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Volumn 7, Issue 2, 2012, Pages 123-133

Hot melt extrusion and its pharmaceutical applications

Author keywords

Amorphous materials; Bioavailability enhancement; Extruder; Plasticizers; Polymers; Solubility enhancement; Sustained release systems; Taste masking

Indexed keywords

CITRIC ACID TRIETHYL ESTER; ETHYL CELLULOSE; GLYCEROL STEARATE; HYDROXYPROPYLCELLULOSE; MACROGOL; PHTHALIC ACID DIETHYL ESTER; PLASTICIZER; POLYMER; POLYMETHACRYLIC ACID; PROPYLENE GLYCOL; SEBACIC ACID DIBUTYL ESTER; TRIACETIN;

EID: 84871406123     PISSN: 18180876     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (29)

References (86)
  • 1
    • 58249121790 scopus 로고    scopus 로고
    • Hot melt extrusion: an emerging drug delivery technology
    • Andrews GPJ, David S, Osama AM, et al. Hot melt extrusion: an emerging drug delivery technology. Pharm Tech Eur. 2009, 21: 24-27.
    • (2009) Pharm Tech Eur , vol.21 , pp. 24-27
    • Andrews, G.P.J.1    David, S.2    Osama, A.M.3
  • 4
    • 34250756010 scopus 로고    scopus 로고
    • Physicochemical properties of film-coated melt-extruded pellets
    • Young CR, Crowley M, Dietzsch C, et al. Physicochemical properties of film-coated melt-extruded pellets. J Microencapsul. 2007, 24: 57-71.
    • (2007) J Microencapsul , vol.24 , pp. 57-71
    • Young, C.R.1    Crowley, M.2    Dietzsch, C.3
  • 6
    • 30544447672 scopus 로고
    • Extrusion in: Kroschwitz J, editors
    • New York: John Wiley and Sons.
    • Kruder GA. Extrusion in: Kroschwitz J, editors. Encyclopedia of Polymer Science and Engineering. New York: John Wiley and Sons, Inc. 1985. 1: 571-631.
    • (1985) Encyclopedia of Polymer Science and Engineering , vol.1 , pp. 571-631
    • Kruder, G.A.1
  • 7
    • 0031744988 scopus 로고    scopus 로고
    • Investigations on the Influence of the type of extruder for pelletization by extrusionspheronization. II. Sphere Characteristics
    • Thoma K, Ziegler I. Investigations on the Influence of the type of extruder for pelletization by extrusionspheronization. II. Sphere Characteristics. Drug Dev Ind Pharm. 1998, 24: 413-422.
    • (1998) Drug Dev Ind Pharm , vol.24 , pp. 413-422
    • Thoma, K.1    Ziegler, I.2
  • 8
    • 1842865536 scopus 로고    scopus 로고
    • Melt Extrusion: From Process to Drug delivery technology
    • Brietenbach J. Melt Extrusion: From Process to Drug delivery technology. Eur J Pharm Biopharm. 2002, 54: 107-117.
    • (2002) Eur J Pharm Biopharm , vol.54 , pp. 107-117
    • Brietenbach, J.1
  • 9
    • 0037173515 scopus 로고    scopus 로고
    • The role of the kneading paddle and the effects of screw revolution speed and water content on the preparation of solid dispersions using a twin screw extruder
    • Nakamichi K, Nakano T, Yasuura H, et al. The role of the kneading paddle and the effects of screw revolution speed and water content on the preparation of solid dispersions using a twin screw extruder. Int J Pharm. 2002, 241: 203-211.
    • (2002) Int J Pharm , vol.241 , pp. 203-211
    • Nakamichi, K.1    Nakano, T.2    Yasuura, H.3
  • 10
    • 79952486267 scopus 로고    scopus 로고
    • Comparison between hot-melt extrusion and spray-drying for manufacturing solid dispersions of the graft copolymer of ethylene glycol and vinylalcohol
    • Sandra G, Aswin D, Pieterjan K, et al. Comparison between hot-melt extrusion and spray-drying for manufacturing solid dispersions of the graft copolymer of ethylene glycol and vinylalcohol. Pharm Res. 2011, 28: 673-682.
    • (2011) Pharm Res , vol.28 , pp. 673-682
    • Sandra, G.1    Aswin, D.2    Pieterjan, K.3
  • 11
    • 0037258305 scopus 로고    scopus 로고
    • Identification of phase separation in solid dispersions of itraconazole and Eudragit® E100 using microthermal analysis
    • Six K, Murphy J, Weuts I, et al. Identification of phase separation in solid dispersions of itraconazole and Eudragit® E100 using microthermal analysis. Pharm Res. 2003, 20: 135-138.
