrant expression of PDC-E2 and HLA-DR on the bile ducts in primary biliary cirrhosis. J Pathol 175:319-325