메뉴 건너뛰기




Volumn 88, Issue 8, 2009, Pages 693-703

Post-translational regulation of Runx2 in bone and cartilage

Author keywords

Degradation; Phosphorylation; PTHrP; Runx2; Ubiquitination

Indexed keywords

RUNX2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR RUNX2;

EID: 70349342805     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/0022034509341629     Document Type: Review
Times cited : (140)

References (122)
  • 2
    • 20144365699 scopus 로고    scopus 로고
    • Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription
    • Afzal F., Pratap J., Ito K., Ito Y., Stein JL, van Wijnen AJ, et al. (2005). Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription. J Cell Physiol 204: 63-72.
    • (2005) J Cell Physiol , vol.204 , pp. 63-72
    • Afzal, F.1    Pratap, J.2    Ito, K.3    Ito, Y.4    Stein, J.L.5    Van Wijnen, A.J.6
  • 4
    • 33846436417 scopus 로고    scopus 로고
    • Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation
    • Bae JS, Gutierrez S., Narla R., Pratap J., Devados R., van Wijnen AJ, et al. (2007). Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation. J Cell Biochem 100: 434-449.
    • (2007) J Cell Biochem , vol.100 , pp. 434-449
    • Bae, J.S.1    Gutierrez, S.2    Narla, R.3    Pratap, J.4    Devados, R.5    Van Wijnen, A.J.6
  • 5
    • 0030794270 scopus 로고    scopus 로고
    • Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex
    • Banerjee C., McCabe LR, Choi JY, Hiebert SW, Stein JL, Stein GS, et al. (1997). Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex. J Cell Biochem 66: 1-8.
    • (1997) J Cell Biochem , vol.66 , pp. 1-8
    • Banerjee, C.1    McCabe, L.R.2    Choi, J.Y.3    Hiebert, S.W.4    Stein, J.L.5    Stein, G.S.6
  • 6
    • 0034878782 scopus 로고    scopus 로고
    • Differential regulation of the two principal Runx2/Cbfa1 n-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype
    • Banerjee C., Javed A., Choi JY, Green J., Rosen V., van Wijnen AJ, et al. (2001). Differential regulation of the two principal Runx2/Cbfa1 n-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype. Endocrinology 142: 4026-4039.
    • (2001) Endocrinology , vol.142 , pp. 4026-4039
    • Banerjee, C.1    Javed, A.2    Choi, J.Y.3    Green, J.4    Rosen, V.5    Van Wijnen, A.J.6
  • 7
    • 10744231292 scopus 로고    scopus 로고
    • Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism
    • Bellido T., Ali AA, Plotkin LI, Fu Q., Gubrij I., Roberson PK, et al. (2003). Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism. J Biol Chem 278: 50259-50272.
    • (2003) J Biol Chem , vol.278 , pp. 50259-50272
    • Bellido, T.1    Ali, A.A.2    Plotkin, L.I.3    Fu, Q.4    Gubrij, I.5    Roberson, P.K.6
  • 8
    • 24744462930 scopus 로고    scopus 로고
    • BMP-2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways
    • Celil AB, Campbell PG (2005). BMP-2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways. J Biol Chem 280: 31353-31359.
    • (2005) J Biol Chem , vol.280 , pp. 31353-31359
    • Celil, A.B.1    Campbell, P.G.2
  • 9
    • 23844506742 scopus 로고    scopus 로고
    • Osx transcriptional regulation is mediated by additional pathways to BMP2/Smad signaling
    • Celil AB, Hollinger JO, Campbell PG (2005). Osx transcriptional regulation is mediated by additional pathways to BMP2/Smad signaling. J Cell Biochem 95: 518-528.
    • (2005) J Cell Biochem , vol.95 , pp. 518-528
    • Celil, A.B.1    Hollinger, J.O.2    Campbell, P.G.3
  • 10
    • 13844299354 scopus 로고    scopus 로고
    • Altered gene expression in human cleidocranial dysplasia dental pulp cells
    • Chen S., Santos L., Wu Y., Vuong R., Gay I., Schulze J., et al. (2005). Altered gene expression in human cleidocranial dysplasia dental pulp cells. Arch Oral Biol 50: 227-236.
    • (2005) Arch Oral Biol , vol.50 , pp. 227-236
    • Chen, S.1    Santos, L.2    Wu, Y.3    Vuong, R.4    Gay, I.5    Schulze, J.6
  • 11
    • 0035902565 scopus 로고    scopus 로고
    • Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development
    • Choi JY, Pratap J., Javed A., Zaidi SK, Xing L., Balint E., et al. (2001). Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development. Proc Natl Acad Sci USA 98: 8650-8655.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8650-8655
    • Choi, J.Y.1    Pratap, J.2    Javed, A.3    Zaidi, S.K.4    Xing, L.5    Balint, E.6
  • 12
    • 0032788735 scopus 로고    scopus 로고
    • Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice
    • D'Souza RN, Aberg T., Gaikwad J., Cavender A., Owen M., Karsenty G., et al. (1999). Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. Development 126: 2911-2920.
    • (1999) Development , vol.126 , pp. 2911-2920
    • D'souza, R.N.1    Aberg, T.2    Gaikwad, J.3    Cavender, A.4    Owen, M.5    Karsenty, G.6
  • 13
    • 38449093315 scopus 로고    scopus 로고
    • Regulation of osteogenic differentiation during skeletal development
    • Deng ZL, Sharff KA, Tang N., Song WX, Luo J., Luo X., et al. (2008). Regulation of osteogenic differentiation during skeletal development. Front Biosci 13: 2001-2021.
    • (2008) Front Biosci , vol.13 , pp. 2001-2021
    • Deng, Z.L.1    Sharff, K.A.2    Tang, N.3    Song, W.X.4    Luo, J.5    Luo, X.6
  • 14
    • 0033881829 scopus 로고    scopus 로고
    • Transcriptional autoregulation of the bone related CBFA1/ RUNX2 gene
    • Drissi H., Luc Q., Shakoori R., Chuva De Sousa Lopes S., Choi JY, Terry A., et al. (2000). Transcriptional autoregulation of the bone related CBFA1/ RUNX2 gene. J Cell Physiol 184: 341-350.
    • (2000) J Cell Physiol , vol.184 , pp. 341-350
    • Drissi, H.1    Luc, Q.2    Shakoori, R.3    Choi, J.Y.4    Terry, A.5
  • 15
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • Ducy P., Zhang R., Geoffroy V., Ridall AL, Karsenty G. (1997). Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89: 747-754.
