An Integrated In Silico Approach to Design Specific Inhibitors Targeting Human Poly(A)-Specific Ribonuclease

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Vlachakis, Dimitrios ^a   Pavlopoulou, Athanasia ^a   Tsiliki, Georgia ^a   Komiotis, Dimitri ^b   Stathopoulos, Constantinos ^c   Balatsos, Nikolaos A A ^b   Kossida, Sophia ^a  

^a BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^b UNIVERSITY OF THESSALY   (Greece)

^c UNIVERSITY OF PATRAS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROPHENOL; AMINO ACID; EXORIBONUCLEASE; NUCLEOSIDE ANALOG; POLY [2' O (2,4 DINITROPHENYL)]POLYADENYLIC ACID; POLYADENYLIC ACID; POLYADENYLIC ACID RIBONUCLEASE; RIBONUCLEASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; COMPUTER MODEL; COMPUTER SIMULATION; DRUG DESIGN; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME MECHANISM; ENZYME REGULATION; ENZYME STRUCTURE; EUKARYOTE; GENOME; HUMAN; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; NONHUMAN; PHARMACOPHORE; PHYLOGENY; PROTEIN TARGETING; STRUCTURAL BIOINFORMATICS; STRUCTURE ACTIVITY RELATION;

CATALYTIC DOMAIN; COMPUTER SIMULATION; DRUG DESIGN; EXORIBONUCLEASES; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

EUKARYOTA;

EID: 84870830654     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051113     Document Type: Article

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