-
1
-
-
0003564810
-
-
Sexually transmitted diseases treatment guidelines, (ac-cessed 2010 Sep 1)
-
Sexually transmitted diseases treatment guidelines, 2010: hepatitis C. Centers for Disease Control and Prevention. http://www.cdc.gov (ac-cessed 2010 Sep 1).
-
(2010)
Centers For Disease Control and Prevention
-
-
Hepatitis, C.1
-
3
-
-
65449136656
-
Diagnosis, management, and treatment of hepatitis C: An update
-
DOI 10.1002/hep.22759
-
Ghany MG, Strader DB, Thomas DL, Seeff LB. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 2009;49:1335-74. DOI 10.1002/hep.22759
-
(2009)
Hepatology
, vol.49
, pp. 1335-1374
-
-
Ghany, M.G.1
Strader, D.B.2
Thomas, D.L.3
Seeff, L.B.4
-
4
-
-
33845441692
-
Hepatitis C virus and liver transplantation
-
DOI 10.1016/j.cld.2006.08.012
-
Verna EC, Brown RS Jr. Hepatitis C virus and liver transplantation. Clin Liver Dis 2006;10:919-40. DOI 10.1016/j.cld.2006.08.012
-
(2006)
Clin Liver Dis
, vol.10
, pp. 919-940
-
-
Verna, E.C.1
Brown Jr., R.S.2
-
5
-
-
0037179698
-
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
-
DOI 10.1056/NEJMoa020047
-
Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002;347: 975-82. DOI 10.1056/NEJMoa020047
-
(2002)
N Engl J Med
, vol.347
, pp. 975-982
-
-
Fried, M.W.1
Shiffman, M.L.2
Reddy, K.R.3
-
6
-
-
0035934568
-
Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
-
DOI 10.1016/S0140-6736(01)06102-5
-
Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001;358: 958-65. DOI 10.1016/S0140-6736(01)06102-5
-
(2001)
Lancet
, vol.358
, pp. 958-965
-
-
Manns, M.P.1
McHutchison, J.G.2
Gordon, S.C.3
-
7
-
-
77953207214
-
Specifically targeted anti-viral therapy for hepatitis C-a new era in therapy
-
DOI 10.1111/j.1365-2036.2010.04317.x
-
Lange CM, Sarrazin C, Zeuzem S. Specifically targeted anti-viral therapy for hepatitis C-a new era in therapy. Aliment Pharmacol Ther 2010; 32:14-28. DOI 10.1111/j.1365-2036.2010.04317.x
-
(2010)
Aliment Pharmacol The
, vol.32
, pp. 14-28
-
-
Lange, C.M.1
Sarrazin, C.2
Zeuzem, S.3
-
9
-
-
33644639990
-
SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells
-
DOI 10.1128/AAC.50.3.1013-1020.2006
-
Malcolm BA, Liu R, Lahser F, et al. SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells. Antimicrob Agents Chemother 2006;50:1013-20. DOI 10.1128/AAC.50.3.1013-1020.2006
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 1013-1020
-
-
Malcolm, B.A.1
Liu, R.2
Lahser, F.3
-
10
-
-
23944485662
-
Evasion of intracellular host defence by hepatitis C virus
-
DOI 10.1038/nature04078
-
Gale M Jr, Foy EM. Evasion of intracellular host defence by hepatitis C virus. Nature 2005;436:939-45. DOI 10.1038/nature04078
-
(2005)
Nature
, vol.436
, pp. 939-945
-
-
Gale Jr., M.1
Foy, E.M.2
-
11
-
-
14544280209
-
Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF
-
DOI 10.1073/pnas.0408824102
-
Li, K, Foy E, Ferreon JC, et al. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A 2005;102:2992-7. DOI 10.1073/pnas.0408824102
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 2992-2997
-
-
Li, K.1
Foy, E.2
Ferreon, J.C.3
-
12
-
-
42349087382
-
Single dose pharmacokinetics of a novel hepatitis C protease inhibitor, SCH 503034, in an oral capsule formulation (abstract 862)
-
