Reactive astrocytes express PARP in the central nervous system of SOD G93A transgenic mice

Brain Research

Volumn 1003, Issue 1-2, 2004, Pages 199-204

  Chung, Yoon Hee ^a   Joo, Kyeung Min ^a   Lee, Yun Jung ^a   Shin, Dong Hoon ^a   Cha, Choong Ik ^a,b  

^a Seoul National University   (South Korea)

^b Korea National Institute of Health   (South Korea)

Author keywords

Amyotrophic lateral sclerosis; Astrocyte; Disorders of the nervous system; Immunohistochemistry; Neuromuscular diseases; Oxidative damage; Poly(ADP ribose) polymerase; Transgenic mouse

Indexed keywords

COPPER; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SUPEROXIDE DISMUTASE; ZINC;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN STEM; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CEREBELLUM NUCLEUS; COCHLEAR NUCLEUS; CONTROLLED STUDY; GLIA CELL; HYPOGLOSSAL NUCLEUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MOTONEURON; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETICULAR FORMATION; SPINAL CORD; STAINING; TRANSGENIC MOUSE; VESTIBULAR NUCLEUS;

ANIMALS; ASTROCYTES; CENTRAL NERVOUS SYSTEM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MICE; MICE, TRANSGENIC; POLY(ADP-RIBOSE) POLYMERASES; SUPEROXIDE DISMUTASE;

EID: 1542268893     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.01.010     Document Type: Article

References (22)

1. Al-Chalabi A., Leigh P.N. Recent advances in amyotrophic lateral sclerosis. Curr. Opin. Neurol. 13:2000;397-405.
2. Andreassen O.A., Dedeoglu A., Friedlich A., Ferrante K.L., Hughes D., Szabo C., Beal M.F. Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice. Exp. Neurol. 168:2001;419-424.
3. Blount B.C., Mack M.M., Wehr C.M., MacGregor J.T., Hiatt R.A., Wang G., Wickramasinghe S.N., Everson R.B., Ames B.N. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc. Natl. Acad. Sci. U. S. A. 94:1997;3290-3295.
4. Cassina P., Peluffo H., Pehar M., Martinez-Palma L., Ressia A., Beckman J.S., Estevez A.G., Barbeito L. Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis. J. Neurosci. Res. 67:2002;21-29.
5. Cha C.I., Chung Y.H., Shin C.M., Shin D.H., Kim Y.S., Gurney M.E., Lee K.W. Immunocytochemical study on the distribution of nitrotyrosine in the brain of the transgenic mice expressing a human Cu/Zn SOD mutation. Brain Res. 853:2000;156-161.
6. Chiarugi A. Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide hypothesis' revisited. Trends Pharmacol. Sci. 23:2002;122-129.
7. Cho K.J., Chung Y.H., Shin C., Shin D.H., Kim Y.S., Gurney M.E., Lee K.W., Cha C.I. Reactive astrocytes express p53 in the spinal cord of transgenic mice expressing a human Cu/Zn SOD mutation. NeuroReport. 10:1999;3939-3943.
8. Chung Y.H., Hong J.J., Shin C.M., Joo K.M., Kim M.J., Cha C.I. Immunohistochemical study on the distribution of homocysteine in the central nervous system of transgenic mice expressing a human Cu/Zn SOD mutation. Brain Res. 967:2003;226-234.
9. Clevel D.W., Rothstein J.D. From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat. Rev., Neurosci. 2:2001;806-819.
10. Cookson M.R., Ince P.G., Shaw P.J. Peroxynitrite and hydrogen peroxide induced cell death in the NSC34 neuroblastoma×spinal cord cell line: role of poly (ADP-ribose) polymerase. J. Neurochem. 70:1998;501-508.
11. Gurney M.E., Pu H., Chiu A.Y., Dal Canto M.C., Polchow C.Y., Alexander D.D., Caliendo J., Hentati A., Kwon Y.W., Deng H.X., Chen W., Zhai P., Sufit R.L., Siddique T. Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation. Science. 264:1994;1772-1775.
12. Hall E.D., Andrus P.K., Oostveen J.A., Fleck T.J., Gurney M.E. Relationship of oxygen radical-induced lipid peroxidative damage to disease onset and progression in a transgenic model of familial ALS. J. Neurosci. Res. 53:1998;66-77.
13. Julien J.P. Amyotrophic lateral sclerosis. Unfolding the toxicity of the misfolded. Cell. 104:2001;581-591.
14. Kim S.H., Henkel J.S., Beers D.R., Sengun I.S., Simpson E.P., Goodman J.C., Engelhardt J.I., Siklos L., Appel S.H. PARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients. J. Neuropathol. Exp. Neurol. 62:2003;88-103.
15. Kruman I.I., Culmsee C., Chan S.L., Kruman Y., Guo Z., Penix L., Mattson M.P. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J. Neurosci. 20:2000;6920-6926.
16. Love S., Barber R., Wilcock G.K. Apoptosis and expression of DNA repair proteins in ischaemic brain injury in man. NeuroReport. 9:1998;955-959.
17. Love S., Barber R., Wilcock G.K. Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease. Brain. 122:1999;247-253.
18. Mandir A.S., Przedborski S., Jackson-Lewis V., Wang Z.Q., Simbulan-Rosenthal C.M., Smulson M.E., Hoffman B.E., Guastella D.B., Dawson V.L., Dawson T.M. Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Proc. Natl. Acad. Sci. U. S. A. 96:1999;5774-5779.
19. Pieper A.A., Blackshaw S., Clements E.E., Brat D.J., Krug D.K., White A.J., Pinto-Garcia P., Favit A., Conover J.R., Snyder S.H., Verma A. Poly(ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate-nitric oxide neurotransmission. Proc. Natl. Acad. Sci. U. S. A. 97:2000;1845-1850.
20. Shibata N., Nagai R., Uchida K., Horiuchi S., Yamada S., Hirano A., Kawaguchi M., Yamamoto T., Sasaki S., Kobayashi M. Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients. Brain Res. 917:2001;97-104.
21. Virag L., Szabo C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol. Rev. 54:2002;375-429.
22. Vispe S., Yung T.M., Ritchot J., Serizawa H., Satoh M.S. A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage. Proc. Natl. Acad. Sci. U. S. A. 97:2000;9886-9891.