    • (2003) Pharm Res , vol.20 , pp. 135-138
    • Six, K.1    Murphy, J.2    Weuts, I.3
  • 12
    • 3042690039 scopus 로고    scopus 로고
    • The use of Near-Infrared spectroscopy for the quantitation of a drug in Hot-melt extruded films
    • Tumuluri SVS, Proddduturi S, Crowley MM, et al. The use of Near-Infrared spectroscopy for the quantitation of a drug in Hot-melt extruded films. Drug Dev Ind Pharm. 2004, 30: 505-511.
    • (2004) Drug Dev Ind Pharm , vol.30 , pp. 505-511
    • Tumuluri, S.V.S.1    Proddduturi, S.2    Crowley, M.M.3
  • 13
    • 34648812679 scopus 로고    scopus 로고
    • Pharmaceutical Applications of Hot Melt Extrusion: Part I
    • Crowley MM, Zhang F, Repka MA, et al. Pharmaceutical Applications of Hot Melt Extrusion: Part I. Drug Dev Ind Pharm. 2007, 33: 909-926.
    • (2007) Drug Dev Ind Pharm , vol.33 , pp. 909-926
    • Crowley, M.M.1    Zhang, F.2    Repka, M.A.3
  • 14
    • 0031836565 scopus 로고    scopus 로고
    • A preliminary evaluation of injection molding as a technology to produce tablets
    • Cuff G, Raouf F. A preliminary evaluation of injection molding as a technology to produce tablets. Pharm Tech. 1998, 6: 97-106.
    • (1998) Pharm Tech , vol.6 , pp. 97-106
    • Cuff, G.1    Raouf, F.2
  • 15
    • 33748514818 scopus 로고    scopus 로고
    • Characterization of poly(ethylene oxide) as a drug carrier in Hot-melt extrusion
    • Li L, Omar A, Shao ZJ. Characterization of poly(ethylene oxide) as a drug carrier in Hot-melt extrusion. Drug Dev Ind Pharm. 2006, 32: 991-1002.
    • (2006) Drug Dev Ind Pharm , vol.32 , pp. 991-1002
    • Li, L.1    Omar, A.2    Shao, Z.J.3
  • 18
    • 0028287352 scopus 로고
    • Evaluation of hot-melt extrusion as a new technique for the production of polymerbased pellets for sustained release capsules containing high loading of freely soluble drugs
    • Follonier N, Doelker E, Cole ET. Evaluation of hot-melt extrusion as a new technique for the production of polymerbased pellets for sustained release capsules containing high loading of freely soluble drugs. Drug Dev Ind Pharm. 1994, 20: 1323-1339.
    • (1994) Drug Dev Ind Pharm , vol.20 , pp. 1323-1339
    • Follonier, N.1    Doelker, E.2    Cole, E.T.3
  • 19
    • 0032899524 scopus 로고    scopus 로고
    • Properties of sustained release tablets prepared by hot melt extrusion
    • Zhang F, McGinity JW. Properties of sustained release tablets prepared by hot melt extrusion. Pharm Dev Technol. 1999, 4: 241-250.
    • (1999) Pharm Dev Technol , vol.4 , pp. 241-250
    • Zhang, F.1    Mcginity, J.W.2
  • 20
    • 75449085105 scopus 로고    scopus 로고
    • Properties of melt extruded enteric matrix pellets
    • Sandra U, Schilling NH, Shah A, et al. Properties of melt extruded enteric matrix pellets, Eur J Pharm Biopharm. 2010, 74: 352-361.
    • (2010) Eur J Pharm Biopharm , vol.74 , pp. 352-361
    • Sandra, U.1    Schilling, N.H.2    Shah, A.3
  • 21
    • 0038353647 scopus 로고    scopus 로고
    • Influence of methylparaben as a solid-state plasticizer on the physicochemical properties of Eudragit RS PO hot-melt extrudates
    • Wu C, McGinity JW. Influence of methylparaben as a solid-state plasticizer on the physicochemical properties of Eudragit RS PO hot-melt extrudates. Eur J Pharm Biopharm. 2003, 56: 95-100.
    • (2003) Eur J Pharm Biopharm , vol.56 , pp. 95-100
    • Wu, C.1    Mcginity, J.W.2
  • 22
    • 0037173529 scopus 로고    scopus 로고
    • Solid-state plasticization of an acrylic polymer with chlorpheniramine maleate and triethyl citrate
    • Zhu Y, Shah NH, Malick AW, et al. Solid-state plasticization of an acrylic polymer with chlorpheniramine maleate and triethyl citrate. Int J Pharm. 2002, 241: 301-310.
    • (2002) Int J Pharm , vol.241 , pp. 301-310
    • Zhu, Y.1    Shah, N.H.2    Malick, A.W.3
  • 23
    • 33746889126 scopus 로고    scopus 로고
    • Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: Stability testing of selected solid dispersions
    • Ghebremeskel NA, Vemavarapu C, Lodaya M. Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: Stability testing of selected solid dispersions. Pharm Res. 2006, 23: 1928-1936.
