-
1
-
-
79957871035
-
Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death
-
Abeti R, Abramov AY, Duchen MR (2011) Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death. Brain 34:1658-1672
-
(2011)
Brain
, vol.34
, pp. 1658-1672
-
-
Abeti, R.1
Abramov, A.Y.2
Duchen, M.R.3
-
2
-
-
0038452658
-
Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity
-
Abramov AY, Canevari L, Duchen MR (2003) Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity. J Neurosci 23:5088-5095
-
(2003)
J Neurosci
, vol.23
, pp. 5088-5095
-
-
Abramov, A.Y.1
Canevari, L.2
Duchen, M.R.3
-
3
-
-
1642499152
-
Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase
-
Abramov AY, Canevari L, Duchen MR (2004) Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J Neurosci 24:565-575
-
(2004)
J Neurosci
, vol.24
, pp. 565-575
-
-
Abramov, A.Y.1
Canevari, L.2
Duchen, M.R.3
-
4
-
-
10044244916
-
Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture
-
Abramov AY, Canevari L, Duchen MR (2004) Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture. Biochim Biophys Acta 1742:81-87
-
(2004)
Biochim Biophys Acta
, vol.1742
, pp. 81-87
-
-
Abramov, A.Y.1
Canevari, L.2
Duchen, M.R.3
-
5
-
-
27144531055
-
Expression and modulation of an NADPH oxidase in mammalian astrocytes
-
Abramov AY, Jacobson J, Wientjes F, Hothersall J, Canevari L, Duchen MR (2005) Expression and modulation of an NADPH oxidase in mammalian astrocytes. J Neurosci 25(40):9176-9184
-
(2005)
J Neurosci
, vol.25
, Issue.40
, pp. 9176-9184
-
-
Abramov, A.Y.1
Jacobson, J.2
Wientjes, F.3
Hothersall, J.4
Canevari, L.5
Duchen, M.R.6
-
6
-
-
33646380409
-
The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides
-
Abramov AY, Duchen MR (2005) The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides. Philos Trans R Soc Lond B Biol Sci 360:2309-2314
-
(2005)
Philos Trans R Soc Lond B Biol Sci
, vol.360
, pp. 2309-2314
-
-
Abramov, A.Y.1
Duchen, M.R.2
-
7
-
-
46349104861
-
Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity
-
Abramov AY, Duchen MR (2008) Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity. Biochim Biophys Acta 1777:953-964
-
(2008)
Biochim Biophys Acta
, vol.1777
, pp. 953-964
-
-
Abramov, A.Y.1
Duchen, M.R.2
-
8
-
-
79960338326
-
Membrane cholesterol content plays a key role in the neurotoxicity of b-amyloid: Implications for Alzheimer's disease
-
Abramov AY, Ionov M, Pavlov E, Duchen MR (2011) Membrane cholesterol content plays a key role in the neurotoxicity of b-amyloid: Implications for Alzheimer's disease. Aging Cell 10(4):595-603
-
(2011)
Aging Cell
, vol.10
, Issue.4
, pp. 595-603
-
-
Abramov, A.Y.1
Ionov, M.2
Pavlov, E.3
Duchen, M.R.4
-
9
-
-
27844467595
-
Non A beta component of Alzheimer's disease amyloid and amyloid beta peptides evoked poly(ADP-ribose) polymerase-dependent release of apoptosis-inducing factor from rat brain mitochondria
-
Adamczyk A, Czapski GA, Jeśko H, Strosznajder RP (2005) Non A beta component of Alzheimer's disease amyloid and amyloid beta peptides evoked poly(ADP-ribose) polymerase-dependent release of apoptosis-inducing factor from rat brain mitochondria. J Physiol Pharmacol 56(Suppl 2):5-13
-
(2005)
J Physiol Pharmacol
, vol.56
, Issue.SUPPL. 2
, pp. 5-13
-
-
Adamczyk, A.1
Czapski, G.A.2
Jeśko, H.3
Strosznajder, R.P.4
-
10
-
-
77957970155
-
Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's Disease
-
Agostinho P, Cunha RA, Oliveira C (2010) Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's Disease. Curr Pharm Des 16(25):2766-2778
-
(2010)
Curr Pharm Des
, vol.16
, Issue.25
, pp. 2766-2778
-
-
Agostinho, P.1
Cunha, R.A.2
Oliveira, C.3
-
12
-
-
35848932089
-
Differences among cell types in NAD(?) compartmentalization: A comparison of neurons, astrocytes, and cardiac myocytes
-
Alano CC, Tran A, Tao R, Ying W, Karliner JS, Swanson RA (2007) Differences among cell types in NAD(?) compartmentalization: A comparison of neurons, astrocytes, and cardiac myocytes. J Neurosci Res 85(15):3378-3385
-
(2007)
J Neurosci Res
, vol.85
, Issue.15
, pp. 3378-3385
-
-
Alano, C.C.1
Tran, A.2
Tao, R.3
Ying, W.4
Karliner, J.S.5
Swanson, R.A.6
-
13
-
-
77949267093
-
