MicroRNAs, Hepatitis C virus, and HCV/HIV-1 Co-infection: New insights in pathogenesis and therapy

Viruses

Volumn 4, Issue 11, 2012, Pages 2485-2513

  Gupta, Archana ^a,b   Swaminathan, Gokul ^a   Martin Garcia, Julio ^a   Navas Marti, Sonia ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Antagomir; Antiviral response; Exosomes; HCV; Hepatitis; Hepatitis C virus; HIV 1; HIV 1 HCV co infection; MicroRNA; miR 122; Therapeutics

Indexed keywords

LET7 MICRORNA; MICRORNA; MICRORNA 122; MICRORNA 141; MICRORNA 149; MICRORNA 199A; MICRORNA 29; MICRORNA 491; MIRAVIRSEN; UNCLASSIFIED DRUG; VIRUS RNA;

BIOINFORMATICS; GENE EXPRESSION; GENETIC REGULATION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LIVER FIBROSIS; MICROARRAY ANALYSIS; MIXED INFECTION; MOLECULAR INTERACTION; NONHUMAN; PATHOGENESIS; PHASE 2 CLINICAL TRIAL (TOPIC); REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; VIROGENESIS; VIRUS CELL INTERACTION; VIRUS GENOME; VIRUS LOAD;

COINFECTION; HEPACIVIRUS; HEPATITIS C; HIV INFECTIONS; HIV-1; HUMANS; MICRORNAS;

HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84870626327     PISSN: 19994915     EISSN: None     Source Type: Journal    
DOI: 10.3390/v4112485     Document Type: Review

References (180)

1. Selbach, M.; Schwanhausser, B.; Thierfelder, N.; Fang, Z.; Khanin, R.; Rajewsky, N. Widespread changes in protein synthesis induced by microRNAs. Nature 2008, 455, 58-63.
2. Guo, H.; Ingolia, N.T.; Weissman, J.S.; Bartel, D.P. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 2010, 466, 835-840.
3. Taganov, K.D.; Boldin, M.P.; Baltimore, D. MicroRNAs and immunity: tiny players in a big field. Immunity 2007, 26, 133-137.
4. Salta, E.; De Strooper, B. Non-coding RNAs with essential roles in neurodegenerative disorders. Lancet Neurol 2012, 11, 189-200.
5. Schoof, C.R.; Botelho, E.L.; Izzotti, A.; Vasques Ldos, R. MicroRNAs in cancer treatment and prognosis. Am J Cancer Res 2012, 2, 414-433.
6. Friedman, R.C.; Farh, K.K.; Burge, C.B.; Bartel, D.P. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009, 19, 92-105.
7. Gottwein, E.; Cullen, B.R. Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell Host Microbe 2008, 3, 375-387.
8. Bazzini, A.A.; Lee, M.T.; Giraldez, A.J. Ribosome profiling shows that miR-430 reduces translation before causing mRNA decay in zebrafish. Science 2012, 336, 233-237.
9. Huntzinger, E.; Izaurralde, E. Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet 2011, 12, 99-110.
10. Cullen, B.R. Viruses and microRNAs: RISCy interactions with serious consequences. Genes Dev 2011, 25, 1881-1894.
11. Houzet, L.; Jeang, K.T. MicroRNAs and human retroviruses. Biochim Biophys Acta 2011, 1809, 686-693.
12. Carnero, E.; Sutherland, J.D.; Fortes, P. Adenovirus and miRNAs. Biochim Biophys Acta 2011, 1809, 660-667.
13. Israsena, N.; Mahavihakanont, A.; Hemachudha, T. Rabies virus infection and microRNAs. Adv Virus Res 2011, 79, 329-344.
14. Liu, W.H.; Yeh, S.H.; Chen, P.J. Role of microRNAs in hepatitis B virus replication and pathogenesis. Biochim Biophys Acta 2011, 1809, 678-685.
15. Tuddenham, L.; Pfeffer, S. Roles and regulation of microRNAs in cytomegalovirus infection. Biochim Biophys Acta 2011, 1809, 613-622.
16. Haasnoot, J.; Berkhout, B. RNAi and cellular miRNAs in infections by mammalian viruses. Methods Mol Biol 2011, 721, 23-41.
17. Grundhoff, A.; Sullivan, C.S. Virus-encoded microRNAs. Virology 2011, 411, 325-343.
18. Pfeffer, S.; Zavolan, M.; Grasser, F.A.; Chien, M.; Russo, J.J.; Ju, J.; John, B.; Enright, A.J.; Marks, D.; Sander, C.; Tuschl, T. Identification of virus-encoded microRNAs. Science 2004, 304, 734-736.
19. Rouha, H.; Thurner, C.; Mandl, C.W. Functional microRNA generated from a cytoplasmic RNA virus. Nucleic Acids Res 2010, 38, 8328-8337.
20. Shapiro, J.S.; Varble, A.; Pham, A.M.; Tenoever, B.R. Noncanonical cytoplasmic processing of viral microRNAs. RNA 2010, 16, 2068-2074.
21. Varble, A.; Chua, M.A.; Perez, J.T.; Manicassamy, B.; Garcia-Sastre, A.; tenOever, B.R. Engineered RNA viral synthesis of microRNAs. Proc Natl Acad Sci U S A 2010, 107, 11519-11524.
22. Hussain, M.; Torres, S.; Schnettler, E.; Funk, A.; Grundhoff, A.; Pijlman, G.P.; Khromykh, A. A.; Asgari, S. West Nile virus encodes a microRNA-like small RNA in the 3' untranslated region which up-regulates GATA4 mRNA and facilitates virus replication in mosquito cells. Nucleic Acids Res 2012, 40, 2210-2223.
23. Bhanja Chowdhury, J.; Shrivastava, S.; Steele, R.; Di Bisceglie, A.M.; Ray, R.; Ray, R.B. Hepatitis C Virus Infection Modulates Expression of Interferon Stimulatory Gene IFITM1 by Upregulating miR-130A. J Virol 2012, 86, 10221-10225.