Presented at: 56th Annual Meeting of the American Association for the Study of Liver Diseases. San Francisco. DOI 10.1002/hep.20926
-
Zhang J, Gupta S, Rouzier R, Calzetta A, Cutler D. Single dose pharmacokinetics of a novel hepatitis C protease inhibitor, SCH 503034, in an oral capsule formulation (abstract 862). Presented at: 56th Annual Meeting of the American Association for the Study of Liver Diseases. San Francisco: Hepatology 2005;42:535A. DOI 10.1002/hep.20926
-
(2005)
Hepatology
, vol.42
-
-
Zhang, J.1
Gupta, S.2
Rouzier, R.3
Calzetta, A.4
Cutler, D.5
-
13
-
-
30344485556
-
Anti-viral activity of SCH 503034, a HCV protease inhibitor, administered as monotherapy in hepatitis C genotype-1 (HCV-1) patients refractory to pegylated interferon (PEG-IFN-α) (abstract 94)
-
Presented at: 56th Annual Meeting of the American Association for the Study of Liver Diseases. San Francisco:, DOI 10.1002/hep.20923
-
Zeuzem S, Sarrazin C, Rouzier R, et al. Anti-viral activity of SCH 503034, a HCV protease inhibitor, administered as monotherapy in hepatitis C genotype-1 (HCV-1) patients refractory to pegylated interferon (PEG-IFN-α) (abstract 94). Presented at: 56th Annual Meeting of the American Association for the Study of Liver Diseases. San Francisco: Hepatology 2005;42:233A-4A. DOI 10.1002/hep.20923
-
(2005)
Hepatology
, vol.42
-
-
Zeuzem, S.1
Sarrazin, C.2
Rouzier, R.3
-
14
-
-
33644758023
-
Combination therapy with the HCV protease inhibitor, SCH 503034, plus peg-intron in hepatitis C genotype-1 peg-intron non-responders: Phase IB results (abstract 201)
-
Presented at: 56th Annual Meeting of the American Association for the Study of Liver Diseases. San Francisco, DOI 10.1002/hep.20923
-
Zeuzem S, Sarrazin C, Wagner F, et al. Combination therapy with the HCV protease inhibitor, SCH 503034, plus peg-intron in hepatitis C genotype-1 peg-intron non-responders: Phase IB results (abstract 201). Presented at: 56th Annual Meeting of the American Association for the Study of Liver Diseases. San Francisco: Hepatology 2005;42:276A-7A. DOI 10.1002/hep.20923
-
(2005)
Hepatology
, vol.42
-
-
Zeuzem, S.1
Sarrazin, C.2
Wagner, F.3
-
15
-
-
34247205808
-
SCH 503034, a novel hepatitis C virus protease inhibitor, plus pegylated interferon alpha-2b for genotype 1 nonresponders
-
DOI 10.1053/j.gastro.2007.01.041
-
Sarrazin C, Rouzier R, Wagner F, et al. SCH 503034, a novel hepatitis C virus protease inhibitor, plus pegylated interferon alpha-2b for genotype 1 nonresponders. Gastroenterology 2007;132:1270-8. DOI 10.1053/j.gastro.2007.01.041
-
(2007)
Gastroenterology
, vol.132
, pp. 1270-1278
-
-
Sarrazin, C.1
Rouzier, R.2
Wagner, F.3
-
16
-
-
80052493106
-
SCH 503034, an oral HCV protease inhibitor, is well-tolerated in patients with varying degrees of hepatic im-pairment (abstract 545)
-
Presented at: 42nd Annual Meeting of the European Association for the Study of the Liver. Barcelona, 2007:S207., DOI 10.1016/S0168-8278(07)62143-6
-
Preston, R, Alonso, A, Feely, W, et al. SCH 503034, an oral HCV protease inhibitor, is well-tolerated in patients with varying degrees of hepatic im-pairment (abstract 545). Presented at: 42nd Annual Meeting of the European Association for the Study of the Liver. Barcelona, 2007:S207. Hepatology 2007;46:S207 DOI 10.1016/S0168-8278(07)62143-6.
