A review size-exclusion chromatography for the analysis of protein biotherapeutics and their aggregates

Journal of Liquid Chromatography and Related Technologies

Volumn 35, Issue 20, 2012, Pages 2923-2950

  Hong, Paula ^a   Koza, Stephan ^a   Bouvier, Edouard S P ^a  

^a WATERS CORPORATION   (United States)

Author keywords

biomolecule; chromatography; monoclonal antibody; protein; size exclusion chromatography (SEC)

Indexed keywords

BIOTHERAPEUTICS; COLUMN LENGTHS; IMMUNOGENICITY; METHOD DEVELOPMENT; MOBILE PHASE; POTENTIAL EFFECTS; PROTEIN ANALYSIS;

AGGREGATES; BIOMOLECULES; CHROMATOGRAPHY; MONOCLONAL ANTIBODIES; PROTEINS;

SIZE EXCLUSION CHROMATOGRAPHY;

SODIUM CHLORIDE;

FIELD FLOW FRACTIONATION; FLOW RATE; GEL PERMEATION CHROMATOGRAPHY; IMMUNOGENICITY; LIGHT SCATTERING; PARTICLE SIZE; PH; PROTEIN ANALYSIS; REVIEW; THERMODYNAMICS;

EID: 84870952537     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826076.2012.743724     Document Type: Review

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