24. Zhang, G.L.; Li, Y.X.; Zheng, S.Q.; Liu, M.; Li, X.; Tang, H. Suppression of hepatitis B virus replication by microRNA-199a-3p and microRNA-210. Antiviral Res 2010, 88, 169-175.
25. Santhakumar, D.; Forster, T.; Laqtom, N.N.; Fragkoudis, R.; Dickinson, P.; Abreu-Goodger, C.; Manakov, S.A.; Choudhury, N.R.; Griffiths, S.J.; Vermeulen, A.; Enright, A.J.; Dutia, B.; Kohl, A.; Ghazal, P.; Buck, A.H. Combined agonist-antagonist genome-wide functional screening identifies broadly active antiviral microRNAs. Proc Natl Acad Sci USA 2010, 107, 13830-13835.
26. Fang, J.; Hao, Q.; Liu, L.; Li, Y.; Wu, J.; Huo, X.; Zhu, Y. Epigenetic changes mediated by microRNA miR29 activate cyclooxygenase 2 and lambda-1 interferon production during viral infection. J Virol 2012, 86, 1010-1020.
27. Ishida, H.; Tatsumi, T.; Hosui, A.; Nawa, T.; Kodama, T.; Shimizu, S.; Hikita, H.; Hiramatsu, N.; Kanto, T.; Hayashi, N.; Takehara, T. Alterations in microRNA expression profile in HCV-infected hepatoma cells: involvement of miR-491 in regulation of HCV replication via the PI3 kinase/Akt pathway. Biochem Biophys Res Commun 2011, 412, 92-97.
28. Hemida, M.G.; Ye, X.; Zhang, H.M.; Hanson, P.J.; Liu, Z.; McManus, B.M.; Yang, D. MicroRNA-203 enhances Coxsackievirus B3 replication through targeting zinc finger protein-148. Cell Mol Life Sci 2012.
29. Jopling, C.L.; Yi, M.; Lancaster, A.M.; Lemon, S.M.; Sarnow, P. Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science 2005, 309, 1577-1581.
30. Jangra, R.K.; Yi, M.; Lemon, S.M. Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122. J Virol 2010, 84, 6615-6625.
31. Shepard, C.W.; Finelli, L.; Alter, M.J. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis 2005, 5, 558-567.
32. Micallef, J.M.; Kaldor, J.M.; Dore, G.J. Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studies. J Viral Hepat 2006, 13, 34-41.
33. Alter, M.J. Epidemiology of hepatitis C in the West. Semin Liver Dis 1995, 15, 5-14.
34. Munir, S.; Saleem, S.; Idrees, M.; Tariq, A.; Butt, S.; Rauff, B.; Hussain, A.; Badar, S.; Naudhani, M.; Fatima, Z.; Ali, M.; Ali, L.; Akram, M.; Aftab, M.; Khubaib, B.; Awan, Z. Hepatitis C treatment: current and future perspectives. Virol J 2010, 7, 296.
35. Asselah, T. Realize the advance in HCV treatment, but remain cautious. J Hepatol 2011, 55, 1457-1460.
36. Foote, B.S.; Spooner, L.M.; Belliveau, P.P. Boceprevir: a protease inhibitor for the treatment of chronic hepatitis C. Ann Pharmacother 2011, 45, 1085-1093.
37. Lanford, R.E.; Hildebrandt-Eriksen, E.S.; Petri, A.; Persson, R.; Lindow, M.; Munk, M.E.; Kauppinen, S.; Orum, H. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 2010, 327, 198-201.
38. Reesink, H.W.; Janssen, H.L. A.; Zeuzem, E.; Lawitz, S.; Rodriguez-Torres, M.; Patel, K.; Chen, A.; Davis, C.; King, B.; Levin, A.; Hodges, M.R. Final Results: Randomized, Double-Blind, Placebo-Controlled Safety, Anti-Viral Proof-of-Concept Study of Miravirsen, an Oligonucleotide Targeting miR-122, in Treatment-Naive Patients with Genotype 1 Chronic HCV Infection. 47th International Liver Congress (EASL). Barcelona, Spain, April 18-22 2012. J. Hepatol. 2012, 56: pS1-S614. Suplement 2, A58.
39. Quinn, S.R.; O'Neill, L.A. A trio of microRNAs that control Toll-like receptor signalling. Int Immunol 2011, 23, 421-425.
40. O'Neill, L.A.; Sheedy, F.J.; McCoy, C.E. MicroRNAs: the fine-tuners of Toll-like receptor signalling. Nat Rev Immunol 2011, 11, 163-175.
41. Swaminathan, G.; Rossi, F.; Sierra, L.J.; Gupta, A.; Navas-Martin, S.; Martin-Garcia, J. A Role for microRNA-155 Modulation in the Anti-HIV-1 Effects of Toll-Like Receptor 3 Stimulation in Macrophages. PLoS Pathog 2012, 8, e1002937.
42. Sulkowski, M.S.; Thomas, D.L. Hepatitis C in the HIV-infected patient. Clin Liver Dis 2003, 7, 179-194.
43. Low, E.; Vogel, M.; Rockstroh, J.; Nelson, M. Acute hepatitis C in HIV-positive individuals. AIDS Rev 2008, 10, 245-253.
44. Koziel, M.J.; Peters, M.G. Viral hepatitis in HIV infection. N Engl J Med 2007, 356, 1445-1454.
45. Sulkowski, M. S.; Thomas, D. L., Hepatitis C in the HIV-Infected Person. Ann Intern Med 2003, 138, 197-207.
46. Kim, A.Y.; Chung, R.T. Coinfection with HIV-1 and HCV--a one-two punch. Gastroenterology 2009, 137, 795-814.
47. Sulkowski, M.S.; Moore, R.D.; Mehta, S.H.; Chaisson, R.E.; Thomas, D.L. Hepatitis C and progression of HIV disease. JAMA 2002, 288, 199-206.
