메뉴 건너뛰기




Volumn 2, Issue 9, 2012, Pages

Waldenström's macroglobulinemia harbors a unique proteome where Ku70 is severely underexpressed as compared with other B-lymphoproliferative disorders

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; KU ANTIGEN;

EID: 84871092807     PISSN: None     EISSN: 20445385     Source Type: Journal    
DOI: 10.1038/bcj.2012.35     Document Type: Article
Times cited : (5)

References (50)
  • 2
    • 0037396214 scopus 로고    scopus 로고
    • Clinicopathological definition of Waldenstrom's macroglobulinemia: Consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia
    • Owen RG, Treon SP, Al-Katib A, Fonseca R, Greipp PR, McMaster ML et al. Clinicopathological definition of Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia. Semin Oncol 2003; 30: 110-115.
    • (2003) Semin Oncol , vol.30 , pp. 110-115
    • Owen, R.G.1    Treon, S.P.2    Al-Katib, A.3    Fonseca, R.4    Greipp, P.R.5    McMaster, M.L.6
  • 3
    • 0028178499 scopus 로고
    • Similar patterns of v kappa gene usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenstrom's macroglobulinemia, and myeloma
    • Wagner SD, Martinelli V, Luzzatto L. Similar patterns of V kappa gene usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenstrom's macroglobulinemia, and myeloma. Blood 1994; 83: 3647-3653.
    • (1994) Blood , vol.83 , pp. 3647-3653
    • Wagner, S.D.1    Martinelli, V.2    Luzzatto, L.3
  • 5
    • 4644230890 scopus 로고    scopus 로고
    • Clonotypic IgM V/D/J sequence analysis in Waldenstrom macroglobulinemia suggests an unusual B-cell origin and an expansion of polyclonal B cells in peripheral blood
    • Kriangkum J, Taylor BJ, Treon SP, Mant MJ, Belch AR, Pilarski LM. Clonotypic IgM V/D/J sequence analysis in Waldenstrom macroglobulinemia suggests an unusual B-cell origin and an expansion of polyclonal B cells in peripheral blood. Blood 2004; 104: 2134-2142.
    • (2004) Blood , vol.104 , pp. 2134-2142
    • Kriangkum, J.1    Taylor, B.J.2    Treon, S.P.3    Mant, M.J.4    Belch, A.R.5    Pilarski, L.M.6
  • 6
    • 0037103306 scopus 로고    scopus 로고
    • Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events
    • Sahota SS, Forconi F, Ottensmeier CH, Provan D, Oscier DG, Hamblin TJ et al. Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events. Blood 2002; 100: 1505-1507.
    • (2002) Blood , vol.100 , pp. 1505-1507
    • Sahota, S.S.1    Forconi, F.2    Ottensmeier, C.H.3    Provan, D.4    Oscier, D.G.5    Hamblin, T.J.6
  • 7
    • 33645527567 scopus 로고    scopus 로고
    • Impaired class switch recombination (CSR) in Waldenstrom macroglobulinemia (WM) despite apparently normal CSR machinery
    • Kriangkum J, Taylor BJ, Strachan E, Mant MJ, Reiman T, Belch AR et al. Impaired class switch recombination (CSR) in Waldenstrom macroglobulinemia (WM) despite apparently normal CSR machinery. Blood 2006; 107: 2920-2927.
    • (2006) Blood , vol.107 , pp. 2920-2927
    • Kriangkum, J.1    Taylor, B.J.2    Strachan, E.3    Mant, M.J.4    Reiman, T.5    Belch, A.R.6
  • 8
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000; 102: 553-563.
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 9
    • 34748863465 scopus 로고    scopus 로고
    • IgH class switching and translocations use a robust non-classical end-joining pathway
    • Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M et al. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature 2007; 449: 478-482.
    • (2007) Nature , vol.449 , pp. 478-482
    • Yan, C.T.1    Boboila, C.2    Souza, E.K.3    Franco, S.4    Hickernell, T.R.5    Murphy, M.6
  • 12
    • 33750619898 scopus 로고    scopus 로고
    • Gene-expression profiling of Waldenstrom macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma
    • Chng WJ, Schop RF, Price-Troska T, Ghobrial I, Kay N, Jelinek DF et al. Gene-expression profiling of Waldenstrom macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma. Blood 2006; 108: 2755-2763.