-
(2007)
Hepatology
, vol.46
-
-
Preston, R.1
Alonso, A.2
Feely, W.3
-
18
-
-
79951868202
-
Characterization of human liver enzymes involved in the biotransformation of boceprevir, a hepatitis C virus protease inhibitor
-
DOI 10.1124/dmd.110.036996
-
Ghosal A, Yuan Y, Tong W, et al. Characterization of human liver enzymes involved in the biotransformation of boceprevir, a hepatitis C virus protease inhibitor. Drug Metab Dispos 2011;39:510-21.DOI 10.1124/dmd.110.036996
-
(2011)
Drug Metab Dispos
, vol.39
, pp. 510-521
-
-
Ghosal, A.1
Yuan, Y.2
Tong, W.3
-
19
-
-
79953173221
-
Boceprevir for untreated chronic HCV genotype 1 infection
-
DOI 10.1056/NEJMoa1010494
-
Poordad F, McCone J Jr, Bacon BR, et al. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med 2011;364:1195-206. DOI 10.1056/NEJMoa1010494
-
(2011)
N Engl J Med
, vol.364
, pp. 1195-1206
-
-
Poordad, F.1
McCone Jr., J.2
Bacon, B.R.3
-
20
-
-
79953176289
-
Boceprevir for previously treated chronic HCV genotype 1 infection
-
DOI 10.1056/NEJMoa1009482
-
Bacon BR, Gordon SC, Lawitz E, et al. Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med 2011;364:1207-17. DOI 10.1056/NEJMoa1009482
-
(2011)
N Engl J Med
, vol.364
, pp. 1207-1217
-
-
Bacon, B.R.1
Gordon, S.C.2
Lawitz, E.3
-
22
-
-
77956268467
-
Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): An open-label, randomised, multicentre phase 2 trial
-
DOI 10.1016/S0140-6736(10)60934-8
-
Kwo, PY, Lawitz EJ, McCone J, et al. Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial. Lancet 2010;376:705-16. DOI 10.1016/S0140-6736(10)60934-8
-
(2010)
Lancet
, vol.376
, pp. 705-716
-
-
Kwo, P.Y.1
Lawitz, E.J.2
McCone, J.3
-
25
-
-
65449152185
-
Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection
-
DOI 10.1056/NEJMoa0806104
-
McHutchison JG, Everson GT, Gordon SC, et al. Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N Engl J Med 2009;360:1827-38. DOI 10.1056/NEJMoa0806104
-
(2009)
N Engl J Med
, vol.360
, pp. 1827-1838
-
-
McHutchison, J.G.1
Everson, G.T.2
Gordon, S.C.3
-
26
-
-
65449171953
-
Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
-
DOI 10.1056/NEJMoa0807650
-
Hezode, C, Forestier, N, Dusheiko, G, et al. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med 2009;360:1839-50. DOI 10.1056/NEJMoa0807650
-
(2009)
N Engl J Med
, vol.360
, pp. 1839-1850
-
-
Hezode, C.1
Forestier, N.2
Dusheiko, G.3
-
27
-
-
0036788338
-
Adherence to combination therapy enhances sustained response in genotype-1-infected patients with chronic hepatitis C
-
DOI 10.1053/gast.2002.35950
-
McHutchison JG, Manns M, Patel K, et al. Adherence to combination therapy enhances sustained response in genotype-1-infected patients with chronic hepatitis C. Gastroenterology 2002;123:1061-9. DOI 10.1053/gast.2002.35950
-
(2002)
Gastroenterology
, vol.123
, pp. 1061-1069
-
-
McHutchison, J.G.1
Manns, M.2
Patel, K.3
-
28
-
-
53049089301
-
Analysis of HCV resistance mutations during combination therapy with protease inhibitor boceprevir and PEG-IFN alpha-2b using TaqMan mismatch amplification mutation assay
-
DOI 10.1016/j.jviromet.2008.07.020
-
Curry S, Qiu P, Tong X. Analysis of HCV resistance mutations during combination therapy with protease inhibitor boceprevir and PEG-IFN alpha-2b using TaqMan mismatch amplification mutation assay. J Virol Methods 2008;153:156-62. DOI 10.1016/j.jviromet.2008.07.020
-
(2008)
J Virol Methods
, vol.153
, pp. 156-162
-
-
Curry, S.1
Qiu, P.2
Tong, X.3
-
29
-
-
73149113353
-
Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients
-
DOI 10.1002/hep.23192
-
Susser, S, Welsch, C, Wang, Y, et al. Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients. Hepatology 2009;50:1709-18. DOI 10.1002/hep.23192
-
(2009)
Hepatology
, vol.50
, pp. 1709-1718
-
-
Susser, S.1
Welsch, C.2
Wang, Y.3
-
30
-
-
33646036163
-
Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034
-
DOI 10.1016/j.antiviral.2005.12.003
-
Tong X, Chase R, Skelton A, Chen T, Wright-Minogue J, Malcolm BA. Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034. Antiviral Res 2006;70:28-38. DOI 10.1016/j.antiviral.2005.12.003
-
(2006)
Antiviral Res
, vol.70
, pp. 28-38
-
-
Tong, X.1
Chase, R.2
Skelton, A.3
Chen, T.4
Wright-Minogue, J.5
Malcolm, B.A.6
-
31
-
-
80052443804
-
-
(abStract 22). Presented at: International HIV & Hepatitis Virus Drug Resistance Workshop & Curative Strategies, Dubrovnik, Croatia
-
Ralston R, Vierling J, Lawitz E, et al. Long-term follow-up of patients treated with boceprevir in combination with PEG-Intron/ribavirin (P/R): durability of responses and rates of reversion of resistance mutations (abstract 22). Presented at: International HIV & Hepatitis Virus Drug Resistance Workshop & Curative Strategies, Dubrovnik, Croatia, 2010.
-
(2010)
Long-term Follow-up of Patients Treated With Boceprevir In Combination With PEG-Intron/ribavirin (P/R): Durability of Responses and Rates of Reversion of Resistance Mutations
-
-
Ralston, R.1
Vierling, J.2
Lawitz, E.3
|