48. Dorrucci, M.; Valdarchi, C.; Suligoi, B.; Zaccarelli, M.; Sinicco, A.; Giuliani, M.; Vlahov, D.; Pezzotti, P.; Rezza, G. The effect of hepatitis C on progression to AIDS before and after highly active antiretroviral therapy. AIDS 2004, 18, 2313-2318.
49. Moradpour, D.; Penin, F.; Rice, C.M. Replication of hepatitis C virus. Nat Rev Microbiol 2007, 5, 453-463.
50. Farci, P. New insights into the HCV quasispecies and compartmentalization. Semin Liver Dis 2011, 31, 356-374.
51. Argentini, C.; Genovese, D.; Dettori, S.; Rapicetta, M. HCV genetic variability: from quasispecies evolution to genotype classification. Future Microbiol. 2009, 4, 359-373.
52. Wang, B.X.; Fish, E.N. The yin and yang of viruses and interferons. Trends Immunol 2012, 33, 190-197.
53. Pedersen, I.M.; Cheng, G.; Wieland, S.; Volinia, S.; Croce, C.M.; Chisari, F.V.; David, M. Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature 2007, 449, 919-922.
54. Murakami, Y.; Aly, H.H.; Tajima, A.; Inoue, I.; Shimotohno, K. Regulation of the hepatitis C virus genome replication by miR-199a. J Hepatol 2009, 50, 453-460.
55. Cheng, J.C.; Yeh, Y.J.; Tseng, C. P.; Hsu, S.D.; Chang, Y.L.; Sakamoto, N.; Huang, H.D. Let-7b is a novel regulator of hepatitis C virus replication. Cell Mol Life Sci 2012, 69, 2621-2633.
56. Sun, J.; Hoshino, H.; Takaku, K.; Nakajima, O.; Muto, A.; Suzuki, H.; Tashiro, S.; Takahashi, S.; Shibahara, S.; Alam, J.; Taketo, M.M.; Yamamoto, M.; Igarashi, K. Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene. EMBO J 2002, 21, 5216-5224.
57. Abdalla, M.Y.; Britigan, B.E.; Wen, F.; Icardi, M.; McCormick, M.L.; LaBrecque, D.R.; Voigt, M.; Brown, K.E.; Schmidt, W.N. Down-regulation of heme oxygenase-1 by hepatitis C virus infection in vivo and by the in vitro expression of hepatitis C core protein. J Infect Dis 2004, 190, 1109-1118.
58. Zhu, Z.; Wilson, A.T.; Mathahs, M.M.; Wen, F.; Brown, K.E.; Luxon, B.A.; Schmidt, W.N. Heme oxygenase-1 suppresses hepatitis C virus replication and increases resistance of hepatocytes to oxidant injury. Hepatology 2008, 48, 1430-1439.
59. Swaminathan, G.; Rossi, F.; Sierra, L.J.; Gupta, A.; Navas-Martin, S.; Martin-Garcia, J. A Role for microRNA-155 Modulation in the Anti-HIV-1 Effects of Toll-Like Receptor 3 Stimulation in Macrophages. PLoS Pathog 2012, 8, e1002937.
60. Sulkowski, M.S.; Thomas, D.L. Hepatitis C in the HIV-infected patient. Clin Liver Dis 2003, 7, 179-194.
61. Low, E.; Vogel, M.; Rockstroh, J.; Nelson, M. Acute hepatitis C in HIV-positive individuals. AIDS Rev 2008, 10, 245-253.
62. Koziel, M.J.; Peters, M.G. Viral hepatitis in HIV infection. N Engl J Med 2007, 356, 1445-1454.
63. Sulkowski, M. S.; Thomas, D. L., Hepatitis C in the HIV-Infected Person. Ann Intern Med 2003, 138, 197-207.
64. Kim, A.Y.; Chung, R.T. Coinfection with HIV-1 and HCV--a one-two punch. Gastroenterology 2009, 137, 795-814.
65. Sulkowski, M.S.; Moore, R.D.; Mehta, S.H.; Chaisson, R.E.; Thomas, D.L. Hepatitis C and progression of HIV disease. JAMA 2002, 288, 199-206.
66. Dorrucci, M.; Valdarchi, C.; Suligoi, B.; Zaccarelli, M.; Sinicco, A.; Giuliani, M.; Vlahov, D.; Pezzotti, P.; Rezza, G. The effect of hepatitis C on progression to AIDS before and after highly active antiretroviral therapy. AIDS 2004, 18, 2313-2318.
67. Moradpour, D.; Penin, F.; Rice, C.M. Replication of hepatitis C virus. Nat Rev Microbiol 2007, 5, 453-463.
68. Farci, P. New insights into the HCV quasispecies and compartmentalization. Semin Liver Dis 2011, 31, 356-374.
69. Argentini, C.; Genovese, D.; Dettori, S.; Rapicetta, M. HCV genetic variability: from quasispecies evolution to genotype classification. Future Microbiol. 2009, 4, 359-373.
70. Wang, B.X.; Fish, E.N. The yin and yang of viruses and interferons. Trends Immunol 2012, 33, 190-197.
71. Pedersen, I.M.; Cheng, G.; Wieland, S.; Volinia, S.; Croce, C.M.; Chisari, F.V.; David, M. Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature 2007, 449, 919-922.
72. Murakami, Y.; Aly, H.H.; Tajima, A.; Inoue, I.; Shimotohno, K. Regulation of the hepatitis C virus genome replication by miR-199a. J Hepatol 2009, 50, 453-460.
73. Cheng, J.C.; Yeh, Y.J.; Tseng, C. P.; Hsu, S.D.; Chang, Y.L.; Sakamoto, N.; Huang, H.D. Let-7b is a novel regulator of hepatitis C virus replication. Cell Mol Life Sci 2012, 69, 2621-2633.