    • (2006) Pharm Res , vol.23 , pp. 1928-1936
    • Ghebremeskel, N.A.1    Vemavarapu, C.2    Lodaya, M.3
  • 24
    • 4344693923 scopus 로고    scopus 로고
    • Influence of a lipophilic thermal lubricant on the processing conditions and drug release properties of chlorpheniramine maleate tablets prepared by hot-melt extrusion
    • Zhu Y, Shah NH, Malick AW, et al. Influence of a lipophilic thermal lubricant on the processing conditions and drug release properties of chlorpheniramine maleate tablets prepared by hot-melt extrusion. STP Pharm Sci. 2004, 14: 313-318.
    • (2004) STP Pharm Sci , vol.14 , pp. 313-318
    • Zhu, Y.1    Shah, N.H.2    Malick, A.W.3
  • 25
    • 0028845775 scopus 로고
    • Various ways of modulating the release of diltiazem hydrochloride from hot-melt extruded sustained release pellets prepared using polymeric materials
    • Follonier N, Doelker E, Cole ET. Various ways of modulating the release of diltiazem hydrochloride from hot-melt extruded sustained release pellets prepared using polymeric materials. J Control Release. 1995, 36: 243-250.
    • (1995) J Control Release , vol.36 , pp. 243-250
    • Follonier, N.1    Doelker, E.2    Cole, E.T.3
  • 26
    • 34447296485 scopus 로고    scopus 로고
    • Stabilization of hot-melt extrusion formulations containing solid solutions using polymer blends
    • Prodduturi S, Urman KL, Otaigbe JU, et al. Stabilization of hot-melt extrusion formulations containing solid solutions using polymer blends. AAPS Pharm Sci Tech. 2007, 8: 50.
    • (2007) AAPS Pharm Sci Tech , vol.8 , pp. 50
    • Prodduturi, S.1    Urman, K.L.2    Otaigbe, J.U.3
  • 27
    • 35648992051 scopus 로고    scopus 로고
    • Pharmaceutical applications of hot melt extrusion: part II
    • Repka MA, Battu SK, Upadhye SB, et al. Pharmaceutical applications of hot melt extrusion: part II. Drug Dev Ind Pharm. 2007, 33: 1043-1057.
    • (2007) Drug Dev Ind Pharm , vol.33 , pp. 1043-1057
    • Repka, M.A.1    Battu, S.K.2    Upadhye, S.B.3
  • 28
    • 0023000410 scopus 로고
    • Continuous extrusion using a raker perkins MP50 multipurpose extruder
    • Gamlen M, Eardley C. Continuous extrusion using a raker perkins MP50 multipurpose extruder. Drug Dev Ind Pharm. 1986, 12: 1701-1713.
    • (1986) Drug Dev Ind Pharm , vol.12 , pp. 1701-1713
    • Gamlen, M.1    Eardley, C.2
  • 29
    • 84871433912 scopus 로고    scopus 로고
    • Effect of solid state plasticizers on the physicochemical stability of solid solutions produced by hot-melt extrusion
    • 10/28/2006-11/2/2006
    • Desai D, Sandhu HK, Zia H, et al. Effect of solid state plasticizers on the physicochemical stability of solid solutions produced by hot-melt extrusion, AAPS Annual Meeting and Exposition. 2006, 10/28/2006-11/2/2006.
    • (2006) AAPS Annual Meeting and Exposition
    • Desai, D.1    Sandhu, H.K.2    Zia, H.3
  • 30
    • 23144460888 scopus 로고    scopus 로고
    • Preparation and evaluation of diltiazem hydrochloride-Gelucire 43/01 floating granules prepared by melt granulation
    • Shimpi S, Chauhan B, Mahadik KR, et al. Preparation and evaluation of diltiazem hydrochloride-Gelucire 43/01 floating granules prepared by melt granulation. AAPS Pharm Sci Tech. 2004, 5: 43.
    • (2004) AAPS Pharm Sci Tech , vol.5 , pp. 43
    • Shimpi, S.1    Chauhan, B.2    Mahadik, K.R.3
  • 31
    • 0033913448 scopus 로고    scopus 로고
    • Properties of hot-melt extruded theophylline tablets containing poly(vinyl acetate)
    • Zhang F, McGinity JW. Properties of hot-melt extruded theophylline tablets containing poly(vinyl acetate). Drug Dev Ind Pharm. 2000, 26: 931-942.
    • (2000) Drug Dev Ind Pharm , vol.26 , pp. 931-942
    • Zhang, F.1    Mcginity, J.W.2
  • 32
    • 41549168295 scopus 로고    scopus 로고
    • The manufacture and characterization of hot-melt extruded enteric tablets
    • Andrews GP, Jones DS, Diak OA, et al. The manufacture and characterization of hot-melt extruded enteric tablets. Eur J Pharm Biopharm. 2008, 69: 264-273.