2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors
-
2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors. Cell Calcium 47(3):264-272
-
(2010)
Cell Calcium
, vol.47
, Issue.3
, pp. 264-272
-
-
Alberdi, E.1
Sánchez-Gómez, M.V.2
Cavaliere, F.3
Pérez-Samartín, A.4
Zugaza, J.L.5
Trullas, R.6
Domercq, M.7
Matute, C.8
-
14
-
-
10644276189
-
Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease
-
Aliev G, Smith MA, de la Torre JC, Perry G (2004) Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease. Mitochondrion 4(5-6):649-663
-
(2004)
Mitochondrion
, vol.4
, Issue.5-6
, pp. 649-663
-
-
Aliev, G.1
Smith, M.A.2
De La Torre, J.C.3
Perry, G.4
-
16
-
-
57649233085
-
Mitochondrial and nuclear cross talk in cell death: Parthanatos
-
Andrabi SA, Dawson TM, Dawson VL (2008) Mitochondrial and nuclear cross talk in cell death: Parthanatos. Ann N Y Acad Sci 1147:233-241
-
(2008)
Ann N Y Acad Sci
, vol.1147
, pp. 233-241
-
-
Andrabi, S.A.1
Dawson, T.M.2
Dawson, V.L.3
-
17
-
-
0025734299
-
The role of oxidative abnormalities in the pathophysiology of Alzheimer's disease
-
Blass JP, Gibson GE (1991) The role of oxidative abnormalities in the pathophysiology of Alzheimer's disease. Rev Neurol (Paris) 147:513-525
-
(1991)
Rev Neurol (Paris
, vol.147
, pp. 513-525
-
-
Blass, J.P.1
Gibson, G.E.2
-
19
-
-
33846794822
-
The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
-
Bedard K, Krause KH (2007) The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology. Physiol Rev 87:245-313
-
(2007)
Physiol Rev
, vol.87
, pp. 245-313
-
-
Bedard, K.1
Krause, K.H.2
-
20
-
-
76449116679
-
Alzheimer's disease and endothelial dysfunction
-
Bomboi G, Castello L, Cosentino F, Giubilei F, Orzi F, Volpe M (2010) Alzheimer's disease and endothelial dysfunction. Neurol Sci 31:1-8
-
(2010)
Neurol Sci
, vol.31
, pp. 1-8
-
-
Bomboi, G.1
Castello, L.2
Cosentino, F.3
Giubilei, F.4
Orzi, F.5
Volpe, M.6
-
22
-
-
79955665348
-
Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease
-
Epub 2010 Oct 13
-
Camandola S, Mattson MP (2011) Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease. Biochim Biophys Acta 1813(5):965-973 (Epub 2010 Oct 13
-
(2011)
Biochim Biophys Acta
, vol.1813
, Issue.5
, pp. 965-973
-
-
Camandola, S.1
Mattson, M.P.2
-
23
-
-
1542377619
-
Toxicity of amyloid beta peptide: Tales of calcium, mitochondria, and oxidative stress
-
Canevari L, Abramov AY, Duchen MR (2004) Toxicity of amyloid beta peptide: Tales of calcium, mitochondria, and oxidative stress. Neurochem Res 29:637-650
-
(2004)
Neurochem Res
, vol.29
, pp. 637-650
-
-
Canevari, L.1
Abramov, A.Y.2
Duchen, M.R.3
-
24
-
-
0032810909
-
Beta-Amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria
-
Canevari L, Clark JB, Bates TE (1999) Beta-Amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Lett 457(1):131-134
-
(1999)
FEBS Lett
, vol.457
, Issue.1
, pp. 131-134
-
-
Canevari, L.1
Clark, J.B.2
Bates, T.E.3
-
25
-
-
84856262919
-
Probing structural features of Alzheimer's amyloid-b pores in bilayers using site-specific amino acid substitutions
-
Capone R, Jang H, Kotler SA, Kagan BL, Nussinov R, Lal R (2012) Probing structural features of Alzheimer's amyloid-b pores in bilayers using site-specific amino acid substitutions. Biochemistry 51(3):776-785
-
(2012)
Biochemistry
, vol.51
, Issue.3
, pp. 776-785
-
-
Capone, R.1
Jang, H.2
Kotler, S.A.3
Kagan, B.L.4
Nussinov, R.5
Lal, R.6
-
26
-
-
4644276796
-
Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model
-
Casas C, Sergeant N, Itier JM, Blanchard V, Wirths O, van der Kolk N, Vingtdeux V, van de Steeg E, Ret G, Canton T, Drobecq H, Clark A, Bonici B, Delacourte A, Benavides J, Schmitz C, Tremp G, Bayer TA, Benoit P, Pradier L (2004) Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model. Am J Pathol 165(4):1289-1300
-
(2004)
Am J Pathol
, vol.165
, Issue.4
, pp. 1289-1300
-
-
Casas, C.1
Sergeant, N.2
Itier, J.M.3
Blanchard, V.4
Wirths, O.5
Van Der Kolk, N.6
Vingtdeux, V.7
Van De Steeg, E.8
Ret, G.9
Canton, T.10
Drobecq, H.11
Clark, A.12
Bonici, B.13
Delacourte, A.14
Benavides, J.15
Schmitz, C.16
Tremp, G.17
Bayer, T.A.18
Benoit, P.19
Pradier, L.20
more..