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 17
    • 0037930017 scopus 로고    scopus 로고
    • Induction of osteoclast differentiation by Runx2 through receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin regulation and partial rescue of osteoclastogenesis in Runx2-/- mice by RANKL transgene
    • Enomoto H., Shiojiri S., Hoshi K., Furuichi T., Fukuyama R., Yoshida CA, et al. (2003). Induction of osteoclast differentiation by Runx2 through receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin regulation and partial rescue of osteoclastogenesis in Runx2-/- mice by RANKL transgene. J Biol Chem 278: 23971-23977.
    • (2003) J Biol Chem , vol.278 , pp. 23971-23977
    • Enomoto, H.1    Shiojiri, S.2    Hoshi, K.3    Furuichi, T.4    Fukuyama, R.5    Yoshida, C.A.6
  • 18
    • 20144371011 scopus 로고    scopus 로고
    • The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts
    • Galindo M., Pratap J., Young DW, Hovhannisyan H., Im HJ, Choi JY, et al. (2005). The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts. J Biol Chem 280: 20274-20285.
    • (2005) J Biol Chem , vol.280 , pp. 20274-20285
    • Galindo, M.1    Pratap, J.2    Young, D.W.3    Hovhannisyan, H.4    Im, H.J.5    Choi, J.Y.6
  • 19
    • 33847375078 scopus 로고    scopus 로고
    • Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development
    • Ge C., Xiao G., Jiang D., Franceschi RT (2007). Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol 176: 709-718.
    • (2007) J Cell Biol , vol.176 , pp. 709-718
    • Ge, C.1    Xiao, G.2    Jiang, D.3    Franceschi, R.T.4
  • 20
    • 0031921591 scopus 로고    scopus 로고
    • Genomic organization, expression of the human CBFA1 gene, and evidence for an alternative splicing event affecting protein function
    • Geoffroy V., Corral DA, Zhou L., Lee B., Karsenty G. (1998). Genomic organization, expression of the human CBFA1 gene, and evidence for an alternative splicing event affecting protein function. Mamm Genome 9: 54-57.
    • (1998) Mamm Genome , vol.9 , pp. 54-57
    • Geoffroy, V.1    Corral, D.A.2    Zhou, L.3    Lee, B.4    Karsenty, G.5
  • 21
    • 33645082395 scopus 로고    scopus 로고
    • PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways
    • Guo J., Chung UI, Yang D., Karsenty G., Bringhurst FR, Kronenberg HM (2006). PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways. Dev Biol 292: 116-128.
    • (2006) Dev Biol , vol.292 , pp. 116-128
    • Guo, J.1    Chung, U.I.2    Yang, D.3    Karsenty, G.4    Bringhurst, F.R.5    Kronenberg, H.M.6
  • 22
    • 53149122891 scopus 로고    scopus 로고
    • Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins
    • Guo R., Yamashita M., Zhang Q., Zhou Q., Chen D., Reynolds DG, et al. (2008). Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins. J Biol Chem 283: 23084-23092.
    • (2008) J Biol Chem , vol.283 , pp. 23084-23092
    • Guo, R.1    Yamashita, M.2    Zhang, Q.3    Zhou, Q.4    Chen, D.5    Reynolds, D.G.6
  • 23
    • 0036861933 scopus 로고    scopus 로고
    • Transcription factors RUNX1/AML1 and RUNX2/Cbfa1 dynamically associate with stationary subnuclear domains
    • Harrington KS, Javed A., Drissi H., McNeil S., Lian JB, Stein JL, et al. (2002). Transcription factors RUNX1/AML1 and RUNX2/Cbfa1 dynamically associate with stationary subnuclear domains. J Cell Sci 115 (Pt 21). 4167-4176.
    • (2002) J Cell Sci , vol.115 , Issue.21 , pp. 4167-4176
    • Harrington, K.S.1    Javed, A.2    Drissi, H.3    McNeil, S.4    Lian, J.B.5    Stein, J.L.6
  • 24
    • 33751106713 scopus 로고    scopus 로고
    • Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium
    • Hinoi E., Bialek P., Chen YT, Rached MT, Groner Y., Behringer RR, et al. (2006). Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. Genes Dev 20: 2937-2942.
    • (2006) Genes Dev , vol.20 , pp. 2937-2942
    • Hinoi, E.1    Bialek, P.2    Chen, Y.T.3    Rached, M.T.4    Groner, Y.5    Behringer, R.R.6
  • 25
    • 0032949156 scopus 로고    scopus 로고
    • Maturational disturbance of chondrocytes in Cbfa1-deficient mice
    • Inada M., Yasui T., Nomura S., Miyake S., Deguchi K., Himeno M., et al. (1999). Maturational disturbance of chondrocytes in Cbfa1-deficient mice. Dev Dyn 214: 279-290.
    • (1999) Dev Dyn , vol.214 , pp. 279-290
    • Inada, M.1    Yasui, T.2    Nomura, S.3    Miyake, S.4    Deguchi, K.5    Himeno, M.6
  • 26
    • 39749130325 scopus 로고    scopus 로고
    • Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner
    • Jensen ED, Schroeder TM, Bailey J., Gopalakrishnan R., Westendorf JJ (2008). Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner. J Bone Miner Res 23: 361-372.
    • (2008) J Bone Miner Res , vol.23 , pp. 361-372
    • Jensen, E.D.1    Schroeder, T.M.2    Bailey, J.3    Gopalakrishnan, R.4    Westendorf, J.J.5
  • 28
    • 0032934596 scopus 로고    scopus 로고
    • Expression of core binding factor Osf2/Cbfa-1 and bone sialoprotein in tooth development
    • Jiang H., Sodek J., Karsenty G., Thomas H., Ranly D., Chen J. (1999). Expression of core binding factor Osf2/Cbfa-1 and bone sialoprotein in tooth development. Mech Dev 81: 169-173.
    • (1999) Mech Dev , vol.81 , pp. 169-173
    • Jiang, H.1    Sodek, J.2    Karsenty, G.3    Thomas, H.4    Ranly, D.5    Chen, J.6
  • 29
    • 0035900793 scopus 로고    scopus 로고
    • CHIP is a U-box-dependent E3 ubiquitin ligase: Identification of Hsc70 as a target for ubiquitylation
    • Jiang J., Ballinger CA, Wu Y., Dai Q., Cyr DM, Hohfeld J., et al. (2001). CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. J Biol Chem 276: 42938-42944.
    • (2001) J Biol Chem , vol.276 , pp. 42938-42944
    • Jiang, J.1    Ballinger, C.A.2    Wu, Y.3    Dai, Q.4    Cyr, D.M.5    Hohfeld, J.6
  • 30
    • 3142720638 scopus 로고    scopus 로고
    • Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation
    • Jin YH, Jeon EJ, Li QL, Lee YH, Choi JK, Kim WJ, et al. (2004). Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. J Biol Chem 279: 29409-29417.