    • (2006) Blood , vol.108 , pp. 2755-2763
    • Chng, W.J.1    Schop, R.F.2    Price-Troska, T.3    Ghobrial, I.4    Kay, N.5    Jelinek, D.F.6
  • 13
    • 33847185954 scopus 로고    scopus 로고
    • Gene expression profiling of B lymphocytes and plasma cells from Waldenstrom's macroglobulinemia: Comparison with expression patterns of the same cell counterparts from chronic lymphocytic leukemia, multiple myeloma and normal individuals
    • Gutierrez NC, Ocio EM, de Las Rivas J, Maiso P, Delgado M, Ferminan E et al. Gene expression profiling of B lymphocytes and plasma cells from Waldenstrom's macroglobulinemia: comparison with expression patterns of the same cell counterparts from chronic lymphocytic leukemia, multiple myeloma and normal individuals. Leukemia 2007; 21: 541-549.
    • (2007) Leukemia , vol.21 , pp. 541-549
    • Gutierrez, N.C.1    Ocio, E.M.2    De Las Rivas, J.3    Maiso, P.4    Delgado, M.5    Ferminan, E.6
  • 14
    • 0242600551 scopus 로고    scopus 로고
    • Proteomic analyses in Waldenstrom's macroglobulinemia and other plasma cell dyscrasias
    • Mitsiades CS, Mitsiades N, Treon SP, Anderson KC. Proteomic analyses in Waldenstrom's macroglobulinemia and other plasma cell dyscrasias. Semin Oncol 2003; 30: 156-160.
    • (2003) Semin Oncol , vol.30 , pp. 156-160
    • Mitsiades, C.S.1    Mitsiades, N.2    Treon, S.P.3    Anderson, K.C.4
  • 16
    • 79961014678 scopus 로고    scopus 로고
    • A unique proteomic profile on surface IgM ligation in unmutated chronic lymphocytic leukemia
    • Perrot A, Pionneau C, Nadaud S, Davi F, Leblond V, Jacob F et al. A unique proteomic profile on surface IgM ligation in unmutated chronic lymphocytic leukemia. Blood 2011; 118: e1-e15.
    • Blood , vol.2011 , Issue.118
    • Perrot, A.1    Pionneau, C.2    Nadaud, S.3    Davi, F.4    Leblond, V.5    Jacob, F.6
  • 17
    • 1242328741 scopus 로고    scopus 로고
    • Fluorescent two-dimensional difference gel electrophoresis unveils the potential of gel-based proteomics
    • Van den Bergh G, Arckens L. Fluorescent two-dimensional difference gel electrophoresis unveils the potential of gel-based proteomics. Curr Opin Biotechnol 2004; 15: 38-43.
    • (2004) Curr Opin Biotechnol , vol.15 , pp. 38-43
    • Van Den Bergh, G.1    Arckens, L.2
  • 18
    • 15344349131 scopus 로고    scopus 로고
    • Microarray-based gene expression profiling of hematologic malignancies: Basic concepts and clinical applications
    • Margalit O, Somech R, Amariglio N, Rechavi G. Microarray-based gene expression profiling of hematologic malignancies: basic concepts and clinical applications. Blood Rev 2005; 19: 223-234.
    • (2005) Blood Rev , vol.19 , pp. 223-234
    • Margalit, O.1    Somech, R.2    Amariglio, N.3    Rechavi, G.4
  • 19
    • 77956900238 scopus 로고    scopus 로고
    • Genomic profiles in B cell lymphoma
    • Seto M. Genomic profiles in B cell lymphoma. Int J Hematol 2010; 92: 238-245.
    • (2010) Int J Hematol , vol.92 , pp. 238-245
    • Seto, M.1
  • 20
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956; 123: 309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 21
    • 0035708631 scopus 로고    scopus 로고
    • From tumor biology to clinical Pet: A review of positron emission tomography (PET) in oncology
    • Kubota K. From tumor biology to clinical Pet: a review of positron emission tomography (PET) in oncology. Ann Nucl Med 2001; 15: 471-486.
