Bone morphogenetic proteins in craniofacial surgery: Current techniques, clinical experiences, and the future of personalized stem cell therapy

Journal of Biomedicine and Biotechnology

Volumn 2012, Issue , 2012, Pages

  Chenard, Kristofer E ^a   Teven, Chad M ^a   He, Tong Chuan ^a   Reid, Russell R ^a  

^a UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 6; NOGGIN; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPONTIN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT OSTEOGENIC PROTEIN 1; TRANSCRIPTION FACTOR DLX5; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1;

BONE BIOPSY; BONE DEFECT; BONE DEVELOPMENT; BONE GRAFT; BONE REGENERATION; BONE TRANSPLANTATION; CELL CULTURE; CELL DIFFERENTIATION; CELL EXPANSION; CELL ISOLATION; CLINICAL EFFECTIVENESS; COMPUTER ASSISTED TOMOGRAPHY; CRANIOFACIAL SURGERY; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; HUMAN; INFLAMMATION; MESENCHYMAL STEM CELL; NONHUMAN; OSSIFICATION; OSTEOBLAST; PROTEIN EXPRESSION; PROTEIN FUNCTION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SIGNAL TRANSDUCTION; STEM CELL TRANSPLANTATION; ANIMAL; CLINICAL TRIAL (TOPIC); FACE; PERSONALIZED MEDICINE; SKULL;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CLINICAL TRIALS AS TOPIC; FACE; HUMANS; INDIVIDUALIZED MEDICINE; SKULL; STEM CELL TRANSPLANTATION;

EID: 84871394287     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2012/601549     Document Type: Review

References (151)

1. Verret D. J., Ducic Y., Oxford L., Smith J., Hydroxyapatite cement in craniofacial reconstruction. Otolaryngology 2005 133 6 897 899 2-s2.0-29144446915 10.1016/j.otohns.2005.09.001 (Pubitemid 41797242)
2. Touzet S., Ferri J., Wojcik T., Raoul G., Complications of calvarial bone harvesting for maxillofacial reconstructions. Journal of Craniofacial Surgery 2011 22 1 178 181 2-s2.0-79551610462 10.1097/SCS.0b013e3181f75300
3. Whitaker L. A., Munro I. R., Salyer K. E., Combined report of problems and complications in 793 craniofacial operations. Plastic and Reconstructive Surgery 1979 64 2 198 203 2-s2.0-0018389127 (Pubitemid 9215474)
4. Clokie C. M. L., Sándor G. K. B., Reconstruction of 10 major mandibular defects using bioimplants containing BMP-7. Journal of the Canadian Dental Association 2008 74 1 67 72 2-s2.0-39749102826
5. Seiler J. G. 3rd, Johnson J., Iliac crest autogenous bone grafting: donor site complications. Journal of the Southern Orthopaedic Association 2000 9 2 91 97 2-s2.0-0034198607
6. Hoard M. A., Bill T. J., Campbell R. L., Reduction in morbidity after iliac crest bone harvesting: the concept of preemptive analgesia. Journal of Craniofacial Surgery 1998 9 5 448 451 2-s2.0-0031694071 (Pubitemid 28454478)
7. Tessier P., Kawamoto H., Matthews D., Posnick J., Raulo Y., Tulasne J. F., Wolfe S. A., Autogenous bone grafts and bone substitutes-tools and techniques: I. A 20,000-case experience in maxillofacial and craniofacial surgery. Plastic and Reconstructive Surgery 2005 116 5, supplement 6S 24S 2-s2.0-26844571828 10.1097/01.prs.0000173862.20563.12 (Pubitemid 41446788)
8. Tessier P., Kawamoto H., Matthews D., Posnick J., Raulo Y., Tulasne J. F., Wolfe S. A., Taking bone grafts from the anterior and posterior ilium-tools and techniques: II. A 6800-case experience in maxillofacial and craniofacial surgery. Plastic and Reconstructive Surgery 2005 116 5, supplement 25S 37S 2-s2.0-26844468519 10.1097/01.prs.0000173951.78715.d7 (Pubitemid 41446789)
9. Tessier P., Kawamoto H., Matthews D., Posnick J., Raulo Y., Tulasne J. F., Wolfe S. A., Taking long rib grafts for facial reconstruction-tools and techniques: III. A 2900-case experience in maxillofacial and craniofacial surgery. Plastic and Reconstructive Surgery 2005 116 5, supplement 38S 46S 2-s2.0-26844562913 10.1097/01.prs.0000173906.35257.e0 (Pubitemid 41446790)
10. Tessier P., Kawamoto H., Matthews D., Posnick J., Raulo Y., Tulasne J. F., Wolfe S. A., Taking tibial grafts in the diaphysis and upper epiphysis-Tools and techniques: IV. A 650-case experience in maxillofacial and craniofacial surgery. Plastic and Reconstructive Surgery 2005 116 5, supplement 47S 53S 2-s2.0-26844581673 10.1097/01.prs.0000175699.15449.a3 (Pubitemid 41446791)
11. Tessier P., Kawamoto H., Posnick J., Raulo Y., Tulasne J. F., Wolfe S. A., Taking calvarial grafts, either split in situ or splitting of the parietal bone flap ex vivo-tools and techniques: V. A 9650-case experience in craniofacial and maxillofacial surgery. Plastic and Reconstructive Surgery 2005 116 5, supplement 54S 71S 2-s2.0-26844433594 10.1097/01.prs.0000173949.51391.d4 (Pubitemid 41446792)
12. Tessier P., Kawamoto H., Posnick J., Raulo Y., Tulasne J. F., Wolfe S. A., Complications of harvesting autogenous bone grafts: a group experience of 20,000 cases. Plastic and Reconstructive Surgery 2005 116 5, supplement 72S 73S 2-s2.0-26844541211 10.1097/01.prs.0000173841.59063.7e (Pubitemid 41446793)
13. Tessier P., Kawamoto H., Posnick J., Raulo Y., Tulasne J. F., Wolfe S. A., Taking calvarial grafts-tools and techniques: VI. The splitting of a parietal bone "flap" Plastic and Reconstructive Surgery 2005 116 5, supplement 74S 88S 2-s2.0-26844496829 10.1097/01.prs.0000177277.36391.28 (Pubitemid 41446794)