    • (2008) Eur J Pharm Biopharm , vol.69 , pp. 264-273
    • Andrews, G.P.1    Jones, D.S.2    Diak, O.A.3
  • 33
    • 12344296445 scopus 로고    scopus 로고
    • Production of enteric capsules by means of hot-melt extrusion
    • Mehuys E, Remon J, Vervaet C. Production of enteric capsules by means of hot-melt extrusion. Eur J Pharm Sci. 2005, 24: 207-212.
    • (2005) Eur J Pharm Sci , vol.24 , pp. 207-212
    • Mehuys, E.1    Remon, J.2    Vervaet, C.3
  • 34
    • 4344596708 scopus 로고    scopus 로고
    • Properties of theophylline tablets powder-coated with methacrylate ester copolymers
    • Zheng W, Cerea M, Sauer D, et al. Properties of theophylline tablets powder-coated with methacrylate ester copolymers. STP Pharm Sci. 2004, 14: 319-325.
    • (2004) STP Pharm Sci , vol.14 , pp. 319-325
    • Zheng, W.1    Cerea, M.2    Sauer, D.3
  • 35
    • 0036323235 scopus 로고    scopus 로고
    • Stability of polyethylene oxide in matrix tablets prepared by hot-melt extrusion
    • Crowley MM, Zhang F, Koleng JJ, et al. Stability of polyethylene oxide in matrix tablets prepared by hot-melt extrusion. Biomaterials. 2002, 23: 4241-4248.
    • (2002) Biomaterials , vol.23 , pp. 4241-4248
    • Crowley, M.M.1    Zhang, F.2    Koleng, J.J.3
  • 36
  • 37
    • 14744273165 scopus 로고    scopus 로고
    • Compression of controlled-release pellets produced by a hot-melt extrusion and spheronization process
    • Young CR, Dietzsch C, McGinity JW. Compression of controlled-release pellets produced by a hot-melt extrusion and spheronization process. Pharm Dev Technol. 2005, 10: 133-139.
    • (2005) Pharm Dev Technol , vol.10 , pp. 133-139
    • Young, C.R.1    Dietzsch, C.2    Mcginity, J.W.3
  • 38
    • 23144462229 scopus 로고    scopus 로고
    • Preparation and characterization of flurbiprofen beads by melt solidification technique
    • Paradkar A, Maheshwari M, Tyagi AK, et al. Preparation and characterization of flurbiprofen beads by melt solidification technique. AAPS Pharm Sci Tech. 2003, 4: 65.
    • (2003) AAPS Pharm Sci Tech , vol.4 , pp. 65
    • Paradkar, A.1    Maheshwari, M.2    Tyagi, A.K.3
  • 39
    • 41549109232 scopus 로고    scopus 로고
    • Influence of formulation and process parameters on the release characteristics of ethyl cellulose sustained-release minimatrices produced by hot-melt extrusion
    • Verhoeven E, De Beer TR, Van den MG, et al. Influence of formulation and process parameters on the release characteristics of ethyl cellulose sustained-release minimatrices produced by hot-melt extrusion. Eur J Pharm Biopharm. 2008, 69: 312-319.
    • (2008) Eur J Pharm Biopharm , vol.69 , pp. 312-319
    • Verhoeven, E.1    Beer, T.R.D.2    Van den, M.G.3
  • 40
    • 0037472069 scopus 로고    scopus 로고
    • Development and evaluation of sustained release mini-matrices prepared via hot melt extrusion
    • De Brabander C, Vervaet C, Remon JP. Development and evaluation of sustained release mini-matrices prepared via hot melt extrusion. J Control Release 2003, 89: 235-247.
    • (2003) J Control Release , vol.89 , pp. 235-247
    • Brabander, C.D.1    Vervaet, C.2    Remon, J.P.3
  • 41
    • 1142309795 scopus 로고    scopus 로고
    • Bioavailability of ibuprofen from hot-melt extruded minimatrices
    • De Brabander C, Vervaet C, Van Bortel L, et al. Bioavailability of ibuprofen from hot-melt extruded minimatrices. Int J Pharm. 2004, 271: 77-84.
    • (2004) Int J Pharm , vol.271 , pp. 77-84
    • Brabander, C.D.1    Vervaet, C.2    Van Bortel, L.3
  • 42
    • 33344472033 scopus 로고    scopus 로고
    • Properties of sustained release hot-melt extruded tablets containing chitosan and xanthan gum
    • Fukuda M, Peppas NA, McGinity JW. Properties of sustained release hot-melt extruded tablets containing chitosan and xanthan gum. Int J Pharm. 2006, 310: 90-100.
