Competitive inhibition of human poly(A)-specific ribonuclease (PARN) by synthetic fluoro-pyranosyl nucleosides

Biochemistry

Volumn 48, Issue 26, 2009, Pages 6044-6051

  Balatsos, Nikolaos A A ^a,c   Vlachakis, Dimitrios ^b   Maragozidis, Panagiotis ^a   Manta, Stella ^a   Anastasakis, Dimitrios ^a   Kyritsis, Athanasios ^a   Vlassi, Metaxia ^b   Komiotis, Dimitri ^a   Stathopoulos, Constantinos ^a,c  

^a UNIVERSITY OF THESSALY   (Greece)

^b INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^c INSTITUTE OF HUMAN PERFORMANCE AND REHABILITATION   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AMINOGLYCOSIDES; CANCER CELL LINES; CATALYTIC AMINO ACIDS; COMPETITIVE INHIBITION; IN-SILICO; IN-VITRO; IN-VIVO; INHIBITORY EFFECT; KINETIC ANALYSIS; MOLECULAR DOCKING; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR LEVELS; MOLECULAR TARGETS; NUCLEOSIDE ANALOGUES; SUGAR MOIETY; TURNOVER RATE;

AMINES; AMINO ACIDS; BIOMOLECULES; CELL CULTURE; DYNAMICS; ENZYMES; GENE EXPRESSION; MOLECULAR DYNAMICS; NUCLEIC ACIDS; ORGANIC ACIDS; SUGAR (SUCROSE); SULFUR COMPOUNDS;

SUGARS;

ADENINE; AMINO ACID; CYTOSINE; FLUORO GLUCOPYRANOSYL; MAGNESIUM ION; NUCLEOSIDE ANALOG; POLYADENYLIC ACID; POLYADENYLIC ACID SPECIFIC RIBONUCLEASE; RECOMBINANT ENZYME; RIBONUCLEASE; SUGAR; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; COMPETITIVE INHIBITION; COMPUTER MODEL; ENZYME KINETICS; HUMAN; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; SIMULATION; TURNOVER TIME;

BINDING, COMPETITIVE; BIOCATALYSIS; CATALYTIC DOMAIN; COMPUTER SIMULATION; ENZYME INHIBITORS; EXORIBONUCLEASES; GLUCOSE; HUMANS; HYDROGEN BONDING; HYDROPHOBICITY; KINETICS; MAGNESIUM; MODELS, MOLECULAR; NUCLEOSIDES; RECOMBINANT PROTEINS;

RUMEX;

EID: 67650086739     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900236k     Document Type: Article

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