74. Sun, J.; Hoshino, H.; Takaku, K.; Nakajima, O.; Muto, A.; Suzuki, H.; Tashiro, S.; Takahashi, S.; Shibahara, S.; Alam, J.; Taketo, M.M.; Yamamoto, M.; Igarashi, K. Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene. EMBO J 2002, 21, 5216-5224.
75. Abdalla, M.Y.; Britigan, B.E.; Wen, F.; Icardi, M.; McCormick, M.L.; LaBrecque, D.R.; Voigt, M.; Brown, K.E.; Schmidt, W.N. Down-regulation of heme oxygenase-1 by hepatitis C virus infection in vivo and by the in vitro expression of hepatitis C core protein. J Infect Dis 2004, 190, 1109-1118.
76. Zhu, Z.; Wilson, A.T.; Mathahs, M.M.; Wen, F.; Brown, K.E.; Luxon, B.A.; Schmidt, W.N. Heme oxygenase-1 suppresses hepatitis C virus replication and increases resistance of hepatocytes to oxidant injury. Hepatology 2008, 48, 1430-1439.
77. Esau, C.; Davis, S.; Murray, S.F.; Yu, X.X.; Pandey, S.K.; Pear, M.; Watts, L.; Booten, S.L.; Graham, M.; McKay, R.; Subramaniam, A.; Propp, S.; Lollo, B. A.; Freier, S.; Bennett, C.F.; Bhanot, S.; Monia, B.P. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab 2006, 3, 87-98.
78. Elmen, J.; Lindow, M.; Schutz, S.; Lawrence, M.; Petri, A.; Obad, S.; Lindholm, M.; Hedtjarn, M.; Hansen, H.F.; Berger, U.; Gullans, S.; Kearney, P.; Sarnow, P.; Straarup, E.M.; Kauppinen, S. LNA-mediated microRNA silencing in non-human primates. Nature 2008, 452, 896-899.
79. Henke, J.I.; Goergen, D.; Zheng, J.; Song, Y.; Schuttler, C.G.; Fehr, C.; Junemann, C.; Niepmann, M. microRNA-122 stimulates translation of hepatitis C virus RNA. EMBO J 2008, 27, 3300-3310.
80. Roberts, A.P.; Lewis, A.P.; Jopling, C.L. miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components. Nucleic Acids Res 2011, 39, 7716-7729.
81. Machlin, E.S.; Sarnow, P.; Sagan, S.M. Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex. Proc Natl Acad Sci U S A 2011, 108, 3193-3198.
82. Chang, J.; Guo, J.T.; Jiang, D.; Guo, H.; Taylor, J.M.; Block, T.M. Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells. J Virol 2008, 82, 8215-8223.
83. Narbus, C.M.; Israelow, B.; Sourisseau, M.; Michta, M.L.; Hopcraft, S.E.; Zeiner, G.M.; Evans, M.J. HepG2 cells expressing miR-122 support the entire hepatitis C virus life cycle. J Virol 2011.
84. Wilson, J.A.; Zhang, C.; Huys, A.; Richardson, C.D. Human Ago2 is required for efficient microRNA 122 regulation of hepatitis C virus RNA accumulation and translation. J Virol 2011, 85, 2342-2350.
85. Kulkarni, M.; Ozgur, S.; Stoecklin, G. On track with P-bodies. Biochem Soc Trans 2010, 38, 242-251.
86. Ariumi, Y.; Kuroki, M.; Kushima, Y.; Osugi, K.; Hijikata, M.; Maki, M.; Ikeda, M.; Kato, N. Hepatitis C virus hijacks P-body and stress granule components around lipid droplets. J Virol 2011, 85, 6882-6892.
87. Jangra, R.K.; Yi, M.; Lemon, S.M. DDX6 (Rck/p54) is required for efficient hepatitis C virus replication but not for internal ribosome entry site-directed translation. J Virol 2010, 84, 6810-6824.
88. Hoffmann, T.W.; Duverlie, G.; Bengrine, A. MicroRNAs and hepatitis C virus: Toward the end of miR-122 supremacy. Virol J 2012, 9, 109.
89. Skalsky, R.L.; Cullen, B.R. Viruses, microRNAs, and host interactions. Annu Rev Microbiol 2010, 64, 123-141.
90. Cullen, B.R. Five questions about viruses and microRNAs. PLoS Pathog 2010, 6, e1000787.
91. Liu, X.; Wang, T.; Wakita, T.; Yang, W. Systematic identification of microRNA and messenger RNA profiles in hepatitis C virus-infected human hepatoma cells. Virology 2010, 398, 57-67.
92. Peveling-Oberhag, J.; Crisman, G.; Schmidt, A.; Doring, C.; Lucioni, M.; Arcaini, L.; Rattotti, S.; Hartmann, S.; Piiper, A.; Hofmann, W.P.; Paulli, M.; Kuppers, R.; Zeuzem, S.; Hansmann, M.L. Dysregulation of global microRNA expression in splenic marginal zone lymphoma and influence of chronic hepatitis C virus infection. Leukemia 2012, 26, 1654-1662.
93. Bihrer, V.; Waidmann, O.; Friedrich-Rust, M.; Forestier, N.; Susser, S.; Haupenthal, J.; Welker, M.; Shi, Y.; Peveling-Oberhag, J.; Polta, A.; von Wagner, M.; Radeke, H.H.; Sarrazin, C.; Trojan, J.; Zeuzem, S.; Kronenberger, B.; Piiper, A. Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma. PLoS One 2011, 6, e26971.
94. Bihrer, V.; Friedrich-Rust, M.; Kronenberger, B.; Forestier, N.; Haupenthal, J.; Shi, Y.; Peveling-Oberhag, J.; Radeke, H.H.; Sarrazin, C.; Herrmann, E.; Zeuzem, S.; Waidmann, O.; Piiper, A. Serum miR-122 as a Biomarker of Necroinflammation in Patients With Chronic Hepatitis C Virus Infection. Am J Gastroenterol 2011, 106, 1663-1669.
