Apoptotic cell death takes its toll

Hepatology

Volumn 46, Issue 5, 2007, Pages 1323-1325

  Torok, Natalie J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; CASPASE 9; DNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROCOLLAGEN; PROCOLLAGEN ALPHA 1; TOLL LIKE RECEPTOR 9; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; COLLAGEN TYPE 1; CYTIDINE PHOSPHATE GUANOSINE DNA; GALACTOSAMINE; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR;

APOPTOSIS; CELL DEATH; CHRONIC LIVER DISEASE; CPG ISLAND; EDITORIAL; EXTRACELLULAR SPACE; HOMEOSTASIS; IMMUNE RESPONSE; LIVER INJURY; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; ANTIGEN PRESENTING CELL; CELL TRANSDIFFERENTIATION; CYTOKINE PRODUCTION; ENDOPLASMIC RETICULUM; FIBROGENESIS; HUMAN; LIVER CELL; MACROPHAGE; PHAGOCYTE; PHENOTYPE; PLASMACYTOID DENDRITIC CELL; SIGNAL TRANSDUCTION; STELLATE CELL;

ANIMALS; APOPTOSIS; CALCIUM SIGNALING; HUMANS; LIVER; LIVER CIRRHOSIS; OLIGODEOXYRIBONUCLEOTIDES; TOLL-LIKE RECEPTOR 9;

EID: 36348931523     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.21968     Document Type: Editorial

References (25)

1. Fadok VA, Henson PM. Apoptosis: getting rid of the bodies. Curr Biol 1998;8:R693-R695.
2. Fadok VA, Chimini G. The phagocytosis of apoptotic cells. Semin Immunol 2001;13:365-372.
3. Robak E, Sysa-Jedrzejowska A, Robak T, Smolewski P. Peripheral blood lymphocyte apoptosis and circulating dendritic cells in patients with systemic lupus erythematosus: correlation with immunological status and disease-related symptoms. Clin Rheumatol 2006;25:225-233.
4. Sidransky D. Circulating DNA. What we know and what we need to learn. Ann N Y Acad Sci 2000;906:1-4.
5. Stroun M, Maurice P, Vasioukhin V, Lyautey J, Lederrey C, Lefort F, et al. The origin and mechanism of circulating DNA. Ann N Y Acad Sci 2000;906:161-168.
6. Sheriff A, Gaipl US, Voll RE, Kalden JR, Herrmann M. Apoptosis and systemic lupus erythematosus. Rheum Dis Clin North Am 2004;30:505-527, viii-ix.
7. Sekigawa I, Kawasaki M, Ogasawara H, Kaneda K, Kaneko H, Takasaki Y, et al. DNA methylation: its contribution to systemic lupus erythematosus. Clin Exp Med 2006;6:99-106.
8. Wagner H. The immunobiology of the TLR9 subfamily. Trends Immunol 2004;25:381-386.
9. Benigni A, Caroli C, Longaretti L, Gagliardini E, Zoja C, Galbusera M, et al. Involvement of renal tubular Toll-like receptor 9 in the development of tubulointerstitial injury in systemic lupus. Arthritis Rheum 2007;56:1569-1578.
10. Anders HJ, Schlondorff D. Toll-like receptors: emerging concepts in kidney disease. Curr Opin Nephrol Hypertens 2007;16:177-183.
11. Tian J, Avalos AM, Mao SY, Chen B, Senthil K, Wu H, et al. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol 2007;8:487-496.
12. Karrar A, Broome U, Sodergren T, Jaksch M, Bergquist A, Bjornstedt M, et al. Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis. Gastroenterology 2007;132:1504-1514.
13. Moritoki Y, Lian ZX, Wulff H, Yang GX, Chuang YH, Lan RY, et al. AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers. HEPATOLOGY 2007;45:314-322.
14. Yi AK, Yoon H, Park JE, Kim BS, Kim HJ, Martinez-Hernandez A. CpG DNA-mediated induction of acute liver injury in D-galactosamine-sensitized mice: the mitochondrial apoptotic pathway-dependent death of hepatocytes. J Biol Chem 2006;281:15001-15012.
15. Zhan SS, Jiang JX, Wu J, Halsted C, Friedman SL, Zern MA, et al. Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo. HEPATOLOGY 2006;43:435-443.
16. Canbay A, Taimr P, Torok N, Higuchi H, Friedman S, Gores GJ. Apoptotic body engulfment by a human stellate cell line is profibrogenic. Lab Invest 2003;83:655-663.
17. Watanabe A, Hashmi A, Gomes DA, Town T, Badou A, Flavell RA, et al. Apoptotic Hepatocyte DNA Inhibits Hepatic Stellate Cell Chemotaxis via TLR9. HEPATOLOGY 2007;46. DOI: 10.1002/hep.21867.
18. Melton AC, Yee HF. Hepatic stellate cell protrusions couple platelet-derived growth factor-BB to chemotaxis. HEPATOLOGY 2007;45:1446-1453.
19. Pinzani M. PDGF and signal transduction in hepatic stellate cells. Front Biosci 2002;7:d1720-d1726.
20. Hashmi AZ, Hakim W, Kruglov EA, Watanabe A, Watkins W, Dranoff JA, et al. Adenosine inhibits cytosolic calcium signals and chemotaxis in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2007;292:G395-G401.
21. Winau F, Hegasy G, Weiskirchen R, Weber S, Cassan C, Sieling PA, et al. Ito cells are liver-resident antigen-presenting cells for activating T cell responses. Immunity 2007;26:117-129.
22. Takeuchi O, Akira S. Toll-like receptors; their physiological role and signal transduction system. Int Immunopharmacol 2001;1:625-635.
23. Anders HJ, Vielhauer V, Eis V, Linde Y, Kretzler M, Perez de Lema G, et al. Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice. FASEB J 2004;18:534-536.
24. Latz E, Schoenemeyer A, Visintin A, Fitzgerald KA, Monks BG, Knetter CF, et al. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol 2004;5:190-198.
25. Doyle SE, O'Connell RM, Miranda GA, Vaidya SA, Chow EK, Liu PT, et al. Toll-like receptors induce a phagocytic gene program through p38. J Exp Med 2004;199:81-90.