14. Citardi M. J., Friedman C. D., Nonvascularized autogenous bone grafts for craniofacial skeletal augmentation and replacement. Otolaryngologic Clinics of North America 1994 27 5 891 910 2-s2.0-0028080078 (Pubitemid 24319267)
15. Smith D. M., Afifi A. M., Cooper G. M., Mooney M. P., Marra K. G., Losee J. E., BMP-2YBased repair of large-scale calvarial defects in an experimental model: regenerative surgery in cranioplasty. Journal of Craniofacial Surgery 2008 19 5 1315 1322 2-s2.0-58249088291 10.1097/SCS.0b013e3181843369
16. Smith D. M., Cooper G. M., Afifi A. M., Mooney M. P., Cray J., Rubin J. P., Marra K. G., Losee J. E., Regenerative surgery in cranioplasty revisited: the role of adipose-derived stem cells and BMP-2. Plastic and Reconstructive Surgery 2011 128 5 1053 1060 2-s2.0-80155187529 10.1097/PRS.0b013e31822b65e4
17. Wan D. C., Aalami O. O., Wang Z., Nacamuli R. P., Lorget F., Derynck R., Longaker M. T., Differential gene expression between juvenile and adult dura mater: a window into what genes play a role in the regeneration of membranous bone. Plastic and Reconstructive Surgery 2006 118 4 851 861 2-s2.0-33748765539 10.1097/01.prs.0000232366.23897.2b (Pubitemid 44412918)
18. Smith D. M., Cooper G. M., Mooney M. P., Marra K. G., Losee J. E., Bone morphogenetic protein 2 therapy for craniofacial surgery. Journal of Craniofacial Surgery 2008 19 5 1244 1259 2-s2.0-58249092177 10.1097/SCS. 0b013e3181843312
19. Moss S. D., Joganic E., Manwaring K. H., Beals S. P., Transplanted demineralized bone graft in cranial reconstructive surgery. Pediatric Neurosurgery 1995 23 4 199 205 2-s2.0-0029586313 (Pubitemid 26043169)
20. Chin M., Ng T., Tom W. K., Carstens M., Repair of alveolar clefts with recombinant human bone morphogenetic protein (rhBMP-2) in patients with clefts. Journal of Craniofacial Surgery 2005 16 5 778 789 2-s2.0-26444469934 10.1097/01.scs.0000166802.49021.01 (Pubitemid 41428923)
21. Carstens M. H., Chin M., Ng T., Tom W. K., Reconstruction of #7 facial cleft with distraction-assisted in situ osteogenesis (DISO): role of recombinant human bone morphogenetic protein-2 with helistat-activated collagen implant. Journal of Craniofacial Surgery 2005 16 6 1023 1032 2-s2.0-33646980299 10.1097/01.scs.0000186310.10957.2b (Pubitemid 44383892)
22. Herford A. S., Boyne P. J., Rawson R., Williams R. P., Bone morphogenetic protein-induced repair of the premaxillary cleft. Journal of Oral and Maxillofacial Surgery 2007 65 11 2136 2141 2-s2.0-35348822409 10.1016/j.joms.2007.06.670 (Pubitemid 47588610)
23. Dickinson B. P., Ashley R. K., Wasson K. L., O'Hara C., Gabbay J., Heller J. B., Bradley J. P., Reduced morbidity and improved healing with bone morphogenic protein-2 in older patients with alveolar cleft defects. Plastic and Reconstructive Surgery 2008 121 1 209 217 2-s2.0-38049013709 10.1097/01.prs.0000293870.64781.12
24. Fallucco M. A., Carstens M. H., Primary reconstruction of alveolar clefts using recombinant human bone morphogenic protein-2: clinical and radiographic outcomes. Journal of Craniofacial Surgery 2009 20 8, supplement 1759 1764 2-s2.0-70350668581 10.1097/SCS.0b013e3181b5d08e
25. Alonso N., Tanikawa D. Y. S., Freitas R. D. S., Canan L., Ozawa T. O., Rocha D. L., Evaluation of maxillary alveolar reconstruction using a resorbable collagen sponge with recombinant human bone morphogenetic protein-2 in cleft lip and palate patients. Tissue Engineering C 2010 16 5 1183 1189 2-s2.0-77957370202 10.1089/ten.tec.2009.0824
26. Moghadam H. G., Urist M. R., Sandor G. K. B., Clokie C. M. L., Successful mandibular reconstruction using a BMP bioimplant. Journal of Craniofacial Surgery 2001 12 2 119 127 2-s2.0-0035745808 (Pubitemid 34863542)
27. Ferretti C., Ripamonti U., Human segmental mandibular defects treated with naturally derived bone morphogenetic proteins. Journal of Craniofacial Surgery 2002 13 3 434 444 2-s2.0-0036333192 (Pubitemid 34863622)
28. Warnke P. H., Wiltfang J., Springer I., Acil Y., Bolte H., Kosmahl M., Russo P. A. J., Sherry E., Lützen U., Wolfart S., Terheyden H., Man as living bioreactor: fate of an exogenously prepared customized tissue-engineered mandible. Biomaterials 2006 27 17 3163 3167 2-s2.0-33644749291 10.1016/j.biomaterials.2006.01.050 (Pubitemid 43344329)
29. Carter T. G., Brar P. S., Tolas A., Beirne O. R., Off-label use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for reconstruction of mandibular bone defects in humans. Journal of Oral and Maxillofacial Surgery 2008 66 7 1417 1425 2-s2.0-45149105632 10.1016/j.joms.2008.01.058 (Pubitemid 351833132)
30. Tieghi R., Consorti G., Clauser L. C., Contouring of the forehead irregularities (washboard effect) with bone biomaterial. Journal of Craniofacial Surgery 2012 23 3 932 934 2-s2.0-84861805059 10.1097/SCS.0b013e3182505593
31. Ehrmantraut S., Naumann A., Willnecker V., Akinyemi S., Körbel C., Scheuer C., Meyer-Lindenberg A., Menger M. D., Laschke M. W., Vitalization of porous polyethylene (Medpor) with chondrocytes promotes early implant vascularization and incorporation into the host tissue. Tissue Engineering A 2012 18 15-16 1562 1572 2-s2.0-84865209918 10.1089/ten.tea.2011.0340