95. Cermelli, S.; Ruggieri, A.; Marrero, J.A.; Ioannou, G.N.; Beretta, L. Circulating MicroRNAs in Patients with Chronic Hepatitis C and Non-Alcoholic Fatty Liver Disease. PLoS One 2011, 6, e23937.
96. Grek, M.; Piekarska, A.; Bartkowiak, J.; Fendler, W.; Kuydowicz, J.; Wroblewski, P.; Paradowski, M.; Sidorkiewicz, M. Coordinated increase of miRNA-155 and miRNA-196b expression correlates with the detection of the antigenomic strand of hepatitis C virus in peripheral blood mononuclear cells. Int J Mol Med 2011, 28, 875-880.
97. Bala, S.; Tilahun, Y.; Taha, O.; Alao, H.; Kodys, K.; Catalano, D.; Szabo, G. Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection. J Transl Med 2012, 10, 151.
98. Wong, Q.W.; Lung, R.W.; Law, P.T.; Lai, P.B.; Chan, K.Y.; To, K.F.; Wong, N. MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. Gastroenterology 2008, 135, 257-269.
99. Zhang, Y.; Wei, W.; Cheng, N.; Wang, K.; Li, B.; Jiang, X.; Sun, S. Hepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling. Hepatology 2012, 10.1002/hep.25849.
100. Frankel, L.B.; Christoffersen, N.R.; Jacobsen, A.; Lindow, M.; Krogh, A.; Lund, A.H. Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J Biol Chem 2008, 283, 1026-1033.
101. Chan, J.A.; Krichevsky, A.M.; Kosik, K.S. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 2005, 65, 6029-6033.
102. Sarasin-Filipowicz, M.; Krol, J.; Markiewicz, I.; Heim, M.H.; Filipowicz, W. Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy. Nat Med 2009, 15, 31-33.
103. Marquez, R.T.; Bandyopadhyay, S.; Wendlandt, E.B.; Keck, K.; Hoffer, B.A.; Icardi, M.S.; Christensen, R.N.; Schmidt, W.N.; McCaffrey, A.P. Correlation between microRNA expression levels and clinical parameters associated with chronic hepatitis C viral infection in humans. Lab Invest 2010, 90, 1727-1736.
104. Sarasin-Filipowicz, M.; Oakeley, E.J.; Duong, F.H.; Christen, V.; Terracciano, L.; Filipowicz, W.; Heim, M.H. Interferon signaling and treatment outcome in chronic hepatitis C. Proc Natl Acad Sci U S A 2008, 105, 7034-7039.
105. Varnholt, H.; Drebber, U.; Schulze, F.; Wedemeyer, I.; Schirmacher, P.; Dienes, H.P.; Odenthal, M. MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma. Hepatology 2008, 47, 1223-1232.
106. Augello, C.; Vaira, V.; Caruso, L.; Destro, A.; Maggioni, M.; Park, Y.N.; Montorsi, M.; Santambrogio, R.; Roncalli, M.; Bosari, S. MicroRNA profiling of hepatocarcinogenesis identifies C19MC cluster as a novel prognostic biomarker in hepatocellular carcinoma. Liver Int 2012, 32, 772-782.
107. Zhang, Q.; Pu, R.; Du, Y.; Han, Y.; Su, T.; Wang, H.; Cao, G. Non-coding RNAs in hepatitis B or C-associated hepatocellular carcinoma: potential diagnostic and prognostic markers and therapeutic targets. Cancer Lett 2012, 321, 1-12.
108. Bouchard, M.J.; Navas-Martin, S. Hepatitis B and C virus hepatocarcinogenesis: lessons learned and future challenges. Cancer Lett 2011, 305, 123-143.
109. Ura, S.; Honda, M.; Yamashita, T.; Ueda, T.; Takatori, H.; Nishino, R.; Sunakozaka, H.; Sakai, Y.; Horimoto, K.; Kaneko, S. Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma. Hepatology 2009, 49, 1098-1112.
110. Bain, C.; Fatmi, A.; Zoulim, F.; Zarski, J.P.; Trepo, C.; Inchauspe, G. Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection. Gastroenterology 2001, 120, 512-524.
111. Simone, O.; Tortorella, C.; Zaccaro, B.; Napoli, N.; Antonaci, S. Impairment of TLR7-dependent signaling in dendritic cells from chronic hepatitis C virus (HCV)-infected non-responders to interferon/ribavirin therapy. J Clin Immunol 2010, 30, 556-565.
112. Villacres, M.C.; Literat, O.; DeGiacomo, M.; Du, W.; Frederick, T.; Kovacs, A. Defective response to Toll-like receptor 3 and 4 ligands by activated monocytes in chronic hepatitis C virus infection. J Viral Hepat 2008, 15, 137-144.
113. Scagnolari, C.; Zingariello, P.; Vecchiet, J.; Selvaggi, C.; Racciatti, D.; Taliani, G.; Riva, E.; Pizzigallo, E.; Antonelli, G. Differential expression of interferon-induced microRNAs in patients with chronic hepatitis C virus infection treated with pegylated interferon alpha. Virol J 2010, 7, 311.
114. Wang, Y.; Kato, N.; Jazag, A.; Dharel, N.; Otsuka, M.; Taniguchi, H.; Kawabe, T.; Omata, M. Hepatitis C virus core protein is a potent inhibitor of RNA silencing-based antiviral response. Gastroenterology 2006, 130, 883-892.
115. Chen, W.; Zhang, Z.; Chen, J.; Zhang, J.; Wu, Y.; Huang, Y.; Cai, X.; Huang, A. HCV core protein interacts with Dicer to antagonize RNA silencing. Virus Res 2008, 133, 250-258.
116. Clement, S.; Peyrou, M.; Sanchez-Pareja, A.; Bourgoin, L.; Ramadori, P.; Suter, D.; Vinciguerra, M.; Guilloux, K.; Pascarella, S.; Rubbia-Brandt, L.; Negro, F.; Foti, M. Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets. Hepatology 2011, 54, 38-49.
