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Volumn 45, Issue 9, 2011, Pages 1085-1093

Boceprevir: A protease inhibitor for the treatment of chronic hepatitis C;Boceprevir: Un inhibidor de proteasa para el tratamiento de hepatitis C crónica

Author keywords

Boceprevir; Hepatitis C virus; SCH 503034; Victrelis

Indexed keywords

BOCEPREVIR; ERYTHROPOIETIN; PEGINTERFERON ALPHA2B; PLACEBO; PROTEINASE INHIBITOR; RIBAVIRIN; VIRUS RNA;

EID: 80052456662     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1P744     Document Type: Review
Times cited : (32)

References (31)
  • 1
    • 0003564810 scopus 로고    scopus 로고
    • Sexually transmitted diseases treatment guidelines, (ac-cessed 2010 Sep 1)
    • Sexually transmitted diseases treatment guidelines, 2010: hepatitis C. Centers for Disease Control and Prevention. http://www.cdc.gov (ac-cessed 2010 Sep 1).
    • (2010) Centers For Disease Control and Prevention
    • Hepatitis, C.1
  • 3
    • 65449136656 scopus 로고    scopus 로고
    • Diagnosis, management, and treatment of hepatitis C: An update
    • DOI 10.1002/hep.22759
    • Ghany MG, Strader DB, Thomas DL, Seeff LB. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 2009;49:1335-74. DOI 10.1002/hep.22759
    • (2009) Hepatology , vol.49 , pp. 1335-1374
    • Ghany, M.G.1    Strader, D.B.2    Thomas, D.L.3    Seeff, L.B.4
  • 4
    • 33845441692 scopus 로고    scopus 로고
    • Hepatitis C virus and liver transplantation
    • DOI 10.1016/j.cld.2006.08.012
    • Verna EC, Brown RS Jr. Hepatitis C virus and liver transplantation. Clin Liver Dis 2006;10:919-40. DOI 10.1016/j.cld.2006.08.012
    • (2006) Clin Liver Dis , vol.10 , pp. 919-940
    • Verna, E.C.1    Brown Jr., R.S.2
  • 5
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • DOI 10.1056/NEJMoa020047
    • Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002;347: 975-82. DOI 10.1056/NEJMoa020047
    • (2002) N Engl J Med , vol.347 , pp. 975-982
    • Fried, M.W.1    Shiffman, M.L.2    Reddy, K.R.3
  • 6
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • DOI 10.1016/S0140-6736(01)06102-5
    • Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001;358: 958-65. DOI 10.1016/S0140-6736(01)06102-5
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3
  • 7
    • 77953207214 scopus 로고    scopus 로고
    • Specifically targeted anti-viral therapy for hepatitis C-a new era in therapy
    • DOI 10.1111/j.1365-2036.2010.04317.x
    • Lange CM, Sarrazin C, Zeuzem S. Specifically targeted anti-viral therapy for hepatitis C-a new era in therapy. Aliment Pharmacol Ther 2010; 32:14-28. DOI 10.1111/j.1365-2036.2010.04317.x
    • (2010) Aliment Pharmacol The , vol.32 , pp. 14-28
    • Lange, C.M.1    Sarrazin, C.2    Zeuzem, S.3
  • 9
    • 33644639990 scopus 로고    scopus 로고
    • SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells
    • DOI 10.1128/AAC.50.3.1013-1020.2006
    • Malcolm BA, Liu R, Lahser F, et al. SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells. Antimicrob Agents Chemother 2006;50:1013-20. DOI 10.1128/AAC.50.3.1013-1020.2006
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 1013-1020
    • Malcolm, B.A.1    Liu, R.2    Lahser, F.3
  • 10
    • 23944485662 scopus 로고    scopus 로고
    • Evasion of intracellular host defence by hepatitis C virus
    • DOI 10.1038/nature04078
    • Gale M Jr, Foy EM. Evasion of intracellular host defence by hepatitis C virus. Nature 2005;436:939-45. DOI 10.1038/nature04078
    • (2005) Nature , vol.436 , pp. 939-945
    • Gale Jr., M.1    Foy, E.M.2
  • 11
    • 14544280209 scopus 로고    scopus 로고
    • Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF
    • DOI 10.1073/pnas.0408824102
    • Li, K, Foy E, Ferreon JC, et al. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A 2005;102:2992-7. DOI 10.1073/pnas.0408824102
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 2992-2997
    • Li, K.1    Foy, E.2    Ferreon, J.C.3
  • 12
    • 42349087382 scopus 로고    scopus 로고
    • Single dose pharmacokinetics of a novel hepatitis C protease inhibitor, SCH 503034, in an oral capsule formulation (abstract 862)
