Analysis of Reduced Monoclonal Antibodies Using Size Exclusion Chromatography Coupled with Mass Spectrometry

Journal of the American Society for Mass Spectrometry

Volumn 20, Issue 12, 2009, Pages 2258-2264

  Liu, Hongcheng ^a   Gaza Bulseco, Georgeen ^a   Chumsae, Chris ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY CONJUGATE; ANTIBODY LIGHT CHAIN; DIRECT COUPLING; DIRECT MEASUREMENT; FREE LIGHT CHAINS; HEAVY CHAIN; LIGHT CHAIN; MOBILE PHASE; MOBILE PHASIS; MOLECULAR WEIGHT MEASUREMENTS; RECOMBINANT MONOCLONAL ANTIBODY; THIOETHERS; TRIFLUOROACETIC ACIDS;

ACETONITRILE; ALLERGIES; CHROMATOGRAPHIC ANALYSIS; FORMIC ACID; MASS SPECTROMETERS; MASS SPECTROMETRY; MERGERS AND ACQUISITIONS; MOLECULAR WEIGHT; MONOCLONAL ANTIBODIES; ORGANIC ACIDS; SIZE SEPARATION; SURFACE PLASMON RESONANCE; WEIGHING;

SIZE EXCLUSION CHROMATOGRAPHY;

ACETONITRILE; FORMIC ACID; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY; SULFIDE; TRIFLUOROACETIC ACID;

ANIMAL CELL; ANTIBODY DETECTION; ARTICLE; CHO CELL; CONTROLLED STUDY; ELUTION; FEMALE; FLOW RATE; GEL PERMEATION CHROMATOGRAPHY; HEAT STRESS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; MASS SPECTROMETRY; MOLECULAR WEIGHT; NONHUMAN; PROCESS OPTIMIZATION; PROTEIN AGGREGATION; REVERSED PHASE LIQUID CHROMATOGRAPHY;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MASS SPECTROMETRY; OXIDATION-REDUCTION;

EID: 70449502850     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2009.08.015     Document Type: Article

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