Study of aggregation, denaturation and reduction of interferon alpha-2 products by size-exclusion high-performance liquid chromatography with fluorescence detection and biological assays

Journal of Chromatography A

Volumn 1217, Issue 19, 2010, Pages 3297-3306

  Diress, Abebaw ^a   Lorbetskie, Barry ^a   Larocque, Louise ^a   Li, Xuguang ^a   Alteen, Matthew ^a   Isbrucker, Richard ^a   Girard, Michel ^a  

^a HEALTH CANADA   (Canada)

Author keywords

HMW aggregate; Interferon alpha 2; Intrinsic fluorescence detection; Protein instability; Size exclusion chromatography; Thermal aggregate

Indexed keywords

ACTIVE INGREDIENTS; ANTIVIRALS; B-STABILITY; BASELINE RESOLUTION; BIOLOGICAL ACTIVITIES; BIOLOGICAL ASSAYS; CHEMICAL CHANGE; CHROMATOGRAPHIC METHODS; CHROMATOGRAPHIC PROFILES; DEGRADATION PROFILES; DRUG SUBSTANCES; FINISHED PRODUCTS; FLUORESCENCE DETECTION; HEPATITIS B; HIGH MOLECULAR WEIGHT; HMW AGGREGATE; INTRINSIC FLUORESCENCE DETECTION; LIMITS OF DETECTION; POTENCY ASSAY; PROTEIN INSTABILITY; THERMAL AGGREGATE;

AGGREGATES; ANTIBIOTICS; ASSAYS; CHEMICAL STABILITY; CHROMATOGRAPHIC ANALYSIS; DRUG PRODUCTS PLANTS; FLUORESCENCE; GLYCOPROTEINS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR WEIGHT; OLIGOMERS; POLYMORPHISM; PROTEINS;

SIZE EXCLUSION CHROMATOGRAPHY;

ALBUMIN; ALPHA2 INTERFERON; ALPHA2A INTERFERON; ALPHA2B INTERFERON; CONSENSUS INTERFERON; DIMER; EXCIPIENT; INTERFERON; INTERFERON BETA SERINE; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT ALPHA2B INTERFERON;

ARTICLE; BIOASSAY; CONTROLLED STUDY; DRUG SCREENING; DRUG STABILITY; FLUORESCENCE ANALYSIS; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DENATURATION; QUANTITATIVE ANALYSIS; REPRODUCIBILITY;

CELL DEATH; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEP G2 CELLS; HUMANS; INTERFERON TYPE I, RECOMBINANT; LINEAR MODELS; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE; TEMPERATURE;

EID: 77951958615     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2009.10.081     Document Type: Article

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