    • (2001) Ann Nucl Med , vol.15 , pp. 471-486
    • Kubota, K.1
  • 22
    • 79959944018 scopus 로고    scopus 로고
    • A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis
    • Cheng NH, Zhang W, Chen WQ, Jin J, Cui X, Butte NF et al. A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis. FEBS J 2011; 278: 2525-2539.
    • FEBS J , vol.2011 , Issue.278 , pp. 2525-2539
    • Cheng, N.H.1    Zhang, W.2    Chen, W.Q.3    Jin, J.4    Cui, X.5    Butte, N.F.6
  • 23
    • 0034657445 scopus 로고    scopus 로고
    • Glyoxalase i is involved in resistance of human leukemia cells to antitumor agent-induced apoptosis
    • Sakamoto H, Mashima T, Kizaki A, Dan S, Hashimoto Y, Naito M et al. Glyoxalase I is involved in resistance of human leukemia cells to antitumor agent-induced apoptosis. Blood 2000; 95: 3214-3218.
    • (2000) Blood , vol.95 , pp. 3214-3218
    • Sakamoto, H.1    Mashima, T.2    Kizaki, A.3    Dan, S.4    Hashimoto, Y.5    Naito, M.6
  • 24
    • 0042568938 scopus 로고    scopus 로고
    • Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression
    • Neumann CA, Krause DS, Carman CV, Das S, Dubey DP, Abraham JL et al. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature 2003; 424: 561-565.
    • (2003) Nature , vol.424 , pp. 561-565
    • Neumann, C.A.1    Krause, D.S.2    Carman, C.V.3    Das, S.4    Dubey, D.P.5    Abraham, J.L.6
  • 25
    • 80052782891 scopus 로고    scopus 로고
    • Of peroxiredoxin 6 has a critical role in tumor necrosis factor-induced apoptosis
    • Kim SY, Chun E, Lee KY. Phospholipase A(2) of peroxiredoxin 6 has a critical role in tumor necrosis factor-induced apoptosis. Cell Death Differ 2011; 18: 1573-1583.
    • Cell Death Differ , vol.2011 , Issue.18 , pp. 1573-1583
    • Kim, S.Y.1    Chun, E.2    Lee, K.Y.3
  • 26
  • 27
    • 0030829514 scopus 로고    scopus 로고
    • Inhibition of apoptosis by the actin-regulatory protein gelsolin
    • Ohtsu M, Sakai N, Fujita H, Kashiwagi M, Gasa S, Shimizu S et al. Inhibition of apoptosis by the actin-regulatory protein gelsolin. EMBO J 1997; 16: 4650-4656.
    • (1997) EMBO J , vol.16 , pp. 4650-4656
    • Ohtsu, M.1    Sakai, N.2    Fujita, H.3    Kashiwagi, M.4    Gasa, S.5    Shimizu, S.6
  • 28
    • 33645066349 scopus 로고    scopus 로고
    • Proteomic analysis reveals a novel role for the actin cytoskeleton in vincristine resistant childhood leukemia-an in vivo study
    • Verrills NM, Liem NL, Liaw TY, Hood BD, Lock RB, Kavallaris M. Proteomic analysis reveals a novel role for the actin cytoskeleton in vincristine resistant childhood leukemia-an in vivo study. Proteomics 2006; 6: 1681-1694.
    • (2006) Proteomics , vol.6 , pp. 1681-1694
    • Verrills, N.M.1    Liem, N.L.2    Liaw, T.Y.3    Hood, B.D.4    Lock, R.B.5    Kavallaris, M.6
  • 30
    • 0019374013 scopus 로고
    • Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap
    • Mimori T, Akizuki M, Yamagata H, Inada S, Yoshida S, Homma M. Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap. J Clin Invest 1981; 68: 611-620.