117. Gummuluru, S.; Emerman, M. Advances in HIV molecular biology. AIDS 2002, 16 Suppl 4, S17-23.
118. Sanchez-Quijano, A.; Andreu, J.; Gavilan, F.; Luque, F.; Abad, M. A.; Soto, B.; Munoz, J.; Aznar, J.M.; Leal, M.; Lissen, E. Influence of human immunodeficiency virus type 1 infection on the natural course of chronic parenterally acquired hepatitis C. Eur J Clin Microbiol Infect Dis 1995, 14, 949-953.
119. Sherman, K.E.; Rouster, S.D.; Chung, R.T.; Rajicic, N. Hepatitis C Virus prevalence among patients infected with Human Immunodeficiency Virus: a cross-sectional analysis of the US adult AIDS Clinical Trials Group. Clin Infect Dis 2002, 34, 831-837.
120. Darby, S.C.; Ewart, D.W.; Giangrande, P.L.; Spooner, R.J.; Rizza, C.R.; Dusheiko, G.M.; Lee, C.A.; Ludlam, C.A.; Preston, F.E. Mortality from liver cancer and liver disease in haemophilic men and boys in UK given blood products contaminated with hepatitis C. UK Haemophilia Centre Directors' Organisation. Lancet 1997, 350, 1425-1431.
121. Bica, I.; McGovern, B.; Dhar, R.; Stone, D.; McGowan, K.; Scheib, R.; Snydman, D.R. Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection. Clin Infect Dis 2001, 32, 492-497.
122. Gadalla, S.M.; Preiss, L.R.; Eyster, M.E.; Goedert, J.J. Correlates of high hepatitis C virus RNA load in a cohort of HIV-negative and HIV-positive individuals with haemophilia. J Viral Hepat 2011, 18, 161-169.
123. Cribier, B.; Schmitt, C.; Rey, D.; Uhl, G.; Lang, J.M.; Vetter, D.; Kirn, A.; Stoll-Keller, F. HIV increases hepatitis C viraemia irrespective of the hepatitis C virus genotype. Res Virol 1997, 148, 267-271.
124. Graham, C.S.; Koziel, M.J. Why should hepatitis C affect immune reconstitution in HIV-1-infected patients? Lancet 2000, 356, 1865-1866.
125. Taya, N.; Torimoto, Y.; Shindo, M.; Hirai, K.; Hasebe, C.; Kohgo, Y. Fas-mediated apoptosis of peripheral blood mononuclear cells in patients with hepatitis C. Br J Haematol 2000, 110, 89-97.
126. Rowland-Jones, S.L.; Pinheiro, S.; Kaul, R.; Hansasuta, P.; Gillespie, G.; Dong, T.; Plummer, F. A.; Bwayo, J.B.; Fidler, S.; Weber, J.; McMichael, A.; Appay, V. How important is the 'quality' of the cytotoxic T lymphocyte (CTL) response in protection against HIV infection? Immunol Lett 2001, 79, 15-20.
127. Deeks, S.G.; Kitchen, C.M.; Liu, L.; Guo, H.; Gascon, R.; Narvaez, A.B.; Hunt, P.; Martin, J. N.; Kahn, J.O.; Levy, J.; McGrath, M.S.; Hecht, F.M. Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load. Blood 2004, 104, 942-947.
128. Hazenberg, M.D.; Otto, S.A.; van Benthem, B.H.; Roos, M.T.; Coutinho, R.A.; Lange, J.M.; Hamann, D.; Prins, M.; Miedema, F. Persistent immune activation in HIV-1 infection is associated with progression to AIDS. AIDS 2003, 17, 1881-1888.
129. Rasmussen, A.L.; Wang, I.M.; Shuhart, M.C.; Proll, S.C.; He, Y.; Cristescu, R.; Roberts, C.; Carter, V.S.; Williams, C.M.; Diamond, D.L.; Bryan, J.T.; Ulrich, R.; Korth, M.J.; Thomassen, L.V.; Katze, M.G. Chronic immune activation is a distinguishing feature of liver and PBMC gene signatures from HCV/HIV coinfected patients and may contribute to hepatic fibrogenesis. Virology 2012, 430, 43-52.
130. Kottilil, S.; Yan, M.Y.; Reitano, K.N.; Zhang, X.; Lempicki, R.; Roby, G.; Daucher, M.; Yang, J.; Cortez, K.J.; Ghany, M.; Polis, M.A.; Fauci, A.S. Human immunodeficiency virus and hepatitis C infections induce distinct immunologic imprints in peripheral mononuclear cells. Hepatology 2009, 50, 34-45.
131. Verani, A.; Gras, G.; Pancino, G. Macrophages and HIV-1: dangerous liaisons. Mol Immunol 2005, 42, 195-212.
132. Marukian, S.; Jones, C.T.; Andrus, L.; Evans, M.J.; Ritola, K.D.; Charles, E.D.; Rice, C.M.; Dustin, L.B. Cell culture-produced hepatitis C virus does not infect peripheral blood mononuclear cells. Hepatology 2008, 48, 1843-1850.
133. Bouffard, P.; Hayashi, P.H.; Acevedo, R.; Levy, N.; Zeldis, J.B. Hepatitis C virus is detected in a monocyte/macrophage subpopulation of peripheral blood mononuclear cells of infected patients. J Infect Dis 1992, 166, 1276-1280.
134. Laskus, T.; Radkowski, M.; Wang, L.F.; Jang, S.J.; Vargas, H.; Rakela, J. Hepatitis C virus quasispecies in patients infected with HIV-1: correlation with extrahepatic viral replication. Virology 1998, 248, 164-171.
135. Swaminathan, S.; Murray, D.D.; Kelleher, A.D. The role of microRNAs in HIV-1 pathogenesis and therapy. AIDS 2012, 26, 1325-1334.