32. Bostrom M. P., Seigerman D. A., The clinical use of allografts, demineralized bone matrices, synthetic bone graft substitutes and osteoinductive growth factors: a survey study. HSS Journal 2005 1 1 9 18
33. Kolk A., Handschel J., Drescher W., Current trends and future perspectives of bone substitute materials-from space holders to innovative biomaterials. Journal of Cranio-Maxillofacial Surgery. In press
34. Wong R. K., Gandolfi B. M., St-Hilaire H., Wise M. W., Moses M., Complications of hydroxyapatite bone cement in secondary pediatric craniofacial reconstruction. Journal of Craniofacial Surgery 2011 22 1 247 251 2-s2.0-79551587343 10.1097/SCS.0b013e3181f7b7db
35. Chen L., Jiang W., Huang J., He B. C., Zuo G. W., Zhang W., Luo Q., Shi Q., Zhang B. Q., Wagner E. R., Luo J., Tang M., Wietholt C., Luo X., Bi Y., Su Y., Liu B., Kim S. H., He C. J., Hu Y., Shen J., Rastegar F., Huang E., Gao Y., Gao J. L., Zhou J. Z., Reid R. R., Luu H. H., Haydon R. C., He T. C., Deng Z. L., Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation. Journal of Bone and Mineral Research 2010 25 11 2447 2459 2-s2.0-78349263031 10.1002/jbmr.133
36. Luo J., Tang M., Huang J., He B. C., Gao J. L., Chen L., Zuo G. W., Zhang W., Luo Q., Shi Q., Zhang B. Q., Bi Y., Luo X., Jiang W., Su Y., Shen J., Kim S. H., Huang E., Gao Y., Zhou J. Z., Yang K., Luu H. H., Pan X., Haydon R. C., Deng Z. L., He T. C., TGF β /BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells. Journal of Biological Chemistry 2010 285 38 29588 29598 2-s2.0-77956516276 10.1074/jbc.M110.130518
37. Kang Q., Song W. X., Luo Q., Tang N., Luo J., Luo X., Chen J., Bi Y., He B. C., Park J. K., Jiang W., Tang Y., Huang J., Su Y., Zhu G. H., He Y., Yin H., Hu Z., Wang Y., Chen L., Zuo G. W., Pan X., Shen J., Vokes T., Reid R. R., Haydon R. C., Luu H. H., He T. C., A Comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells and Development 2009 18 4 545 558 2-s2.0-67649271549 10.1089/scd.2008.0130
38. Sharff K. A., Song W. X., Luo X., Tang N., Luo J., Chen J., Bi Y., He B. C., Huang J., Li X., Jian W., Zhu G. H., Su Y., He Y., Shen J., Wang Y., Chen L., Zuo G. W., Liu B., Pan X., Reid R. R., Luu H. H., Haydon R. C., He T. C., Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. Journal of Biological Chemistry 2009 284 1 649 659 2-s2.0-58649085508 10.1074/jbc.M806389200
39. Tang N., Song W. X., Luo J., Luo X., Chen J., Sharff K. A., Bi Y., He B. C., Huang J. Y., Zhu G. H., Su Y. X., Jiang W., Tang M., He Y., Wang Y., Chen L., Zuo G. W., Shen J., Pan X., Reid R. R., Luu H. H., Haydon R. C., He T. C., BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/ β -catenin signalling. Journal of Cellular and Molecular Medicine 2009 13 8 B 2448 2464 2-s2.0-72949110602 10.1111/j.1582-4934. 2008.00569.x
40. Kang Q., Sun M. H., Cheng H., Peng Y., Montag A. G., Deyrup A. T., Jiang W., Luu H. H., Luo J., Szatkowski J. P., Vanichakarn P., Park J. Y., Li Y., Haydon R. C., He T. C., Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. Gene Therapy 2004 11 17 1312 1320 2-s2.0-4444329294 10.1038/sj.gt.3302298 (Pubitemid 39213996)
41. Cheng H., Jiang W., Phillips F. M., Haydon R. C., Peng Y., Zhou L., Luu H. H., An N., Breyer B., Vanichakarn P., Szatkowski J. P., Park J. Y., He T. C., Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs). Journal of Bone and Joint Surgery A 2003 85 8 1544 1552 2-s2.0-0042134565 (Pubitemid 36951140)
42. Peng Y., Kang Q., Cheng H., Li X., Sun M. H., Jiang W., Luu H. H., Park J. Y., Haydon R. C., He T. C., Transcriptional characterization of bone morphogenetic proteins (BMPs)-mediated osteogenic signaling. Journal of Cellular Biochemistry 2003 90 6 1149 1165 2-s2.0-0345305861 10.1002/jcb.10744 (Pubitemid 37485051)
43. He T. C., Distinct osteogenic activity of BMPs and their orthopaedic applications. Journal of Musculoskeletal Neuronal Interactions 2005 5 4 363 366 2-s2.0-33644521697
44. Glied A. N., Kraut R. A., Off-label use of rhBMP-2 for reconstruction of critical-sized mandibular defects. The New York State Dental Journal 2010 76 4 32 35 2-s2.0-78049428922
45. Herford A. S., Stoffella E., Tandon R., Reconstruction of mandibular defects using bone morphogenic protein: can growth factors replace the need for autologous bone grafts? A systematic review of the literature. Plastic Surgery International 2011 2011 7 10.1155/2011/165824 165824
46. Lee K. B., Murray S. S., Taghavi C. E., Song K. J., Brochmann E. J., Johnson J. S., Keorochana G., Liao J. C., Wang J. C., Bone morphogenetic protein-binding peptide reduces the inflammatory response to recombinant human bone morphogenetic protein-2 and recombinant human bone morphogenetic protein-7 in a rodent model of soft-tissue inflammation. Spine Journal 2011 11 6 568 576 2-s2.0-79959959003 10.1016/j.spinee.2011.02.001
47. Lee K.-B., Taghavi C. E., Murray S. S., Song K.-J., Keorochana G., Wang J. C., BMP induced inflammation: a comparison of rhBMP-7 and rhBMP-2. Journal of Orthopaedic Research 2012 30 12 1985 1994 2-s2.0-84861700644 10.1002/jor.22160
