Application of size-exclusion chromatography in the investigation of the in vitro stability of proinsulin and its cleaved metabolites in human serum and plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 8-9, 2009, Pages 689-696

  Bowsher, Ronald R ^a,b   Santa, Paula F ^c  

^a B2S Consulting   (United States)

^b Millipore Corporation   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Diabetes; Immunoassay; Insulin; Metabolism; Peptide; Proinsulin; Protease; Radioimmunoassay; Size exclusion chromatography; Stability

Indexed keywords

AMINES; AMINO ACIDS; ANIMAL CELL CULTURE; ANTIGENS; BIOCHEMISTRY; BIODEGRADATION; BIOMOLECULES; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; COLUMN CHROMATOGRAPHY; IMMUNOLOGY; INSULIN; METABOLISM; METABOLITES; PLASMAS; SIZE EXCLUSION CHROMATOGRAPHY;

DIABETES; IMMUNOASSAY; PROINSULIN; PROTEASE; RADIOIMMUNOASSAY;

PLASMA STABILITY;

BIOLOGICAL MARKER; EDETIC ACID; PEPTIDE; PROINSULIN; PROTEIN; PROTEINASE;

ADULT; ARTICLE; ELUTION; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; ISOTOPE LABELING; METABOLITE; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; QUANTITATIVE ANALYSIS; RADIOIMMUNOASSAY; RELIABILITY; SERUM;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, GEL; HUMANS; INSULIN; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PEPTIDE HYDROLASES; PROINSULIN;

EID: 61349156192     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.01.035     Document Type: Article

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