136. Sun, G.; Li, H.; Wu, X.; Covarrubias, M.; Scherer, L.; Meinking, K.; Luk, B.; Chomchan, P.; Alluin, J.; Gombart, A.F.; Rossi, J.J. Interplay between HIV-1 infection and host microRNAs. Nucleic Acids Res 2012, 40, 2181-2196.
137. Han, Y.; Siliciano, R.F. Keeping quiet: microRNAs in HIV-1 latency. Nat Med 2007, 13, 1138-1140.
138. Huang, J.; Wang, F.; Argyris, E.; Chen, K.; Liang, Z.; Tian, H.; Huang, W.; Squires, K.; Verlinghieri, G.; Zhang, H. Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes. Nat Med 2007, 13, 1241-1247.
139. Wang, X.; Ye, L.; Hou, W.; Zhou, Y.; Wang, Y.J.; Metzger, D.S.; Ho, W.Z. Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection. Blood 2009, 113, 671-674.
140. Swaminathan, S.; Zaunders, J.; Wilkinson, J.; Suzuki, K.; Kelleher, A.D. Does the presence of anti-HIV miRNAs in monocytes explain their resistance to HIV-1 infection? Blood 2009, 113, 5029-5030; author reply 5030-5021.
141. Sung, T.L.; Rice, A.P. miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1. PLoS Pathog 2009, 5, e1000263.
142. Chiang, K.; Sung, T.L.; Rice, A.P. Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes. J Virol 2012, 86, 3244-3252.
143. Goergen, D.; Niepmann, M. Stimulation of Hepatitis C Virus RNA translation by microRNA-122 occurs under different conditions in vivo and in vitro. Virus Res 2012, 167, 343-352.
144. Triboulet, R.; Mari, B.; Lin, Y.L.; Chable-Bessia, C.; Bennasser, Y.; Lebrigand, K.; Cardinaud, B.; Maurin, T.; Barbry, P.; Baillat, V.; Reynes, J.; Corbeau, P.; Jeang, K. T.; Benkirane, M. Suppression of microRNA-silencing pathway by HIV-1 during virus replication. Science 2007, 315, 1579-1582.
145. Manfe, V.; Biskup, E.; Rosbjerg, A.; Kamstrup, M.; Skov, A.G.; Lerche, C.M.; Lauenborg, B. T.; Odum, N.; Gniadecki, R. miR-122 regulates p53/Akt signalling and the chemotherapy-induced apoptosis in cutaneous T-cell lymphoma. PLoS One 2012, 7, e29541.
146. Ahluwalia, J.K.; Khan, S.Z.; Soni, K.; Rawat, P.; Gupta, A.; Hariharan, M.; Scaria, V.; Lalwani, M.; Pillai, B.; Mitra, D.; Brahmachari, S.K. Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication. Retrovirology 2008, 5, 117.
147. Hariharan, M.; Scaria, V.; Pillai, B.; Brahmachari, S.K. Targets for human encoded microRNAs in HIV genes. Biochem Biophys Res Commun 2005, 337, 1214-1218.
148. Kaul, D.; Ahlawat, A.; Gupta, S.D. HIV-1 genome-encoded hiv1-mir-H1 impairs cellular responses to infection. Mol Cell Biochem 2009, 323, 143-148.
149. Murakami, Y.; Toyoda, H.; Tanaka, M.; Kuroda, M.; Harada, Y.; Matsuda, F.; Tajima, A.; Kosaka, N.; Ochiya, T.; Shimotohno, K. The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families. PLoS One 2011, 6, e16081.
150. Dolganiuc, A.; Petrasek, J.; Kodys, K.; Catalano, D.; Mandrekar, P.; Velayudham, A.; Szabo, G. MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice. Alcohol Clin Exp Res 2009, 33, 1704-1710.
151. Romilda, C.; Marika, P.; Alessandro, S.; Enrico, L.; Marina, B.; Andromachi, K.; Umberto, C.; Giacomo, Z.; Claudia, M.; Massimo, R.; Fabio, F. Oxidative DNA damage correlates with cell immortalization and mir-92 expression in hepatocellular carcinoma. BMC Cancer 2012, 12, 177.
152. Hayes, A.M.; Qian, S.; Yu, L.; Boris-Lawrie, K. Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1. Retrovirology 2011, 8, 36.
153. Swaminathan, S.; Suzuki, K.; Seddiki, N.; Kaplan, W.; Cowley, M.J.; Hood, C.L.; Clancy, J.L.; Murray, D.D.; Mendez, C.; Gelgor, L.; Anderson, B.; Roth, N.; Cooper, D.A.; Kelleher, A.D. Differential regulation of the Let-7 family of microRNAs in CD4+ T cells alters IL-10 expression. J Immunol 2012, 188, 6238-6246.
154. Russo, A.; Potenza, N. Antiviral effects of human microRNAs and conservation of their target sites. FEBS Lett 2011, 585, 2551-2555.
155. Wittmann, J.; Jack, H.M. Serum microRNAs as powerful cancer biomarkers. Biochim Biophys Acta 2010, 1806, 200-207.
156. Turchinovich, A.; Weiz, L.; Langheinz, A.; Burwinkel, B. Characterization of extracellular circulating microRNA. Nucleic Acids Res 2011, 39, 7223-7233.
157. Hunter, M.P.; Ismail, N.; Zhang, X.; Aguda, B.D.; Lee, E.J.; Yu, L.; Xiao, T.; Schafer, J.; Lee, M.L.; Schmittgen, T.D.; Nana-Sinkam, S.P.; Jarjoura, D.; Marsh, C.B. Detection of microRNA expression in human peripheral blood microvesicles. PLoS One 2008, 3, e3694.
158. Arroyo, J.D.; Chevillet, J.R.; Kroh, E.M.; Ruf, I.K.; Pritchard, C.C.; Gibson, D.F.; Mitchell, P. S.; Bennett, C.F.; Pogosova-Agadjanyan, E.L.; Stirewalt, D.L.; Tait, J.F.; Tewari, M. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci U S A 2011, 108, 5003-5008.