    • (2004) J Biol Chem , vol.279 , pp. 29409-29417
    • Jin, Y.H.1    Jeon, E.J.2    Li, Q.L.3    Lee, Y.H.4    Choi, J.K.5    Kim, W.J.6
  • 32
    • 0025039291 scopus 로고
    • Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer
    • Kamachi Y., Ogawa E., Asano M., Ishida S., Murakami Y., Satake M., et al. (1990). Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer. J Virol 64: 4808-4819.
    • (1990) J Virol , vol.64 , pp. 4808-4819
    • Kamachi, Y.1    Ogawa, E.2    Asano, M.3    Ishida, S.4    Murakami, Y.5    Satake, M.6
  • 33
    • 33645226966 scopus 로고    scopus 로고
    • Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts
    • Kaneki H., Guo R., Chen D., Yao Z., Schwarz EM, Zhang YE, et al. (2006). Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts. J Biol Chem 281: 4326-4833.
    • (2006) J Biol Chem , vol.281 , pp. 4326-4833
    • Kaneki, H.1    Guo, R.2    Chen, D.3    Yao, Z.4    Schwarz, E.M.5    Zhang, Y.E.6
  • 34
    • 23044448510 scopus 로고    scopus 로고
    • Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3
    • Kang JS, Alliston T., Delston R., Derynck R. (2005). Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J 24: 2543-2555.
    • (2005) EMBO J , vol.24 , pp. 2543-2555
    • Kang, J.S.1    Alliston, T.2    Delston, R.3    Derynck, R.4
  • 35
    • 34547906444 scopus 로고    scopus 로고
    • Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts
    • Kanno T., Takahashi T., Tsujisawa T., Ariyoshi W., Nishihara T. (2007). Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts. J Cell Biochem 101: 1266-1277.
    • (2007) J Cell Biochem , vol.101 , pp. 1266-1277
    • Kanno, T.1    Takahashi, T.2    Tsujisawa, T.3    Ariyoshi, W.4    Nishihara, T.5
  • 36
    • 0028057743 scopus 로고
    • Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene
    • Karaplis AC, Luz A., Glowacki J., Bronson RT, Tybulewicz VL, Kronenberg HM, et al. (1994). Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev 8: 277-289.
    • (1994) Genes Dev , vol.8 , pp. 277-289
    • Karaplis, A.C.1    Luz, A.2    Glowacki, J.3    Bronson, R.T.4    Tybulewicz, V.L.5    Kronenberg, H.M.6
  • 37
    • 33644505810 scopus 로고    scopus 로고
    • Runx2 phosphorylation induced by fibroblast growth factor-2/protein kinase C pathways
    • Kim BG, Kim HJ, Park HJ, Kim YJ, Yoon WJ, Lee SJ, et al. (2006). Runx2 phosphorylation induced by fibroblast growth factor-2/protein kinase C pathways. Proteomics 6: 1166-1174.
    • (2006) Proteomics , vol.6 , pp. 1166-1174
    • Kim, B.G.1    Kim, H.J.2    Park, H.J.3    Kim, Y.J.4    Yoon, W.J.5    Lee, S.J.6
  • 38
    • 0037414760 scopus 로고    scopus 로고
    • The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2
    • Kim HJ, Kim JH, Bae SC, Choi JY, Kim HJ, Ryoo HM (2003). The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. J Biol Chem 278: 319-326.
    • (2003) J Biol Chem , vol.278 , pp. 319-326
    • Kim, H.J.1    Kim, J.H.2    Bae, S.C.3    Choi, J.Y.4    Kim, H.J.5    Ryoo, H.M.6
  • 39
    • 33644921001 scopus 로고    scopus 로고
    • Four novel RUNX2 mutations including a splice donor site result in the cleidocranial dysplasia phenotype
    • Kim HJ, Nam SH, Kim HJ, Park HS, Ryoo HM, Kim SY, et al. (2006). Four novel RUNX2 mutations including a splice donor site result in the cleidocranial dysplasia phenotype. J Cell Physiol 207: 114-122.
    • (2006) J Cell Physiol , vol.207 , pp. 114-122
    • Kim, H.J.1    Nam, S.H.2    Kim, H.J.3    Park, H.S.4    Ryoo, H.M.5    Kim, S.Y.6
  • 40
    • 0033014044 scopus 로고    scopus 로고
    • Regulation of chondrocyte differentiation by Cbfa1
    • Kim IS, Otto F., Zabel B., Mundlos S. (1999). Regulation of chondrocyte differentiation by Cbfa1. Mech Dev 80: 159-170.
    • (1999) Mech Dev , vol.80 , pp. 159-170
    • Kim, I.S.1    Otto, F.2    Zabel, B.3    Mundlos, S.4
  • 42
    • 33749320835 scopus 로고    scopus 로고
    • Type II/III Runx2/Cbfa1 is required for tooth germ development
    • Kobayashi I., Kiyoshima T., Wada H., Matsuo K., Nonaka K., Honda JY, et al. (2006). Type II/III Runx2/Cbfa1 is required for tooth germ development. Bone 38: 836-844.
    • (2006) Bone , vol.38 , pp. 836-844
    • Kobayashi, I.1    Kiyoshima, T.2    Wada, H.3    Matsuo, K.4    Nonaka, K.5    Honda, J.Y.6
  • 43
    • 0036333497 scopus 로고    scopus 로고
    • PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps
    • Kobayashi T., Chung UI, Schipani E., Starbuck M., Karsenty G., Katagiri T., et al. (2002). PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps. Development 129: 2977-2986.
    • (2002) Development , vol.129 , pp. 2977-2986
    • Kobayashi, T.1    Chung, U.I.2    Schipani, E.3    Starbuck, M.4    Karsenty, G.5    Katagiri, T.6
  • 44
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • Komori T., Yagi H., Nomura S., Yamaguchi A., Sasaki K., Deguchi K., et al. (1997). Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89: 755-764.
    • (1997) Cell , vol.89 , pp. 755-764
    • Komori, T.1    Yagi, H.2    Nomura, S.3    Yamaguchi, A.4    Sasaki, K.5    Deguchi, K.6
  • 45
  • 46
    • 37549003675 scopus 로고    scopus 로고
    • Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression
    • Lamour V., Detry C., Sanchez C., Henrotin Y., Castronovo V., Bellahcene A. (2007). Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression. J Biol Chem 282: 36240-36249.
    • (2007) J Biol Chem , vol.282 , pp. 36240-36249
    • Lamour, V.1    Detry, C.2    Sanchez, C.3    Henrotin, Y.4    Castronovo, V.5    Bellahcene, A.6
  • 47
    • 9344241375 scopus 로고    scopus 로고
    • PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth
    • Lanske B., Karaplis AC, Lee K., Luz A., Vortkamp A., Pirro A., et al. (1996). PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 273: 663-666.
