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Volumn 39, Issue 8, 2012, Pages 703-708

Impaired post-transcriptional regulation in Alzheimer's disease

Author keywords

Alzhemer's disease; Non coding RNAs (ncRNAs); Post transcriptional regulation; RNA binding proteins (RBPs); RNA spicing

Indexed keywords


EID: 84870910852     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1206.2012.00211     Document Type: Review
Times cited : (3)

References (96)
  • 1
    • 0029815467 scopus 로고    scopus 로고
    • Glycosylation of microtubule-associated protein tau: An abnormal posttranslational modification in Alzheimer's disease
    • DOI 10.1038/nm0896-871
    • Wang J Z, Grundke-Iqbal I, Iqbal K. Glycosylation of microrubuleassociated protein tau: An abnormal posttranslational modification in Alzheimer's disease. Nat Med, 1996, 2(8): 871-875 (Pubitemid 26296756)
    • (1996) Nature Medicine , vol.2 , Issue.8 , pp. 871-875
    • Wang, J.-Z.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 2
    • 84655160766 scopus 로고    scopus 로고
    • Proteolytic processing of Alzheimer's β-amyloid precursor protein
    • Zhang H, Ma Q, Zhang Y W, et al. Proteolytic processing of Alzheimer's β-amyloid precursor protein. J Neurochem, 2012, 120( Suppl 1): 9-21
    • (2012) J Neurochem , vol.120 , Issue.SUPPL. 1 , pp. 9-21
    • Zhang, H.1    Ma, Q.2    Zhang, Y.W.3
  • 3
  • 4
    • 58849112575 scopus 로고    scopus 로고
    • Biogenesis of small RNAs in animals
    • Kim V N, Han J, Siomi M C. Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol, 2009, 10( 2): 126-139
    • (2009) Nat Rev Mol Cell Biol , vol.10 , Issue.2 , pp. 126-139
    • Kim, V.N.1    Han, J.2    Siomi, M.C.3
  • 5
    • 0032543684 scopus 로고    scopus 로고
    • Association of missense and 5 [prime]-splice-site mutations in tau with the inherited dementia FTDP-17
    • Hutton M, Lendon C L, Rizzu P, et al. Association of missense and 5 [prime]-splice-site mutations in tau with the inherited dementia FTDP-17. Nature, 1998, 393( 6686): 702-705
    • (1998) Nature , vol.393 , Issue.6686 , pp. 702-705
    • Hutton, M.1    Lendon, C.L.2    Rizzu, P.3
  • 6
    • 33645102446 scopus 로고    scopus 로고
    • Shift in the ratio of threerepeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease
    • Ginsberg S D, Che S, Counts S E, et al. Shift in the ratio of threerepeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. J Neurochem, 2006, 96( 5): 1401-1408
    • (2006) J Neurochem , vol.96 , Issue.5 , pp. 1401-1408
    • Ginsberg, S.D.1    Che, S.2    Counts, S.E.3
  • 8
    • 24644502657 scopus 로고    scopus 로고
    • From birth to death: The complex lives of eukaryotic mRNAs
    • DOI 10.1126/science.1111443
    • Moore M J. From birth to death: The complex lives of eukaryotic mRNAs. Science, 2005, 309(5740): 1514-1518 (Pubitemid 41266467)
    • (2005) Science , vol.309 , Issue.5740 , pp. 1514-1518
    • Moore, M.J.1
  • 9
    • 41949135532 scopus 로고    scopus 로고
    • EJCs at the heart of translational control
    • DOI 10.1016/j.cell.2008.04.002, PII S0092867408004509
    • Le Hir H, Séraphin B. EJCs at the heart of translational control. Cell, 2008, 133(2): 213-216 (Pubitemid 351508309)
    • (2008) Cell , vol.133 , Issue.2 , pp. 213-216
    • Le, H.H.1    Seraphin, B.2
  • 10
    • 48949115091 scopus 로고    scopus 로고
    • RNA-binding proteins in human genetic disease
    • Lukong K E, Chang K W, Khandjian E W, et al. RNA-binding proteins in human genetic disease. Trends in Genetics, 2008, 24( 8): 416-425
    • (2008) Trends in Genetics , vol.24 , Issue.8 , pp. 416-425
    • Lukong, K.E.1    Chang, K.W.2    Khandjian, E.W.3
  • 11
    • 48249148310 scopus 로고    scopus 로고
