Oxidative DNA damage correlates with cell immortalization and mir-92 expression in hepatocellular carcinoma

BMC Cancer

Volumn 12, Issue , 2012, Pages

  Cardin, Romilda1 ^a   Piciocchi, Marika1 ^a   Sinigaglia, Alessandro ^a   Lavezzo, Enrico ^a   Bortolami, Marina ^a   Kotsafti, Andromachi ^a   Cillo, Umberto ^a   Zanus, Giacomo ^a   Mescoli, Claudia ^a   Rugge, Massimo ^a   Farinati, Fabio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

8 hydroxydeoxyguanosine; Hepatocellular carcinoma; Mir 92; OGG1 gene; Telomeric dysfunction

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALANINE AMINOTRANSFERASE; DNA; GAMMA GLUTAMYLTRANSFERASE; GENOMIC DNA; MESSENGER RNA; MICRORNA; MICRORNA 122; MICRORNA 145; MICRORNA 195; MICRORNA 199A; MICRORNA 199B; MICRORNA 222; MICRORNA 92; MICRORNA 92A; PROTEIN BAD; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; TELOMERASE; UNCLASSIFIED DRUG;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; APOPTOSIS; ARTICLE; CANCER PATIENT; CANCER STAGING; CANCER TISSUE; CELL DEATH; CELL DIFFERENTIATION; CELL IMMORTALIZATION; CELL PROLIFERATION; CHOLECYSTECTOMY; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GENE; GENE EXPRESSION; GENE FUNCTION; GENE OVEREXPRESSION; GENETIC POLYMORPHISM; HEPATITIS B; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; OGG1 GENE; OXIDATIVE STRESS; PERCUTANEOUS BIOPSY; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SIGNAL TRANSDUCTION; TELOMERE HOMEOSTASIS; TRANSCRIPTION REGULATION; UPREGULATION;

EID: 84865291603     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-12-177     Document Type: Article

References (51)

