Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis

Journal of Clinical Investigation

Volumn 102, Issue 10, 1998, Pages 1831-1840

  Shimoda, Shinji ^a,b   Van De Water, Judy ^a   Ansari, Aftab ^c   Nakamura, Minoru ^b   Ishibashi, Hiromi ^b   Coppel, Ross L ^d   Lake, Jack ^e   Keeffe, Emmet B ^f   Roche, Thomas E ^g   Gershwin, M Eric ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KYUSHU UNIVERSITY   (Japan)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MONASH UNIVERSITY   (Australia)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^g KANSAS STATE UNIVERSITY   (United States)

Author keywords

Autoreactive T cells; Epitopes; Liver; Primary biliary cirrhosis; Pyruvate dehydrogenase

Indexed keywords

AUTOANTIGEN; EPITOPE; MITOCHONDRION ANTIBODY; PYRUVATE DEHYDROGENASE;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EPITOPE MAPPING; FEMALE; HUMAN; HUMAN CELL; LIVER MITOCHONDRION; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 7844229417     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI4213     Document Type: Article

References (43)

1. Kaplan, M.M. 1996. Primary biliary cirrhosis. N. Engl. J. Med. 21:1570-1580.
2. Gershwin, M.E., I.R. Mackay, A. Sturgess, and R.L. Coppel. 1987. Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis. J. Immunol. 138:3525-3531.
3. Yeaman, S.J., S.P. Fussey, D.J. Danner, O.F. James, D.J. Mutimer, and M.F. Bassendine. 1988. Primary biliary cirrhosis: identification of two major M2 mitochondrial autoantigens. Lancet. 1:1067-1070.
4. Coppel, R.L., L.J. McNeilage, C.D. Surh, J. Van de Water, T.W. Spithill, S. Whittingham, and M.E. Gershwin. 1988. Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase. Proc. Natl. Acad. Sci. USA. 85:7317-7321.
5. Fussey, S.P., J.R. Guest, O.F. James, M.F. Bassendine, and S.J. Yeaman. 1988. Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis. Proc. Nad. Acad. Sci. USA. 85:8654-8658.
6. Van de Water, J., M.E. Gershwin, P. Leung, A. Ansari, and R.L. Coppel. 1988. The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase. J. Exp. Med. 167:1791-1799.
7. Fussey, S.P., S.T. Ali, J.R. Guest, O.F. James, M.F. Bassendine, and S.J. Yeaman. 1990. Reactivity of primary biliary cirrhosis sera with Escherichia coli dihydrolipoamide acetyltransferase (E2p): characterization of the main immunogenic region. Proc. Natl. Acad. Sci. USA. 87:3987-3991.
8. Matsui, M., M. Nakamura, H. Ishibashi, K. Koike, J. Kudo, and Y. Niho. 1993. Human monoclonal antibodies from a patient with primary biliary cirrhosis that recognize two distinct autoepitopes in the E2 component of the pyruvate dehydrogenase complex. Hepatology. 18:1069-1077.
9. Fregeau, D.R., T. Prindiville, R.L. Coppel, M. Kaplan, E.R. Dickson, and M.E. Gershwin. 1990. Inhibition of alpha-ketoglutarate dehydrogenase activity by a distinct population of autoantibodies recognizing dihydrolipoamide succinyltransferase in primary biliary cirrhosis. Hepatology. 11:975-981.
10. Moteki, S., P.S.C. Leung, E.R. Dickson, D.H. Van Thiel, C. Galperin, T. Buch, D. Alarcon-Segovia, D. Kershenobich, K. Kawano, R.L. Coppel, et al. 1996. Epitope mapping and reactivity of autoantibodies to the E2 component of 2-oxoglutarate dehydrogenase complex (OGDC-E2) in primary biliary cirrhosis using recombinant OGDC-E2. Hepatology. 23:436-444.
11. Nakanuma, Y., and N. Kono. 1991. Expression of HLA-DR antigens on interlobular bile ducts in primary biliary cirrhosis and other hepatobiliary diseases: an immunohistochemical study. Hum. Pathol. 22:431-436.
12. Ballardini, G., R. Mirakian, F.B. Bianchi, E. Pisi, D. Doniach, and G.F. Bottazzo. 1984. Aberrant expression of HLA-DR antigens on bile duct epithelium in primary biliary cirrhosis: relevance to pathogenesis. Lancet. 2:1009-1013.
13. Krams, S.M., J. Van de Water, R.L. Coppel, C. Esquivel, J. Roberts, A. Ansari, and M.E. Gershwin. 1990. Analysis of hepatic T lymphocyte and immunoglobulin deposits in patients with primary biliary cirrhosis. Hepatology. 12: 306-313.
14. Van de Water, J., A. Ansari, T. Prindiville, R. Coppel, N. Ricalton, B.L. Kotzin, S. Liu, T.E. Roche, S.M. Krams, S. Munoz, et al. 1995. Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis. J. Exp. Med. 181:723-733.
15. Shimoda, S., M. Nakamura, H. Ishibashi, K. Hayashida, and Y. Niho. 1995. HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases. J. Exp. Med. 181:1835-1845.
16. Rahmatullah, M., S. Gopalakrishnan, P.C. Andrews, C.L. Chang, G.A. Radke, and T.E. Roche. 1989. Subunit associations in the mammalian pyruvate dehydrogenase complex. Structure and role of protein X and the pyruvate dehydrogenase component binding domain of the dihydrolipoyl transacetylase component. J. Biol. Chem. 264:2221-2228.
17. Roche, T.E., M. Rahmatullah, S. Liu, G.A. Radke, C.L. Chang, and S.L. Powers-Greenwood. 1989. Lipoyl-containing components of the pyruvate dehydrogenase complex: roles in modulating and anchoring the PDH kinase and the PDH phosphatase. Ann. NY Acad. Sci. 573:168-173.