-
27
-
-
0036272650
-
Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities
-
Casley CS, Canevari L, Land JM, Clark JB, Sharpe MA (2002) Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J Neurochem 80(1):91-100
-
(2002)
J Neurochem
, vol.80
, Issue.1
, pp. 91-100
-
-
Casley, C.S.1
Canevari, L.2
Land, J.M.3
Clark, J.B.4
Sharpe, M.A.5
-
28
-
-
0141815741
-
Production of reactive oxygen species by mitochondria: Central role of complex III
-
Chen Q, Vazquez EJ, Moghaddas S, Hoppel CL, Lesnefsky EJ (2003) Production of reactive oxygen species by mitochondria: Central role of complex III. J Biol Chem 278:36027-36031
-
(2003)
J Biol Chem
, vol.278
, pp. 36027-36031
-
-
Chen, Q.1
Vazquez, E.J.2
Moghaddas, S.3
Hoppel, C.L.4
Lesnefsky, E.J.5
-
29
-
-
0036499892
-
Poly(ADP-ribose) polymerase: Killer or conspirator? The 'suicide hypothesis' revisited
-
Chiarugi A (2002) Poly(ADP-ribose) polymerase: Killer or conspirator? The 'suicide hypothesis' revisited. Trends Pharmacol Sci 23:122-129
-
(2002)
Trends Pharmacol Sci
, vol.23
, pp. 122-129
-
-
Chiarugi, A.1
-
30
-
-
1542268893
-
Reactive astrocytes express PARP in the central nervous system of SOD(G93A) transgenic mice
-
Chung YH, Joo KM, Lee YJ, Shin DH, Cha CI (2004) Reactive astrocytes express PARP in the central nervous system of SOD(G93A) transgenic mice. Brain Res 1-2:199-204
-
(2004)
Brain Res
, vol.1-2
, pp. 199-204
-
-
Chung, Y.H.1
Joo, K.M.2
Lee, Y.J.3
Shin, D.H.4
Cha, C.I.5
-
31
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
-
Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261:921-923
-
(1993)
Science
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
Schmechel, D.E.4
Gaskell, P.C.5
Small, G.W.6
Roses, A.D.7
Haines, J.L.8
Pericak-Vance, M.A.9
-
32
-
-
79960017316
-
New therapeutic targets in Alzheimer's disease: Brain deregulation of calcium and zinc
-
Corona C, Pensalfini A, Frazzini V, Sensi SL (2011) New therapeutic targets in Alzheimer's disease: Brain deregulation of calcium and zinc. Cell Death Dis 2:e176
-
(2011)
Cell Death Dis
, vol.2
-
-
Corona, C.1
Pensalfini, A.2
Frazzini, V.3
Sensi, S.L.4
-
33
-
-
0037200117
-
Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability
-
Dahlgren KN, Manelli AM, Stine WB Jr, Baker LK, Krafft GA, LaDu MJ (2002) Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability. J Biol Chem 277:32046-32053
-
(2002)
J Biol Chem
, vol.277
, pp. 32046-32053
-
-
Dahlgren, K.N.1
Manelli, A.M.2
Stine Jr., W.B.3
Baker, L.K.4
Krafft, G.A.5
LaDu, M.J.6
-
34
-
-
0033198919
-
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
-
D'Amours D, Desnoyers S, D'Silva I, Poirier GG (1999) Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J 342(Pt 2):249-268
-
(1999)
Biochem J
, vol.342
, Issue.PART 2
, pp. 249-268
-
-
D'Amours, D.1
Desnoyers, S.2
D'Silva, I.3
Poirier, G.G.4
-
35
-
-
0032522224
-
Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: A link between DNA strand break detection and DNA replication
-
Dantzer F, Nasheuer HP, Vonesch JL, de Murcia G, Ménissier-de Murcia J (1998) Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: A link between DNA strand break detection and DNA replication. Nucleic Acids Res 26(8):1891-1898
-
(1998)
Nucleic Acids Res
, vol.26
, Issue.8
, pp. 1891-1898
-
-
Dantzer, F.1
Nasheuer, H.P.2
Vonesch, J.L.3
De Murcia, G.4
Ménissier-De Murcia, J.5
-
36
-
-
0032717347
-
Involvement of poly(ADP-ribose) polymerase in base excision repair
-
(Review
-
Dantzer F, Schreiber V, Niedergang C, Trucco C, Flatter E, De La Rubia G, Oliver J, Rolli V, Ménissier-de Murcia J, de Murcia G (1999) Involvement of poly(ADP-ribose) polymerase in base excision repair. Biochimie 81(1-2):69-75 (Review)
-
(1999)
Biochimie
, vol.81