48. Shah M. M., Smyth M. D., Woo A. S., Adverse facial edema associated with off-label use of recombinant human bone morphogenetic protein-2 in cranial reconstruction for craniosynostosis: case report. Journal of Neurosurgery 2008 1 3 255 257 2-s2.0-40449105644 10.3171/PED/2008/1/3/255 (Pubitemid 351346517)
49. Perri B., Cooper M., Lauryssen C., Anand N., Adverse swelling associated with use of rh-BMP-2 in anterior cervical discectomy and fusion: a case study. Spine Journal 2007 7 2 235 239 2-s2.0-33847041526 10.1016/j.spinee.2006.04.010
50. Tumialan L. M., Rodts G. E., Adverse swelling associated with use of rh-BMP-2 in anterior cervical discectomy and fusion. Spine Journal 2007 7 4 509 510
51. Laursen M., Hoy K., Hansen E. S., Gelineck J., Christensen F. B., Bünger C. E., Recombinant bone morphogenetic protein-7 as an intracorporal bone growth stimulator in unstable thoracolumbar burst fractures in humans: preliminary results. European Spine Journal 1999 8 6 485 490 2-s2.0-0033387455 10.1007/s005860050210 (Pubitemid 30080570)
52. Jeppsson C., Aspenberg P., BMP-2 can inhibit bone healing: bone-chamber study in rabbits. Acta Orthopaedica 1996 67 6 589 592 2-s2.0-0030455198 10.3109/17453679608997762
53. Attisano L., Wrana J. L., Signal transduction by the TGF- β superfamily. Science 2002 296 5573 1646 1647 2-s2.0-0037204990 10.1126/science.1071809 (Pubitemid 34579152)
54. Blobe G. C., Schiemann W. P., Lodish H. F., Role of transforming growth factor β in human disease. New England Journal of Medicine 2000 342 18 1350 1358 2-s2.0-0034604110 10.1056/NEJM200005043421807 (Pubitemid 30408720)
55. Derynck R., Feng X. H., TGF-beta receptor signaling. Biochimica et Biophysica Acta 1997 1333 2 F105 F150
56. Massagué J., Chen Y.-G., Controlling TGF- β signaling. Genes and Development 2000 14 6 627 644 2-s2.0-0034034049
57. Massague J., The transforming growth factor- β family. Annual Review of Cell Biology 1990 6 597 641 2-s2.0-0025222517
58. Ross S., Hill C. S., How the Smads regulate transcription. International Journal of Biochemistry and Cell Biology 2008 40 3 383 408 2-s2.0-39049121312 10.1016/j.biocel.2007.09.006 (Pubitemid 351241229)
59. Olsen B. R., Reginato A. M., Wang W., Bone development. Annual Review of Cell and Developmental Biology 2000 16 191 220 2-s2.0-0034521277 10.1146/annurev.cellbio.16.1.191 (Pubitemid 32037505)
60. Amand T. R. S., Zhang Y., Semina E. V., Zhao X., Hu Y., Nguyen L., Murray J. C., Chen Y., Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth-forming anlage. Developmental Biology 2000 217 2 323 332 2-s2.0-0034650899 10.1006/dbio.1999.9547 (Pubitemid 30060880)
61. Ozkaynak E., Schnegelsberg P. N. J., Jin D. F., Clifford G. M., Warren F. D., Drier E. A., Oppermann H., Osteogenic protein-2. A new member of the transforming growth factor- β superfamily expressed early in embryogenesis. Journal of Biological Chemistry 1992 267 35 25220 25227 2-s2.0-0026459795
62. Wozney J. M., Rosen V., Celeste A. J., Mitsock L. M., Whitters M. J., Kriz R. W., Hewick R. M., Wang E. A., Novel regulators of bone formation: molecular clones and activities. Science 1988 242 4885 1528 1534 2-s2.0-0024256133 (Pubitemid 19023695)
63. Hollinger J. O., Schmitt J. M., Buck D. C., Shannon R., Joh S.-P., Zegzula H. D., Wozney J., Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration. Journal of Biomedical Materials Research 1998 43 4 356 364 2-s2.0-0032400860 10.1002/(SICI)1097-4636(199824)43:4<356::AID- JBM3>3.0.CO;2-7 (Pubitemid 28544095)
64. Hammonds R. G., Schwall R., Dudley A., Berkemeier L., Lai C., Lee J., Cunningham N., Reddi A. H., Wood W. I., Mason A. J., Bone-inducing activity of mature BMP-2b produced from a hybrid BMP-2a/2b precursor. Molecular Endocrinology 1991 5 1 149 155 2-s2.0-0025851697 (Pubitemid 21902094)
65. Wang E. A., Rosen V., D'Alessandro J. S., Bauduy M., Cordes P., Harada T., Israel D. I., Hewick R. M., Kerns K. M., LaPan P., Luxenberg D. P., McQuaid D., Moutsatsos I. K., Nove J., Wozney J. M., Recombinant human bone morphogenetic protein induces bone formation. Proceedings of the National Academy of Sciences of the United States of America 1990 87 6 2220 2224 2-s2.0-0025216220
66. Urist M. R., Bone: formation by autoinduction. Science 1965 150 3698 893 899 2-s2.0-34250019537
67. Hogan B. L. M., Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes and Development 1996 10 13 1580 1594 2-s2.0-0029737070 (Pubitemid 26268864)
68. Heldin C. H., Miyazono K., Ten Dijke P., TGF- β signalling from cell membrane to nucleus through SMAD proteins. Nature 1997 390 6659 465 471 2-s2.0-0031438047 10.1038/37284 (Pubitemid 28013118)
69. Massague J., TGF-beta signal transduction. Annual Review of Biochemistry 1998 67 753 791
70. Massagué J., Weis-Garcia F., Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals. Cancer Surveys 1996 27 41 64 2-s2.0-0029904671 (Pubitemid 26363822)
71. Shi Y., Massagué J., Mechanisms of TGF- β signaling from cell membrane to the nucleus. Cell 2003 113 6 685 700 2-s2.0-0038682002 10.1016/S0092-8674(03)00432-X (Pubitemid 36724933)
72. Yamashita H., Ten Dijke P., Heldin C. H., Miyazono K., Bone morphogenetic protein receptors. Bone 1996 19 6 569 574 2-s2.0-0030461022 10.1016/S8756-3282(96)00259-1 (Pubitemid 27035834)