    • (1981) J Clin Invest , vol.68 , pp. 611-620
    • Mimori, T.1    Akizuki, M.2    Yamagata, H.3    Inada, S.4    Yoshida, S.5    Homma, M.6
  • 31
    • 0028158320 scopus 로고
    • Chromosomal location and expression of the genes coding for Ku p70 and p80 in human cell lines and normal tissues
    • Cai QQ, Plet A, Imbert J, Lafage-Pochitaloff M, Cerdan C, Blanchard JM. Chromosomal location and expression of the genes coding for Ku p70 and p80 in human cell lines and normal tissues. Cytogenet Cell Genet 1994; 65: 221-227.
    • (1994) Cytogenet Cell Genet , vol.65 , pp. 221-227
    • Cai, Q.Q.1    Plet, A.2    Imbert, J.3    Lafage-Pochitaloff, M.4    Cerdan, C.5    Blanchard, J.M.6
  • 32
    • 0027468265 scopus 로고
    • Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks
    • Blier PR, Griffith AJ, Craft J, Hardin JA. Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks. J Biol Chem 1993; 268: 7594-7601.
    • (1993) J Biol Chem , vol.268 , pp. 7594-7601
    • Blier, P.R.1    Griffith, A.J.2    Craft, J.3    Hardin, J.A.4
  • 33
    • 0027397867 scopus 로고
    • The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
    • Gottlieb TM, Jackson SP. The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 1993; 72: 131-142.
    • (1993) Cell , vol.72 , pp. 131-142
    • Gottlieb, T.M.1    Jackson, S.P.2
  • 34
    • 0030885974 scopus 로고    scopus 로고
    • Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination in vivo
    • Ouyang H, Nussenzweig A, Kurimasa A, Soares VC, Li X, Cordon-Cardo C et al. Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo. J Exp Med 1997; 186: 921-929.
    • (1997) J Exp Med , vol.186 , pp. 921-929
    • Ouyang, H.1    Nussenzweig, A.2    Kurimasa, A.3    Soares, V.C.4    Li, X.5    Cordon-Cardo, C.6
  • 36
    • 0030576534 scopus 로고    scopus 로고
    • Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of v (D) J recombination intermediates
    • Zhu C, Bogue MA, Lim DS, Hasty P, Roth DB. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 1996; 86: 379-389.
    • (1996) Cell , vol.86 , pp. 379-389
    • Zhu, C.1    Bogue, M.A.2    Lim, D.S.3    Hasty, P.4    Roth, D.B.5
  • 37
    • 0030858967 scopus 로고    scopus 로고
    • Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support v (D) J recombination
    • Gu Y, Jin S, Gao Y, Weaver DT, Alt FW. Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proc Natl Acad Sci USA 1997; 94: 8076-8081.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8076-8081
    • Gu, Y.1    Jin, S.2    Gao, Y.3    Weaver, D.T.4    Alt, F.W.5
  • 38
    • 0034612308 scopus 로고    scopus 로고
    • The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
    • Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA et al. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc Natl Acad Sci USA 2000; 97: 6630-6633.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6630-6633
    • Ferguson, D.O.1    Sekiguchi, J.M.2    Chang, S.3    Frank, K.M.4    Gao, Y.5    Depinho, R.A.6
  • 39
    • 0034732239 scopus 로고    scopus 로고
    • DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
    • Difilippantonio MJ, Zhu J, Chen HT, Meffre E, Nussenzweig MC, Max EE et al. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature 2000; 404: 510-514.
    • (2000) Nature , vol.404 , pp. 510-514
    • Difilippantonio, M.J.1    Zhu, J.2    Chen, H.T.3    Meffre, E.4    Nussenzweig, M.C.5    Max, E.E.6
  • 40
    • 0032189843 scopus 로고    scopus 로고
    • DNA-Dependent protein kinase activity correlates with clinical and in vitro sensitivity of chronic lymphocytic leukemia lymphocytes to nitrogen mustards
    • Muller C, Christodoulopoulos G, Salles B, Panasci L. DNA-Dependent protein kinase activity correlates with clinical and in vitro sensitivity of chronic lymphocytic leukemia lymphocytes to nitrogen mustards. Blood 1998; 92: 2213-2219.