    • (2006) Int J Pharm , vol.310 , pp. 90-100
    • Fukuda, M.1    Peppas, N.A.2    Mcginity, J.W.3
  • 43
    • 23944507088 scopus 로고    scopus 로고
    • Physicochemical characterization and mechanism of release of theophylline from melt-extruded dosage forms based on a methacrylic acid copolymer
    • Young CR, Dietzsch C, Cerea M, et al. Physicochemical characterization and mechanism of release of theophylline from melt-extruded dosage forms based on a methacrylic acid copolymer. Int J Pharm. 2005, 301: 112-120.
    • (2005) Int J Pharm , vol.301 , pp. 112-120
    • Young, C.R.1    Dietzsch, C.2    Cerea, M.3
  • 44
    • 3242710180 scopus 로고    scopus 로고
    • The influence of guaifenesin and ketoprofen on the properties of hot-melt extruded polyethylene oxide films
    • Crowley MM, Fredersdorf A, Schroeder B, et al. The influence of guaifenesin and ketoprofen on the properties of hot-melt extruded polyethylene oxide films. Eur J Pharm Sci. 2004, 22: 409-418.
    • (2004) Eur J Pharm Sci , vol.22 , pp. 409-418
    • Crowley, M.M.1    Fredersdorf, A.2    Schroeder, B.3
  • 45
    • 34248641967 scopus 로고    scopus 로고
    • The incorporation of an organically modified layered silicate in monolithic polymeric matrices produced using hot melt extrusion
    • Lyons JG, Holehonnur H, Devine DM, et al. The incorporation of an organically modified layered silicate in monolithic polymeric matrices produced using hot melt extrusion. Mater Chem Phys. 2007, 103: 419-426.
    • (2007) Mater Chem Phys , vol.103 , pp. 419-426
    • Lyons, J.G.1    Holehonnur, H.2    Devine, D.M.3
  • 46
    • 33746581777 scopus 로고    scopus 로고
    • The use of agar as a novel filler for monolithic matrices produced using hot melt extrusion
    • Lyons JG, Devine DM, Kennedy JE, et al. The use of agar as a novel filler for monolithic matrices produced using hot melt extrusion. Eur J Pharm Biopharm. 2006, 64: 75-81.
    • (2006) Eur J Pharm Biopharm , vol.64 , pp. 75-81
    • Lyons, J.G.1    Devine, D.M.2    Kennedy, J.E.3
  • 47
    • 9644279429 scopus 로고    scopus 로고
    • Properties of hotmelt extruded tablet formulations for the colonic delivery of 5-amino-salicylic acid
    • Bruce LD, Shah NH, Malick WA, et al. Properties of hotmelt extruded tablet formulations for the colonic delivery of 5-amino-salicylic acid. Eur J Pharm Biopharm. 2005, 59: 85-97.
    • (2005) Eur J Pharm Biopharm , vol.59 , pp. 85-97
    • Bruce, L.D.1    Shah, N.H.2    Malick, W.A.3
  • 48
    • 33749581070 scopus 로고    scopus 로고
    • Floating hot-melt extruded tablets for gastro-retentive controlled drug release system
    • Fukuda M, Peppas NA, McGinity JW. Floating hot-melt extruded tablets for gastro-retentive controlled drug release system. J Control Release. 2006, 115: 121-129.
    • (2006) J Control Release , vol.115 , pp. 121-129
    • Fukuda, M.1    Peppas, N.A.2    Mcginity, J.W.3
  • 49
    • 36048929753 scopus 로고    scopus 로고
    • Twice a day ocular inserts of acyclovir by melt extrusion technique
    • Jain SP, Shah S, Rajadhyaksha N, et al. Twice a day ocular inserts of acyclovir by melt extrusion technique. Indian J Pharm Sci. 2007, 69: 562-567.
    • (2007) Indian J Pharm Sci , vol.69 , pp. 562-567
    • Jain, S.P.1    Shah, S.2    Rajadhyaksha, N.3
  • 51
    • 79952209959 scopus 로고    scopus 로고
    • Application of melt granulation technology using twin-screw extruder in development of high-dose modified-release tablet formulation
    • Vasanthavada M, Wang Y, Haefele T, et al. Application of melt granulation technology using twin-screw extruder in development of high-dose modified-release tablet formulation. J Pharm Sci. 2011, 100(5),1923-1934.
    • (2011) J Pharm Sci , vol.100 , Issue.5 , pp. 1923-1934
    • Vasanthavada, M.1    Wang, Y.2    Haefele, T.3
  • 53
    • 77953370013 scopus 로고    scopus 로고
    • Fast dissolving oral films: an innovative drug delivery system and dosage form
    • Arya A, Chandra A, Sharma V, et al. Fast dissolving oral films: an innovative drug delivery system and dosage form. Int J Chem Tech Res. 2010, 2: 576-583.