18. Surh, C.D., A. Ahmed-Ansari, and M.E. Gershwin. 1990. Comparative epitope mapping of murine monoclonal and human autoantibodies to human PDH-E2, the major mitochondrial autoantigen of primary biliary cirrhosis. J. Immunol. 144:2647-2652.
19. Berzofsky, J.A., K.B. Cease, J.L. Cornette, J.L. Spouge, H. Margalit, I.J. Berkower, M.F. Good, L.H. Miller, and C. Delisi. 1987. Protein antigenic structures recognized by T cells: potential applications to vaccine design. Immunol. Rev. 98:9-52.
20. Zhang, J., S. Markovic-Plese, B. Lacet, J. Raus, H.L. Weiner, and D.A. Hafler. 1994. Increased frequency of IL-2 responsive T cells specific for myelin basic protein (MBP) and proteolipid protein (PLP) in peripheral blood and cerebrospinal fluid (CSF) of patients with multiple sclerosis. J. Exp. Med. 179:973-984.
21. Fey, K., I. Melchers, and K. Eichmann. 1983. Quantitative studies on T cell diversity. J. Exp. Med. 158:40-52.
22. Lefkovits, I., and H. Waldmann. 1984. Limiting dilution analysis of the cells of immune system. 1 and 2. The clonal basis of the immune response. Immunol. Today. 5:265-267.
23. Hemmer, B., B. Fleckenstein, M. Vergelli, G. Jung, H. McFarland, R. Martin, and K. Wiesmüller. 1997. Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone. J. Exp. Med. 185:1651-1659.
24. Wucherpfennig, K.W., and J.L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 80:695-705.
25. Coppel, R.L., and M.E. Gershwin. 1995. Primary biliary cirrhosis: the molecule and the mimic. Immunol. Rev. 144:17-49.
26. Lehmann, P.V., T. Forsthuber, A. Miller, and E.E. Sercarz. 1992. Spreading of T cell autoimmunity to cryptic determinants of autoantigens. Nature. 358:155-157.
27. Bieganowska. K.D., L.J. Ausubel, Y. Modabber, E. Slovik, W. Messersmith, and D.A. Hofler. 1997. Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease. J. Exp. Med. 185:1585-1594.
28. Cohen, I.R. 1992. The cognitive principle challenges clonal selection. Immunol. Today. 13:441-444.
29. Martin, R., D. Jaraquemada, M. Flerlage, J. Richert, J. Whitaker, E.O. Long, D.E. McFarlin, and H.F. McFarland. 1990. Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals. J. Immunol. 145:540-548.
30. Pette, M., K. Fujita, D. Wilkinson, D.M. Altmann, J. Trowsdale, G. Giegerich, A. Hinkkanen, J.T. Epplen, L. Kappos, and H. Wekerle. 1990. Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors. Proc. Natl. Acad. Sci. USA. 87:7968-7972.
31. + cells of myasthenia gravis patients and healthy subjects. J. Clin. Invest. 93:1020-1028.
32. Martin, R., M.D. Howell, D. Jaraquemada, M. Flerlage, J. Richert, S. Brostoff, E.O. Long, D.E. McFarlin, and H.F. McFarland. 1991. A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis. J. Exp. Med. 173:19-24.
33. + cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106. J. Immunol. 148:1359-1366.
34. Wucherpfennig, K.W., A. Sette, S. Southwood, C. Oseroff, M. Matsui, J.L. Strominger, and D.A. Hafler. 1994. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J. Exp. Med. 179:279-290.
35. Ota, K., M. Matsui, E.L. Milford, G.A. Mackin, H.L. Weiner, and D.A. Hafler. 1990. T cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature. 346:183-187.
36. Chou, Y.K., D.N. Bourdette, H. Offner, R. Whitham, R.Y. Wang, G.A. Gashim, and A.A. Vandenbark. 1992. Frequency on T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid.in multiple sclerosis. J. Neuroimmunol. 38:105-114.
37. Matsuno, K., T. Ezaki, S. Kudo, and Y. Uehara. 1996. A life stage of particle-laden rat dendritic cells in vivo: their terminal division, active phagocytosis, and translocation from the liver to the draining lymph. J. Exp. Med. 183: 1865-1878.
38. Guery, J.C., and L. Adorini. 1995. Dendritic cells are the most efficient in presenting endogeneous naturally processed self-epitopes to class II-restricted T cells. J. Immunol. 154:536-544.
39. Bjorkland, A., L. Loof, I. Mendel-Hartvig, and T.H. Totterman. 1994. Primary biliary cirrhosis. High proportions of B cells in blood and liver tissue produce anti-mitochondrial antibodies of several Ig classes. J. Immunol. 153: 2750-2757.
40. Lanzavecchia, A. 1985. Antigen-specific interaction between T and B cells. Nature. 314:537-539.
41. Lanzavecchia, A. 1990. Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes. Annu. Rev. Immunol. 8:773-793.
42. Surh, C.D., R. Coppel, and M.E. Gershwin. 1990. Structural requirement for autoreactivity on human pyruvate dehydrogenase-E2, the major autoantigen of primary biliary cirrhosis. Implication for a conformational autoepitope. J. Immunol. 144:3367-3374.
43. Wucherpfennig, K.W., I. Catz, S. Hausmann, J.L. Strominger, L. Steinman, and K.G. Warren. 1997. Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. J. Clin. Invest. 100:1114-1122.