    • (1996) Science , vol.273 , pp. 663-666
    • Lanske, B.1    Karaplis, A.C.2    Lee, K.3    Luz, A.4    Vortkamp, A.5    Pirro, A.6
  • 48
    • 0030927622 scopus 로고    scopus 로고
    • Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia
    • Lee B., Thirunavukkarasu K., Zhou L., Pastore L., Baldini A., Hecht J., et al. (1997). Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia. Nat Genet 16: 307-310.
    • (1997) Nat Genet , vol.16 , pp. 307-310
    • Lee, B.1    Thirunavukkarasu, K.2    Zhou, L.3    Pastore, L.4    Baldini, A.5    Hecht, J.6
  • 49
    • 0034460993 scopus 로고    scopus 로고
    • Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12
    • Lee KS, Kim HJ, Li QL, Chi XZ, Ueta C., Komori T., et al. (2000). Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol Cell Biol 20: 8783-8792.
    • (2000) Mol Cell Biol , vol.20 , pp. 8783-8792
    • Lee, K.S.1    Kim, H.J.2    Li, Q.L.3    Chi, X.Z.4    Ueta, C.5    Komori, T.6
  • 50
    • 0033120916 scopus 로고    scopus 로고
    • Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation
    • Lee MH, Javed A., Kim HJ, Shin HI, Gutierrez S., Choi JY, et al. (1999). Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation. J Cell Biochem 73: 114-125.
    • (1999) J Cell Biochem , vol.73 , pp. 114-125
    • Lee, M.H.1    Javed, A.2    Kim, H.J.3    Shin, H.I.4    Gutierrez, S.5    Choi, J.Y.6
  • 51
    • 18444406568 scopus 로고    scopus 로고
    • The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons
    • Levanon D., Bettoun D., Harris-Cerruti C., Woolf E., Negreanu V., Eilam R., et al. (2002). The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J 21: 3454-3463.
    • (2002) EMBO J , vol.21 , pp. 3454-3463
    • Levanon, D.1    Bettoun, D.2    Harris-Cerruti, C.3    Woolf, E.4    Negreanu, V.5    Eilam, R.6
  • 52
    • 2942512933 scopus 로고    scopus 로고
    • Structure and regulated expression of mammalian RUNX genes
    • Levanon D., Groner Y. (2004). Structure and regulated expression of mammalian RUNX genes. Oncogene 23: 4211-4219.
    • (2004) Oncogene , vol.23 , pp. 4211-4219
    • Levanon, D.1    Groner, Y.2
  • 53
    • 18344389720 scopus 로고    scopus 로고
    • Causal relationship between the loss of RUNX3 expression and gastric cancer
    • Li QL, Ito K., Sakakura C., Fukamachi H., Inoue K., Chi XZ, et al. (2002). Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 109: 113-124.
    • (2002) Cell , vol.109 , pp. 113-124
    • Li, Q.L.1    Ito, K.2    Sakakura, C.3    Fukamachi, H.4    Inoue, K.5    Chi, X.Z.6
  • 54
    • 45349097474 scopus 로고    scopus 로고
    • CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation
    • Li X., Huang M., Zheng H., Wang Y., Ren F., Shang Y., et al. (2008). CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation. J Cell Biol 181: 959-972.
    • (2008) J Cell Biol , vol.181 , pp. 959-972
    • Li, X.1    Huang, M.2    Zheng, H.3    Wang, Y.4    Ren, F.5    Shang, Y.6
  • 55
    • 33751103183 scopus 로고    scopus 로고
    • Advances in Runx2 regulation and its isoforms
    • Li YL, Xiao ZS (2007). Advances in Runx2 regulation and its isoforms. Med Hypotheses 68: 169-175.
    • (2007) Med Hypotheses , vol.68 , pp. 169-175
    • Li, Y.L.1    Xiao, Z.S.2
  • 56
    • 48649104139 scopus 로고    scopus 로고
    • Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1
    • Lu K., Yin X., Weng T., Xi S., Li L., Xing G., et al. (2008). Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1. Nat Cell Biol 10: 994-1002.
    • (2008) Nat Cell Biol , vol.10 , pp. 994-1002
    • Lu, K.1    Yin, X.2    Weng, T.3    Xi, S.4    Li, L.5    Xing, G.6
  • 57
    • 41249084399 scopus 로고    scopus 로고
    • Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells
    • Makita N., Suzuki M., Asami S., Takahata R., Kohzaki D., Kobayashi S., et al. (2008). Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells. Gene 413: 8-17.
    • (2008) Gene , vol.413 , pp. 8-17
    • Makita, N.1    Suzuki, M.2    Asami, S.3    Takahata, R.4    Kohzaki, D.5    Kobayashi, S.6
  • 58
    • 0027409947 scopus 로고
    • Sequence specificity of the core-binding factor
    • Melnikova IN, Crute BE, Wang S., Speck NA (1993). Sequence specificity of the core-binding factor. J Virol 67: 2408-2411.
    • (1993) J Virol , vol.67 , pp. 2408-2411
    • Melnikova, I.N.1    Crute, B.E.2    Wang, S.3    Speck, N.A.4
  • 59
    • 3843082088 scopus 로고    scopus 로고
    • Neural crest contribution to mammalian tooth formation
    • Miletich I., Sharpe PT (2004). Neural crest contribution to mammalian tooth formation. Birth Defects Res C Embryo Today 72: 200-212.
    • (2004) Birth Defects Res C Embryo Today , vol.72 , pp. 200-212
    • Miletich, I.1    Sharpe, P.T.2
  • 61
    • 15444351110 scopus 로고    scopus 로고
    • Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia
    • Mundlos S., Otto F., Mundlos C., Mulliken JB, Aylsworth AS, Albright S., et al. (1997). Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell 89: 773-779.
    • (1997) Cell , vol.89 , pp. 773-779
    • Mundlos, S.1    Otto, F.2    Mundlos, C.3    Mulliken, J.B.4    Aylsworth, A.S.5    Albright, S.6
  • 63
    • 0027184229 scopus 로고
    • Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha
    • Ogawa E., Inuzuka M., Maruyama M., Satake M., Naito-Fujimoto M., Ito Y., et al. (1993). Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. Virology 194: 314-331.
    • (1993) Virology , vol.194 , pp. 314-331
    • Ogawa, E.1    Inuzuka, M.2    Maruyama, M.3    Satake, M.4    Naito-Fujimoto, M.5    Ito, Y.6
  • 64
    • 0030061554 scopus 로고    scopus 로고
    • AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
    • Okuda T., van Deursen J., Hiebert SW, Grosveld G., Downing JR (1996). AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84: 321-330.