    • (2010) Int J Chem Tech Res , vol.2 , pp. 576-583
    • Arya, A.1    Chandra, A.2    Sharma, V.3
  • 54
    • 80052676653 scopus 로고    scopus 로고
    • Orally fast dissolving films: Innovations in formulation and technology
    • Bhyan B, Jangra S, Kaur M, et al. Orally fast dissolving films: Innovations in formulation and technology. Int J Pharm Sci Rev Res. 2011, 9: 9.
    • (2011) Int J Pharm Sci Rev Res , vol.9 , pp. 9
    • Bhyan, B.1    Jangra, S.2    Kaur, M.3
  • 55
    • 4444235907 scopus 로고    scopus 로고
    • Influence of human nail etching for the assessment of topical onychomycosis therapies
    • Repka MA, Mididoddi PK, Stodghill SP. Influence of human nail etching for the assessment of topical onychomycosis therapies. Int J Pharm. 2004, 282: 95-106.
    • (2004) Int J Pharm , vol.282 , pp. 95-106
    • Repka, M.A.1    Mididoddi, P.K.2    Stodghill, S.P.3
  • 56
    • 0042347581 scopus 로고    scopus 로고
    • Production and characterization of hot-melt extruded films containing clotrimazole
    • Repka MA, Prodduturi S, Stodghill SP. Production and characterization of hot-melt extruded films containing clotrimazole. Drug Develop Ind Pharm. 2003, 29: 757-765.
    • (2003) Drug Develop Ind Pharm , vol.29 , pp. 757-765
    • Repka, M.A.1    Prodduturi, S.2    Stodghill, S.P.3
  • 57
    • 10644271650 scopus 로고    scopus 로고
    • Water vapor sorption isotherms of hot-melt extruded hydroxypropyl cellulose films: Effect on physico-mechanical properties, release characteristics and stability
    • Prodduturi S, Manek RV, Kolling B, et al. Water vapor sorption isotherms of hot-melt extruded hydroxypropyl cellulose films: Effect on physico-mechanical properties, release characteristics and stability. J Pharm Sci. 2004, 93: 3047-3056.
    • (2004) J Pharm Sci , vol.93 , pp. 3047-3056
    • Prodduturi, S.1    Manek, R.V.2    Kolling, B.3
  • 59
    • 33749478702 scopus 로고    scopus 로고
    • Influence of Tartaric acid on the bioadhesion and mechanical properties of hot-melt extruded hydroxypropyl cellulose films for the human nail
    • Mididoddi PK, Prodduturi S, Repka MA. Influence of Tartaric acid on the bioadhesion and mechanical properties of hot-melt extruded hydroxypropyl cellulose films for the human nail. Drug Dev Ind Pharm. 2006, 32: 1059-1066.
    • (2006) Drug Dev Ind Pharm , vol.32 , pp. 1059-1066
    • Mididoddi, P.K.1    Prodduturi, S.2    Repka, M.A.3
  • 60
    • 0035936977 scopus 로고    scopus 로고
    • Bioadhesive properties of hydroxypropylcellulose topical films produced by hot-melt extrusion
    • Repka MA, McGinity JW. Bioadhesive properties of hydroxypropylcellulose topical films produced by hot-melt extrusion. J Control Release. 2001, 70: 341-351.
    • (2001) J Control Release , vol.70 , pp. 341-351
    • Repka, M.A.1    Mcginity, J.W.2
  • 61
    • 33947161961 scopus 로고    scopus 로고
    • Characterization of hot-melt extruded drug delivery systems for onychomycosis
    • Mididoddi PK, Repka MA. Characterization of hot-melt extruded drug delivery systems for onychomycosis. Eur J Pharm Biopharm. 2007, 66: 95-105.
    • (2007) Eur J Pharm Biopharm , vol.66 , pp. 95-105
    • Mididoddi, P.K.1    Repka, M.A.2
  • 62
    • 27944478066 scopus 로고    scopus 로고
    • Solidstate stability and characterization of hot-melt extruded poly(ethylene oxide) films
    • Prodduturi S, Manek RV, Kolling WM, et al. Solidstate stability and characterization of hot-melt extruded poly(ethylene oxide) films. J Pharm Sci. 2005, 94: 2232-2245.
    • (2005) J Pharm Sci , vol.94 , pp. 2232-2245
    • Prodduturi, S.1    Manek, R.V.2    Kolling, W.M.3
  • 63
    • 9644291420 scopus 로고    scopus 로고
    • Characterization of cellulosic hot-melt extruded films containing lidocaine
    • Repka MA, Gutta K, Prodduturi S, et al. Characterization of cellulosic hot-melt extruded films containing lidocaine. Eur J Pharm Biopharm. 2005, 59: 189-196.