    • (1998) Blood , vol.92 , pp. 2213-2219
    • Muller, C.1    Christodoulopoulos, G.2    Salles, B.3    Panasci, L.4
  • 42
    • 16844381831 scopus 로고    scopus 로고
    • Mechanisms of B-cell lymphoma pathogenesis
    • Kuppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 2005; 5: 251-262.
    • (2005) Nat Rev Cancer , vol.5 , pp. 251-262
    • Kuppers, R.1
  • 43
    • 0037312006 scopus 로고    scopus 로고
    • Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis
    • Moshous D, Pannetier C, Chasseval Rd R, Deist Fl F, Cavazzana-Calvo M, Romana S et al. Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis. J Clin Invest 2003; 111: 381-387.
    • (2003) J Clin Invest , vol.111 , pp. 381-387
    • Moshous, D.1    Pannetier, C.2    Chasseval Rd, R.3    Deist Fl, F.4    Cavazzana-Calvo, M.5    Romana, S.6
  • 44
    • 0036909535 scopus 로고    scopus 로고
    • Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination
    • Roddam PL, Rollinson S, O'Driscoll M, Jeggo PA, Jack A, Morgan GJ. Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination. J Med Genet 2002; 39: 900-905.
    • (2002) J Med Genet , vol.39 , pp. 900-905
    • Roddam, P.L.1    Rollinson, S.2    O'Driscoll, M.3    Jeggo, P.A.4    Jack, A.5    Morgan, G.J.6
  • 45
    • 33751193888 scopus 로고    scopus 로고
    • Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes
    • Hill DA, Wang SS, Cerhan JR, Davis S, Cozen W, Severson RK et al. Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes. Blood 2006; 108: 3161-3167.
    • (2006) Blood , vol.108 , pp. 3161-3167
    • Hill, D.A.1    Wang, S.S.2    Cerhan, J.R.3    Davis, S.4    Cozen, W.5    Severson, R.K.6
  • 47
    • 3042547739 scopus 로고    scopus 로고
    • Expression of DNA-PKcs and Ku86, but not Ku70, differs between lymphoid malignancies
    • Holgersson A, Erdal H, Nilsson A, Lewensohn R, Kanter L. Expression of DNA-PKcs and Ku86, but not Ku70, differs between lymphoid malignancies. Exp Mol Pathol 2004; 77: 1-6.
    • (2004) Exp Mol Pathol , vol.77 , pp. 1-6
    • Holgersson, A.1    Erdal, H.2    Nilsson, A.3    Lewensohn, R.4    Kanter, L.5
  • 48
    • 77949817210 scopus 로고    scopus 로고
    • Non-homologous end-joining gene profiling reveals distinct expression patterns associated with lymphoma and multiple myeloma
    • Roddam PL, Allan JM, Dring AM, Worrillow LJ, Davies FE, Morgan GJ. Non-homologous end-joining gene profiling reveals distinct expression patterns associated with lymphoma and multiple myeloma. Br J Haematol 2010; 149: 258-262.
    • Br J Haematol , vol.2010 , Issue.149 , pp. 258-262
    • Roddam, P.L.1    Allan, J.M.2    Dring, A.M.3    Worrillow, L.J.4    Davies, F.E.5    Morgan, G.J.6
  • 49
    • 77957366600 scopus 로고    scopus 로고
    • Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology
    • Sacco A, Issa GC, Zhang Y, Liu Y, Maiso P, Ghobrial IM et al. Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology. J Hematol Oncol 2010; 3: 38.
    • J Hematol Oncol , vol.2010 , Issue.3 , pp. 38
    • Sacco, A.1    Issa, G.C.2    Zhang, Y.3    Liu, Y.4    Maiso, P.5    Ghobrial, I.M.6
  • 50
    • 18444395232 scopus 로고    scopus 로고
    • Blimp1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program
    • Shaffer AL, Lin KI, Kuo TC, Yu X, Hurt EM, Rosenwald A et al. Blimp1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity 2002; 17: 51-62.
    • (2002) Immunity , vol.17 , pp. 51-62
    • Shaffer, A.L.1    Lin, K.I.2    Kuo, T.C.3    Yu, X.4    Hurt, E.M.5    Rosenwald, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.