, Issue.1-2
, pp. 69-75
-
-
Dantzer, F.1
Schreiber, V.2
Niedergang, C.3
Trucco, C.4
Flatter, E.5
De La Rubia, G.6
Oliver, J.7
Rolli, V.8
Ménissier-De Murcia, J.9
De Murcia, G.10
-
37
-
-
0035425899
-
Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism
-
Davidovic L, Vodenicharov M, Affar EB, Poirier GG (2001) Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism. Exp Cell Res 268:7-13
-
(2001)
Exp Cell Res
, vol.268
, pp. 7-13
-
-
Davidovic, L.1
Vodenicharov, M.2
Affar, E.B.3
Poirier, G.G.4
-
38
-
-
63849115360
-
Parthanatos, a messenger of death
-
David KK, Andrabi SA, Dawson TM, Dawson VL (2009) Parthanatos, a messenger of death. Front Biosci 1(14):1116-1128
-
(2009)
Front Biosci
, vol.1
, Issue.14
, pp. 1116-1128
-
-
David, K.K.1
Andrabi, S.A.2
Dawson, T.M.3
Dawson, V.L.4
-
39
-
-
0000102949
-
Poly(ADP-ribose) polymerase: A molecular nick-sensor
-
de Murcia G, Ménissier de Murcia J (1994) Poly(ADP-ribose) polymerase: A molecular nick-sensor. Trends Biochem Sci 19(4):172-176
-
(1994)
Trends Biochem Sci
, vol.19
, Issue.4
, pp. 172-176
-
-
De Murcia, G.1
Ménissier De Murcia, J.2
-
41
-
-
18544381071
-
Introduction to poly(ADP-ribose) metabolism
-
Diefenbach J, Burkle A (2005) Introduction to poly(ADP-ribose) metabolism. Cell Mol Life Sci 62:721-730
-
(2005)
Cell Mol Life Sci
, vol.62
, pp. 721-730
-
-
Diefenbach, J.1
Burkle, A.2
-
42
-
-
78649815388
-
Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
-
Du H, Guo L, Yan S, Sosunov AA, McKhann GM, Yan SS (2010) Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model. Proc Natl Acad Sci USA 107:18670-18675
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 18670-18675
-
-
Du, H.1
Guo, L.2
Yan, S.3
Sosunov, A.A.4
McKhann, G.M.5
Yan, S.S.6
-
43
-
-
37249047093
-
Ca2 +-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity
-
Duan Y, Gross RA, Sheu SS (2007) Ca2 +-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity. J Physiol 585:741-758
-
(2007)
J Physiol
, vol.585
, pp. 741-758
-
-
Duan, Y.1
Gross, R.A.2
Sheu, S.S.3
-
44
-
-
0030842946
-
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
-
Eliasson MJ, Sampei K, Mandir AS, Hurn PD, Traystman RJ, Bao J, Pieper A, Wang ZQ, Dawson TM, Snyder SH, Dawson VL (1997) Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med 3:1089-1095
-
(1997)
Nat Med
, vol.3
, pp. 1089-1095
-
-
Eliasson, M.J.1
Sampei, K.2
Mandir, A.S.3
Hurn, P.D.4
Traystman, R.J.5
Bao, J.6
Pieper, A.7
Wang, Z.Q.8
Dawson, T.M.9
Snyder, S.H.10
Dawson, V.L.11
-
45
-
-
33947096956
-
The topography of grey matter involvement in early and late onset Alzheimer's disease
-
Frisoni GB, Pievani M, Testa C, Sabattoli F, Bresciani L, Bonetti M, Beltramello A, Hayashi KM, Toga AW, Thompson PM (2007) The topography of grey matter involvement in early and late onset Alzheimer's disease. Brain 130(Pt 3):720-730
-
(2007)
Brain
, vol.130
, Issue.PART 3
, pp. 720-730
-
-
Frisoni, G.B.1
Pievani, M.2
Testa, C.3
Sabattoli, F.4
Bresciani, L.5
Bonetti, M.6
Beltramello, A.7
Hayashi, K.M.8
Toga, A.W.9
Thompson, P.M.10
-
46
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy J, Allsop D (1991) Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 12:383-388
-
(1991)
Trends Pharmacol Sci
, vol.12
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
47
-
-
0035796025
-
Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death
-
Herceg Z, Wang ZQ (2001) Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. Mutat Res 477:97-110
-
(2001)
Mutat Res
, vol.477
, pp. 97-110
-
-
Herceg, Z.1
Wang, Z.Q.2
-
48
-
-
0035341254
-
Mitochondrial abnormalities in Alzheimer's disease
-
Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, Petersen RB, Perry G, Smith MA (2001) Mitochondrial abnormalities in Alzheimer's disease. J Neurosci 21:3017-3023