    • Tau exon 10 alternative splicing and tauopathies
    • Liu F, Gong C X. Tau exon 10 alternative splicing and tauopathies. Molecular Neurodegeneration, 2008, 3( 1): 8
    • (2008) Molecular Neurodegeneration , vol.3 , Issue.1 , pp. 8
    • Liu, F.1    Gong, C.X.2
  • 12
    • 0038819945 scopus 로고    scopus 로고
    • Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2
    • DOI 10.1074/jbc.M301800200
    • Jiang Z, Tang H, Havlioglu N, et al. Mutations in Tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2β. J Biol Chem, 2003, 278(21): 18997-19007 (Pubitemid 36799284)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.21 , pp. 18997-19007
    • Jiang, Z.1    Tang, H.2    Havlioglu, N.3    Zhang, X.4    Stamm, S.5    Yan, R.6    Wu, J.Y.7
  • 13
    • 1542330117 scopus 로고    scopus 로고
    • Tra2β, SF2/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA
    • DOI 10.1111/j.1356-9597.2004.00709.x
    • Kondo S, Yamamoto N, Murakami T, et al. Tra2β, SF2/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA. Genes to Cells, 2004, 9(2): 121-130 (Pubitemid 38312956)
    • (2004) Genes to Cells , vol.9 , Issue.2 , pp. 121-130
    • Kondo, S.1    Yamamoto, N.2    Murakami, T.3    Okumura, M.4    Mayeda, A.5    Imaizumi, K.6
  • 14
    • 33645107783 scopus 로고    scopus 로고
    • The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's disease
    • Glatz D C, Rujescu D, Tang Y, et al. The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's disease. J Neurochem, 2006, 96( 3): 635-644
    • (2006) J Neurochem , vol.96 , Issue.3 , pp. 635-644
    • Glatz, D.C.1    Rujescu, D.2    Tang, Y.3
  • 15
    • 33748660487 scopus 로고    scopus 로고
    • SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy
    • DOI 10.1128/MCB.00739-06
    • Wu J Y, Kar A, Kuo D, et al. SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy. Molecular and Cellular Biology, 2006, 26(18): 6739-6747 (Pubitemid 44387625)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.18 , pp. 6739-6747
    • Wu, J.Y.1    Kar, A.2    Kuo, D.3    Yu, B.4    Havlioglu, N.5
  • 16
    • 33845914335 scopus 로고    scopus 로고
    • SR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutations
    • DOI 10.1016/j.mcn.2006.10.004, PII S1044743106002168
    • Gao L, Wang J, Wang Y, et al. SR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutations. Molecular and Cellular Neuroscience, 2007,34(1): 48-58 (Pubitemid 46026933)
    • (2007) Molecular and Cellular Neuroscience , vol.34 , Issue.1 , pp. 48-58
    • Gao, L.1    Wang, J.2    Wang, Y.3    Andreadis, A.4
  • 17
    • 33747739192 scopus 로고    scopus 로고
    • RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion
    • DOI 10.1074/jbc.M603971200
    • Kar A, Havlioglu N, Tarn W Y, et al. RBM4 interacts with an intronic element and stimulates Tau exon 10 inclusion. J Biol Chem, 2006, 281(34): 24479-24488 (Pubitemid 44274222)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.34 , pp. 24479-24488
    • Kar, A.1    Havlioglu, N.2    Tarn, W.-Y.3    Wu, J.Y.4
  • 18
    • 80855123708 scopus 로고    scopus 로고
    • PSF suppresses Tau exon 10 inclusion by interacting with a stem-loop structure downstream of exon 10
    • Ray P, Kar A, Fushimi K, et al. PSF suppresses Tau exon 10 inclusion by interacting with a stem-loop structure downstream of exon 10. J Mol Neuro, 2011, 45( 3): 453-466
    • (2011) J Mol Neuro , vol.45 , Issue.3 , pp. 453-466
    • Ray, P.1    Kar, A.2    Fushimi, K.3
  • 19
    • 79955379829 scopus 로고    scopus 로고
    • RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site
    • Kar A, Fushimi K, Zhou X, et al. RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site. Molecular and Cellular Biology, 2011, 31( 9): 1812-1821