    • Presented at: 56th Annual Meeting of the American Association for the Study of Liver Diseases. San Francisco. DOI 10.1002/hep.20926
    • Zhang J, Gupta S, Rouzier R, Calzetta A, Cutler D. Single dose pharmacokinetics of a novel hepatitis C protease inhibitor, SCH 503034, in an oral capsule formulation (abstract 862). Presented at: 56th Annual Meeting of the American Association for the Study of Liver Diseases. San Francisco: Hepatology 2005;42:535A. DOI 10.1002/hep.20926
    • (2005) Hepatology , vol.42
    • Zhang, J.1    Gupta, S.2    Rouzier, R.3    Calzetta, A.4    Cutler, D.5
  • 13
    • 30344485556 scopus 로고    scopus 로고
    • Anti-viral activity of SCH 503034, a HCV protease inhibitor, administered as monotherapy in hepatitis C genotype-1 (HCV-1) patients refractory to pegylated interferon (PEG-IFN-α) (abstract 94)
    • Presented at: 56th Annual Meeting of the American Association for the Study of Liver Diseases. San Francisco:, DOI 10.1002/hep.20923
    • Zeuzem S, Sarrazin C, Rouzier R, et al. Anti-viral activity of SCH 503034, a HCV protease inhibitor, administered as monotherapy in hepatitis C genotype-1 (HCV-1) patients refractory to pegylated interferon (PEG-IFN-α) (abstract 94). Presented at: 56th Annual Meeting of the American Association for the Study of Liver Diseases. San Francisco: Hepatology 2005;42:233A-4A. DOI 10.1002/hep.20923
    • (2005) Hepatology , vol.42
    • Zeuzem, S.1    Sarrazin, C.2    Rouzier, R.3
  • 14
    • 33644758023 scopus 로고    scopus 로고
    • Combination therapy with the HCV protease inhibitor, SCH 503034, plus peg-intron in hepatitis C genotype-1 peg-intron non-responders: Phase IB results (abstract 201)
    • Presented at: 56th Annual Meeting of the American Association for the Study of Liver Diseases. San Francisco, DOI 10.1002/hep.20923
    • Zeuzem S, Sarrazin C, Wagner F, et al. Combination therapy with the HCV protease inhibitor, SCH 503034, plus peg-intron in hepatitis C genotype-1 peg-intron non-responders: Phase IB results (abstract 201). Presented at: 56th Annual Meeting of the American Association for the Study of Liver Diseases. San Francisco: Hepatology 2005;42:276A-7A. DOI 10.1002/hep.20923
    • (2005) Hepatology , vol.42
    • Zeuzem, S.1    Sarrazin, C.2    Wagner, F.3
  • 15
    • 34247205808 scopus 로고    scopus 로고
    • SCH 503034, a novel hepatitis C virus protease inhibitor, plus pegylated interferon alpha-2b for genotype 1 nonresponders
    • DOI 10.1053/j.gastro.2007.01.041
    • Sarrazin C, Rouzier R, Wagner F, et al. SCH 503034, a novel hepatitis C virus protease inhibitor, plus pegylated interferon alpha-2b for genotype 1 nonresponders. Gastroenterology 2007;132:1270-8. DOI 10.1053/j.gastro.2007.01.041
    • (2007) Gastroenterology , vol.132 , pp. 1270-1278
    • Sarrazin, C.1    Rouzier, R.2    Wagner, F.3
  • 16
    • 80052493106 scopus 로고    scopus 로고
    • SCH 503034, an oral HCV protease inhibitor, is well-tolerated in patients with varying degrees of hepatic im-pairment (abstract 545)
    • Presented at: 42nd Annual Meeting of the European Association for the Study of the Liver. Barcelona, 2007:S207., DOI 10.1016/S0168-8278(07)62143-6
    • Preston, R, Alonso, A, Feely, W, et al. SCH 503034, an oral HCV protease inhibitor, is well-tolerated in patients with varying degrees of hepatic im-pairment (abstract 545). Presented at: 42nd Annual Meeting of the European Association for the Study of the Liver. Barcelona, 2007:S207. Hepatology 2007;46:S207 DOI 10.1016/S0168-8278(07)62143-6.
    • (2007) Hepatology , vol.46
    • Preston, R.1    Alonso, A.2    Feely, W.3
  • 18
    • 79951868202 scopus 로고    scopus 로고
    • Characterization of human liver enzymes involved in the biotransformation of boceprevir, a hepatitis C virus protease inhibitor
    • DOI 10.1124/dmd.110.036996
    • Ghosal A, Yuan Y, Tong W, et al. Characterization of human liver enzymes involved in the biotransformation of boceprevir, a hepatitis C virus protease inhibitor. Drug Metab Dispos 2011;39:510-21.DOI 10.1124/dmd.110.036996
    • (2011) Drug Metab Dispos , vol.39 , pp. 510-521
    • Ghosal, A.1    Yuan, Y.2    Tong, W.3
  • 19