-
(2001)
J Neurosci
, vol.21
, pp. 3017-3023
-
-
Hirai, K.1
Aliev, G.2
Nunomura, A.3
Fujioka, H.4
Russell, R.L.5
Atwood, C.S.6
Johnson, A.B.7
Kress, Y.8
Vinters, H.V.9
Tabaton, M.10
Shimohama, S.11
Cash, A.D.12
Siedlak, S.L.13
Harris, P.L.14
Jones, P.K.15
Petersen, R.B.16
Perry, G.17
Smith, M.A.18
-
49
-
-
35748982126
-
Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease
-
Howlett DR, Bowler K, Soden PE, Riddell D, Davis JB, Richardson JC, Burbidge SA, Gonzalez MI, Irving EA, Lawman A, Miglio G, Dawson EL, Howlett ER, Hussain I (2008) Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease. Histol Histopathol 23:67-76
-
(2008)
Histol Histopathol
, vol.23
, pp. 67-76
-
-
Howlett, D.R.1
Bowler, K.2
Soden, P.E.3
Riddell, D.4
Davis, J.B.5
Richardson, J.C.6
Burbidge, S.A.7
Gonzalez, M.I.8
Irving, E.A.9
Lawman, A.10
Miglio, G.11
Dawson, E.L.12
Howlett, E.R.13
Hussain, I.14
-
51
-
-
0035577283
-
Quantitative imaging of glutathione in hippocampal neurons and glia in culture using monochlorobimane
-
Keelan J, Allen NJ, Antcliffe D, Pal S, Duchen MR (2001) Quantitative imaging of glutathione in hippocampal neurons and glia in culture using monochlorobimane. J Neurosci Res 66(5):873-884
-
(2001)
J Neurosci Res
, vol.66
, Issue.5
, pp. 873-884
-
-
Keelan, J.1
Allen, N.J.2
Antcliffe, D.3
Pal, S.4
Duchen, M.R.5
-
52
-
-
80155179258
-
Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid b
-
Kauppinen TM, Suh SW, Higashi Y, Berman AE, Escartin C, Won SJ, Wang C, Cho SH, Gan L, Swanson RA (2011) Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid b. J Neuroinflammation 8:152
-
(2011)
J Neuroinflammation
, vol.8
, pp. 152
-
-
Kauppinen, T.M.1
Suh, S.W.2
Higashi, Y.3
Berman, A.E.4
Escartin, C.5
Won, S.J.6
Wang, C.7
Cho, S.H.8
Gan, L.9
Swanson, R.A.10
-
53
-
-
0037047008
-
Contribution of APOE promoter polymorphisms to Alzheimer's disease risk
-
Lambert JC et al (2002) Contribution of APOE promoter polymorphisms to Alzheimer's disease risk. Neurology 59:59-66
-
(2002)
Neurology
, vol.59
, pp. 59-66
-
-
Lambert, J.C.1
-
54
-
-
77956955758
-
The role of microglia in amyloid clearance from the AD brain
-
Lee CY, Landreth GE (2010) The role of microglia in amyloid clearance from the AD brain. J Neural Transm 117:949-960
-
(2010)
J Neural Transm
, vol.117
, pp. 949-960
-
-
Lee, C.Y.1
Landreth, G.E.2
-
55
-
-
84856002072
-
Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity
-
Lee HP, Pancholi N, Esposito L, Previll LA, Wang X, Zhu X, Smith MA, Lee HG (2012) Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity. PLoS One 7(1):e28033
-
(2012)
PLoS One
, vol.7
, Issue.1
-
-
Lee, H.P.1
Pancholi, N.2
Esposito, L.3
Previll, L.A.4
Wang, X.5
Zhu, X.6
Smith, M.A.7
Lee, H.G.8
-
56
-
-
0034960785
-
Mitochondrial dysfunction in cardiac disease: Ischemia-reperfusion, aging, and heart failure
-
Lesnefsky EJ, Moghaddas S, Tandler B, Kerner J, Hoppel CL (2001) Mitochondrial dysfunction in cardiac disease: Ischemia-reperfusion, aging, and heart failure. J Mol Cell Cardiol 33:1065-1089
-
(2001)
J Mol Cell Cardiol
, vol.33
, pp. 1065-1089
-
-
Lesnefsky, E.J.1
Moghaddas, S.2
Tandler, B.3
Kerner, J.4
Hoppel, C.L.5
-
57
-
-
0034426011
-
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
-
Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van SM, Gwinn-Hardy K, Paul MM, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin WL, Yen SH, Dickson DW, Davies P, Hutton M (2000) Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet 25:402-405
-
(2000)
Nat Genet
, vol.25
, pp. 402-405
-
-
Lewis, J.1
McGowan, E.2
Rockwood, J.3
Melrose, H.4
Nacharaju, P.5
Van, S.M.6
Gwinn-Hardy, K.7
Paul, M.M.8
Baker, M.9
Yu, X.10