1. Marx J. Inflammation and cancer: the link grows stronger. Science 2004, 306:966-968. 10.1126/science.306.5698.966, 15528423.
2. Klaunig JE, Kamendulis LM, Hocevar BA. Oxidative stress and oxidative damage in carcinogenesis. Toxicol Pathol 2010, 38:96-109. 10.1177/0192623309356453, 20019356.
3. Bartsch H, Nair J. Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage and repair. Langenbecks Arch Surg 2006, 391:499-510. 10.1007/s00423-006-0073-1, 16909291.
4. Liou GY, Storz P. Reactive oxygen species in cancer. Free Radical Res 2010, 44:479-496.
5. Kuchino Y, Mori F, Kasai H, Inoue H, Iwai S, Miura K, Ohtsuka E, Nishimura S. Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues. Nature 1987, 327:77-79. 10.1038/327077a0, 3574469.
6. Sasaki Y. Does oxidative stress participate in the development of hepatocellular carcinoma?. J Gastroenterol 2006, 41:1135-1148.
7. Tsai WL, Chung RT. Viral hepatocarcinogenesis. Oncogene 2010, 29:2309-2324. 10.1038/onc.2010.36, 3148694, 20228847.
8. Farinati F, Cardin R, Bortolami M, Guido M, Rugge M. Oxidative damage, pro-inflammatory cytokines, TGF-alpha and c-myc in chronic HCV-related hepatitis and cirrhosis. World J Gastroenterol 2006, 12:2065-2069.
9. Farinati F, Cardin R, Bortolami M, Burra P, Russo FP, Rugge M, Guido M, Sergio A, Naccarato R. Hepatitis C virus: from oxygen free radicals to hepatocellular carcinoma. J Viral Hepat 2007, 14:821-829.
10. Fujita N, Horiike S, Sugimoto R, Tanaka H, Iwasa M, Kobayashi Y, Hasegawa K, Ma N, Kawanishi S, Adachi Y, Kaito M. Hepatic oxidative DNA damage correlates with iron overload in chronic hepatitis C patients. Free Rad Biol Med 2007, 42:353-362. 10.1016/j.freeradbiomed.2006.11.001, 17210448.
11. Fujita N, Sugimoto R, Ma N, Tanaka H, Iwasa M, Kobayashi Y, Kawanishi S, Watanabe S, Kaito M, Takei Y. Comparison of hepatic oxidative DNA damage in patients with chronic hepatitis B and C. J Viral Hepat 2008, 15:498-507. 10.1111/j.1365-2893.2008.00972.x, 18331251.
12. Ide H, Kotera M. Human DNA glycosylases involved in the repair of oxidatively damaged DNA. Biol Pharm Bull 2004, 27:480-485. 10.1248/bpb.27.480, 15056851.
13. Shinmura K, Yokota J. The OGG1 gene encodes a repair enzyme for oxidatively damaged DNA and is involved in human carcinogenesis. Antioxid Redox Signal 2001, 3:597-609. 10.1089/15230860152542952, 11554447.
14. Wang Z, Liu Y, Han N, Chen X, Yu W, Zhang W, Zou F. Profiles of oxidative stress-related microRNA and mRNA expression in auditory cells. Brain Res 2010, 1346:14-25.
15. Ladeiro Y, Couchy G, Balabaud C, Bioulac-Sage P, Pelletier L, Rebouissou S, Zucman-Rossi J. MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology 2008, 47:1955-1963. 10.1002/hep.22256, 18433021.
16. Braconi C, Patel T. MicroRNA expression profiling: a molecular tool for defining the phenotype of hepatocellular tumors. Hepatology 2008, 47:1807-1809. 10.1002/hep.22326, 18506877.
17. Gramantieri L, Ferracin M, Fornari F, Veronese A, Sabbioni S, Liu CG, Calin GA, Ferrazzi E, Grazi GL, Croce CM, Bolondi L, Negrini M. Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. Cancer Res 2007, 67:6092-6099. 10.1158/0008-5472.CAN-06-4607, 17616664.
18. Gramantieri L, Fornari F, Callegari E, Sabbioni S, Lanza G, Croce CM, Bolondi L, Negrini M. MicroRNA involvment in hepatocellular carcinoma. J Cell Mol Med 2008, 12:2104-2189.
19. Xu T, Zhu Y, Xiong Y, Ge YY, Yun JP, Zhuang SM. MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells. Hepatology 2009, 50:113-121. 10.1002/hep.22919, 19441017.
20. Ji J, Yamashita T, Budhu A, Forgues M, Jia HL, Li C, Deng C, Wauthier E, Reid LM, Ye QH, Qin LX, Yang W, Wang HY, Tang ZY, Croce CM, Wang XW. Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology 2009, 50:472-480. 10.1002/hep.22989, 2721019, 19585654.
21. Koziel JE, Fox MJ, Steding CE, Sprouse AA, Herbert BS. Medical genetics and epigenetics of telomerase. J Cell Mol Med 2011, 15:457-467. 10.1111/j.1582-4934.2011.01276.x, 21323862.
22. Nishikawa T, Nakajima T, Katagishi T, Okada Y, Jo M, Kagawa K, Okanoue T, Itoh Y, Yoshikawa T. Oxidative stress may enhance the malignant potential of human hepatocellular carcinoma by telomerase activation. Liver Int 2009, 29:846-856. 10.1111/j.1478-3231.2008.01963.x, 19141026.
23. Oikawa S, Kawanishi S. Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening. FEBS Lett 1999, 453:365-368. 10.1016/S0014-5793(99)00748-6, 10405177.
24. Matusomi K, Hahn WC. Telomerase and tumorigenesis. Cancer Lett 2003, 194:163-172. 10.1016/S0304-3835(02)00703-6, 12757974.
25. Artandi SE, DePinho RA. Telomeres and telomerase in cancer. Carcinogenesis 2010, 31:9-18. 10.1093/carcin/bgp268, 3003493, 19887512.
26. Kotsafti A, Farinati F, Cardin R, Burra P, Bortolami M. Bax inhibitor-1 down-regulation in the progression of chronic liver diseases. BMC Gastroenterol 2010, 10:35-42. 10.1186/1471-230X-10-35, 2873598, 20359348.
27. Kohno T, Shinmura K, Tosaka M, Tani M, Kim SR, Sugimura H, Nohmi T, Kasai H, Yokota J. Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA. Oncogene 1998, 16:3219-3225. 10.1038/sj.onc.1201872, 9681819.
28. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res 2002, 30:e47. 10.1093/nar/30.10.e47, 115301, 12000852.
