Development of a high performance size exclusion chromatography method to determine the stability of Human Serum Albumin in a lyophilized formulation of Interferon alfa-2b

Journal of Chromatography A

Volumn 1194, Issue 1, 2008, Pages 48-56

  Qian, Jin ^a   Tang, Qinglin ^a   Cronin, Bart ^b   Markovich, Robert ^a   Rustum, Abu ^a  

^a Global Quality Services Analytical Sciences   (United States)

^b Schering Plough (Brinny) Co   (Ireland)

Author keywords

High performance size exclusion chromatography; Human Serum Albumin; Interferon alfa 2b; Intron Powder for Injection; Stability

Indexed keywords

BIOASSAY; OLIGOMERS; POROUS MATERIALS; SIZE EXCLUSION CHROMATOGRAPHY;

HUMAN SERUM ALBUMIN; INTERFERON ALFA-2B;

PROTEINS;

ALPHA2B INTERFERON; HUMAN SERUM ALBUMIN; PHOSPHATE BUFFERED SALINE; SODIUM SULFATE; SUCROSE;

ACCURACY; AMINO ACID COMPOSITION; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; FLOW RATE; FREEZE DRYING; GEL PERMEATION CHROMATOGRAPHY; HUMAN; MOLECULAR WEIGHT; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SHELF LIFE; ULTRAVIOLET SPECTROPHOTOMETRY;

CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; FREEZE DRYING; HUMANS; INTERFERON ALFA-2B; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SERUM ALBUMIN; SPECTROPHOTOMETRY, ULTRAVIOLET;

HEPATITIS C VIRUS;

EID: 44549089068     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2008.01.040     Document Type: Article

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