Duff, K.11
Hardy, J.12
Corral, A.13
Lin, W.L.14
Yen, S.H.15
Dickson, D.W.16
Davies, P.17
Hutton, M.18
-
58
-
-
77953490057
-
Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease
-
Liu HP, Lin WY, Wu BT, Liu SH, Wang WF, Tsai CH, Lee CC, Tsai FJ (2010) Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease. J Clin Lab Anal 24:182-186
-
(2010)
J Clin Lab Anal
, vol.24
, pp. 182-186
-
-
Liu, H.P.1
Lin, W.Y.2
Wu, B.T.3
Liu, S.H.4
Wang, W.F.5
Tsai, C.H.6
Lee, C.C.7
Tsai, F.J.8
-
59
-
-
0032901904
-
Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease
-
Love S, Barber R, Wilcock GK (1999) Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease. Brain 122(Pt 2):247-253
-
(1999)
Brain
, vol.122
, Issue.PART 2
, pp. 247-253
-
-
Love, S.1
Barber, R.2
Wilcock, G.K.3
-
60
-
-
0034329823
-
NMDA but not non-NMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase
-
Mandir AS, Poitras MF, Berliner AR, Herring WJ, Guastella DB, Feldman A, Poirier GG, Wang ZQ, Dawson TM, Dawson VL (2000) NMDA but not non-NMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase. J Neurosci 20:8005-8011
-
(2000)
J Neurosci
, vol.20
, pp. 8005-8011
-
-
Mandir, A.S.1
Poitras, M.F.2
Berliner, A.R.3
Herring, W.J.4
Guastella, D.B.5
Feldman, A.6
Poirier, G.G.7
Wang, Z.Q.8
Dawson, T.M.9
Dawson, V.L.10
-
61
-
-
0033545925
-
Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,36- tetrahydropyridine (MPTP)-induced parkinsonism
-
Mandir AS, Przedborski S, Jackson-Lewis V, Wang ZQ, Simbulan-Rosenthal CM, Smulson ME, Hoffman BE, Guastella DB, Dawson VL, Dawson TM (1999) Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Proc Natl Acad Sci USA 96:5774-5779
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 5774-5779
-
-
Mandir, A.S.1
Przedborski, S.2
Jackson-Lewis, V.3
Wang, Z.Q.4
Simbulan-Rosenthal, C.M.5
Smulson, M.E.6
Hoffman, B.E.7
Guastella, D.B.8
Dawson, V.L.9
Dawson, T.M.10
-
62
-
-
26844567298
-
Abeta immunotherapy and other means to remove amyloid
-
(Review
-
McGeer EG, McGeer PL (2005) Abeta immunotherapy and other means to remove amyloid. Curr Drug Targets CNS Neurol Disord 4(5):569-573 (Review
-
(2005)
Curr Drug Targets CNS Neurol Disord
, vol.4
, Issue.5
, pp. 569-573
-
-
McGeer, E.G.1
McGeer, P.L.2
-
63
-
-
80053212816
-
The role of tau in Alzheimer's disease and related disorders
-
Medeiros R, Baglietto-Vargas D, Laferla FM (2010) The role of tau in Alzheimer's disease and related disorders. CNS Neurosci Ther 17(5):514-524
-
(2010)
CNS Neurosci Ther
, vol.17
, Issue.5
, pp. 514-524
-
-
Medeiros, R.1
Baglietto-Vargas, D.2
Laferla, F.M.3
-
64
-
-
0042536471
-
Neuronal and glial calcium signaling in Alzheimer's disease
-
Mattson MP, Chan SL (2003) Neuronal and glial calcium signaling in Alzheimer's disease. Cell Calcium 34:385-397
-
(2003)
Cell Calcium
, vol.34
, pp. 385-397
-
-
Mattson, M.P.1
Chan, S.L.2
-
65
-
-
38649092421
-
Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage
-
Moroni F (2008) Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage. Curr Opin Pharmacol 8:96-103
-
(2008)
Curr Opin Pharmacol
, vol.8
, pp. 96-103
-
-
Moroni, F.1
-
66
-
-
84863126436
-
Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase
-
Moroni F, Cozzi A, Chiarugi A, Formentini L, Camaioni E, Pellegrini-Giampietro D, Chen Y, Liang S, Zaleska M, Gonzales C, Wood A, Pellicciari R (2012) Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase. Br J Pharmacol 165:1487-1500
-
(2012)
Br J Pharmacol
, vol.165
, pp. 1487-1500
-
-
Moroni, F.1
Cozzi, A.2
Chiarugi, A.3
Formentini, L.4
Camaioni, E.5
Pellegrini-Giampietro, D.6
Chen, Y.7
Liang, S.8
Zaleska, M.9
Gonzales, C.10
Wood, A.11
Pellicciari, R.12
-
67
-
-
0033785079
-
Defending genomic stability over life span: A proposed role for PARP-1