73. Chen D., Zhao M., Mundy G. R., Bone morphogenetic proteins. Growth Factors 2004 22 4 233 241 2-s2.0-12344291865 10.1080/08977190412331279890 (Pubitemid 40136452)
74. Itoh S., Itoh F., Goumans M. J., Dijke P. T., Signaling of transforming growth factor- β family members through Smad proteins. European Journal of Biochemistry 2000 267 24 6954 6967 2-s2.0-0034533657 10.1046/j.1432-1327.2000. 01828.x (Pubitemid 32009435)
75. Attisano L., Wrana J. L., Smads as transcriptional co-modulators. Current Opinion in Cell Biology 2000 12 2 235 243 2-s2.0-0034104591 10.1016/S0955-0674(99)00081-2 (Pubitemid 30142572)
76. Javed A., Afzal F., Bae J. S., Gutierrez S., Zaidi K., Pratap J., Van Wijnen A. J., Stein J. L., Stein G. S., Lian J. B., Specific residues of RUNX2 are obligatory for formation of BMP2-induced RUNX2-SMAD complex to promote osteoblast differentiation. Cells Tissues Organs 2008 189 1-4 133 137 2-s2.0-57449098472 10.1159/000151719
77. Lee K. S., Kim H. J., Li Q. L., Chi X. Z., Ueta C., Komori T., Wozney J. M., Kim E. G., Choi J. Y., Ryoo H. M., Bae S. C., Runx2 is a common target of transforming growth factor β 1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Molecular and Cellular Biology 2000 20 23 8783 8792 2-s2.0-0034460993 10.1128/MCB.20.23.8783-8792.2000 (Pubitemid 32245911)
78. Phimphilai M., Zhao Z., Boules H., Roca H., Franceschi R. T., BMP signaling is required for RUNX2-dependent induction of the osteoblast phenotype. Journal of Bone and Mineral Research 2006 21 4 637 646 2-s2.0-33645351946 10.1359/jbmr.060109
79. Zhang Y. W., Yasui N., Ito K., Huang G., Fujii M., Hanai J. I., Nogami H., Ochi T., Miyazono K., Ito Y., A RUNX2/PEBP2 α A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proceedings of the National Academy of Sciences of the United States of America 2000 97 19 10549 10554 2-s2.0-0034641617
80. Miyazono K., Ten Dijke P., Heldin C. H., TGF- β signaling by smad proteins. Advances in Immunology 2000 75 115 157 2-s2.0-0033932667
81. Dijke P. T., Goumans M. J., Itoh F., Itoh S., Regulation of cell proliferation by Smad proteins. Journal of Cellular Physiology 2002 191 1 1 16 2-s2.0-0036189844 10.1002/jcp.10066 (Pubitemid 34195213)
82. Miyazono K., Ten Dijke P., Heldin C. H., TGF- β signaling by Smad proteins. Advances in Immunology 2000 75 115 157 2-s2.0-0033932667
83. Wrana J. L., Regulation of Smad activity. Cell 2000 100 2 189 192 2-s2.0-0034695511 (Pubitemid 30064906)
84. Chen G., Deng C., Li Y.-P., TGF- β and BMP signaling in osteoblast differentiation and bone formation. International Journal of Biological Sciences 2012 8 2 272 288 2-s2.0-84155184243 10.7150/ijbs.2929
85. Lee K. S., Hong S. H., Bae S. C., Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor- β and bone morphogenetic protein. Oncogene 2002 21 47 7156 7163 2-s2.0-0037126380 10.1038/sj.onc.1205937 (Pubitemid 35305602)
86. Nishimura R., Hata K., Matsubara T., Wakabayashi M., Yoneda T., Regulation of bone and cartilage development by network between BMP signalling and transcription factors. Journal of Biochemistry 2012 151 3 247 254 2-s2.0-79955021459 10.1093/jb/mvs004
87. Luther G., Wagner E. R., Zhu G., Kang Q., Luo Q., Lamplot J., Bi Y., Luo X., Luo J., Teven C., Shi Q., Kim S. H., Gao J. L., Huang E., Yang K., Rames R., Liu X., Li M., Hu N., Liu H., Su Y., Chen L., He B. C., Zuo G. W., Deng Z. L., Reid R. R., Luu H. H., Haydon R. C., He T. C., BMP-9 induced osteogenic differentiation of mesenchymal stem cells: molecular mechanism and therapeutic potential. Current Gene Therapy 2011 11 3 229 240 2-s2.0-79958202199
88. Luo J., Sun M. H., Kang Q., Peng Y., Jiang W., Luu H. H., Luo Q., Park J. Y., Li Y., Haydon R. C., He T. C., Gene therapy for bone regeneration. Current Gene Therapy 2005 5 2 167 179 2-s2.0-20144389396 10.2174/1566523053544218 (Pubitemid 40439587)
89. Luu H. H., Song W. X., Luo X., Manning D., Luo J., Deng Z. L., Sharff K. A., Montag A. G., Haydon R. C., He T. C., Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells. Journal of Orthopaedic Research 2007 25 5 665 677 2-s2.0-34248355601 10.1002/jor.20359 (Pubitemid 46730519)
90. Reya T., Clevers H., Wnt signalling in stem cells and cancer. Nature 2005 434 7035 843 850 2-s2.0-17244376814 10.1038/nature03319 (Pubitemid 40558990)
91. Jonason J. H., Xiao G., Zhang M., Xing L., Chen D., Post-translational regulation of Runx2 in bone and cartilage. Journal of Dental Research 2009 88 8 693 703 2-s2.0-70349342805 10.1177/0022034509341629
92. Komori T., Yagi H., Nomura S., Yamaguchi A., Sasaki K., Deguchi K., Shimizu Y., Bronson R. T., Gao Y. H., Inada M., Sato M., Okamoto R., Kitamura Y., Yoshiki S., Kishimoto T., Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 1997 89 5 755 764 2-s2.0-0030684749 (Pubitemid 27516178)
93. Otto F., Thornell A. P., Crompton T., Denzel A., Gilmour K. C., Rosewell I. R., Stamp G. W. H., Beddington R. S. P., Mundlos S., Olsen B. R., Selby P. B., Owen M. J., Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 1997 89 5 765 771 2-s2.0-0030666372 (Pubitemid 27516179)