    • (2011) Molecular and Cellular Biology , vol.31 , Issue.9 , pp. 1812-1821
    • Kar, A.1    Fushimi, K.2    Zhou, X.3
  • 20
    • 0036529621 scopus 로고    scopus 로고
    • Comparative genomics and evolution of proteins involved in RNA metabolism
    • Anantharaman V, Koonin E V, Aravind L. Comparative genomics and evolution of proteins involved in RNA metabolism. Nucleic Acids Research, 2002, 30(7): 1427-1464 (Pubitemid 34679722)
    • (2002) Nucleic Acids Research , vol.30 , Issue.7 , pp. 1427-1464
    • Anantharaman, V.1    Koonin, E.V.2    Aravind, L.3
  • 21
    • 0034922092 scopus 로고    scopus 로고
    • Paraneoplastic neurologic disease antigens: RNA-binding proteins and signaling proteins in neuronal degeneration
    • DOI 10.1146/annurev.neuro.24.1.239
    • Musunuru K, Darnell R B. Paraneoplastic neurologic disease antigens: RNA-binding proteins and signaling proteins in neuronal degeneration. Annu Rev Neurosci, 2001, 24: 239-262 (Pubitemid 32695229)
    • (2001) Annual Review of Neuroscience , vol.24 , pp. 239-262
    • Musunuru, K.1    Darnell, R.B.2
  • 22
    • 34249316905 scopus 로고    scopus 로고
    • RNA-binding proteins: Modular design for efficient function
    • DOI 10.1038/nrm2178, PII NRM2178
    • Lunde B M, Moore C, Varani G. RNA-binding proteins: modular design for efficient function. Nat Rev Mol Cell Biol, 2007, 8(6): 479-490 (Pubitemid 46809150)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.6 , pp. 479-490
    • Lunde, B.M.1    Moore, C.2    Varani, G.3
  • 25
    • 59249097160 scopus 로고    scopus 로고
    • Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies
    • Arai T, Mackenzie I, Hasegawa M, et al. Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies. Acta Neuropathologica, 2009, 117( 2): 125-136
    • (2009) Acta Neuropathologica , vol.117 , Issue.2 , pp. 125-136
    • Arai, T.1    Mackenzie, I.2    Hasegawa, M.3
  • 26
    • 77649258646 scopus 로고    scopus 로고
    • A Drosophila model for TDP-43 proteinopathy
    • Li Y, Ray P, Rao E J, et al. A Drosophila model for TDP-43 proteinopathy. Proc Natl Acad Sci USA, 2010, 107( 7): 3169-3174
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.7 , pp. 3169-3174
    • Li, Y.1    Ray, P.2    Rao, E.J.3
  • 27
    • 79960040173 scopus 로고    scopus 로고
    • An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity
    • Guo W, Chen Y, Zhou X, et al. An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity. Nat Struct Mol Biol, 2011, 18( 7): 822-830
    • (2011) Nat Struct Mol Biol , vol.18 , Issue.7 , pp. 822-830
    • Guo, W.1    Chen, Y.2    Zhou, X.3
  • 28
    • 80053477918 scopus 로고    scopus 로고
    • Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function
    • Delay C, Calon F, Mathews P, et al. Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function. Mol Neurodegeneration, 2011, 6( 1): 70
    • (2011) Mol Neurodegeneration , vol.6 , Issue.1 , pp. 70
    • Delay, C.1    Calon, F.2    Mathews, P.3
  • 30
    • 78650692019 scopus 로고    scopus 로고
    • In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs
    • Smith P, Al Hashimi A, Girard J, et al. In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs. J Neurochem, 2011, 116( 2): 240-247
    • (2011) J Neurochem , vol.116 , Issue.2 , pp. 240-247
    • Smith, P.1    Al Hashimi, A.2    Girard, J.3
  • 31
    • 77953319294 scopus 로고    scopus 로고
    • MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons
    • Vilardo E, Barbato C, Ciotti M, el al. MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons. J Biol Chem, 2010, 285( 24): 18344-18351
    • (2010) J Biol Chem , vol.285 , Issue.24 , pp. 18344-18351