159. Gupta, A.; Nagilla, P.; Le, H.S.; Bunney, C.; Zych, C.; Thalamuthu, A.; Bar-Joseph, Z.; Mathavan, S.; Ayyavoo, V. Comparative expression profile of miRNA and mRNA in primary peripheral blood mononuclear cells infected with human immunodeficiency virus (HIV-1). PLoS One 2011, 6, e22730.
160. Fabbri, M.; Paone, A.; Calore, F.; Galli, R.; Gaudio, E.; Santhanam, R.; Lovat, F.; Fadda, P.; Mao, C.; Nuovo, G.J.; Zanesi, N.; Crawford, M.; Ozer, G.H.; Wernicke, D.; Alder, H.; Caligiuri, M.A.; Nana-Sinkam, P.; Perrotti, D.; Croce, C.M. MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci USA 2012, 109, E2110-2116.
161. Lehmann, S.M.; Kruger, C.; Park, B.; Derkow, K.; Rosenberger, K.; Baumgart, J.; Trimbuch, T.; Eom, G.; Hinz, M.; Kaul, D.; Habbel, P.; Kalin, R.; Franzoni, E.; Rybak, A.; Nguyen, D.; Veh, R.; Ninnemann, O.; Peters, O.; Nitsch, R.; Heppner, F.L.; Golenbock, D.; Schott, E.; Ploegh, H. L.; Wulczyn, F.G.; Lehnardt, S. An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci 2012, 15, 827-835.
162. Bang, C.; Thum, T. Exosomes: New players in cell-cell communication. Int J Biochem Cell Biol 2012, 44, 2060-2064.
163. Vickers, K.C.; Remaley, A.T. Lipid-based carriers of microRNAs and intercellular communication. Curr Opin Lipidol 2012, 23, 91-97.
164. Montecalvo, A.; Larregina, A.T.; Shufesky, W.J.; Stolz, D.B.; Sullivan, M.L.; Karlsson, J.M.; Baty, C.J.; Gibson, G.A.; Erdos, G.; Wang, Z.; Milosevic, J.; Tkacheva, O.A.; Divito, S.J.; Jordan, R.; Lyons-Weiler, J.; Watkins, S.C.; Morelli, A.E. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood 2012, 119, 756-766.
165. Umezu T; Ohyashiki K; Kuroda M; JH, O. Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene 2012, in press, doi: 10.1038/onc.2012.1295. [Epub ahead of print].
166. Kosaka, N.; Ochiya, T. Unraveling the Mystery of Cancer by Secretory microRNA: Horizontal microRNA Transfer between Living Cells. Front Genet 2011, 2, 97.
167. Henderson, M.C.; Azorsa, D.O. The genomic and proteomic content of cancer cell-derived exosomes. Front Oncol 2012, 2, 38.
168. Lages, E.; Ipas, H.; Guttin, A.; Nesr, H.; Berger, F.; Issartel, J.P. MicroRNAs: molecular features and role in cancer. Front Biosci 2012, 17, 2508-2540.
169. Chiba, M.; Kimura, M.; Asari, S. Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines. Oncol Rep 2012, 28, 1551-1558.
170. Umezu, T.; Ohyashiki, K.; Kuroda, M.; Ohyashiki, J.H. Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene 2012.
171. Mittelbrunn, M.; Gutierrez-Vazquez, C.; Villarroya-Beltri, C.; Gonzalez, S.; Sanchez-Cabo, F.; Gonzalez, M.A.; Bernad, A.; Sanchez-Madrid, F. Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat Commun 2011, 2, 282.
172. Pan, Q.; Ramakrishnaiah, V.; Henry, S.; Fouraschen, S.; de Ruiter, P.E.; Kwekkeboom, J.; Tilanus, H.W.; Janssen, H.L.; van der Laan, L.J. Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNA interference (RNAi). Gut 2012, 61, 1330-1339.
173. Bala, S.; Petrasek, J.; Mundkur, S.; Catalano, D.; Levin, I.; Ward, J.; Alao, H.; Kodys, K.; Szabo, G. Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases. Hepatology 2012, 10.1002/hep.25873 [Epub ahead of print]
174. Lai, C.P.; Breakefield, X.O. Role of exosomes/microvesicles in the nervous system and use in emerging therapies. Front Physiol 2012, 3, 228.
175. Delabranche, X.; Berger, A.; Boisrame-Helms, J.; Meziani, F. Microparticles and infectious diseases. Med Mal Infect 2012, 42, 335-343.
176. Meckes, D.G., Jr.; Shair, K.H.; Marquitz, A.R.; Kung, C.P.; Edwards, R.H.; Raab-Traub, N. Human tumor virus utilizes exosomes for intercellular communication. Proc Natl Acad Sci U S A 2010, 107, 20370-20375.
177. Wurdinger, T.; Gatson, N.N.; Balaj, L.; Kaur, B.; Breakefield, X.O.; Pegtel, D.M. Extracellular vesicles and their convergence with viral pathways. Adv Virol 2012, 2012, 767694.
178. Kadiu, I.; Narayanasamy, P.; Dash, P.K.; Zhang, W.; Gendelman, H.E. Biochemical and Biologic Characterization of Exosomes and Microvesicles as Facilitators of HIV-1 Infection in Macrophages. J Immunol 2012, 189, 744-754.
179. Masciopinto, F.; Giovani, C.; Campagnoli, S.; Galli-Stampino, L.; Colombatto, P.; Brunetto, M.; Yen, T.S.; Houghton, M.; Pileri, P.; Abrignani, S. Association of hepatitis C virus envelope proteins with exosomes. Eur J Immunol 2004, 34, 2834-2842.
180. Pegtel, D.M.; van de Garde, M.D.; Middeldorp, J.M. Viral miRNAs exploiting the endosomal-exosomal pathway for intercellular cross-talk and immune evasion. Biochim Biophys Acta 2011, 1809, 715-721.