    • (2005) Eur J Pharm Biopharm , vol.59 , pp. 189-196
    • Repka, M.A.1    Gutta, K.2    Prodduturi, S.3
  • 64
    • 32344452213 scopus 로고    scopus 로고
    • Temper-ature stability and bioadhesive properties of d9-tetrahydrocannabinol incorporated hydroxypropyl cellulose polymer matrix systems
    • Repka MA, Munjal M, Elsohly MA, et al. Temper-ature stability and bioadhesive properties of d9-tetrahydrocannabinol incorporated hydroxypropyl cellulose polymer matrix systems. Drug Dev Ind Pharm. 2006, 32: 21-32.
    • (2006) Drug Dev Ind Pharm , vol.32 , pp. 21-32
    • Repka, M.A.1    Munjal, M.2    Elsohly, M.A.3
  • 68
    • 33750430305 scopus 로고    scopus 로고
    • Industrially feasible alternative approaches in the manufacture of solid dispersions: a technical report
    • Karanth H, Shenoy VS, Murthy RR. Industrially feasible alternative approaches in the manufacture of solid dispersions: a technical report. AAPS Pharm Sci Tech. 2006, 7: 87.
    • (2006) AAPS Pharm Sci Tech , vol.7 , pp. 87
    • Karanth, H.1    Shenoy, V.S.2    Murthy, R.R.3
  • 69
    • 65649103171 scopus 로고    scopus 로고
    • Solubility enhancement strategies for poorly water soluble drugs in solid dispersions-a review
    • Sharma DK, Joshi SB. Solubility enhancement strategies for poorly water soluble drugs in solid dispersions-a review. Asian J Pharm. 2007, 1: 9-19.
    • (2007) Asian J Pharm , vol.1 , pp. 9-19
    • Sharma, D.K.1    Joshi, S.B.2
  • 70
    • 84871412616 scopus 로고    scopus 로고
    • Influence of drug/polymer ratio on the dissolution enhancement for a poorly water-soluble model drug (BCS Class II) using hot melt extrusion
    • 11/7/2009-11/12/2009
    • Andrews GP, Jones DS, Tipping S, et al. Influence of drug/polymer ratio on the dissolution enhancement for a poorly water-soluble model drug (BCS Class II) using hot melt extrusion, AAPS Annual Meeting and Exposition. 2009, 11/7/2009-11/12/2009.
    • (2009) AAPS Annual Meeting and Exposition
    • Andrews, G.P.1    Jones, D.S.2    Tipping, S.3
  • 71
    • 38349153803 scopus 로고    scopus 로고
    • Influence of sulfobutyl ether β-cyclodextrin (Captisol®) on the dissolution properties of a poorly soluble drug from extrudates prepared by hot-melt extrusion
    • Fukuda M, Miller D, Peppas NA, et al. Influence of sulfobutyl ether β-cyclodextrin (Captisol®) on the dissolution properties of a poorly soluble drug from extrudates prepared by hot-melt extrusion. Int J Pharm. 2008, 350: 88-96.
    • (2008) Int J Pharm , vol.350 , pp. 88-96
    • Fukuda, M.1    Miller, D.2    Peppas, N.A.3
  • 75
    • 77951205335 scopus 로고    scopus 로고
    • Formulation of nano/micro-dispersions with improved dissolution properties upon dispersion of ritonavir melt extrudate in aqueous media
    • Tho I, Liepold B, Rosenberg J, et al. Formulation of nano/micro-dispersions with improved dissolution properties upon dispersion of ritonavir melt extrudate in aqueous media. Eur J Pharm Sci. 2010, 40: 25-32.
    • (2010) Eur J Pharm Sci , vol.40 , pp. 25-32
    • Tho, I.1    Liepold, B.2    Rosenberg, J.3
  • 76
    • 84871437030 scopus 로고    scopus 로고
    • High dose solid unit oral pharmaceutical dosage form of amorphous nelfinavir mesylate and process for making same
    • Infeld MH, Phuapradit W, Shah NH, et al. High dose solid unit oral pharmaceutical dosage form of amorphous nelfinavir mesylate and process for making same. U.S. Patent 7014866, 2006.
    • (2006) U.S. Patent , pp. 7014866
    • Infeld, M.H.1    Phuapradit, W.2    Shah, N.H.3
  • 77
    • 34547223558 scopus 로고    scopus 로고
    • Part I: Characterization of solid dispersions of nimodipine prepared by Hot-Melt extrusion
    • Zheng X, Yang R, Tang X, et al. Part I: Characterization of solid dispersions of nimodipine prepared by Hot-Melt extrusion. Drug Dev Ind Pharm. 2007, 33: 791-802.