    • Vilardo, E.1    Barbato, C.2    Ciotti, M.3
  • 32
    • 38749095507 scopus 로고    scopus 로고
    • The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of β-site amyloid precursor protein-cleaving enzyme 1
    • Wang W X, Rajeev B W, Stromberg A J, et al. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of β-site amyloid precursor protein-cleaving enzyme 1. J Neurosci, 2008, 28( 5): 1213-1223
    • (2008) J Neurosci , vol.28 , Issue.5 , pp. 1213-1223
    • Wang, W.X.1    Rajeev, B.W.2    Stromberg, A.J.3
  • 33
    • 59049087888 scopus 로고    scopus 로고
    • MicroRNA-298 and microRNA-328 regulate expression of mouse β-Amyloid precursor protein-converting enzyme 1
    • Boissonneault V, Plante I, Rivest S, et al. MicroRNA-298 and microRNA-328 regulate expression of mouse β-Amyloid precursor protein-converting enzyme 1. J Biol Chem, 2009, 284 ( 4): 1971-1981
    • (2009) J Biol Chem , vol.284 , Issue.4 , pp. 1971-1981
    • Boissonneault, V.1    Plante, I.2    Rivest, S.3
  • 34
    • 77957735016 scopus 로고    scopus 로고
    • Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration
    • Hébert S S, Papadopoulou A S, Smith P, et al. Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. Human Molecular Genetics, 2010, 19( 20): 3959-3969
    • (2010) Human Molecular Genetics , vol.19 , Issue.20 , pp. 3959-3969
    • Hébert, S.S.1    Papadopoulou, A.S.2    Smith, P.3
  • 35
    • 80053167649 scopus 로고    scopus 로고
    • MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy
    • Smith P Y, Delay C, Girard J, et al. MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy. Human Molecular Genetics, 2011, 20( 20): 4016-4024
    • (2011) Human Molecular Genetics , vol.20 , Issue.20 , pp. 4016-4024
    • Smith, P.Y.1    Delay, C.2    Girard, J.3
  • 36
    • 78650594380 scopus 로고    scopus 로고
    • 17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease
    • Massone S, Vassallo I, Fiorino G, et al. 17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease. Neurobiology of Disease, 2011, 41( 2): 308-317
    • (2011) Neurobiology of Disease , vol.41 , Issue.2 , pp. 308-317
    • Massone, S.1    Vassallo, I.2    Fiorino, G.3
  • 37
    • 46749083733 scopus 로고    scopus 로고
    • Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of [beta]-secretase
    • Faghihi M A, Modarresi F, Khalil A M, et al. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of [beta]-secretase. Nat Med, 2008, 14( 7): 723-730
    • (2008) Nat Med , vol.14 , Issue.7 , pp. 723-730
    • Faghihi, M.A.1    Modarresi, F.2    Khalil, A.M.3
  • 38
    • 77951962298 scopus 로고    scopus 로고
    • Recent progress in neurodegenerative disorder research in China
    • Zhou J W. Recent progress in neurodegenerative disorder research in China. Sci China Life Sci, 2010, 53( 3): 348-355
    • (2010) Sci China Life Sci , vol.53 , Issue.3 , pp. 348-355
    • Zhou, J.W.1
  • 39
    • 78449288804 scopus 로고    scopus 로고
    • Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimer's disease
    • Cong L, Jia J. Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimer's disease. Neurobiol Aging, 2011, 32( 1): 54-62
    • (2011) Neurobiol Aging , vol.32 , Issue.1 , pp. 54-62
    • Cong, L.1    Jia, J.2
  • 40
    • 84879265725 scopus 로고    scopus 로고
    • Accumulated hippocampal formaldehyde induces age-dependent memory decline
    • DOI: 10.1007/s11357-012-9388-8
    • Tong Z Q, Han C S, Luo W H, et al. Accumulated hippocampal formaldehyde induces age-dependent memory decline. Age, 2012, DOI: 10.1007/s11357-012-9388-8
    • (2012) Age
    • Tong, Z.Q.1    Han, C.S.2    Luo, W.H.3
  • 42
    • 78449301205 scopus 로고    scopus 로고
    • Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia
    • Tong Z Q, Zhang J L, Luo W H, et al. Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia. Neurobiology of Aging, 2011, 32( 1): 31-41
    • (2011) Neurobiology of Aging , vol.32 , Issue.1 , pp. 31-41
    • Tong, Z.Q.1    Zhang, J.L.2    Luo, W.H.3
  • 43
    • 80051617317 scopus 로고    scopus 로고
    • A novel molecular mechanism for nitrated α-synuclein-induced cell death
    • Liu Y, Qiang M, Wei Y, et al. A novel molecular mechanism for nitrated α-synuclein-induced cell death. J Mol Cell Biol, 2011, 3( 4): 239-249
    • (2011) J Mol Cell Biol , vol.3 , Issue.4 , pp. 239-249
    • Liu, Y.1    Qiang, M.2    Wei, Y.3
  • 46
    • 77951961804 scopus 로고    scopus 로고
    • Progress in neural plasticity
    • Zhang X H, Poo M M. Progress in neural plasticity. Sci China Life Sci, 2010, 53( 3): 322-329
    • (2010) Sci China Life Sci , vol.53 , Issue.3 , pp. 322-329
    • Zhang, X.H.1    Poo, M.M.2
  • 47
    • 77951943759 scopus 로고    scopus 로고
    • Synapse formation and remodeling. Axon guidance and neuronal migration research in China
    • Luo Z G. Synapse formation and remodeling. Axon guidance and neuronal migration research in China. Sci China Life Sci, 2010, 53( 3): 315-321
    • (2010) Sci China Life Sci , vol.53 , Issue.3 , pp. 315-321
    • Luo, Z.G.1
  • 48
    • 76649089967 scopus 로고    scopus 로고
    • A meta-analysis of oxidative stress markers in schizophrenia
    • Zhang M, Zhao Z M, He L, et al. A meta-analysis of oxidative stress markers in schizophrenia. Sci China Life Sci, 2010, 53( 1): 112-124
    • (2010) Sci China Life Sci , vol.53 , Issue.1 , pp. 112-124
    • Zhang, M.1    Zhao, Z.M.2    He, L.3
  • 49
    • 77949282876 scopus 로고    scopus 로고
    • TLR4 signaling induced TLR2 expression in the process of mimic cerebral ischemia/reperfusion in vitro
    • Sun P, Zhang Q, Han J Y, et al. TLR4 signaling induced TLR2 expression in the process of mimic cerebral ischemia/reperfusion in vitro. Sci China Life Sci, 2010, 53( 2): 223-228
    • (2010) Sci China Life Sci , vol.53 , Issue.2 , pp. 223-228
    • Sun, P.1    Zhang, Q.2    Han, J.Y.3
  • 50
    • 77951966903 scopus 로고    scopus 로고
    • Ion channels in neuronal survival
    • Wang Y Z, Xu T L. Ion channels in neuronal survival. Sci China Life Sci, 2010, 53( 6): 342-347
    • (2010) Sci China Life Sci , vol.53 , Issue.6 , pp. 342-347
    • Wang, Y.Z.1    Xu, T.L.2
  • 51
    • 79959613455 scopus 로고    scopus 로고
    • Copper ions influence the toxicity of β-amyloid (1-42) in a concentration-dependent manner in a caenorhab ditis elegans model of Alzheimer's disease
    • Luo Y F, Zhang J, Liu N Q, et al. Copper ions influence the toxicity of β-amyloid (1-42) in a concentration-dependent manner in a caenorhab ditis elegans model of Alzheimer's disease. Sci China Life Sci, 2011, 54( 6): 527-534
    • (2011) Sci China Life Sci , vol.54 , Issue.6 , pp. 527-534
    • Luo, Y.F.1    Zhang, J.2    Liu, N.Q.3
  • 53
    • 0023132387 scopus 로고
    • Characterization and chromosomal localization of a cDNA encodingbrain amyloid of Alzheimer's disease
    • Goldgaber D, Lerman M I, McBride O W, et al. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science, 1987, 235(4791): 877-880 (Pubitemid 17019124)
    • (1987) Science , vol.235 , Issue.4791 , pp. 877-880
    • Goldgaber, D.1    Lerman, M.I.2    McBride, O.W.3
  • 55
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • DOI 10.1038/325733a0
    • Kang J, Lemaire H G, Unterbeck A, et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature, 1987, 325(6106): 733-736 (Pubitemid 17054046)
    • (1987) Nature , vol.325 , Issue.6106 , pp. 733-736