    • 79953173221 scopus 로고    scopus 로고
    • Boceprevir for untreated chronic HCV genotype 1 infection
    • DOI 10.1056/NEJMoa1010494
    • Poordad F, McCone J Jr, Bacon BR, et al. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med 2011;364:1195-206. DOI 10.1056/NEJMoa1010494
    • (2011) N Engl J Med , vol.364 , pp. 1195-1206
    • Poordad, F.1    McCone Jr., J.2    Bacon, B.R.3
  • 20
    • 79953176289 scopus 로고    scopus 로고
    • Boceprevir for previously treated chronic HCV genotype 1 infection
    • DOI 10.1056/NEJMoa1009482
    • Bacon BR, Gordon SC, Lawitz E, et al. Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med 2011;364:1207-17. DOI 10.1056/NEJMoa1009482
    • (2011) N Engl J Med , vol.364 , pp. 1207-1217
    • Bacon, B.R.1    Gordon, S.C.2    Lawitz, E.3
  • 22
    • 77956268467 scopus 로고    scopus 로고
    • Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): An open-label, randomised, multicentre phase 2 trial
    • DOI 10.1016/S0140-6736(10)60934-8
    • Kwo, PY, Lawitz EJ, McCone J, et al. Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial. Lancet 2010;376:705-16. DOI 10.1016/S0140-6736(10)60934-8
    • (2010) Lancet , vol.376 , pp. 705-716
    • Kwo, P.Y.1    Lawitz, E.J.2    McCone, J.3
  • 25
    • 65449152185 scopus 로고    scopus 로고
    • Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection
    • DOI 10.1056/NEJMoa0806104
    • McHutchison JG, Everson GT, Gordon SC, et al. Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N Engl J Med 2009;360:1827-38. DOI 10.1056/NEJMoa0806104
    • (2009) N Engl J Med , vol.360 , pp. 1827-1838
    • McHutchison, J.G.1    Everson, G.T.2    Gordon, S.C.3
  • 26
    • 65449171953 scopus 로고    scopus 로고
    • Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
    • DOI 10.1056/NEJMoa0807650
    • Hezode, C, Forestier, N, Dusheiko, G, et al. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med 2009;360:1839-50. DOI 10.1056/NEJMoa0807650
    • (2009) N Engl J Med , vol.360 , pp. 1839-1850
    • Hezode, C.1    Forestier, N.2    Dusheiko, G.3
  • 27
    • 0036788338 scopus 로고    scopus 로고
    • Adherence to combination therapy enhances sustained response in genotype-1-infected patients with chronic hepatitis C
    • DOI 10.1053/gast.2002.35950
    • McHutchison JG, Manns M, Patel K, et al. Adherence to combination therapy enhances sustained response in genotype-1-infected patients with chronic hepatitis C. Gastroenterology 2002;123:1061-9. DOI 10.1053/gast.2002.35950
    • (2002) Gastroenterology , vol.123 , pp. 1061-1069
    • McHutchison, J.G.1    Manns, M.2    Patel, K.3
  • 28
    • 53049089301 scopus 로고    scopus 로고
    • Analysis of HCV resistance mutations during combination therapy with protease inhibitor boceprevir and PEG-IFN alpha-2b using TaqMan mismatch amplification mutation assay
    • DOI 10.1016/j.jviromet.2008.07.020
    • Curry S, Qiu P, Tong X. Analysis of HCV resistance mutations during combination therapy with protease inhibitor boceprevir and PEG-IFN alpha-2b using TaqMan mismatch amplification mutation assay. J Virol Methods 2008;153:156-62. DOI 10.1016/j.jviromet.2008.07.020
    • (2008) J Virol Methods , vol.153 , pp. 156-162
    • Curry, S.1    Qiu, P.2    Tong, X.3
  • 29
    • 73149113353 scopus 로고    scopus 로고
    • Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients
    • DOI 10.1002/hep.23192
    • Susser, S, Welsch, C, Wang, Y, et al. Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients. Hepatology 2009;50:1709-18. DOI 10.1002/hep.23192
    • (2009) Hepatology , vol.50 , pp. 1709-1718
    • Susser, S.1    Welsch, C.2    Wang, Y.3
  • 30
    • 33646036163 scopus 로고    scopus 로고
    • Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034
    • DOI 10.1016/j.antiviral.2005.12.003
    • Tong X, Chase R, Skelton A, Chen T, Wright-Minogue J, Malcolm BA. Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034. Antiviral Res 2006;70:28-38. DOI 10.1016/j.antiviral.2005.12.003
    • (2006) Antiviral Res , vol.70 , pp. 28-38
    • Tong, X.1    Chase, R.2    Skelton, A.3    Chen, T.4    Wright-Minogue, J.5    Malcolm, B.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.