94. Kobayashi H., Gao Y. H., Ueta C., Yamaguchi A., Komori T., Multilineage differentiation of Cbfa1-deficient calvarial cells in vitro. Biochemical and Biophysical Research Communications 2000 273 2 630 636 2-s2.0-0033876760 10.1006/bbrc.2000.2981 (Pubitemid 30599036)
95. Lai C. F., Cheng S. L., Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor- β in normal human osteoblastic cells. Journal of Biological Chemistry 2002 277 18 15514 15522 2-s2.0-0037013229 10.1074/jbc.M200794200 (Pubitemid 34967818)
96. Takahashi N., Maeda K., Ishihara A., Uehara S., Kobayashi Y., Regulatory mechanism of osteoclastogenesis by RANKL and Wnt signals. Frontiers in Bioscience 2011 16 1 21 30 2-s2.0-79954483045 10.2741/3673
97. Kugimiya F., Kawaguchi H., Kamekura S., Chikuda H., Ohba S., Yano F., Ogata N., Katagiri T., Harada Y., Azuma Y., Nakamura K., Chung U. I., Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation. Journal of Biological Chemistry 2005 280 42 35704 35712 2-s2.0-27444433077 10.1074/jbc.M505166200 (Pubitemid 41532763)
98. Wu X. B., Li Y., Schneider A., Yu W., Rajendren G., Iqbal J., Yamamoto M., Alam M., Brunet L. J., Blair H. C., Zaidi M., Abe E., Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice. Journal of Clinical Investigation 2003 112 6 924 934 2-s2.0-0142186683 10.1172/JCI200315543 (Pubitemid 38063750)
99. Gazzerro E., Pereira R. C., Jorgetti V., Olson S., Economides A. N., Canalis E., Skeletal overexpression of gremlin impairs bone formation and causes osteopenia. Endocrinology 2005 146 2 655 665 2-s2.0-12344262661 10.1210/en.2004-0766 (Pubitemid 40129821)
100. Devlin R. D., Du Z., Pereira R. C., Kimble R. B., Economides A. N., Jorgetti V., Canalis E., Skeletal overexpression of noggin results in osteopenia and reduced bone formation. Endocrinology 2003 144 5 1972 1978 2-s2.0-0037733130 10.1210/en.2002-220918 (Pubitemid 36543336)
101. Tsuji K., Bandyopadhyay A., Harfe B. D., Cox K., Kakar S., Gerstenfeld L., Einhorn T., Tabin C. J., Rosen V., BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nature Genetics 2006 38 12 1424 1429 2-s2.0-33751506452 10.1038/ng1916 (Pubitemid 44837565)
102. Farhadieh R. D., Dickinson R., Yu Y., Gianoutsos M. P., Walsh W. R., The role of transforming growth factor-beta, insulin-like growth factor I, and basic fibroblast growth factor in distraction osteogenesis of the mandible. Journal of Craniofacial Surgery 1999 10 1 80 86 2-s2.0-0032901761 (Pubitemid 29045891)
103. Farhadieh R. D., Gianoutsos M. P., Yu Y., Walsh W. R., The role of bone morphogenetic proteins BMP-2 and BMP-4 and their related postreceptor signaling system (Smads) in distraction osteogenesis of the mandible. The Journal of Craniofacial Surgery 2004 15 5 714 718 2-s2.0-13444313194
104. Khanal A., Yoshioka I., Tominaga K., Furuta N., Habu M., Fukuda J., The BMP signaling and its Smads in mandibular distraction osteogenesis. Oral Diseases 2008 14 4 347 355 2-s2.0-42149091190 10.1111/j.1601-0825.2007.01388.x (Pubitemid 351533588)
105. He T. C., Zhou S., Da Costa L. T., Yu J., Kinzler K. W., Vogelstein B., A simplified system for generating recombinant adenoviruses. Proceedings of the National Academy of Sciences of the United States of America 1998 95 5 2509 2514 2-s2.0-0032478271 10.1073/pnas.95.5.2509 (Pubitemid 28145972)
106. Bahamonde M. E., Lyons K. M., BMP3: to be or not to be a BMP. Journal of Bone and Joint Surgery A 2001 83 1 S56 S62 2-s2.0-0035221549
107. Peng Y., Kang Q., Luo Q., Jiang W., Si W., Liu B. A., Luu H. H., Park J. K., Li X., Luo J., Montag A. G., Haydon R. C., He T. C., Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells. Journal of Biological Chemistry 2004 279 31 32941 32949 2-s2.0-3543041812 10.1074/jbc.M403344200 (Pubitemid 39014754)
108. Nickel J., Dreyer M. K., Kirsch T., Sebald W., The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists. Journal of Bone and Joint Surgery A 2001 83 supplement 1 S7 S14 2-s2.0-0001141094
109. Brown M. A., Zhao Q., Baker K. A., Naik C., Chen C., Pukac L., Singh M., Tsareva T., Parice Y., Mahoney A., Roschke V., Sanya I., Choe S., Crystal structure of BMP-9 and functional interactions with pro-region and receptors. Journal of Biological Chemistry 2005 280 26 25111 25118 2-s2.0-21644461778 10.1074/jbc.M503328200 (Pubitemid 40934603)
110. Hassanein A. H., Couto R. A., Kurek K. C., Rogers G. F., Mulliken J. B., Greene A. K., Experimental comparison of cranial particulate bone graft, rhBMP-2, and split cranial bone graft for inlay cranioplasty. The Cleft Palate-Craniofacial Journal. In press
111. Kinsella C. R., Cray J. J., Smith D. M., Rottgers S. A., Mooney M. P., Cooper G. M., Losee J. E., Novel model of calvarial defect in an infected unfavorable wound: reconstruction with rhBMP-2. part II. Journal of Craniofacial Surgery 2012 23 2 410 414 2-s2.0-79951601964 10.1097/SCS.0b013e318240feb8
112. Decesare G. E., Cooper G. M., Smith D. M., Cray J. J., Durham E. L., Kinsella C. R., Mooney M. P., Losee J. E., Novel animal model of calvarial defect in an infected unfavorable wound: reconstruction with rhBMP-2. Plastic and Reconstructive Surgery 2011 127 2 588 594 2-s2.0-79951601964 10.1097/PRS.0b013e3181fed5c5