    • Kang, J.1    Lemaire, H.-G.2    Unterbeck, A.3
  • 57
    • 0033518251 scopus 로고    scopus 로고
    • Purification and cloning of amyloid precursor protein beta-secretase from human brain
    • Sinha S, Anderson J P, Barbour R, et al. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature, 1999, 402( 6761): 537-540
    • (1999) Nature , vol.402 , Issue.6761 , pp. 537-540
    • Sinha, S.1    Anderson, J.P.2    Barbour, R.3
  • 58
    • 0033595706 scopus 로고    scopus 로고
    • Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
    • Vassar R, Bennett B D, Babu-Khan S, et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science, 1999, 286( 5440): 735-741
    • (1999) Science , vol.286 , Issue.5440 , pp. 735-741
    • Vassar, R.1    Bennett, B.D.2    Babu-Khan, S.3
  • 59
    • 0035853821 scopus 로고    scopus 로고
    • A splice variant of betasecretase deficient in the amyloidogenic processing of the amyloid precursor protein
    • Bodendorf U, Fischer F, Bodian D, et al. A splice variant of betasecretase deficient in the amyloidogenic processing of the amyloid precursor protein. J Biol Chem, 2001, 276( 15): 12019-12023
    • (2001) J Biol Chem , vol.276 , Issue.15 , pp. 12019-12023
    • Bodendorf, U.1    Fischer, F.2    Bodian, D.3
  • 60
    • 0035971166 scopus 로고    scopus 로고
    • The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain
    • Shi X P, Chen E, Yin K C, et al. The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain. J Biol Chem, 2001, 276 ( 13): 10366-10373
    • (2001) J Biol Chem , vol.276 , Issue.13 , pp. 10366-10373
    • Shi, X.P.1    Chen, E.2    Yin, K.C.3
  • 61
    • 79959196089 scopus 로고    scopus 로고
    • Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase
    • Hogl S, Kuhn P H, Colombo A, et al. Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase. PLoS One, 2011, 6( 6): e21337
    • (2011) PLoS One , vol.6 , Issue.6
    • Hogl, S.1    Kuhn, P.H.2    Colombo, A.3
  • 62
    • 7444250507 scopus 로고    scopus 로고
    • Degradation of BACE by the ubiquitin-proteasome pathway
    • Qing H, Zhou W, Christensen M A, el al. Degradation of BACE by the ubiquitin-proteasome pathway. Faseb J, 2004, 18( 13): 1571-1573
    • (2004) Faseb J , vol.18 , Issue.13 , pp. 1571-1573
    • Qing, H.1    Zhou, W.2    Christensen, M.A.3
  • 64
  • 65
    • 67649220624 scopus 로고    scopus 로고
    • Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons
    • Cho H J, Jin S M, Son S M, et al. Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons. Biochem Biophys Res Commun, 2009, 386( 1): 175-180
    • (2009) Biochem Biophys Res Commun , vol.386 , Issue.1 , pp. 175-180
    • Cho, H.J.1    Jin, S.M.2    Son, S.M.3
  • 66
    • 40549129366 scopus 로고    scopus 로고
    • Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling
    • DOI 10.1111/j.1474-9726.2007.00360.x
    • Cho H J, Jin S M, Youn H D, et al. Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling. Aging Cell, 2008, 7(2): 137-147 (Pubitemid 351359647)
    • (2008) Aging Cell , vol.7 , Issue.2 , pp. 137-147
    • Cho, H.-J.1    Jin, S.M.2    Youn, H.D.3    Huh, K.4    Mook-Jung, I.5
  • 67
    • 84856428468 scopus 로고    scopus 로고
    • Increased NF-kappaB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease
    • Chen C H, Zhou W, Liu S, et al. Increased NF-kappaB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. Int J Neuropsychopharmacol, 2012, 15( 1): 77-90
    • (2012) Int J Neuropsychopharmacol , vol.15 , Issue.1 , pp. 77-90
    • Chen, C.H.1    Zhou, W.2    Liu, S.3
  • 68
    • 33644920657 scopus 로고    scopus 로고
    • Control of APP processing and Aβ generation level by BACE1 enzymatic activity and transcription