    • (1996) Cell , vol.84 , pp. 321-330
    • Okuda, T.1    Van Deursen, J.2    Hiebert, S.W.3    Grosveld, G.4    Downing, J.R.5
  • 66
    • 0030666372 scopus 로고    scopus 로고
    • Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
    • Otto F., Thornell AP, Crompton T., Denzel A., Gilmour KC, Rosewell IR, et al. (1997). Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89: 765-771.
    • (1997) Cell , vol.89 , pp. 765-771
    • Otto, F.1    Thornell, A.P.2    Crompton, T.3    Denzel, A.4    Gilmour, K.C.5    Rosewell, I.R.6
  • 67
    • 0036186852 scopus 로고    scopus 로고
    • Mutations in the RUNX2 gene in patients with cleidocranial dysplasia
    • Otto F., Kanegane H., Mundlos S. (2002). Mutations in the RUNX2 gene in patients with cleidocranial dysplasia. Hum Mutat 19: 209-216.
    • (2002) Hum Mutat , vol.19 , pp. 209-216
    • Otto, F.1    Kanegane, H.2    Mundlos, S.3
  • 68
    • 0037129340 scopus 로고    scopus 로고
    • MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2
    • Pelletier N., Champagne N., Stifani S., Yang XJ (2002). MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2. Oncogene 21: 2729-2740.
    • (2002) Oncogene , vol.21 , pp. 2729-2740
    • Pelletier, N.1    Champagne, N.2    Stifani, S.3    Yang, X.J.4
  • 69
    • 33644966988 scopus 로고    scopus 로고
    • Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation
    • Phillips JE, Gersbach CA, Wojtowicz AM, Garcia AJ (2006). Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation. J Cell Sci 119 (Pt 3). 581-591.
    • (2006) J Cell Sci , vol.119 , Issue.3 , pp. 581-591
    • Phillips, J.E.1    Gersbach, C.A.2    Wojtowicz, A.M.3    Garcia, A.J.4
  • 70
    • 5644236459 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathway
    • Qiao M., Shapiro P., Kumar R., Passaniti A. (2004). Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathway. J Biol Chem 279: 42709-42718.
    • (2004) J Biol Chem , vol.279 , pp. 42709-42718
    • Qiao, M.1    Shapiro, P.2    Kumar, R.3    Passaniti, A.4
  • 71
    • 33646350024 scopus 로고    scopus 로고
    • Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation
    • Qiao M., Shapiro P., Fosbrink M., Rus H., Kumar R., Passaniti A. (2006). Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. J Biol Chem 281: 7118-7128.
    • (2006) J Biol Chem , vol.281 , pp. 7118-7128
    • Qiao, M.1    Shapiro, P.2    Fosbrink, M.3    Rus, H.4    Kumar, R.5    Passaniti, A.6
  • 72
    • 34047117981 scopus 로고    scopus 로고
    • Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells
    • Rajgopal A., Young DW, Mujeeb KA, Stein JL, Lian JB, van Wijnen AJ, et al. (2007). Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells. J Cell Biochem 100: 1509-1517.
    • (2007) J Cell Biochem , vol.100 , pp. 1509-1517
    • Rajgopal, A.1    Young, D.W.2    Mujeeb, K.A.3    Stein, J.L.4    Lian, J.B.5    Van Wijnen, A.J.6
  • 73
    • 28144448363 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors promote osteoblast maturation
    • Schroeder TM, Westendorf JJ (2005). Histone deacetylase inhibitors promote osteoblast maturation. J Bone Miner Res 20: 2254-2263.
    • (2005) J Bone Miner Res , vol.20 , pp. 2254-2263
    • Schroeder, T.M.1    Westendorf, J.J.2
  • 74
    • 4744349390 scopus 로고    scopus 로고
    • Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation
    • Schroeder TM, Kahler RA, Li X., Westendorf JJ (2004). Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation. J Biol Chem 279: 41998-42007.
    • (2004) J Biol Chem , vol.279 , pp. 41998-42007
    • Schroeder, T.M.1    Kahler, R.A.2    Li, X.3    Westendorf, J.J.4
  • 75
    • 26844574658 scopus 로고    scopus 로고
    • Runx2: A master organizer of gene transcription in developing and maturing osteoblasts
    • Schroeder TM, Jensen ED, Westendorf JJ (2005). Runx2: a master organizer of gene transcription in developing and maturing osteoblasts. Birth Defects Res C Embryo Today 75: 213-225.
    • (2005) Birth Defects Res C Embryo Today , vol.75 , pp. 213-225
    • Schroeder, T.M.1    Jensen, E.D.2    Westendorf, J.J.3
  • 76
    • 0034681454 scopus 로고    scopus 로고
    • Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor alpha1
    • Selvamurugan N., Pulumati MR, Tyson DR, Partridge NC (2000). Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor alpha1. J Biol Chem 275: 5037-5042.
    • (2000) J Biol Chem , vol.275 , pp. 5037-5042
    • Selvamurugan, N.1    Pulumati, M.R.2    Tyson, D.R.3    Partridge, N.C.4
  • 77
    • 33645647676 scopus 로고    scopus 로고
    • Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation
    • Shen R., Chen M., Wang YJ, Kaneki H., Xing L., O'Keefe RJ, Chen D. (2006 a). Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation. J Biol Chem 281: 3569-3576.
    • (2006) J Biol Chem , vol.281 , pp. 3569-3576
    • Shen, R.1    Chen, M.2    Wang, Y.J.3    Kaneki, H.4    Xing, L.5    O'keefe, R.J.6    Chen, D.7
  • 78
    • 33745184891 scopus 로고    scopus 로고
    • Cyclin D1-cdk4 induce runx2 ubiquitination and degradation
    • Shen R., Wang X., Drissi H., Liu F., O'Keefe RJ, Chen D. (2006 b). Cyclin D1-cdk4 induce runx2 ubiquitination and degradation. J Biol Chem 281: 16347-16353.
    • (2006) J Biol Chem , vol.281 , pp. 16347-16353
    • Shen, R.1    Wang, X.2    Drissi, H.3    Liu, F.4    O'keefe, R.J.5    Chen, D.6
  • 79
    • 12244296438 scopus 로고    scopus 로고
    • Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells
    • Shui C., Spelsberg TC, Riggs BL, Khosla S. (2003). Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells. J Bone Miner Res 18: 213-221.
    • (2003) J Bone Miner Res , vol.18 , pp. 213-221
    • Shui, C.1    Spelsberg, T.C.2    Riggs, B.L.3    Khosla, S.4
  • 80
    • 0037405123 scopus 로고    scopus 로고
    • Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity
    • Sierra J., Villagra A., Paredes R., Cruzat F., Gutierrez S., Javed A., et al. (2003). Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity. Mol Cell Biol 23: 3339-3351.