29. Jungst C, Cheng B, Gehrke R, Schmitz V, Nischalke HD, Ramakers J, Schramel P, Schirmacher P, Sauerbruch T, Caselmann WH. Oxidative DNA damage is increased in human liver tissue adjacent to hepatocellular carcinoma. Hepatology 2004, 39:1663-1672. 10.1002/hep.20241, 15185308.
30. Obtulowicz T, Swoboda M, Speina E, Gackowski D, Rozalski R, Siomek A, Janik J, Janowska B, Ciesla JM, Jawien A, Banaszkiewicz Z, Guz J, Dziaman T, Szpila A, Olinski R, Tudek B. Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients. Mutagenesis 2010, 25:463-471. 10.1093/mutage/geq028, 20534734.
31. Yuan W, Xu L, Feng Y, Yang Y, Chen W, Wang J, Pang D, Li D. The hOGG1 Ser326Cys polymorphism and breast cancer risk: a meta-analysis. Breast Cancer Res Treat 2010, 122:835-842. 10.1007/s10549-009-0722-5, 20058067.
32. Farinati F, Cardin R, Bortolami M, Nitti D, Basso D, de Bernard M, Cassaro M, Sergio A, Rugge M. Oxidative DNA damage in gastric cancer: CagA status and OGG1 gene polymorphism. Int J Cancer 2008, 123:51-55. 10.1002/ijc.23473, 18366059.
33. Mitra S, Boldogh I, Izumi T, Hazra TK. Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage. Environ Mol Mutagen 2001, 38:180-190. 10.1002/em.1070, 11746753.
34. Liu DY, Peng ZH, Qiu GQ, Zhou CZ. Expression of telomerase activity and oxidative stress in human hepatocellular carcinoma with cirrhosis. World J Gastroenterol 2003, 9:1859-1862.
35. Saini N, Srinivasan R, Chawla Y, Sharma S, Chakraborti A, Rajwanshi A. Telomerase activity, telomere length and human telomerase reverse transcriptase expression in hepatocellular carcinoma is independent of hepatitis virus status. Liver Int 2009, 29:1162-1170. 10.1111/j.1478-3231.2009.02082.x, 19627485.
36. Ozturk M, Arslan-Ergul A, Bagislar S, Senturk S, Yuzugullu H. Senescence and immortality in hepatocellular carcinoma. Cancer Lett 2009, 286:103-113. 10.1016/j.canlet.2008.10.048, 19070423.
37. Jiang J, Gusev Y, Aderca I, Mettler TA, Nagorney DM, Brackett DJ, Roberts LR, Schmittgen TD. Association of MicroRNA Expression in Hepatocellular Carcinomas with Hepatitis Infection, Cirrhosis and Patient Survival. Clin Cancer Res 2008, 14:419-427. 10.1158/1078-0432.CCR-07-0523, 2755230, 18223217.
38. Budhu A, Jia H-L, Forgues M, Liu C-G, Goldstein D, Lam A, Zanetti KA, Ye Q-H, Qin L-X, Croce CM, Tang Z-Y, Wang XW. Identification of Metastasis- Related MicroRNAs in Hepatocellular Carcinoma. Hepatology 2008, 47:897-907. 10.1002/hep.22160, 18176954.
39. Nam EJ, Yoon H, Kim SW, Kim H, Kim YT, Kim JH, Kim JW, Kim S. MicroRNA expression profiles in serous ovarian carcinoma. Clin Cancer Res 2008, 14:2690-2695. 10.1158/1078-0432.CCR-07-1731, 18451233.
40. Ichimi T, Enokida H, Okuno Y, Kunimoto R, Chiyomaru T, Kawamoto K, Kawahara K, Toki K, Kawakami K, Nishiyama K, Tsujimoto G, Nakagawa M, Seki N. Identification of novel microRNA targets based on microRNA signatures in bladder cancer. Int J Cancer 2009, 125:345-352. 10.1002/ijc.24390, 19378336.
41. Song B, Ju J. Impact of miRNAs in gastrointestinal cancer diagnosis and prognosis. Expert Rev Mol Med 2010, 12:e33.
42. Petrocca F, Vecchione A, Croce CM. Emerging Role of miR-106b-25/miR-17-92 Clusters in the Control of Transforming Growth Factor β Signaling. Cancer Res 2008, 68:8191-8194. 10.1158/0008-5472.CAN-08-1768, 18922889.
43. Manni I, Artuso S, Careccia S, Rizzo MG, Baserga R, Piaggio G, Sacchi A. The micro RNA miR-92 increases proliferation of myeloid cells and by targeting p63 modulates the abundance of its isoforms. FASEB J 2009, 23:3957-3966. 10.1096/fj.09-131847, 19608627.
44. Garofalo M, Croce CM. MicroRNAs: Master Regulators as Potential Therapeutics in Cancer. Annu Rev Pharmacol Toxicol 2011, 51:25-43. 10.1146/annurev-pharmtox-010510-100517, 20809797.
45. Lin YW, Sheu JC, Liu LY, Chen CH, Lee HS, Huang GT, Wang JT, Lee PH, Lu FJ. Loss of heterozygosity at chromosome 13q in hepatocellular carcinoma: identification of three independent regions. Eur J Cancer 1999, 35:1730-1734. 10.1016/S0959-8049(99)00205-1, 10674021.
46. Zhang L, Huang J, Yang N, Greshock J, Megraw MS, Giannakakis A, Liang S, Naylor TL, Barchetti A, Ward MR, Yao G, Medina A, O'brien-Jenkins A, Katsaros D, Hatzigeorgiou A, Gimotty PA, Weber BL, Coukos G. MicroRNAs exhibit high frequency genomic alterations in human cancer. Proc Natl Acad Sci USA 2006, 103:9136-9141. 10.1073/pnas.0508889103, 1474008, 16754881.
47. Mendell JT. Myriad roles for the miR-17-92 cluster in development and disease. Cell 2008, 133:217-222. 10.1016/j.cell.2008.04.001, 2732113, 18423194.
48. Hossain A, Kuo MT, Saunders GF. Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA. Mol Cell Biol 2006, 26:8191-8201. 10.1128/MCB.00242-06, 1636750, 16940181.
49. Li G, Luna C, Qiu J, Epstein DL, Gonzalez P. Alteration in miRNA expression in stress-induced cellular senescence. Mech Ageing Dev 2009, 130:731-741. 10.1016/j.mad.2009.09.002, 2795064, 19782699.
50. Babar IA, Slack FJ, Weidhaas JB. miRNA modulation of the cellular stress response. Future Oncol 2008, 4:289-298. 10.2217/14796694.4.2.289, 18407740.
51. Danial NN. BAD: undertaker by night, candyman by day. Oncogene 2009, 27:S53-S70.