    • DOI 10.1096/fj.05-4986com
    • Li Y, Zhou W, Tong Y, et al. Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription. Faseb J, 2006, 20(2): 285-292 (Pubitemid 44933176)
    • (2006) FASEB Journal , vol.20 , Issue.2 , pp. 285-292
    • Li, Y.1    Zhou, W.2    Tong, Y.3    He, G.4    Song, W.5
  • 70
    • 33646244775 scopus 로고    scopus 로고
    • Leaky scanning and reinitiation regulate BACE1 gene expression
    • Zhou W, Song W. Leaky scanning and reinitiation regulate BACE1 gene expression. Mol Cell Biol, 2006, 26( 9): 3353-3364
    • (2006) Mol Cell Biol , vol.26 , Issue.9 , pp. 3353-3364
    • Zhou, W.1    Song, W.2
  • 72
    • 33746572249 scopus 로고    scopus 로고
    • Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in down syndrome
    • DOI 10.1096/fj.05-5628com
    • Sun X, Tong Y, Qing H, et al. Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome. Faseb J, 2006, 20(9):1361-1368 (Pubitemid 44943844)
    • (2006) FASEB Journal , vol.20 , Issue.9 , pp. 1361-1368
    • Sun, X.1    Tong, Y.2    Qing, H.3    Chen, C.-H.4    Song, W.5
  • 75
    • 0025739254 scopus 로고
    • Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1
    • Schreck R, Rieber P, Baeuerle P A. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. Embo J, 1991, 10(8): 2247-2258 (Pubitemid 21905698)
    • (1991) EMBO Journal , vol.10 , Issue.8 , pp. 2247-2258
    • Schreck, R.1    Rieber, P.2    Baeuerle, P.A.3
  • 76
    • 0028982454 scopus 로고
    • Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease
    • Motter R, Vigo-Pelfrey C, Kholodenko D, et al. Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease. Ann Neurol, 1995, 38( 4): 643-648
    • (1995) Ann Neurol , vol.38 , Issue.4 , pp. 643-648
    • Motter, R.1    Vigo-Pelfrey, C.2    Kholodenko, D.3
  • 77
    • 0141738373 scopus 로고    scopus 로고
    • CSF markers for incipient Alzheimer's disease
    • DOI 10.1016/S1474-4422(03)00530-1
    • Blennow K, Hampel H. CSF markers for incipient Alzheimer's disease. Lancet Neurol, 2003, 2(10): 605-613 (Pubitemid 37162569)
    • (2003) Lancet Neurology , vol.2 , Issue.10 , pp. 605-613
    • Blennow, K.1    Hampel, H.2
  • 79
    • 49449108546 scopus 로고    scopus 로고
    • Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease
    • Zetterberg H, Andreasson U, Hansson O, et al. Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease. Arch Neurol, 2008, 65( 8): 1102-1107
    • (2008) Arch Neurol , vol.65 , Issue.8 , pp. 1102-1107
    • Zetterberg, H.1    Andreasson, U.2    Hansson, O.3
  • 81
    • 44949221768 scopus 로고    scopus 로고
    • Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease
    • Ewers M, Zhong Z, Burger K, et al. Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease. Brain, 2008, 131( Pt 5): 1252-1258
    • (2008) Brain , vol.131 , Issue.PART 5 , pp. 1252-1258
    • Ewers, M.1    Zhong, Z.2    Burger, K.3
  • 82
    • 80053484102 scopus 로고    scopus 로고
    • Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
    • Jiang H, Hampel H, Prvulovic D, et al. Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease. Mol Neurodegener, 2011, 6( 1): 69
    • (2011) Mol Neurodegener , vol.6 , Issue.1 , pp. 69
    • Jiang, H.1    Hampel, H.2    Prvulovic, D.3
  • 83
    • 77951962298 scopus 로고    scopus 로고
    • Recent progress in neurodegenerative disorder research in China
    • Zhou J W. Recent progress in neurodegenerative disorder research in China. Sci China Life Sci, 2010, 53( 3): 348-355
    • (2010) Sci China Life Sci , vol.53 , Issue.3 , pp. 348-355
    • Zhou, J.W.1
  • 84
    • 78449288804 scopus 로고    scopus 로고
    • Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimer's disease