    • (2003) Mol Cell Biol , vol.23 , pp. 3339-3351
    • Sierra, J.1    Villagra, A.2    Paredes, R.3    Cruzat, F.4    Gutierrez, S.5    Javed, A.6
  • 81
    • 0030741019 scopus 로고    scopus 로고
    • Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): Evidence for a new myc collaborating oncogene
    • Stewart M., Terry A., Hu M., O'Hara M., Blyth K., Baxter E., et al. (1997). Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene. Proc Natl Acad Sci USA 94: 8646-8651.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8646-8651
    • Stewart, M.1    Terry, A.2    Hu, M.3    O'hara, M.4    Blyth, K.5    Baxter, E.6
  • 82
    • 23944447687 scopus 로고    scopus 로고
    • Control of RUNX2 isoform expression: The role of promoters and enhancers
    • Stock M., Otto F. (2005). Control of RUNX2 isoform expression: the role of promoters and enhancers. J Cell Biochem 95: 506-517.
    • (2005) J Cell Biochem , vol.95 , pp. 506-517
    • Stock, M.1    Otto, F.2
  • 83
    • 0036569779 scopus 로고    scopus 로고
    • Role of Runx genes in chondrocyte differentiation
    • Stricker S., Fundele R., Vortkamp A., Mundlos S. (2002). Role of Runx genes in chondrocyte differentiation. Dev Biol 245: 95-108.
    • (2002) Dev Biol , vol.245 , pp. 95-108
    • Stricker, S.1    Fundele, R.2    Vortkamp, A.3    Mundlos, S.4
  • 84
    • 0035976775 scopus 로고    scopus 로고
    • Translational regulation is a control point in RUNX2/Cbfa1 gene expression
    • Sudhakar S., Li Y., Katz MS, Elango N. (2001). Translational regulation is a control point in RUNX2/Cbfa1 gene expression. Biochem Biophys Res Commun 289: 616-622.
    • (2001) Biochem Biophys Res Commun , vol.289 , pp. 616-622
    • Sudhakar, S.1    Li, Y.2    Katz, M.S.3    Elango, N.4
  • 85
    • 2942752288 scopus 로고    scopus 로고
    • Regulation of TGFbeta1-mediated growth inhibition and apoptosis by RUNX2 isoforms in endothelial cells
    • Sun L., Vitolo MI, Qiao M., Anglin IE, Passaniti A. (2004). Regulation of TGFbeta1-mediated growth inhibition and apoptosis by RUNX2 isoforms in endothelial cells. Oncogene 23: 4722-4734.
    • (2004) Oncogene , vol.23 , pp. 4722-4734
    • Sun, L.1    Vitolo, M.I.2    Qiao, M.3    Anglin, I.E.4    Passaniti, A.5
  • 86
    • 0038039410 scopus 로고    scopus 로고
    • Hedgehog signaling enhances core-binding factor a1 and receptor activator of nuclear factor-kappaB ligand (RANKL) gene expression in chondrocytes
    • Takamoto M., Tsuji K., Yamashita T., Sasaki H., Yano T., Taketani Y., et al. (2003). Hedgehog signaling enhances core-binding factor a1 and receptor activator of nuclear factor-kappaB ligand (RANKL) gene expression in chondrocytes. J Endocrinol 177: 413-421.
    • (2003) J Endocrinol , vol.177 , pp. 413-421
    • Takamoto, M.1    Tsuji, K.2    Yamashita, T.3    Sasaki, H.4    Yano, T.5    Taketani, Y.6
  • 87
    • 0035118709 scopus 로고    scopus 로고
    • Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice
    • Takeda S., Bonnamy JP, Owen MJ, Ducy P., Karsenty G. (2001). Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev 15: 467-481.
    • (2001) Genes Dev , vol.15 , pp. 467-481
    • Takeda, S.1    Bonnamy, J.P.2    Owen, M.J.3    Ducy, P.4    Karsenty, G.5
  • 88
    • 3242782563 scopus 로고    scopus 로고
    • Conservation and expression of an alternative 3ĝ€2 exon of Runx2 encoding a novel proline-rich C-terminal domain
    • Terry A., Kilbey A., Vaillant F., Stewart M., Jenkins A., Cameron E., et al. (2004). Conservation and expression of an alternative 3ĝ€2 exon of Runx2 encoding a novel proline-rich C-terminal domain. Gene 336: 115-125.
    • (2004) Gene , vol.336 , pp. 115-125
    • Terry, A.1    Kilbey, A.2    Vaillant, F.3    Stewart, M.4    Jenkins, A.5    Cameron, E.6
  • 89
    • 0030560840 scopus 로고    scopus 로고
    • Tooth morphogenesis and cell differentiation
    • Thesleff I., Nieminen P. (1996). Tooth morphogenesis and cell differentiation. Curr Opin Cell Biol 8: 844-850.
    • (1996) Curr Opin Cell Biol , vol.8 , pp. 844-850
    • Thesleff, I.1    Nieminen, P.2
  • 90
    • 0031836965 scopus 로고    scopus 로고
    • Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfbeta
    • Thirunavukkarasu K., Mahajan M., McLarren KW, Stifani S., Karsenty G. (1998). Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfbeta. Mol Cell Biol 18: 4197-4208.
    • (1998) Mol Cell Biol , vol.18 , pp. 4197-4208
    • Thirunavukkarasu, K.1    Mahajan, M.2    McLarren, K.W.3    Stifani, S.4    Karsenty, G.5
  • 91
    • 0032849244 scopus 로고    scopus 로고
    • Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation
    • Tintut Y., Parhami F., Le V., Karsenty G., Demer LL (1999). Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation. J Biol Chem 274: 28875-28879.
    • (1999) J Biol Chem , vol.274 , pp. 28875-28879
    • Tintut, Y.1    Parhami, F.2    Le, V.3    Karsenty, G.4    Demer, L.L.5
  • 92
    • 0035950447 scopus 로고    scopus 로고
    • Regulation of human cbfa1 gene transcription in osteoblasts by selective estrogen receptor modulators (SERMs)
    • Tou L., Quibria N., Alexander JM (2001). Regulation of human cbfa1 gene transcription in osteoblasts by selective estrogen receptor modulators (SERMs). Mol Cell Endocrinol 183: 71-79.
    • (2001) Mol Cell Endocrinol , vol.183 , pp. 71-79
    • Tou, L.1    Quibria, N.2    Alexander, J.M.3
  • 93
    • 0031594665 scopus 로고    scopus 로고
    • Expression of the PEBP2alphaA/AML3/ CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type i collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells
    • Tsuji K., Ito Y., Noda M. (1998). Expression of the PEBP2alphaA/AML3/ CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells. Bone 22: 87-92.
    • (1998) Bone , vol.22 , pp. 87-92
    • Tsuji, K.1    Ito, Y.2    Noda, M.3
  • 94
    • 0035795405 scopus 로고    scopus 로고
    • Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes
    • Ueta C., Iwamoto M., Kanatani N., Yoshida C., Liu Y., Enomoto-Iwamoto M., et al. (2001). Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J Cell Biol 153: 87-100.