113. Li J., Hong J., Zheng Q., Guo X., Lan S., Cui F., Pan H., Zou Z., Chen C., Repair of rat cranial bone defects with nHAC/PLLA and BMP-2-related peptide or rhBMP-2. Journal of Orthopaedic Research 2011 29 11 1745 1752 2-s2.0-79955120588 10.1002/jor.21439
114. Aghaloo T., Cowan C. M., Zhang X., Freymiller E., Soo C., Wu B., Ting K., Zhang Z., The effect of NELL1 and bone morphogenetic protein-2 on calvarial bone regeneration. Journal of Oral and Maxillofacial Surgery 2010 68 2 300 308 2-s2.0-73949149208 10.1016/j.joms.2009.03.066
115. Lee J. H., Kim C. S., Choi K. H., Jung U. W., Yun J. H., Choi S. H., Cho K. S., The induction of bone formation in rat calvarial defects and subcutaneous tissues by recombinant human BMP-2, produced in Escherichia coli. Biomaterials 2010 31 13 3512 3519 2-s2.0-77249145300 10.1016/j.biomaterials.2010.01.075
116. Sawyer A. A., Song S. J., Susanto E., Chuan P., Lam C. X. F., Woodruff M. A., Hutmacher D. W., Cool S. M., The stimulation of healing within a rat calvarial defect by mPCL-TCP/collagen scaffolds loaded with rhBMP-2. Biomaterials 2009 30 13 2479 2488 2-s2.0-60849085973 10.1016/j.biomaterials. 2008.12.055
117. Hong S. J., Kim C. S., Han D. K., Cho I. H., Jung U. W., Choi S. H., Kim C. K., Cho K. S., The effect of a fibrin-fibronectin/ β -tricalcium phosphate/recombinant human bone morphogenetic protein-2 system on bone formation in rat calvarial defects. Biomaterials 2006 27 20 3810 3816 2-s2.0-33646480103 10.1016/j.biomaterials.2006.02.045
118. Springer I. N. G., Açil Y., Kuchenbecker S., Bolte H., Warnke P. H., Abboud M., Wiltfang J., Terheyden H., Bone graft versus BMP-7 in a critical size defect-cranioplasty in a growing infant model. Bone 2005 37 4 563 569 2-s2.0-24944529153 10.1016/j.bone.2005.05.010 (Pubitemid 41317329)
119. Sheehan J. P., Sheehan J. M., Seeherman H., Quigg M., Helm G. A., The safety and utility of recombinant human bone morphogenetic protein-2 for cranial procedures in a nonhuman primate model. Journal of Neurosurgery 2003 98 1 125 130 2-s2.0-0037220194 (Pubitemid 36050455)
120. Sawada Y., Hokugo A., Nishiura A., Hokugo R., Matsumoto N., Morita S., Tabata Y., A trial of alveolar cleft bone regeneration by controlled release of bone morphogenetic protein: an experimental study in rabbits. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology 2009 108 6 812 820 2-s2.0-71849111655 10.1016/j.tripleo.2009.06.040
121. Takahashi Y., Yamamoto M., Yamada K., Kawakami O., Tabata Y., Skull bone regeneration in nonhuman primates by controlled release of bone morphogenetic protein-2 from a biodegradable hydrogel. Tissue Engineering 2007 13 2 293 300 2-s2.0-33847046788 10.1089/ten.2006.0088
122. Schultze-Mosgau S., Lehner B., Rödel F., Wehrhan F., Amann K., Kopp J., Thorwarth M., Nkenke E., Grabenbauer G., Expression of bone morphogenic protein 2/4, transforming growth factor- β 1, and bone matrix protein expression in healing area between vascular tibia grafts and irradiated bone-experimental model of osteonecrosis. International Journal of Radiation Oncology Biology Physics 2005 61 4 1189 1196 2-s2.0-14844325757 10.1016/j.ijrobp.2004.12.008 (Pubitemid 40340915)
123. Springer I. N. G., Niehoff P., Açil Y., Marget M., Lange A., Warnke P. H., Pielenz H., Roldán J. C., Wiltfang J., BMP-2 and bFGF in an irradiated bone model. Journal of Cranio-Maxillofacial Surgery 2008 36 4 210 217 2-s2.0-42749084585 10.1016/j.jcms.2007.09.001
124. Sailer H. F., Kolb E., Application of purified hone morphogenetic protein (BMP) preparations in cranio-maxillo-facial surgery. Reconstruction in craniofacial malformations and post-traumatic or operative defects of the skull with lyophilized cartilage and BMP. Journal of Cranio-Maxillo-Facial Surgery 1994 22 4 191 199 2-s2.0-0028016276
125. Sailer H. F., Kolb E., Application of purified bone morphogenetic protein (BMP) in cranio- maxillo-facial surgery. BMP in compromised surgical reconstructions using titanium implants. Journal of Cranio-Maxillo-Facial Surgery 1994 22 1 2 11 2-s2.0-0028044568
126. Chao M., Donovan T., Sotelo C., Carstens M. H., In situ osteogenesis of hemimandible with rhBMP-2 in a 9-year-old boy: osteoinduction via stem cell concentration. Journal of Craniofacial Surgery 2006 17 3 405 412 2-s2.0-33747601619 (Pubitemid 44314832)
127. Herford A. S., Boyne P. J., Reconstruction of mandibular continuity defects with bone morphogenetic protein-2 (rhBMP-2). Journal of Oral and Maxillofacial Surgery 2008 66 4 616 624 2-s2.0-40749112395 10.1016/j.joms.2007. 11.021 (Pubitemid 351381799)
128. van Hout W. M. M. T., van der Molen A. B. M., Breugem C. C., Koole R., van Cann E. M., Reconstruction of the alveolar cleft: can growth factor-aided tissue engineering replace autologous bone grafting? A literature review and systematic review of results obtained with bone morphogenetic protein-2. Clinical Oral Investigations 2011 15 3 297 303 2-s2.0-79955843652 10.1007/s00784-011-0547-6
129. Herford A. S., rhBMP-2 as an option for reconstructing mandibular continuity defects. Journal of Oral and Maxillofacial Surgery 2009 67 12 2679 2684 2-s2.0-71549114513 10.1016/j.joms.2009.07.096