    • Cong L, Jia J. Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimer's disease. Neurobiol Aging, 2011, 32( 1): 54-62
    • (2011) Neurobiol Aging , vol.32 , Issue.1 , pp. 54-62
    • Cong, L.1    Jia, J.2
  • 85
    • 84879265725 scopus 로고    scopus 로고
    • Accumulated hippocampal formaldehyde induces age-dependent memory decline
    • DOI: 10.1007/s11357-012-9388-8
    • Tong Z Q, Han C S, Luo W H, et al. Accumulated hippocampal formaldehyde induces age-dependent memory decline. AGE ( 2012) DOI: 10.1007/s11357-012-9388-8
    • (2012) AGE
    • Tong, Z.Q.1    Han, C.S.2    Luo, W.H.3
  • 87
    • 78449301205 scopus 로고    scopus 로고
    • Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia
    • Tong Z Q, Zhang J L, Luo W H, et al. Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia. Neurobiology of Aging, 2011, 32( 1): 31-41
    • (2011) Neurobiology of Aging , vol.32 , Issue.1 , pp. 31-41
    • Tong, Z.Q.1    Zhang, J.L.2    Luo, W.H.3
  • 88
    • 80051617317 scopus 로고    scopus 로고
    • A novel molecular mechanism for nitrated a-synuclein-induced cell death
    • Liu Y Y, Qiang M, Wei Y, et al. A novel molecular mechanism for nitrated a-synuclein-induced cell death. J Mol Cell Biol, 2011, 3( 4): 239-249
    • (2011) J Mol Cell Biol , vol.3 , Issue.4 , pp. 239-249
    • Liu, Y.Y.1    Qiang, M.2    Wei, Y.3
  • 90
    • 77951961804 scopus 로고    scopus 로고
    • Progress in neural plasticity
    • Zhang X H, Poo M M. Progress in neural plasticity. Sci China Life Sci, 2010, 53( 3): 322-329
    • (2010) Sci China Life Sci , vol.53 , Issue.3 , pp. 322-329
    • Zhang, X.H.1    Poo, M.M.2
  • 91
    • 77951943759 scopus 로고    scopus 로고
    • Synapse formation and remodeling. Axon guidance and neuronal migration research in China
    • Luo Z G. Synapse formation and remodeling. Axon guidance and neuronal migration research in China. Sci China Life Sci, 2010, 53( 3): 315-321
    • (2010) Sci China Life Sci , vol.53 , Issue.3 , pp. 315-321
    • Luo, Z.G.1
  • 92
    • 76649089967 scopus 로고    scopus 로고
    • A meta-analysis of oxidative stress markers in schizophrenia
    • Zhang M, Zhao Z M, He L, et al. A meta-analysis of oxidative stress markers in schizophrenia. Sci China Life Sci, 2010, 53( 1): 112-124
    • (2010) Sci China Life Sci , vol.53 , Issue.1 , pp. 112-124
    • Zhang, M.1    Zhao, Z.M.2    He, L.3
  • 93
    • 77949282876 scopus 로고    scopus 로고
    • TLR4 signaling induced TLR2 expression in the process of mimic cerebral ischemia/reperfusion in vitro
    • Sun P, Zhang Q, Han J Y, et al. TLR4 signaling induced TLR2 expression in the process of mimic cerebral ischemia/reperfusion in vitro. Sci China Life Sci, 2010, 53( 1): 112-124
    • (2010) Sci China Life Sci , vol.53 , Issue.1 , pp. 112-124
    • Sun, P.1    Zhang, Q.2    Han, J.Y.3
  • 94
    • 77951966903 scopus 로고    scopus 로고
    • Ion channels in neuronal survival
    • Wang Y Z, Xu T L. Ion channels in neuronal survival. Sci China Life Sci, 2010, 53 ( 3): 342-347
    • (2010) Sci China Life Sci , vol.53 , Issue.3 , pp. 342-347
    • Wang, Y.Z.1    Xu, T.L.2
  • 95
    • 79959613455 scopus 로고    scopus 로고
    • Copper ions influence the toxicity of β-amyloid (1-42) in a concentration-dependent manner in a Caenorhabditis elegans model of Alzheimer's disease
    • Luo Y F, Zhang J, Liu N Q, et al. Copper ions influence the toxicity of β-amyloid (1-42) in a concentration-dependent manner in a Caenorhabditis elegans model of Alzheimer's disease. Sci China Life Sci, 2011, 54( 6): 527-534
    • (2011) Sci China Life Sci , vol.54 , Issue.6 , pp. 527-534
    • Luo, Y.F.1    Zhang, J.2    Liu, N.Q.3


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