    • (2001) J Cell Biol , vol.153 , pp. 87-100
    • Ueta, C.1    Iwamoto, M.2    Kanatani, N.3    Yoshida, C.4    Liu, Y.5    Enomoto-Iwamoto, M.6
  • 95
    • 39749130982 scopus 로고    scopus 로고
    • Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2
    • Usui M., Xing L., Drissi H., Zuscik M., O'Keefe R., Chen D., et al. (2008). Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2. J Bone Miner Res 23: 314-325.
    • (2008) J Bone Miner Res , vol.23 , pp. 314-325
    • Usui, M.1    Xing, L.2    Drissi, H.3    Zuscik, M.4    O'keefe, R.5    Chen, D.6
  • 96
    • 8344261349 scopus 로고    scopus 로고
    • Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis
    • Vega RB, Matsuda K., Oh J., Barbosa AC, Yang X., Meadows E., et al. (2004). Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell 119: 555-566.
    • (2004) Cell , vol.119 , pp. 555-566
    • Vega, R.B.1    Matsuda, K.2    Oh, J.3    Barbosa, A.C.4    Yang, X.5    Meadows, E.6
  • 97
    • 0037192760 scopus 로고    scopus 로고
    • Superoxide mediates shock wave induction of ERK-dependent osteogenic transcription factor (CBFA1) and mesenchymal cell differentiation toward osteoprogenitors
    • Wang FS, Wang CJ, Sheen-Chen SM, Kuo YR, Chen RF, Yang KD (2002). Superoxide mediates shock wave induction of ERK-dependent osteogenic transcription factor (CBFA1) and mesenchymal cell differentiation toward osteoprogenitors. J Biol Chem 277: 10931-10937.
    • (2002) J Biol Chem , vol.277 , pp. 10931-10937
    • Wang, F.S.1    Wang, C.J.2    Sheen-Chen, S.M.3    Kuo, Y.R.4    Chen, R.F.5    Yang, K.D.6
  • 98
    • 0029918597 scopus 로고    scopus 로고
    • Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
    • Wang Q., Stacy T., Binder M., Marin-Padilla M., Sharpe AH, Speck NA (1996). Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci USA 93: 3444-3449.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3444-3449
    • Wang, Q.1    Stacy, T.2    Binder, M.3    Marin-Padilla, M.4    Sharpe, A.H.5    Speck, N.A.6
  • 99
    • 34249846564 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2
    • Wang Q., Wei X., Zhu T., Zhang M., Shen R., Xing L., et al. (2007). Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2. J Biol Chem 282: 10742-10748.
    • (2007) J Biol Chem , vol.282 , pp. 10742-10748
    • Wang, Q.1    Wei, X.2    Zhu, T.3    Zhang, M.4    Shen, R.5    Xing, L.6
  • 100
    • 0027256023 scopus 로고
    • Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor
    • Wang S., Wang Q., Crute BE, Melnikova IN, Keller SR, Speck NA (1993). Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol 13: 3324-3339.
    • (1993) Mol Cell Biol , vol.13 , pp. 3324-3339
    • Wang, S.1    Wang, Q.2    Crute, B.E.3    Melnikova, I.N.4    Keller, S.R.5    Speck, N.A.6
  • 101
    • 0026502459 scopus 로고
    • Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers
    • Wang SW, Speck NA (1992). Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers. Mol Cell Biol 12: 89-102.
    • (1992) Mol Cell Biol , vol.12 , pp. 89-102
    • Wang, S.W.1    Speck, N.A.2
  • 102
    • 15544385745 scopus 로고    scopus 로고
    • Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth
    • Wang XP, Aberg T., James MJ, Levanon D., Groner Y., Thesleff I. (2005). Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth. J Dent Res 84: 138-143.
    • (2005) J Dent Res , vol.84 , pp. 138-143
    • Wang, X.P.1    Aberg, T.2    James, M.J.3    Levanon, D.4    Groner, Y.5    Thesleff, I.6
  • 103
    • 0036774003 scopus 로고    scopus 로고
    • Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms
    • Wee HJ, Huang G., Shigesada K., Ito Y. (2002). Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms. EMBO Rep 3: 967-974.
    • (2002) EMBO Rep , vol.3 , pp. 967-974
    • Wee, H.J.1    Huang, G.2    Shigesada, K.3    Ito, Y.4
  • 104
    • 0036840499 scopus 로고    scopus 로고
    • Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter
    • Westendorf JJ, Zaidi SK, Cascino JE, Kahler R., van Wijnen AJ, Lian JB, et al. (2002). Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. Mol Cell Biol 22: 7982-7992.
    • (2002) Mol Cell Biol , vol.22 , pp. 7982-7992
    • Westendorf, J.J.1    Zaidi, S.K.2    Cascino, J.E.3    Kahler, R.4    Van Wijnen, A.J.5    Lian, J.B.6
  • 105
    • 0036133374 scopus 로고    scopus 로고
    • Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells
    • Xiao G., Gopalakrishnan R., Jiang D., Reith E., Benson MD, Franceschi RT (2002). Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J Bone Miner Res 17: 101-110.
    • (2002) J Bone Miner Res , vol.17 , pp. 101-110
    • Xiao, G.1    Gopalakrishnan, R.2    Jiang, D.3    Reith, E.4    Benson, M.D.5    Franceschi, R.T.6
  • 106
    • 0034905168 scopus 로고    scopus 로고
    • Characterization of the upstream mouse Cbfa1/Runx2 promoter
    • Xiao ZS, Liu SG, Hinson TK, Quarles LD (2001). Characterization of the upstream mouse Cbfa1/Runx2 promoter. J Cell Biochem 82: 647-659.
    • (2001) J Cell Biochem , vol.82 , pp. 647-659
    • Xiao, Z.S.1    Liu, S.G.2    Hinson, T.K.3    Quarles, L.D.4
  • 107
    • 0037441520 scopus 로고    scopus 로고
    • IRES-dependent translational control of Cbfa1/Runx2 expression
    • Xiao ZS, Simpson LG, Quarles LD (2003). IRES-dependent translational control of Cbfa1/Runx2 expression. J Cell Biochem 88: 493-505.
    • (2003) J Cell Biochem , vol.88 , pp. 493-505
    • Xiao, Z.S.1    Simpson, L.G.2    Quarles, L.D.3
  • 108
    • 17044414102 scopus 로고    scopus 로고
    • Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation
    • Yamashita M., Ying SX, Zhang GM, Li C., Cheng SY, Deng CX, et al. (2005). Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 121: 101-113.
