Kinetic and in silico analysis of the slow-binding inhibition of human poly(A)-specific ribonuclease (PARN) by novel nucleoside analogues

Biochimie

Volumn 94, Issue 1, 2012, Pages 214-221

  Balatsos, Nikolaos ^a   Vlachakis, Dimitrios ^b   Chatzigeorgiou, Vassiliki ^a   Manta, Stella ^a   Komiotis, Dimitri ^a   Vlassi, Metaxia ^b   Stathopoulos, Constantinos ^c  

^a UNIVERSITY OF THESSALY   (Greece)

^b INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^c UNIVERSITY OF PATRAS   (Greece)

Author keywords

Deadenylation; Nucleoside analogues; PARN; Slow binding inhibition

Indexed keywords

1 (3' DEOXY 3' FLUORO BETA DEXTRO GLUCOPYRANOSYL) 5 FLUOROURACIL; 1 (3' DEOXY 3' FLUORO BETA DEXTRO GLUCOPYRANOSYL)THYMINE; 1 (3' DEOXY 3' FLUORO BETA DEXTRO GLUCOPYRANOSYL)URACIL; 1 (3',4', DIDEOXY 3' FLUORO BETA DEXTRO GLUCOPYRANOSYL) N4 BENZOYL ADENINE; 3 DEOXY 3 FLUORO GLUCOPYRANOSE; 9 (3',4', DIDEOXY 3' FLUORO BETA DEXTRO GLUCOPYRANOSYL) N6 BENZOYL ADENINE; ADENINE DERIVATIVE; EXODEOXYRIBONUCLEASE; FLUOROURACIL; GLUCOSE DERIVATIVE; NUCLEOSIDE ANALOG; POLYADENYLIC ACID SPECIFIC RIBONUCLEASE; RECOMBINANT ENZYME; RIBONUCLEASE INHIBITOR; THYMINE DERIVATIVE; UNCLASSIFIED DRUG; URACIL;

ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME PURIFICATION; HUMAN; INHIBITION KINETICS; MOLECULAR DOCKING; MOLECULAR INTERACTION;

CATALYTIC DOMAIN; ENZYME INHIBITORS; EXORIBONUCLEASES; HUMANS; KINETICS; NUCLEOSIDES; PROTEIN BINDING;

EID: 83455172585     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2011.10.011     Document Type: Article

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