-
Muiras ML, Burkle A (2000) Defending genomic stability over life span: A proposed role for PARP-1. Exp Gerontol 35:703-709
-
(2000)
Exp Gerontol
, vol.35
, pp. 703-709
-
-
Muiras, M.L.1
Burkle, A.2
-
68
-
-
18344372177
-
ApoE epsilon3-haplotype modulates Alzheimer beta-amyloid deposition in the brain
-
Myllykangas L, Polvikoski T, Reunanen K, Wavrant-De VF, Ellis C, Hernandez D, Sulkava R, Kontula K, Verkkoniemi A, Notkola IL, Hardy J, Perez-Tur J, Haltia MJ, Tienari PJ (2002) ApoE epsilon3-haplotype modulates Alzheimer beta-amyloid deposition in the brain. Am J Med Genet 114:288-291
-
(2002)
Am J Med Genet
, vol.114
, pp. 288-291
-
-
Myllykangas, L.1
Polvikoski, T.2
Reunanen, K.3
Wavrant-De, V.F.4
Ellis, C.5
Hernandez, D.6
Sulkava, R.7
Kontula, K.8
Verkkoniemi, A.9
Notkola, I.L.10
Hardy, J.11
Perez-Tur, J.12
Haltia, M.J.13
Tienari, P.J.14
-
69
-
-
0034573392
-
Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes
-
Noh KM, Koh JY (2000) Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes. J Neurosci 20:RC111
-
(2000)
J Neurosci
, vol.20
-
-
Noh, K.M.1
Koh, J.Y.2
-
70
-
-
0033362084
-
Poly(ADP-ribose) polymerase in the cellular response to DNA damage, apoptosis, and disease
-
Oliver FJ, Menissier-de Murcia J, de Murcia G (1999) Poly(ADP-ribose) polymerase in the cellular response to DNA damage, apoptosis, and disease. Am J Hum Genet 64(5):1282-1288
-
(1999)
Am J Hum Genet
, vol.64
, Issue.5
, pp. 1282-1288
-
-
Oliver, F.J.1
Menissier-De Murcia, J.2
De Murcia, G.3
-
71
-
-
0027282035
-
Apolipoprotein E polymorphism and Alzheimer's disease
-
Poirier J, Davignon J, Bouthillier D, Kogan S, Bertrand P, Gauthier S (1993) Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 342:697-699
-
(1993)
Lancet
, vol.342
, pp. 697-699
-
-
Poirier, J.1
Davignon, J.2
Bouthillier, D.3
Kogan, S.4
Bertrand, P.5
Gauthier, S.6
-
72
-
-
79959246028
-
Mitochondria, amyloid b, and Alzheimer's Disease
-
Readnower RD, Sauerbeck AD, Sullivan PG (2011) Mitochondria, amyloid b, and Alzheimer's Disease. Int J Alzheimers Dis 22(2011):104545
-
(2011)
Int J Alzheimers Dis
, vol.22
, Issue.2011
, pp. 104545
-
-
Readnower, R.D.1
Sauerbeck, A.D.2
Sullivan, P.G.3
-
73
-
-
1642308537
-
Poly(ADP-ribosyl)ated chromatin domains: Access granted
-
Rouleau M, Aubin RA, Poirier GG (2004) Poly(ADP-ribosyl)ated chromatin domains: Access granted. J Cell Sci 117(Pt 6):815-825
-
(2004)
J Cell Sci
, vol.117
, Issue.PART 6
, pp. 815-825
-
-
Rouleau, M.1
Aubin, R.A.2
Poirier, G.G.3
-
74
-
-
80052646443
-
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis
-
Supnet C, Bezprozvanny I (2011) Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis. Cell Calcium 50(3):303-309
-
(2011)
Cell Calcium
, vol.50
, Issue.3
, pp. 303-309
-
-
Supnet, C.1
Bezprozvanny, I.2
-
75
-
-
77950607663
-
Influence of PARP-1 polymorphisms in patients after traumatic brain injury
-
Sarnaik AA, Conley YP, Okonkwo DO, Barr TL, Fink EL, Szabo C, Kochanek PM, Clark RS (2010) Influence of PARP-1 polymorphisms in patients after traumatic brain injury. J Neurotrauma 27:465-471
-
(2010)
J Neurotrauma
, vol.27
, pp. 465-471
-
-
Sarnaik, A.A.1
Conley, Y.P.2
Okonkwo, D.O.3
Barr, T.L.4
Fink, E.L.5
Szabo, C.6
Kochanek, P.M.7
Clark, R.S.8
-
77
-
-
0030923869
-
Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease
-
Sheehan JP, Swerdlow RH, Miller SW, Davis RE, Parks JK, Parker WD, Tuttle JB (1997) Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease. J Neurosci 17(12):4612-4622
-
(1997)
J Neurosci
, vol.17
, Issue.12
, pp. 4612-4622
-
-
Sheehan, J.P.1
Swerdlow, R.H.2
Miller, S.W.3
Davis, R.E.4
Parks, J.K.5
Parker, W.D.6
Tuttle, J.B.7
-
78
-
-
0028168336
-