    • (2007) Drug Dev Ind Pharm , vol.33 , pp. 791-802
    • Zheng, X.1    Yang, R.2    Tang, X.3
  • 78
    • 34547143790 scopus 로고    scopus 로고
    • Part II: Bioavailability in beagle dogs of Nimodipine solid dispersions prepared by hot-melt extrusion
    • Zheng X, Yang R, Zhang Y, et al. Part II: Bioavailability in beagle dogs of Nimodipine solid dispersions prepared by hot-melt extrusion. Drug Dev Ind Pharm. 2007, 33: 783-789.
    • (2007) Drug Dev Ind Pharm , vol.33 , pp. 783-789
    • Zheng, X.1    Yang, R.2    Zhang, Y.3
  • 79
    • 0038493711 scopus 로고    scopus 로고
    • Itraconazole formulation studies of the melt extrusion process with mixture design
    • Rambali B, Verreck G, Baert L, et al. Itraconazole formulation studies of the melt extrusion process with mixture design. Drug Dev Ind Pharm. 2003, 29: 641-652.
    • (2003) Drug Dev Ind Pharm , vol.29 , pp. 641-652
    • Rambali, B.1    Verreck, G.2    Baert, L.3
  • 80
    • 33847663431 scopus 로고    scopus 로고
    • Hot-melt extrusion for enhanced delivery of drug particles
    • Miller DA MJT, Yang W, Williams RO, et al. Hot-melt extrusion for enhanced delivery of drug particles. J Pharm Sci. 2006, 96: 361-376.
    • (2006) J Pharm Sci , vol.96 , pp. 361-376
    • Miller, D.A.M.J.1    Yang, W.2    Williams, R.O.3
  • 81
    • 77952503676 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of fenofibrate solid dispersion prepared by hotmelt extrusion
    • He HB, Yang R, Tang X, et al. In vitro and in vivo evaluation of fenofibrate solid dispersion prepared by hotmelt extrusion. Drug Dev Ind Pharm. 2010, 36: 681-687.
    • (2010) Drug Dev Ind Pharm , vol.36 , pp. 681-687
    • He, H.B.1    Yang, R.2    Tang, X.3
  • 82
    • 79955969587 scopus 로고    scopus 로고
    • Enhanced in vivo absorption of CB-1 antagonist in rats via solid solutions prepared by hot-melt extrusion
    • Ranzani LS, Font J, Galimany F, et al. Enhanced in vivo absorption of CB-1 antagonist in rats via solid solutions prepared by hot-melt extrusion. Drug Dev Ind Pharm. 2011, 37: 694-701.
    • (2011) Drug Dev Ind Pharm , vol.37 , pp. 694-701
    • Ranzani, L.S.1    Font, J.2    Galimany, F.3
  • 83
    • 79957644800 scopus 로고    scopus 로고
    • Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion
    • Gryczke A, Schminke S, Maniruzzaman M, et al. Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion. Colloids Surf B Biointerfaces. 2011, 86: 275-284.
    • (2011) Colloids Surf B Biointerfaces , vol.86 , pp. 275-284
    • Gryczke, A.1    Schminke, S.2    Maniruzzaman, M.3
  • 84
    • 33745603041 scopus 로고    scopus 로고
    • Controlled release of a poorly water-soluble drug from hot-melt extrudates containing acrylic polymers
    • Zhu Y, Shah NH, Malick AW, et al. Controlled release of a poorly water-soluble drug from hot-melt extrudates containing acrylic polymers. Drug Dev Ind Pharm. 2006, 32: 569-583.
    • (2006) Drug Dev Ind Pharm , vol.32 , pp. 569-583
    • Zhu, Y.1    Shah, N.H.2    Malick, A.W.3
  • 85
    • 0035845751 scopus 로고    scopus 로고
    • Selection of excipients for melt extrusion with two poorly water-soluble drugs by solubility parameter calculation and thermal analysis
    • Forster A, Hempenstall J, Tucker I, et al. Selection of excipients for melt extrusion with two poorly water-soluble drugs by solubility parameter calculation and thermal analysis. Int J Pharm. 2001, 226: 147-161.
    • (2001) Int J Pharm , vol.226 , pp. 147-161
    • Forster, A.1    Hempenstall, J.2    Tucker, I.3
  • 86
    • 33747159897 scopus 로고    scopus 로고
    • Polymeric systems for amorphous d9-tetrahydrocannabinol produced by a hot-melt method. Part I: chemical and thermal stability during processing
    • Munjal M, Stodghill SP, Elsohly MA, et al. Polymeric systems for amorphous d9-tetrahydrocannabinol produced by a hot-melt method. Part I: chemical and thermal stability during processing. J Pharm Sci. 2006, 95: 1841-1853.
    • (2006) J Pharm Sci , vol.95 , pp. 1841-1853
    • Munjal, M.1    Stodghill, S.P.2    Elsohly, M.A.3


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