    • (2005) Cell , vol.121 , pp. 101-113
    • Yamashita, M.1    Ying, S.X.2    Zhang, G.M.3    Li, C.4    Cheng, S.Y.5    Deng, C.X.6
  • 109
    • 11144354938 scopus 로고    scopus 로고
    • Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog
    • Yoshida CA, Yamamoto H., Fujita T., Furuichi T., Ito K., Inoue K., et al. (2004). Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev 18: 952-963.
    • (2004) Genes Dev , vol.18 , pp. 952-963
    • Yoshida, C.A.1    Yamamoto, H.2    Fujita, T.3    Furuichi, T.4    Ito, K.5    Inoue, K.6
  • 110
    • 0037624892 scopus 로고    scopus 로고
    • Functional analysis of RUNX2 mutations in cleidocranial dysplasia: Novel insights into genotype-phenotype correlations
    • Yoshida T., Kanegane H., Osato M., Yanagida M., Miyawaki T., Ito Y., et al. (2003). Functional analysis of RUNX2 mutations in cleidocranial dysplasia: novel insights into genotype-phenotype correlations. Blood Cells Mol Dis 30: 184-193.
    • (2003) Blood Cells Mol Dis , vol.30 , pp. 184-193
    • Yoshida, T.1    Kanegane, H.2    Osato, M.3    Yanagida, M.4    Miyawaki, T.5    Ito, Y.6
  • 111
    • 33846489816 scopus 로고    scopus 로고
    • Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2
    • Young DW, Hassan MQ, Pratap J., Galindo M., Zaidi SK, Lee SH, et al. (2007). Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2. Nature 445: 442-446.
    • (2007) Nature , vol.445 , pp. 442-446
    • Young, D.W.1    Hassan, M.Q.2    Pratap, J.3    Galindo, M.4    Zaidi, S.K.5    Lee, S.H.6
  • 112
    • 0034789271 scopus 로고    scopus 로고
    • A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene
    • Zaidi SK, Javed A., Choi JY, van Wijnen AJ, Stein JL, Lian JB, et al. (2001). A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene. J Cell Sci 114 (Pt 17). 3093-3102.
    • (2001) J Cell Sci , vol.114 , Issue.17 , pp. 3093-3102
    • Zaidi, S.K.1    Javed, A.2    Choi, J.Y.3    Van Wijnen, A.J.4    Stein, J.L.5    Lian, J.B.6
  • 113
    • 0344736684 scopus 로고    scopus 로고
    • Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells
    • Zaidi SK, Young DW, Pockwinse SM, Javed A., Lian JB, Stein JL, et al. (2003). Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells. Proc Natl Acad Sci USA 100: 14852-14857.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 14852-14857
    • Zaidi, S.K.1    Young, D.W.2    Pockwinse, S.M.3    Javed, A.4    Lian, J.B.5    Stein, J.L.6
  • 115
    • 12644284483 scopus 로고    scopus 로고
    • Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors
    • Zeng C., van Wijnen AJ, Stein JL, Meyers S., Sun W., Shopland L., et al. (1997). Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors. Proc Natl Acad Sci USA 94: 6746-6751.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 6746-6751
    • Zeng, C.1    Van Wijnen, A.J.2    Stein, J.L.3    Meyers, S.4    Sun, W.5    Shopland, L.6
  • 116
    • 67650538541 scopus 로고    scopus 로고
    • (2009). PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin D1-dependent Runx2 and Runx3 phosphorylation, ubiquitination and proteasome degradation
    • Zhang M., Xie R., Hou W., Shen R., Wang X., Wang Q., et al. (2009). PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin D1-dependent Runx2 and Runx3 phosphorylation, ubiquitination and proteasome degradation. J Cell Sci 122 (Pt 9). 1382-1389.
    • J Cell Sci , vol.122 , Issue.9 , pp. 1382-1389
    • Zhang, M.1    Xie, R.2    Hou, W.3    Shen, R.4    Wang, X.5    Wang, Q.6
  • 117
    • 0041845297 scopus 로고    scopus 로고
    • E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation
    • Zhao M., Qiao M., Oyajobi BO, Mundy GR, Chen D. (2003). E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation. J Biol Chem 278: 27939-27944.
    • (2003) J Biol Chem , vol.278 , pp. 27939-27944
    • Zhao, M.1    Qiao, M.2    Oyajobi, B.O.3    Mundy, G.R.4    Chen, D.5
  • 118
    • 1842477311 scopus 로고    scopus 로고
    • Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo
    • Zhao M., Qiao M., Harris SE, Oyajobi BO, Mundy GR, Chen D. (2004). Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo. J Biol Chem 279: 12854-12859.
    • (2004) J Biol Chem , vol.279 , pp. 12854-12859
    • Zhao, M.1    Qiao, M.2    Harris, S.E.3    Oyajobi, B.O.4    Mundy, G.R.5    Chen, D.6
  • 119
    • 0032718003 scopus 로고    scopus 로고
    • CBFA1 mutation analysis and functional correlation with phenotypic variability in cleidocranial dysplasia
    • Zhou G., Chen Y., Zhou L., Thirunavukkarasu K., Hecht J., Chitayat D., et al. (1999). CBFA1 mutation analysis and functional correlation with phenotypic variability in cleidocranial dysplasia. Hum Mol Genet 8: 2311-2316.
    • (1999) Hum Mol Genet , vol.8 , pp. 2311-2316
    • Zhou, G.1    Chen, Y.2    Zhou, L.3    Thirunavukkarasu, K.4    Hecht, J.5    Chitayat, D.6
  • 120
    • 0034641606 scopus 로고    scopus 로고
    • A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures
    • Zhou YX, Xu X., Chen L., Li C., Brodie SG, Deng CX (2000). A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures. Hum Mol Genet 9: 2001-2008.
    • (2000) Hum Mol Genet , vol.9 , pp. 2001-2008
    • Zhou, Y.X.1    Xu, X.2    Chen, L.3    Li, C.4    Brodie, S.G.5    Deng, C.X.6
  • 121
    • 0033549789 scopus 로고    scopus 로고
    • A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
    • Zhu H., Kavsak P., Abdollah S., Wrana JL, Thomsen GH (1999). A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400: 687-693.
    • (1999) Nature , vol.400 , pp. 687-693
    • Zhu, H.1    Kavsak, P.2    Abdollah, S.3    Wrana, J.L.4    Thomsen, G.H.5
  • 122
    • 0037189499 scopus 로고    scopus 로고
    • The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells
    • Ziros PG, Gil AP, Georgakopoulos T., Habeos I., Kletsas D., Basdra EK, et al. (2002). The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells. J Biol Chem 277: 23934-23941.
    • (2002) J Biol Chem , vol.277 , pp. 23934-23941
    • Ziros, P.G.1    Gil, A.P.2    Georgakopoulos, T.3    Habeos, I.4    Kletsas, D.5    Basdra, E.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.