Amyloid-beta aggregation: Selective inhibition of aggregation in mixtures of amyloid with different chain lengths
-
Snyder SW, Ladror US, Wade WS, Wang GT, Barrett LW, Matayoshi ED, Huffaker HJ, Krafft GA, Holzman TF (1994) Amyloid-beta aggregation: Selective inhibition of aggregation in mixtures of amyloid with different chain lengths. Biophys J 67:1216-1228
-
(1994)
Biophys J
, vol.67
, pp. 1216-1228
-
-
Snyder, S.W.1
Ladror, U.S.2
Wade, W.S.3
Wang, G.T.4
Barrett, L.W.5
Matayoshi, E.D.6
Huffaker, H.J.7
Krafft, G.A.8
Holzman, T.F.9
-
79
-
-
84868151452
-
Poly(ADP-ribose) Polymerase-1 in Amyloid Beta Toxicity and Alzheimer's Disease
-
Strosznajder JB, Czapski GA, Adamczyk A, Strosznajder RP (2012) Poly(ADP-ribose) Polymerase-1 in Amyloid Beta Toxicity and Alzheimer's Disease. Mol Neurobiol 46(1):78-84
-
(2012)
Mol Neurobiol
, vol.46
, Issue.1
, pp. 78-84
-
-
Strosznajder, J.B.1
Czapski, G.A.2
Adamczyk, A.3
Strosznajder, R.P.4
-
80
-
-
34548493024
-
Zinc inhibits astrocyte glutamate uptake by activation of poly(ADP-ribose) polymerase-1
-
Suh SW, Aoyama K, Alano CC, Anderson CM, Hamby AM, Swanson RA (2007) Zinc inhibits astrocyte glutamate uptake by activation of poly(ADP-ribose) polymerase-1.MolMed 13:344-349
-
(2007)
MolMed
, vol.13
, pp. 344-349
-
-
Suh, S.W.1
Aoyama, K.2
Alano, C.C.3
Anderson, C.M.4
Hamby, A.M.5
Swanson, R.A.6
-
81
-
-
0033521741
-
Molecular characterization of mitochondrial apoptosis-inducing factor
-
Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397:441-446
-
(1999)
Nature
, vol.397
, pp. 441-446
-
-
Susin, S.A.1
Lorenzo, H.K.2
Zamzami, N.3
Marzo, I.4
Snow, B.E.5
Brothers, G.M.6
Mangion, J.7
Jacotot, E.8
Costantini, P.9
Loeffler, M.10
Larochette, N.11
Goodlett, D.R.12
Aebersold, R.13
Siderovski, D.P.14
Penninger, J.M.15
Kroemer, G.16
-
82
-
-
0041573041
-
+ repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes
-
+ repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes. Biochem Biophys Res Commun 308:809-813
-
(2003)
Biochem Biophys Res Commun
, vol.308
, pp. 809-813
-
-
Ying, W.1
Garnier, P.2
Swanson, R.A.3
-
83
-
-
0032105394
-
The role of A beta 42 in Alzheimer's disease
-
Younkin SG (1998) The role of A beta 42 in Alzheimer's disease. J Physiol Paris 92:289-292
-
(1998)
J Physiol Paris
, vol.92
, pp. 289-292
-
-
Younkin, S.G.1
-
84
-
-
0033981680
-
Mitochondrial defects in cardiomyopathy and neuromuscular disease
-
Wallace DC (2000) Mitochondrial defects in cardiomyopathy and neuromuscular disease. Am Heart J 139:S70-S85
-
(2000)
Am Heart J
, vol.139
-
-
Wallace, D.C.1
-
85
-
-
67649526000
-
Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos
-
Wang Y, Dawson VL, Dawson TM (2009) Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos. Exp Neurol 218:193-202
-
(2009)
Exp Neurol
, vol.218
, pp. 193-202
-
-
Wang, Y.1
Dawson, V.L.2
Dawson, T.M.3
-
86
-
-
67649491430
-
Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos)
-
Epub 2009 May 13
-
Wang Y, Kim NS, Li X, Greer PA, Koehler RC, Dawson VL, Dawson TM (2009) Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos). J Neurochem 110(2):687-696 (Epub 2009 May 13)
-
(2009)
J Neurochem
, vol.110
, Issue.2
, pp. 687-696
-
-
Wang, Y.1
Kim, N.S.2
Li, X.3
Greer, P.A.4
Koehler, R.C.5
Dawson, V.L.6
Dawson, T.M.7
-
87
-
-
79953840957
-
Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos
-
Wang Y, Kim NS, Haince JF, Kang HC, David KK, Andrabi SA, Poirier GG, Dawson VL, Dawson TM (2011) Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos). Sci Signal ra4(167):20
-
(2011)
Sci Signal ra
, vol.4
, Issue.167
, pp. 20
-
-
Wang, Y.1
Kim, N.S.2
Haince, J.F.3
Kang, H.C.4
David, K.K.5
Andrabi, S.A.6
Poirier, G.G.7
Dawson, V.L.8
Dawson, T.M.9
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