130. Herford A. S., Boyne P. J., Reconstruction of mandibular continuity defects with bone morphogenetic protein-2 (rhBMP-2). Journal of Oral and Maxillofacial Surgery 2008 66 4 616 624 2-s2.0-40749112395 10.1016/j.joms.2007. 11.021 (Pubitemid 351381799)
131. Herford A. S., Cicciù M., Recombinant human bone morphogenetic protein type 2 jaw reconstruction in patients affected by giant cell tumor. Journal of Craniofacial Surgery 2010 21 6 1970 1975 2-s2.0-78650559159 10.1097/SCS.0b013e3181f502fa
132. Herford A. S., Boyne P. J., Williams R. P., Clinical applications of rhBMP-2 in maxillofacial surgery. Journal of the California Dental Association 2007 35 5 335 341 2-s2.0-35148820057
133. Bruder S. P., Jaiswal N., Haynesworth S. E., Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. Journal of Cellular Biochemistry 1997 64 2 278 294 2-s2.0-0031012465 10.1002/(SICI)1097- 4644(199702)64:2<278::AID-JCB11>3.0.CO;2-F (Pubitemid 27065442)
134. Haynesworth S. E., Baber M. A., Caplan A. I., Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone 1992 13 1 69 80 2-s2.0-0026525255
135. Haynesworth S. E., Goshima J., Goldberg V. M., Caplan A. I., Characterization of cells with osteogenic potential from human marrow. Bone 1992 13 1 81 88 2-s2.0-0026578530
136. Soleimani M., Nadri S., A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow. Nature Protocols 2009 4 1 102 106 2-s2.0-61449210913 10.1038/nprot.2008.221
137. Jaiswal N., Haynesworth S. E., Caplan A. I., Bruder S. P., Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. Journal of Cellular Biochemistry 1997 64 2 295 312 2-s2.0-0030826763 10.1002/(SICI)1097-4644(199702)64:2<295::AID-JCB12>3.0.CO;2-I (Pubitemid 27065443)
138. Baksh D., Song L., Tuan R. S., Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. Journal of Cellular and Molecular Medicine 2004 8 3 301 316 2-s2.0-20444429578 (Pubitemid 44145494)
139. Bianco P., Riminucci M., Gronthos S., Robey P. G., Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 2001 19 3 180 192 2-s2.0-0034988303 (Pubitemid 32524539)
140. Pittenger M. F., Mackay A. M., Beck S. C., Jaiswal R. K., Douglas R., Mosca J. D., Moorman M. A., Simonetti D. W., Craig S., Marshak D. R., Multilineage potential of adult human mesenchymal stem cells. Science 1999 284 5411 143 147 2-s2.0-0033515827 10.1126/science.284.5411.143 (Pubitemid 29282067)
141. Beresford J. N., Bennett J. H., Devlin C., Leboy P. S., Owen M. E., Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. Journal of Cell Science 1992 102 2 341 351 2-s2.0-0026718865
142. Bennett J. H., Joyner C. J., Triffitt J. T., Owen M. E., Adipocytic cells cultured from marrow have osteogenic potential. Journal of Cell Science 1991 99 1 131 139 2-s2.0-0025865559
143. Zeng Y., Qu X., Li H., Huang S., Wang S., Xu Q., Lin R., Han Q., Li J., Zhao R. C., MicroRNA-100 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells by targeting BMPR2. FEBS Letters 2012 586 16 2375 2381 2-s2.0-84864286762 10.1016/j.febslet.2012.05.049
144. Locke M., Feisst V., Dunbar P. R., Concise review: human adipose-derived stem cells: separating promise from clinical need. Stem Cells 2011 29 3 404 411 2-s2.0-79953007054 10.1002/stem.593
145. Wang S., Qu X., Zhao R. C., Mesenchymal stem cells hold promise for regenerative medicine. Frontiers of Medicine in China 2011 5 4 372 378 2-s2.0-80055078628 10.1007/s11684-011-0164-4
146. Cowan C. M., Shi Y. Y., Aalami O. O., Chou Y. F., Mari C., Thomas R., Quarto N., Contag C. H., Wu B., Longaker M. T., Adipose-derived adult stromal cells heal critical-size mouse calvarial defects. Nature Biotechnology 2004 22 5 560 567 2-s2.0-2342586660 10.1038/nbt958 (Pubitemid 38585908)
147. Szpalski C., Barr J., Wetterau M., Saadeh P. B., Warren S. M., Cranial bone defects: current and future strategies. Neurosurgical Focus 2010 29 6 1 11 2-s2.0-78650291815 10.3171/2010.9.FOCUS10201
148. Nakahara H., Misawa H., Hayashi T., Kondo E., Yuasa T., Kubota Y., Seita M., Kawamoto H., Hassan W. A. R. A., Hassan R. A. R. A., Javed S. M., Tanaka M., Endo H., Noguchi H., Matsumoto S., Takata K., Tashiro Y., Nakaji S., Ozaki T., Kobayashi N., Bone repair by transplantation of hTERT-immortalized human mesenchymal stem cells in mice. Transplantation 2009 88 3 346 353 2-s2.0-69449095008 10.1097/TP.0b013e3181ae5ba2
149. Bruder S. P., Kurth A. A., Shea M., Hayes W. C., Jaiswal N., Kadiyala S., Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells. Journal of Orthopaedic Research 1998 16 2 155 162 2-s2.0-0032029899 10.1002/jor.1100160202 (Pubitemid 28249153)
150. Steinert D. M., Blakely L. J., Salganick J., Trent J. C., Molecular targets in therapy for human soft-tissue and bone sarcomas. Current Oncology Reports 2003 5 4 295 303 2-s2.0-0037658619 (Pubitemid 38898796)
151. Wagner E. R., Luther G., Zhu G., Luo Q., Shi Q., Kim S. H., Gao J. L., Huang E., Gao Y., Yang K., Wang L., Teven C., Luo X., Liu X., Li M., Hu N., Su Y., Bi Y., He B. C., Tang N., Luo J., Chen L., Zuo G., Rames R., Haydon R. C., He T. C., Defective osteogenic differentiation in the development of osteosarcoma. Sarcoma 2011 2011 2-s2.0-79955082926 10.1155/2011/325238 325238